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All Journal Jurnal Tumbuhan Obat Indonesia Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Indonesian Journal of Cancer Chemoprevention Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmascience Indonesian Journal of Chemical Science Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmiah Cendekia Eksakta Media Farmasi Indonesia Jurnal Farmasi Sains dan Praktis Jurnal Kefarmasian Indonesia

Devi Nisa Hidayati

Universitas Wahid Hasyim

Author-ID : 281750

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Pengujian Aktivitas Antioksidan Ekstrak Dan Fraksi Jantung Pisang Mas (Musa acuminata Colla) Menggunakan Metode DPPH Devi Nisa Hidayati; Ibrahim Arifin; Yuni Antika; Amalina Firdaus; Nur Kussamawari Ardian
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 14 No. 01 Juli 2017
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (701.906 KB)

Jantung pisang mas mengandung senyawa yang dapat menangkap radikal bebas antara lain saponin, fenol, flavonoid. Penelitian ini bertujuan untuk mengetahui adanya aktivitas antioksidan ekstrak etanol, fraksi etil asetat, dan fraksi air jantung pisang mas (Musa acuminata Colla) dengan metode DPPH (2,2-difenil-1-pikrilhidrazil). Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 70%, dilanjutkan fraksinasi cair-cair menggunakan pelarut etil asetat dan air. Penentuan aktivitas antioksidan ekstrak etanol dan fraksi air dilakukan pada seri konsentrasi 5, 10, 15, 20, dan 25 μg/ml. Sedangkan untuk fraksi etil asetat digunakan konsentrasi sebesar 4, 8, 12, 16, dan 20 μg/ml. Persentase aktivitas antioksidan diperoleh dari data absorbansi. Nilai IC50 didapatkan dari regresi linier antara konsentrasi larutan seri uji dengan persentase aktivitas antioksidan. Identifikasi senyawa flavonoid dilakukan dengan metode KLT. Hasil penelitian menunjukkan bahwa ekstrak etanol dan fraksi etil asetat ekstrak etanol jantung pisang mas memiliki aktivitas antioksidan kuat, sedangkan fraksi air memiliki aktivitas antioksidan lemah. Nilai IC50 ekstrak etanol, fraksi etil asetat, dan fraksi air jantung pisang mas berturut-turut sebesar 68,742; 56,132; dan 201,151 μg/ml.

AKTIVITAS SITOTOKSIK DAN PENGHAMBATAN MIGRASI SEL KANKER 4T1 DARI EKSTRAK DAUN WARU (Hibiscus tiliaceus Linn.) Devi Nisa Hidayati; Erika Indah Safitri; Dwi Lutvi Alviani; Masita Nur Amalia Putri
Jurnal Tumbuhan Obat Indonesia Vol 15 No 1 (2022): Jurnal Tumbuhan Obat Indonesia
Publisher : Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jtoi.v15i1.5710

Kanker payudara merupakan jenis penyakit kanker dengan prevalensi tertinggi di Indonesia. Kegagalan dalam terapi kanker akibat resistensi sel telah mendorong upaya pengembangan obat anti kanker, terutama dari bahan alam. Beberapa penelitian menunjukkan daun waru memiliki aktivitas sitotoksik. Penelitian ini bertujuan untuk mengetahui aktivitas sitotoksik dan penghambatan migrasi sel oleh ekstrak daun waru terhadap sel kanker payudara 4T1. Ekstrak daun waru (Hibiscus tiliaceus Linn.) diperoleh dengan metode maserasi. Uji sitotoksisitas ekstrak daun waru dilakukan dengan MTT assay. Uji penghambatan migrasi sel dilakukan dengan metode scratch wound healing. Hasil penelitian menunjukkan nilai IC50 pada sel 4T1 sebesar 892,4 µg/mL. Ekstrak daun waru konsentrasi 892 μg/mL, 446 dan 223 µg/mL mampu menghambat migrasi sel kanker payudara 4T1 berdasarkan persentase penutupan sel pada jam ke 18, 24 dan 42. Dengan demikian, ekstrak daun waru berpotensi untuk dikembangkan lebih lanjut sebagai agen antimigrasi pada sel kanker payudara 4T1.

