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All Journal Jurnal Tumbuhan Obat Indonesia Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Indonesian Journal of Chemical Science Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Jurnal SOLMA PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmiah Cendekia Eksakta Jurnal Abdi Insani Media Farmasi Indonesia Jurnal Farmasi Sains dan Praktis Jurnal Kefarmasian Indonesia Journal of Pharmascience
Devi Nisa Hidayati
Universitas Wahid Hasyim
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Antibacterial activity of ethanol extracts of hibiscus tiliaceus l. leaves from different extraction methods against Escherichia coli and Staphylococcus aureus Devi Nisa Hidayati; Hanik Rohmatul Maghfiroh; Aysah Safitri
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (584.316 KB) | DOI: 10.12928/pharmaciana.v13i1.24671

Abstract

The leaves of sea hibiscus (Hibiscus tiliaceus L.) are known to have good antibacterial activity against Escherichia coli and Staphylococcus aureus, which is associated with the saponin, flavonoid, polyphenol, and tannin contents. Chemical compounds in plant extracts are, however, influenced by the extraction method used. This study aimed to determine the antibacterial activity of the ethanol extracts of Hibiscus tiliaceus L. leaves obtained using four different extraction methods against E. coli and S. aureus. In the maceration, percolation, reflux, or Soxhlet method, 200 g of the crude drug (i.e., dried sea hibiscus leaf powder) was extracted with 96% ethanol, and the derived extract was tested at 1%, 2%, 3%, 4%, and 5% concentrations. The disk diffusion method was used to test the antibacterial activity by observing and statistically analyzing the diameter of the zones of inhibition. Results showed that all the ethanol extracts have antibacterial properties against E. coli and S. aureus,with the maceration-produced extract forming significantly different zones of inhibition from the other methods (percolation, reflux, and the Soxhlet) at all concentrations.
Antibacterial Activities Of Papaya Seed (Carica papaya L.) Ethanol Extract With MAE And UAE Extraction Methods Towards Staphylococcus aureus Fini Hartanti; Devi Nisa Hidayati
Media Farmasi: Jurnal Ilmu Farmasi Vol 20, No 2: September 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i2.24704

Abstract

Ethanol extract of papaya seeds produced by the maceration method has been shown to have antibacterial activity against S. aureus, P. aeruginous, S. thypi, and E. coli. This study aims to compare the antibacterial activity of the ethanol extract of papaya seeds obtained using the Microwave Assisted Extraction (MAE) and Ultrasound-Assisted Extraction (UAE) extraction methods on the growth of Staphylococcus aureus bacteria.Papaya seed powder was extracted using MAE and UAE extraction methods using 70% ethanol as a solvent in concentrations of 20%, 40%, 60%, and 80%. DMSO was used as negative control and chloramphenicol 30 g/disk as a positive control. The antibacterial activity test method used the disk diffusion method. The parameter observed was DDH (Diameter of Inhibitory Area) which was statistically analyzed using Two Way Anova at a 95% confidence level.The results showed that the ethanol extract of papaya seeds produced from the MAE and UAE extraction methods had antibacterial activity against Staphylococcus aureus in all concentration series. The statistical test showed a significant difference (p<0.05) in antibacterial activity against Staphylococcus aureus extracts obtained from two extraction methods: MAE and UAE. UAE method is recommended use. 
FORMULASI TABLET PARASETAMOL MENGGUNAKAN TEPUNG BONGGOL PISANG KEPOK (Musa paradisiaca cv. Kepok) SEBAGAI BAHAN PENGIKAT -, Sugiyono; Komariyatun, Siti; Hidayati, Devi Nisa
Media Farmasi Indonesia Vol. 12 No. 1 (2017): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (380.477 KB)

Abstract

ABSTRAK Telah dilakukan penelitian tentang formulasi tablet parasetamol menggunakan tepung bonggol pisang (Musa paradisiaca cv. Kepok) sebagai bahan pengikat tablet. Tablet parasetamol dicetak menggunakan metode granulasi basah dengan menambahkan bahan pengikat untuk meningkatkan kekompakan antar partikel. Penelitian ini bertujuan untuk mengetahui pengaruh tepung bonggol pisang kepok sebagai bahan pengikat terhadap sifat fisik dan kimia tablet parasetamol. Konsentrasi tepung bonggol pisang yang ditambahkan sebagai pengikat yaitu pada FI: 10%, FII: 12,5%, FIII: 15%, FIV: 17,5%, dan FV: 20%. Tablet yang dihasilkan diperiksa sifat fisiknya yang meliputi keseragaman bobot, kekerasan, kerapuhan, waktu hancur serta pelepasan obat. Data yang diperoleh dianalisis secara statistik menggunakan analisis regresi linier. Hasil yang diperoleh bahwa variasi konsentrasi tepung bonggol pisang kepok mempengaruhi kekerasan, kerapuhan dan waktu hancur tablet tetapi tidak berpengaruh pada dan pelepasan obat. Semakin tinggi konsentrasi tepung bonggol pisang kepok, semakin tinggi kekerasan dan semakin lama waktu hancur tablet tetapi kerapuhan semakin menurun.
MIGRATION INHIBITION ACTIVITY BY METHANOL EXTRACT Hibiscus tiliaceus Linn. ON 4T1 BREAST CANCER Alviani, Dwi Lutvi; Safitri, Erika Indah; Hidayati, Devi Nisa
Jurnal Farmasi Sains dan Praktis Vol 10 No 2 (May-August 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i2.9393

