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All Journal Jurnal Tumbuhan Obat Indonesia Journal of the Medical Sciences (Berkala Ilmu Kedokteran) e-Journal Pustaka Kesehatan Pharmaciana: Jurnal Kefarmasian Jurnal Pengembangan Pendidikan Jurnal Riset Kimia UNEJ e-Proceeding JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurdimas (Jurnal Pengabdian Kepada Masyarakat) Royal Jurnal Ilmu Kefarmasian Indonesia Journal of Pharmaceutical Care Anwar Medika Berkala Penelitian Hayati Journal of Tropical Pharmacy and Chemistry
Mochammad Amrun Hidayat
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Pengaruh Metode Ekstraksi terhadap Kadar Fenol dan Flavonoid Total, Aktivitas Antioksidan serta Antilipase Daun Jati Belanda (Guazuma ulmifolia) Nuri Nuri; Endah Puspitasari; Mochammad Amrun Hidayat; Indah Yulia Ningsih; Bawon Triatmoko; Dewi Dianasari
Jurnal Sains Farmasi & Klinis Vol 7, No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (917.154 KB) | DOI: 10.25077/jsfk.7.2.143-150.2020

Abstract

The leaf of Guazuma ulmifolia has been used traditionally for antiobesity. The activity of antiobesity was affected by the content of bioactive compounds. Extraction is the primary step to obtain bioactive compounds from plant material. The method and solvent used for extraction are crucial factors to produce extracts that have a high amount of active compounds. This study aims to determine the total phenolic and total flavonoids content from ethanolic extracts, water extract, and infusions of G. ulmifolia leaf and to evaluate the antioxidant and antilipase activity. Folin-Ciocalteu method was used to determine the phenolic content, while flavonoid content determination was done using aluminium chloride colorimetric assay. The antioxidant activity was done using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and the antilipase activity was quantified using p-nitrophenol release from p-nitrophenyl butyrate (p-NPB) substrate-colorimetric assay. The result of G. ulmifolia leaf extraction showed that the highest yield was obtained from water extraction (10.50%). Whereas, the ethanolic extract was showed the highest total phenolic content (67.761±1.811 mg GAE/g extract) and the highest total flavonoid content (124.643 ± 1.033 mg QE/g extract). The same extract also exhibited the highest antioxidant activity (IC50 = 6.544 ± 0.271 µg/mL) and antilipase activity (IC50 = 307.280 ± 21.430 µg/mL).
SKINCARE LEARNING YOUTH EDUCATION PROGRAM FOR KNOWLEDGE IMPROVEMENT AT SMA NEGERI 1 SUBOH SITUBONDO Ika Puspita Dewi; Diana Holidah; Mochammad Amrun Hidayat
UNEJ e-Proceeding 2022: E-Prosiding Kolokium Hasil Penelitian dan Pengabdian kepada Masyarakat
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Teenagers' lack of knowledge of cosmetics causes the risk of using dangerous or illegal products. Students at SMA Negeri 1 Suboh Situbondo have never received special material regarding the selection and use of beauty products. The outcome of this educational program is to increase the knowledge of SMA Negeri 1 Suboh students about how to use and choose the right and safe skincare. This program is carried out by offline method at SMA Negeri 1 Suboh Situbondo and online method with the Zoom Meeting. The materials given to students are various teenage skin problems, introduction to skincare ingredients, and choosing the right skincare. The results of the survey related to the skin characteristics of the participants showed that most of the skin types owned by students of SMA Negeri 1 Suboh were oily (38.09%), with most of them having skin problems (79.37%), and the majority problem was acne (42.68%), while 79.37% of participants had used skincare. The results of the post-test showed that the average score of the participants was 88.57, which indicates most of the participants had understood the materials given. This program has succeeded in providing information about the correct, appropriate, and safe use of skincare to the students of SMA Negeri 1 Suboh Situbondo. Keywords: knowledge, skincare, SMA Negeri 1 Suboh Situbondo, teenager
Effect of Robusta coffee extract gel on fibroblast and collagen during proliferative phase of IIB degree-burn on Long Evans rats Ulfa Elfiah; Muhammad Fahmi Naufal; Mochammad Amrun Hidayat
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 54, No 3 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005403202201