EFEK SITOTOKSIK EKSTRAK ETANOL DAUN BERENUK (Crescentia cujete Linn) TERHADAP SEL MCF-7 Devi Nisa Hidayati; Fitriasih Fitriasih; Siti Mega Komariah; Nenni Pratiwi
CENDEKIA EKSAKTA Vol 5, No 1 (2020)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.3194/ce.v5i1.3315

Kanker payudara merupakan penyakit yang mempunyai prevalensi tertinggi di Indonesia. Kegagalan dalam terapi kanker akibat resistensi sel telah mendorong usaha pengembangan obat anti kanker termasuk dari bahan alam. Daun berenuk terbukti memiliki aktivitas sitotoksik. Penelitian ini bertujuan untuk mengetahui apakah ekstrak daun berenuk memiliki aktivitas sitotoksik terhadap sel kanker payudara MCF-7. Ekstrak etanol daun berenuk (Crescentia cujete Linn.) diperoleh dengan metode maserasi. Ekstrak etanol daun berenuk (EEDB) konsentrasi 1000; 500; 250; 31,25; 15,625 μg/ml dilakukan uji sitotoksisitas dengan MTT assay. Analisis nilai IC50 menggunakan regresi linier. Hasil penelitian menyatakan bahwa perlakuan dengan ekstrak etanol daun berenuk memperlihatkan perubahan morfologi sel dibandingkan dengan kontrol sel. Nilai IC50 ekstrak etanol daun berenuk adalah 643 µg/mL. Kata kunci : daun (Crescentia cujete Linn.), Sitotoksik, MCF-7.

STANDARISASI NON SPESIFIK EKSTRAK ETANOL DAUN DAN KULIT BATANG BERENUK (Crescentia cujete Linn) Devi Nisa Hidayati; Cicih Sumiarsih; Umroh Mahmudah
CENDEKIA EKSAKTA Vol 3, No 1 (2018)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.3194/ce.v3i1.2139

Penelitian ini bertujuan untuk membuktikan ekstrak etanol daun dan kulit batang (Crescentia cujete Linn.) memenuhi parameter non spesifik dalam standarisasi ekstrak. Ekstrak etanol daun dan kulit batang (Crescentia cujete Linn.) diperoleh dengan metode maserasi. Ekstrak yang diperoleh diamati parameter non spesifik yang meliputi susut pengeringan, kadar air, kadar abu total, dan kadar abu tidak larut asam. Parameter non spesifik dibandingkan dengan acuan penetapan parameter standar. Hasil pengujian parameter non spesifik ekstrak etanol daun dan kulit batang berenuk dari Gunungpati didapatkan hasil susut pengeringan 10,76±0,33% dan 22,68±0,29%, kadar air 14,35±0,27% dan 25,48±0,23%, kadar abu total 3,65±0,28% dan 0,63±0,03%, kadar abu tidak larut asam 0,25±0,03% dan 0,54±0,02%. Berdasarkan hasil tersebut ekstrak daun berenuk memenuhi standar parameter susut pengeringan, kadar abu total dan kadar abu tidak larut asam. Sedangkan, ekstrak kulit batang berenuk memenuhi standar parameter kadar abu total dan kadar abu tidak larut asam. Kata kunci : daun dan kulit batang, Crescentia cujete Linn, Standarisasi non spesifik