Abstract

The prevalence of breast cancer cases in Indonesia is increasing along with the ability of cancer cells to migrate or move from the primary tumor mass and form new colonies elsewhere. The migration of cancer cells has encouraged the develop anticancer drugs from natural ingredients. Waru leaves have been shown to have cytotoxic activity. This study aims to determine the inhibition activity of migration of breast cancer cells 4T1 from methanol extract of waru leaves. Waru leaves methanol extract was obtained using the maceration method. Cytotoxic test of methanol extract of waru leaves (MEWL) was the migration test used in the scratch wound healing method at concentrations 162.5, 325, and 650 μg/mL at 0, 18, 24, and 42 hours after treatment. Analysis of IC50 using linear regression, while large areas were analyzed using Image-J software. The percentage of data closure was analyzed statistically with the Anova Repeated Measure test. All concentrations of Methanol Extract of Waru Leaves had significant inhibition of cell migration (p<0,05) compared to control at each observation time at 0, 18, 24, and 42 hours after treatment. So, MEWL is able to inhibit migration in 4T1 cells
Cytotoxic Activity of Eugenia polyantha Wight Young Leaves Purification Extract and Fraction on T47D Hidayati, Devi Nisa; Safitri, Erika Indah; Yumni, Gharsina Ghaisani; Salsabiila, Iqna; Rahayu, Putri
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6607

Abstract

Breast cancer is a cancer that ranks the highest incidence in Indonesia. One of the plants that can be used for this treatment is a bay leaf (Eugenia polyantha Wight). Purification techniques can optimize the extraction of flavonoid compounds to create larger concentrations of these substances. Old bay leaves' ethyl acetate fraction has lethal effects on T47D cancer cells. In this work, the amounts of flavonoids and the cytotoxic activity of young bay leaves' pure extract and ethyl acetate fraction against T47D cells are to be determined. By using the maceration process, two phases of methanol extraction from young bay leaves were produced. In the first stage, ethyl acetate was used to partially purify the material, and in the second stage, n-hexane, ethyl acetate, and water. Cytotoxic tests of purified extract and ethyl acetate fraction of young bay leaves were carried out at 200; 350; 500; 750; and 1000 µg/mL. Cytotoxicity test using the MTT assay method. IC50 value analysis using linear regression. Determination of total flavonoid content using a UV-Visible spectrophotometer with a comparator compound, quercetin. The results showed that the purified extract of young bay leaves and the ethyl acetate fraction of methanol extract of young bay leaves had cytotoxic activity with IC50 values of 570.57 ± 30.72 µg/mL and  588.45 ± 6.90 µg/mL, respectively. Total flavonoid levels were 9.80 ± 0.05 mgQE/g and 5.99 ± 0.06 mgQE/g.The purified extract and ethyl acetate fraction on young bay leaf extract (Eugenia polyantha Wight) had cytotoxic activity on T47D cells and the highest levels of flavonoids in the purified extract.
Effect of ultrasonic-assisted extraction (UAE) method extraction time on the cytotoxic activity of young bay leaf extract (Eugenia polyantha Wight) on T47D breast cancer cells and determination of flavonoid levels Sufa , Riisyda Faila; Hidayati, Devi Nisa
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.29279