Abstract

IIB Degree-burn takes longer to heal because only a small epithelium component remains. It requires a topical agent that can accelerate the wound healing process. One of the wound healing signs is the increased collagen formation as an extracellular matrix produced by fibroblast in the proliferative phase. This study aimed to prove the effect of Robusta coffee extract gel as a topical agent on increasing the number of fibroblasts and collagen density in IIB degree-burn treatment on Long Evans rats. This study used 24 Long Evans rats which were divided into three groups, namely positive control (silver sulfadiazine), negative control (gel base), and treatment group (2.5% of Robusta coffee extract gel). The results showed a higher number of fibroblast (p<0.05) and a denser collagen density (p<0.05) of the Robusta coffee extract gel compared to the control group on day 8 and day 14. These results indicated that the number of fibroblasts and collagen increases that can scavenge free radicals and stimulate the release of cytokines that play a role in increasing fibroblast proliferation. Robusta coffee affects expanding the number of fibroblasts and collagen density to be an alternative topical agent of second-degree burns treatment.
Pengembangan Sensor Kimia Berbasis Kertas Untuk Penetapan Kadar Kafein Sampel Kopi Mochammad Amrun Hidayat; Noviani Tri Wahyuning; Indah Yulia Ningsih; Bambang Kuswandi
Jurnal Riset Kimia Vol. 14 No. 1 (2023): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v14i1.589

Abstract

The caffeine chemical sensor was developed by co-immobilizing sodium periodate (NaIO4), 3-methyl-2-benzothiazolinone hydrazone (MBTH), and acetic acid (CH3COOH) onto paper by using an adsorption technique. The addition of caffeine solution could change the color of the sensor from white to pale blue which can be then captured by using a flatbed scanner and quantified by the ImageJ program, known as a scanometric technique. Method validation such as linearity, LOD, LOQ, precision, and accuracy of the sensor was done by using caffeine standards. The result of caffeine analysis using the developed chemical sensor-scanometric method agreed with that of the spectrophotometric method, suggesting that the developed sensor with scanometric technique can be used as an alternative method for caffeine assay in coffee samples.
Pengembangan Sensor Antioksidan berbasis Kertas Zonamikro dengan Imobilisasi DPPH pada Sampel Ekstrak Tanaman Muhammad Fantoni; Indah Yulia Ningsih; Moch. Amrun Hidayat; Bambang Kuswandi
Pustaka Kesehatan Vol 11 No 2 (2023): Volume 11 No.2, 2023
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v11i2.12958

Abstract

Development of a paper-based antioxidant sensor using DPPH reagent. This sensor is made using a screen-printing method to create a 5 mm diameter detection zone which is immobilized with DPPH reagents. The analysis was carried out in one step by immobilizing antioxidants/samples in the detection zone. After reduction by antioxidants, DPPH radicals become stable DPPH molecules, resulting in a change in color from purple to pale yellow. The purple intensity of DPPH was inversely proportional to the antioxidant activity of the sample and was measured using the help of ImageJ software. The optimal conditions for using DPPH reagents at a concentration of 5 mM and the volume in each detection zone were 3 µL. Characterization of this sensor analysis was carried out on gallic acid with the response time in the 12-minute, linearity with r = 0,9895, detection limit (LOD) value 0,0349 mM GAE, the quantitation limit (LOQ) value was 0,1164 mM GAE, with precision <2% (RSD), and meets the accuracy range of 97-103%. This sensor is then validated against DPPH spectrophotometry UV-Vis by analyzing antioxidant activity from plant extracts. The results showed no significant differences for the gallic acid equivalent for all samples obtained from the two methods at a confidence level of 97-103%, indicating that the method developed could be relied upon to analyze antioxidant activity from real samples. Finally, the paper-based antioxidant sensor is known to be stable for three days when stored in the refrigerator (2- 4 °C), stable for 2 hours at room temperature (25ºC), and makes paper sensors easy to use for end users.
Pengaruh Pemberian Gel Ekstrak Kopi Robusta (Coffea canephora) Terhadap Gambaran Makroskopis dan Mikroskopis Luka Bakar Derajat IIB Pada Tikus Long Evans Ulfa Elfiah; Maidy Frista Rosanti; Fatimatuzzahra Fatimatuzzahra; Mochammad Amrun Hidayat
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 2 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i2.56152