AKTIVITAS ANTIJAMUR KRIM EKSTRAK ETANOL DAUN JAMBU MONYET (Anacardium occidentale L.) DAN KULIT BATANG RAMBUTAN (Nephelium lappaceum) TERHADAP Candida albicans Devi Nisa Hidayati; Ulya Felasufah; Amaliyah Ayu Nurfitriani; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 2 Desember 2017
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Ethanol extract of Anacardium occidentale and rambutan bark (Nephelium lappaceum) proved to have antifungal activity agains Candida albicans. Efforts to improve comfort and ease of use then made in the form of cream formulation.The aim of study is to know the antifungal activity of cream with various concentration of Anacardium occidentaleleaf extract and rambutan bark againstCandida albicans. Extraction of ethanol extractAnacardium occidentale leaf (EAOL) and rambutan bark (ERB) used maceration method. Solvents used ethanol 70% and ethanol 96%, respectively. Formulation cream of EAOL and ERB was maked 3 formulation. Formulation cream EAOL with concentration of variations extract are FI (10,5%), FII (12,5%), FIII (14,5%). Formulation cream ERB with concentration of varions extract are FI (10%), FII (15%), FIII (20%). Antifungal activity was determined in the cream using agar diffusion method and zone of inhibitionwere analyzed using descriptive. The results showed that antifungal activity against Candida albicans of cream EAOL concentration 14,5% with zone of inhibition is 7,16 ± 0,28 mm and cream ERB concentration 20% with zone of inhibition is 9,5 ± 0,5 mm. Kata Kunci : Antifungal, Anacardium occidentale, Nephelium lappaceum, Formulation ofcream

PENINGKATAN EFEK ANTIHIPERTENSI KAPTOPRIL OLEH EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L.) PADA TIKUS HIPERTENSI YANG DIINDUKSI MONOSODIUM GLUTAMAT Devi Nisa Hidayati; Yance Anas; Siti Nurikha
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Hypertension is one of the degenerative disease of health problem in among people. Bilimbi leaves (Averrhoa bilimbi L.) is one of plants which is have antihypertension effect and contains phytol, dietil phtalat, flavonoid. This research is aimed to know influence of ethanol extract of bilimbi leaves (EEBL) through its on the increase of the antihypertensive effect of captopril in hypertensive rats. This research used a pre-test and post-test matched control group design. Sample were 30 male Wistar rats treated with MSG 100 mg/kgBW/day (po) for 14 days to induce hypertension. Hypertensive rats were divided into six treatment groups are hypertension control group (0.5% CMC-Na 12.5 mL/kgBW/day) and positive control group (captopril 2.5 mg/kgBW/day), and treatment hypertensive rats EEBL (60 and 120) mg/kgBW/day, combination of EEBL-captopril (60+2.5)mg/kgBW/day and combination EEBL-captopril (120+2.5) mg/kgBW/day. Suspension test were given for 14 days. Observed data is a decrease in blood pressure after giving of the suspension test. Data analysis was performed with the parametric t-test paired and nonparametric Wilcoxon with 95% level of confidence. The result shows that MSG can be as inducer of hypertension. EEBL (60 and 120) mg/kgBW/day has antihypertensive effect. The increase antihypertensive effect of captopril on systolic blood pressure is showed in the treatment EEBL 120 mg/kgBW/day. Keywords: Hypertension, Monosodium glutamate, Averrhoa bilimbi L.

FORMULASI TABLET HISAP EKSTRAK ETANOLIK DAUN KEMANGI (Ocimum sanctum L.) DENGAN VARIASI PEMANIS MANITOL DAN LAKTOSA Devi Nisa Hidayati; Lusyana Setiawati Marwan; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No. 1 Juni 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Holy basil leaves (Ocimum sanctum L.) traditionally used by the people as a stomatitis aphtosa medication. Bacteria could cause stomatitis aphtosa. Flavonoids in holy basil leaves had antibacterial activity. The usage of holy basil leaves traditionally were not practice so formulated more acceptable such lozenges. Acceptability is influenced by a taste. This study aims was to determine sweeteners variations which is mannitol and lactose from the lozenges formulation of holy basil leaves extract on the physical properties and the level of consumer acceptance taste. Holy basil leaves extract made by maceration method using 70% ethanol. Lozenges made within 5 based on the variation concentration of mannitol and lactose are FI (100%:0%), FII (75%:25%), FIII (50%:50%), FIV (25%:75%), dan FV (0%:100%) and manufactured by wet granulation method. The granules obtained were tested for physical properties include flowability, angle of repose, and compressibility. The tablets obtained were tested for physical properties including weight uniformity, hardness, friability, dissolve time, responsive taste test, and the active substance with TLC methods. The data obtained were analyzed statistically using one way ANOVA and Kruskal Wallis, except acceptability taste analyzed descriptionally. The results showed that all formulas provide lozenges which conform the quality specification. Lozenges most accepted by the respondents was formula I. Keywords: holy basil leaves, lozenges, mannitol, lactose