Abstract

The most common type of cancer in Indonesia is breast cancer. Anticancer medications made of natural ingredients are beginning to be produced. Methanol extract of young bay leaves (Eugenia polyantha) has anticancer activity at moderate levels. The compounds that function as anticancer are flavonoids. The duration and extraction technique can have an impact on how active chemicals are extracted from natural materials. Through variations in the duration of the extraction process for young bay leaves, this study seeks to ascertain the amounts of flavonoids and the cytotoxic activity of T47D breast cancer.Young bay leaf ethanol extract (EEDSM) was obtained using the Ultrasonic assisted extraction (UAE) method with 70% ethanol solvent and varying extraction times of 5, 15, and 25 minutes. EEDSM total flavonoid content was tested using the UV-visible spectrophotometric method with quercetin as a comparison. The cytotoxic test of the ethanol extract of young bay leaves was carried out using the MTT assay method. Determining the IC50 value uses linear regression and probit analysis. It will also use One Way ANOVA to quantitatively determine the significance of the difference between the effect of extraction time and the IC50 value on T47D breast cancer cells. The results showed that EEDSM with extraction times of 5, 15, and 25 minutes had total flavonoid levels of 2.13mgQE/g, 2.36mgQE/g, and 2.61mgQE/g and cytotoxic activity with an IC50 value of 843μg/mL; 1007μg/mL; and 735μg/mL. EEDSM 5 and 25 minutes were shown to have moderate levels of cytotoxic activity.
Antibacterial Activities Of Papaya Seed (Carica papaya L.) Ethanol Extract With MAE And UAE Extraction Methods Towards Staphylococcus aureus Hartanti, Fini; Hidayati, Devi Nisa
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 2: September 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i2.24704

Abstract

Ethanol extract of papaya seeds produced by the maceration method has been shown to have antibacterial activity against S. aureus, P. aeruginous, S. thypi, and E. coli. This study aims to compare the antibacterial activity of the ethanol extract of papaya seeds obtained using the Microwave Assisted Extraction (MAE) and Ultrasound-Assisted Extraction (UAE) extraction methods on the growth of Staphylococcus aureus bacteria.Papaya seed powder was extracted using MAE and UAE extraction methods using 70% ethanol as a solvent in concentrations of 20%, 40%, 60%, and 80%. DMSO was used as negative control and chloramphenicol 30 g/disk as a positive control. The antibacterial activity test method used the disk diffusion method. The parameter observed was DDH (Diameter of Inhibitory Area) which was statistically analyzed using Two Way Anova at a 95% confidence level.The results showed that the ethanol extract of papaya seeds produced from the MAE and UAE extraction methods had antibacterial activity against Staphylococcus aureus in all concentration series. The statistical test showed a significant difference (p<0.05) in antibacterial activity against Staphylococcus aureus extracts obtained from two extraction methods: MAE and UAE. UAE method is recommended use. 
Penyuluhan dan Praktik Pengelolaan Pascapanen Tanaman Obat di Plalangan Gunungpati Semarang: The Socialization and Practice of Post-harvest Management for Medicinal Plants at Plalangan Gunungpati Semarang Mulangsri, Dewi Andini Kunti; Hidayati, Devi Nisa; Puspitasari, Anita Dwi; Rahmatun, Mutia; Pasha, Salsabilla Putri Buana; Fikriyyah, Shafa
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 1 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i1.5771

Abstract

Post-harvest management is essential because it will affect the final results. Post-harvest management products can be classified as simplicia because the stages include wet sorting, washing, draining, changing shape, drying, packaging, and storage. These steps must be paid attention to to ensure the content of active compounds in simplicia. The Bejo Bintang Toedjoe herbal garden at the Plalangan Gunungpati sub-district is managed by women from the Plalangan sub-district, both housewives and workers. Community service was implemented by preparing and making leaflets/brochures, conducting site surveys, conducting pretests and posttests, and monitoring and evaluating the practical results. This activity was attended by 25 participants, not only participants from the managers of the Bejo Bintang Toedjoe herbal garden but also residents from representatives of several community associations. The discussion session was opened after the counseling had been delivered. After the discussion session is finished, it continues with practice. The results of the pretest analysis showed that most participants still need to learn the effect of direct heating with sunlight for drying medicinal plant materials. Some participants also needed to learn that the tools used to cut medicinal plant materials were stainless steel. The posttest results showed that there was an increase in knowledge after conducting counseling and post-harvest management practices of medicinal plants.
PENINGKATAN PENGETAHUAN DAN KETERAMPILAN PEMBUATAN ROLL ON AROMATERAPI DARI MINYAK SEREH SEBAGAI ANTI REPELLENT Yumni, Gharsina Ghaisani; Hidayati, Devi Nisa; K. M., Dewi Andini
Jurnal Abdi Insani Vol 11 No 3 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i3.1839