Abstract

Perawatan luka bakar memerlukan penanganan khusus. Penggunaan sediaan obat topikal seperti silver sulfadiazine serta hydrocolloids yang berfungsi sebagai absorptive dressings merupakan salah satu prosedur terapi yang digunakan untuk mempercepat penyembuhan luka. Perawatan kasus luka bakar di Indonesia masih kurang optimal karena adanya pembatasan biaya perawatan oleh sistem jaminan kesehatan Indonesia, oleh karena itu, perlu adanya alternatif perawatan luka bakar dengan mengembangkan bahan-bahan herbal sebagai dressing topikal seperti ekstrak dari kopi. Tujuan dari penelitian ini ialah untuk membuktikan pengaruh pemberian gel ekstrak kopi robusta (Coffea canephora) terhadap gambaran makroskopis dan mikroskopis luka bakar derajat IIB pada tikus long evans. Metode penelitian yang digunakan adalah true experimental laboratories dengan rancangan post-test only control group design. Tikus sebanyak 24 ekor terbagi menjadi 3 kelompok perlakuan. Kelompok kontrol negatif yaitu diberi basis gel, kelompok positif diberi silver sulfadiazine, dan kelompok perlakuan diberi gel ekstrak kopi robusta 2,5%. Data luas luka bakar, perubahan intensitas warna, dan ketebalan epitel luka bakar yang telah diperoleh selanjutnya diuji secara statistik menggunakan One Way ANOVA maupun Kruskal-Wallis dan dilanjutkan dengan uji Post-Hoc. Hasil penelitian menunjukkan pada kelompok perlakuan terjadi penurunan luas makroskopis (p < 0,05), perbaikan intensitas warna (p < 0,05), dan peningkatan ketebalan epitel (p < 0,05) antara gel ekstrak kopi robusta dibandingkan dengan kelompok kelompok negatif. Kesimpulan penelitian ini adalah bahwa gel ekstrak kopi robusta (Coffea canephora) terbukti memberikan pengaruh terhadap penyembuhan luka baik secara makroskopis maupun mikroskopis sehingga gel ekstrak kopi dapat terus dikembangkan menjadi salah satu alternatif dressing dalam perawatan luka bakar.
Penyuluhan Dan Pelatihan Pengolahan Makanan Sehat Berbasis Kelor Dalam Rangka Penanganan Stunting Desa Maskuning Indah Yulia Ningsih; Ika Barokah Suryaningsih; Mochammad Amrun Hidayat
Jurdimas (Jurnal Pengabdian Kepada Masyarakat) Royal Vol 6, No 4 (2023): Oktober 2023
Publisher : STMIK Royal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33330/jurdimas.v6i4.2863

Abstract

Stunting is a health problem currently the government's primary concern because it affects the quality of human resources. One of the areas that is still being targeted for handling stunting is Maskuning Wetan Village, Pujer District, Bondowoso Regency, East Java, with 14.36% of stunting cases. Diet, including the food type, is important in managing stunting. Most mothers in this area have lack knowledge in healthy food processing. Therefore, in this service program, several steps to handle stunting related to healthy food processing were carried out through counselling and training activities. The main ingredient used is the Moringa plant, which is known in many countries to overcome malnutrition because it is rich in nutrients, obtained easily, and affordable. The activity program is hoped to support the government's efforts in reducing the prevalence of stunting in Maskuning Wetan Village.           Keywords: healthy food; moringa; stunting  Abstrak: Stunting merupakan masalah kesehatan yang menjadi perhatian utama pemerintah hingga saat ini karena berpengaruh pada kualitas sumber daya manusia. Salah satu daerah yang masih menjadi sasaran penanganan stunting adalah Desa Maskuning Wetan, Kecamatan Pujer, Kabupaten Bondowoso, Jawa Timur dengan kasus stunting sebanyak 14,36%. Pola makan termasuk jenis makanan berperan penting dalam penanganan stunting. Sebagian besar ibu di daerah tersebut masih banyak yang belum mengetahui cara pengolahan makanan sehat. Oleh karena itu, pada program pengabdian ini dilakukan beberapa langkah penanganan stunting terkait pengolahan makanan sehat berupa kegiatan penyuluhan dan pelatihan. Bahan utama yang digunakan adalah tanaman kelor yang telah dikenal di berbagai negara untuk mengatasi malnutrisi karena kaya akan kandungan nutrisi, mudah diperoleh, dan terjangkau. Dengan adanya program kegiatan ini diharapkan dapat mendukung upaya pemerintah dalam menurunkan prevalensi stunting di Desa Maskuning Wetan.Kata kunci: kelor; makanan sehat; stunting
Genistein Content and Tyrosinase Inhibitory Activity of Edamame (Glycine max) Extracts Indah Yulia Ningsih; Lisa Kusuma Wardhani; Annisa Ragdha Eka Nuryuanda; Endah Puspitasari; Mochammad Amrun Hidayat
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 2 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i2.461

Abstract

The study aimed to determine genistein content and tyrosinase inhibition activity of 70% ethanolic and ethyl acetate extracts of edamame (Glycine max) with an extraction time of 15, 30, and 60 minutes. Extraction was performed using the ultrasonication method. Determination of genistein content was carried out using TLC-densitometry. Furthermore, all samples were tested for their tyrosinase inhibition activity using the spectrophotometric assay. Ethyl acetate extract with 60 min of extraction time exhibited the highest extraction yield (6.414% w/w), the highest genistein content (0.169 ± 0.007% w/w), and the highest tyrosinase inhibition activity (IC50 = 72.420 ± 0.550 µg/mL). It was known that the genistein content of 70% ethanolic and ethyl acetate extracts affected tyrosinase inhibition activity with correlation coefficient (r) values of 0.9973 and 0.9826, respectively. G. max was suggested as a tyrosinase inhibitor agent from natural sources for skin whitening product development due to its isoflavones content, mainly genistein.
Pengaruh Metode Ekstraksi terhadap Kadar Fenol dan Flavonoid Total, Aktivitas Antioksidan serta Antilipase Daun Jati Belanda (Guazuma ulmifolia) Nuri, Nuri; Puspitasari, Endah; Hidayat, Mochammad Amrun; Ningsih, Indah Yulia; Triatmoko, Bawon; Dianasari, Dewi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.2.143-150.2020