Abstract

Dengue fever (DF) is a global health problem. The epidemiology of dengue fever in Indonesia varies but continues to increase. Dengue fever itself is caused by the Aedes aegypti (Linn.) mosquito. Indonesia's tropical geographical location provides conditions that support the breeding of disease-carrying mosquitoes. This demonstrates the urgency with which disease-carrying mosquito eradication must be carried out. Currently, mosquito control strategies rely on the use of chemical drugs to control mosquitoes, which often cause side effects. Therefore, many mosquito repellents have been developed based on natural ingredients. Cymbopogon nardus, the plant that yields citronella essential oil, is one of them. The purpose of this PkM project is to increase knowledge regarding the benefits of citronella oil. In addition, it also improves the skills of participants to produce citronella oil as an anti-repellent. This training method is a combination of lectures, demonstrations, and practical actions. Participants will be given counseling regarding the benefits of citronella oil for health. The making of roll-on preparations begins with watching tutorials and live demonstrations by the team which are then followed by the participants. The results of this activity showed an increase in participants' knowledge and skills in making lemongrass aromatherapy roll-on preparations. This can be seen in the PkM product in the form of a roll-on aromatherapy preparation that has a distinctive lemongrass aroma, warm and stable at room temperature. Participants can also plan to make roll-on preparations using other essential oils. The knowledge gained is expected to be developed by participants as entrepreneurial capital. The community service activities were carried out smoothly and according to target. The PkM team succeeded in increasing the knowledge and skills of the participants through PkM activities.
Cytotoxic Activity and Apoptosis by Extract and Ethyl Acetate Fraction of Hibiscus tiliaceus Linn in 4T1 Cell Line Hidayati, Devi Nisa; Safitri, Erika Indah; Surayya, Anis; Alviani, Dwi Lutvi; Putri, Masita Nur Amalia
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 1, FEBRUARY 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Waru leaves are proven to have cytotoxic activity. The activity of waru leaves needs to be developed in a molecular direction to see its apoptotic activity. This study aims to determine the cytotoxic activity of methanol extract (EWL) and ethyl acetate fraction fraction (EAFWL) of Hibiscus tiliaceus Linn as well as the induction of apoptosis in 4T1 cells. The methanol extract of hibiscus leaves was obtained by the maceration method, followed by a fractionation process with n-hexane, ethyl acetate, and water as solvents. Cytotoxic test of EWL was carried out at a concentration of 31.25; 62.5; 125; 250; 500 and 1000 μg/mL while EAFWL was at a concentration of 100; 200; 400; 600 and 100 μg/mL, using MTT assay. Analysis of IC50 values using linear regression. The apoptosis induction test at IC50 and ½ IC50 concentrations using flowcytometry. Data on the percentage of apoptosis were analyzed using One Way Anova statistical analysis. The results were EWL and EAFWL cytotoxic tests against 4T1 had IC50 values of 649 μg/mL and 746 μg/mL. EWL obtained a percentage of total apoptosis at a concentration of 324.5 μg/mL of 48.76%; 649 μg/mL was 67.06% and control cells were 36.16%. EAFWL percentage of total apoptosis at a concentration of 746 μg/mL of 30.8%; 373 μg/mL was 42.13% and control cells were 9.6%. So EWL and EAFWL can induce apoptosis of 4T1 cells.
Co-Authors Alviani, Dwi Lutvi Amalina Firdaus Amaliyah Ayu Nurfitriani Anita Dwi Puspitasari Aqnes Budiarti Aristya Kurniasih Awal Prichatin Kusumadewi Aysah Safitri Chasani, Failasufia Maulida Cicih Sumiarsih Cicih Sumiarsih Dewi Andini Kunti Mulangsri, Dewi Andini Kunti Dwi Lutvi Alviani Edy Meiyanto Erika Indah Safitri Esa Evinda Farikha Maharani Fatimatuz Zahroh Fatimatuz Zahroh Fauzizah, Nisa Ferry Sandra Fikriyyah, Shafa Fini Hartanti Fitriasih Fitriasih Fitriasih Fitriasih Gharsina Ghaisani Yumni Hanik Rohmatul Maghfiroh Hartanti, Fini Ibrahim Arifin Ibrahim Arifin Indah Hartati Jenie, Riris Istighfari K. M., Dewi Andini Komariyatun, Siti Laili Nailul Muna Laili Nailul Muna Lalu Ksatria D.S. Lilis Rejeki Lina Wahyuni Lina Wahyuni Lusyana Setiawati Marwan Masita Nur Amalia Putri Mufrod Mufrod Nenni Pratiwi Nenni Pratiwi Nilam Eka Putri Nugroho, Agung NUR AINI Nur Kussamawari Ardian Nur Rahayu Fitriana Nurul Hidayati Parusiza, Intan Meyta Pasha, Salsabilla Putri Buana Pia Annisa Pramesti Dewi Putri, Masita Nur Amalia Rahayu, Putri Rahmatun, Mutia Ririn Lispita Wulandari Riris Istighfari Jenie risha fillah fithria Rumiyati Rumiyati Salsabiila, Iqna Salsabila, Unik Hanifah Siti Mega Komariah Siti Mega Komariyah Siti Nur Chasanah, Siti Nur Siti Nurikha Siti Wahidatun Nisa Sri Susilowati Sufa , Riisyda Faila Sugiyono - Surayya, Anis Syahrul Iqbal Setiawan Tabah Priangkoso Ulya Felasufah Umroh Mahmudah Umroh Mahmudah Yance Anas Yuni Antika