Abstract

The leaf of Guazuma ulmifolia has been used traditionally for antiobesity. The activity of antiobesity was affected by the content of bioactive compounds. Extraction is the primary step to obtain bioactive compounds from plant material. The method and solvent used for extraction are crucial factors to produce extracts that have a high amount of active compounds. This study aims to determine the total phenolic and total flavonoids content from ethanolic extracts, water extract, and infusions of G. ulmifolia leaf and to evaluate the antioxidant and antilipase activity. Folin-Ciocalteu method was used to determine the phenolic content, while flavonoid content determination was done using aluminium chloride colorimetric assay. The antioxidant activity was done using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and the antilipase activity was quantified using p-nitrophenol release from p-nitrophenyl butyrate (p-NPB) substrate-colorimetric assay. The result of G. ulmifolia leaf extraction showed that the highest yield was obtained from water extraction (10.50%). Whereas, the ethanolic extract was showed the highest total phenolic content (67.761±1.811 mg GAE/g extract) and the highest total flavonoid content (124.643 ± 1.033 mg QE/g extract). The same extract also exhibited the highest antioxidant activity (IC50 = 6.544 ± 0.271 µg/mL) and antilipase activity (IC50 = 307.280 ± 21.430 µg/mL).
Ethnopharmacology study of medicinal plants utilization for antidiarrheal remedies by Tengger tribe in Tosari District, Indonesia Ningsih, Indah Yulia; Mandasari, Virda Fitra; Pratama, Antonius Nugraha Widhi; Hidayat, Mochammad Amrun
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.28099

Abstract

Tengger is one of the tribes in East Java Province, Indonesia practising traditional medicine by using mantras and medicinal plants. A disease with a high incidence rate and widely treated with medicinal plants in Indonesia, including in Tosari District, Pasuruan Regency, is diarrhoea. To conserve traditional medicine, mainly the utilization of medicinal plants as anti-diarrhoea agents, it is necessary to develop a database that keeps up with technological advances. The study aimed to determine medicinal plants utilization for antidiarrheal remedies by the Tengger tribe in four villages of Tosari District, Pasuruan Regency, namely Wonokitri, Tosari, Ngadiwono, and Podokoyo. The study employed the snowball sampling method, which involved conducting semi-structured interviews. The result showed nine medicinal plants for traditional antidiarrheal remedies, with Musaceae (23%) as the most widely used plant family. Most informants used immature plant (56.25%) and fruits (89.58%). In addition, most plants were administered orally (98%) without specific compounding methods (76%). The value of Factor of the informant's consensus (Fic) of plants used for diarrhoea was 0.74. The highest Fidelity Level (FL) and Choice Value (CV) were obtained from Elaeocarpus longifolius Blume at 69% and 2.4, respectively. Based on the findings of the study, E. longifolius has the potential to be further investigated for development in antidiarrheal treatment.
Co-Authors Afif Rifqie Maulana Annisa Ragdha Eka Nuryuanda Antonius Nugraha Widhi Pratama, Antonius Nugraha Widhi Bambang Kuswandi Bambang Kuswandi Bambang Kuswandi Bawon Triatmoko Dewi Dianasari Diana Holidah Dianasari, Dewi Endah Puspitasari Endah Puspitasari ESTIKA YUNINDARWATI Evi Umayah U Evi Umayah Ulfa Fatimatuz Zuhro Fatimatuzzahra Fatimatuzzahra Ika Barokah Suryaningsih Ika Puspita Dewi Indah Yulia Ningsih Indah Yulia Ningsih Lisa Kusuma Wardhani Maidy Frista Rosanti Mandasari, Virda Fitra Muhammad Fahmi Naufal Muhammad Fantoni Novi Prasetyaningrum Noviani Tri Wahyuning Nuri Nuri Nuri Nuri Oktavia Catur Xenograf Panida, Rahma Riska Putu Gita Maya Widyaswari Mahayasih Sari, Dewi Diana Seniarta, I Wayan TRI HANDOYO Ubaidillah Abdel Barsyaif Ulfa Elfiah Umiyah Umiyah Weka Sidha Bhagawan YUNITA