UJI SITOTOKSISITAS FRAKSI ETIL ASETAT EKSTRAK ETANOL HERBA ALFALFA (Medicago sativa L.) TERHADAP SEL KANKER PAYUDARA T47D DAN SEL KANKER LEHER RAHIM (SEL HeLa) SERTA UJI KANDUNGAN SENYAWA KIMIANYA Devi Nisa Hidayati; Ibrahim Arifin; Sri Susilowati Susilowati
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peranan dan Kontribusi Herbal dalam Terapi Penyakit Degeneratif"
Publisher : Universitas Wahid Hasyim Semarang

Kanker payudara dan kanker leher rahim merupakan jenis penyakit ganas di Indonesia maupun dunia. Penelitian ini bertujuan untuk mengetahui potensi sitotoksik fraksi etil asetat dari ekstrak etanol herba alfalfa terhadap sel kanker payudara (sel T47D) dan sel kanker leher rahim (sel HeLa) serta mengetahui kandungan kimianya. Proses ekstraksi herba alfalfa dilakukan dengan metode sokletasi menggunakan pelarut etanol kemudian dilanjutkan fraksinasi secara bertingkat menggunakan n-heksan, kloroform, dietil eter dan etil asetat. Uji sitotoksisitas menggunakan metode MTT dengan seri konsentrasi fraksi uji 1000; 500; 250; 125; 62,5 µg/ml terhadap kultur sel T47D dan sel HeLa. Data berupa absorbansi sel hidup digunakan untuk menghitung persentase kehidupan sel T47D dan sel HeLa kemudian ditetapkan IC50 dengan analisis probit menggunakan SPSS 16 for Windows. Uji kandungan kimia dilakukan dengan pereaksi kimia kemudian dilanjutkan dengan kromatografi lapis tipis (KLT). Hasil penelitian menunjukkan bahwa fraksi etil asetat ekstrak etanol herba alfalfa memiliki efek sitotoksik terhadap sel T47D namun tidak memiliki efek sitotoksik pada sel HeLa. Potensi sitotoksik fraksi etil asetat ekstrak etanol herba alfalfa terhadap sel T47D yang dinyatakan dalam nilai IC50 sebesar 1893,4 µg/ml. Fraksi etil asetat dari ekstrak etanol herba alfalfa mengandung flavonoid. Kata kunci: Uji sitotoksisitas, fraksi etil asetat ekstrak etanol herba alfalfa (Medicago sativa L.), sel T47D, sel HeLa, flavonoid

IDENTIFIKASI AWAL POTENSI EKSTRAK ETANOL RIMPANG JAHE MERAH (Zingiber officinale Rosc. var. rubrum) SEBAGAI OBAT OSTEOPOROSIS Aqnes Budiarti; Devi Nisa Hidayati; Nur Aini
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 2 Desember 2017
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Reduced bone density is an indication of osteoporosis. The study of osteoporosis is conducted by measure the influence of triggering compound to the enhancement of bone density of ovariectomized rat that have been lifted ovaries. Ovariectomy caused rats have been deficiency of estrogen hormone whose function to maintain bone density.Compound that can increase bone density has the potential as osteoporosis drug. Red ginger rhizome contains flavonoid compound as phytoestrogen whose estrogenic effect that can replace the function of estrogen. Flavonoid is easy to be solved in ethanol so that was extracted using ethanol. The purpose of this study was to measure the enhancement of bone density of ovariectomized rats due to the trigger of ethanol extract of red ginger (EERJM). Research was conducted experimentally to the female Wistar rats by the post test only controlled group design. Treatment was given for 30 days and the determination of bone density using Dual X-Ray radiography method. Data of bone density values were statistically analyzed by One Way ANOVA followed by Tukey test. The results showed that the administration of EERJM dose 500 and 1000 mg/kg BW enhanced bone density of ovariectomized rat. Keywords: bone density, ovariectomized rat, red ginger, osteoporosis

AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) DAN DAUN ANGSANA (Pterocarpus indicus Wild.) PADA MENCIT JANTAN GALUR BALB/C Yance Anas; Devi Nisa Hidayati; Aristya Kurniasih; Lalu Ksatria D.S.
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI & FARMASI KLINIK VOL. 13 NO. 1 JUNI 2016
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Traditionally, jackfruit leaves (Artocarpus heterophyllus Lam.) and angsana leaves (Pterocarpus indicus Wild.) have been used as an herb for diarrhea treatment. The purpose of this experimental study was to investigate the antidiarrheal effect of jackfruit leaves ethanol extract (JLEE) and angsana leaves ethanol extract (ALEE) on Balb/C male mice with castor oil-induced diarrhea method. The study design is a randomized matched two group post test-only. JLEE and ALEE produced by maceration. An antidiarrheal activity of both of extracts compared with loperamide-HCl 10 mg/Kg BW. JLEE (100, 200 and 400) mg/Kg BW and ALEE (80, 160 and 320) mg/Kg BW significantly (p <0.05) decrease the amount of liquid and soft feces, and delay the onset of diarrhea compared with controls (NaCl 0.9% 10 mL/Kg BW). The ability JLEE 400 mg/Kg BW and EEDA 320 mg/Kg BW on inhibiting the formation liquid and soft feces are higher than loperamide HCl 10 mg/Kg BW with antidiarrheal effect amounted to 72.31%, 65.47%, and 54.46% respectively. The potency of JLEE and ALEE as antidiarrheal (ED50) are (20.85 and 3.52) mg/Kg BW respectively. However, in this study, a single dose of loperamide-HCl, JLEE and ALEE treatments are not able to heal the diarrhea symptom (p> 0.05). Keywords: Antidiarrheal, castor oil-induced diarrhea,ethanol extract, Artocarpus heterophyllus Lam., Pterocarpus indicus Wild.

Co-Authors Alviani, Dwi Lutvi Amalina Firdaus Amaliyah Ayu Nurfitriani Anita Dwi Puspitasari Aqnes Budiarti Aristya Kurniasih Awal Prichatin Kusumadewi Aysah Safitri Cicih Sumiarsih Cicih Sumiarsih Dewi Andini Kunti Mulangsri, Dewi Andini Kunti Dwi Lutvi Alviani Edy Meiyanto Erika Indah Safitri Esa Evinda Fatimatuz Zahroh Fatimatuz Zahroh Fauzizah, Nisa Ferry Sandra Fini Hartanti Fitriasih Fitriasih Fitriasih Fitriasih Gharsina Ghaisani Yumni Hanik Rohmatul Maghfiroh Hartanti, Fini Ibrahim Arifin Ibrahim Arifin Jenie, Riris Istighfari Komariyatun, Siti Laili Nailul Muna Laili Nailul Muna Lalu Ksatria D.S. Lilis Rejeki Lina Wahyuni Lina Wahyuni Lusyana Setiawati Marwan Masita Nur Amalia Putri Mufrod Mufrod Mutia Rahmatun Nenni Pratiwi Nenni Pratiwi Nilam Eka Putri NUR AINI Nur Kussamawari Ardian Nur Rahayu Fitriana Nurul Hidayati Parusiza, Intan Meyta Pia Annisa Pramesti Dewi Rahayu, Putri Ririn Lispita Wulandari Riris Istighfari Jenie risha fillah fithria Rumiyati Rumiyati Salsabiila, Iqna Salsabila, Unik Hanifah Salsabilla Putri Buana Pasha Shafa Fikriyyah Siti Mega Komariah Siti Mega Komariyah Siti Nurikha Siti Wahidatun Nisa Sri Susilowati Sufa , Riisyda Faila Sugiyono - Syahrul Iqbal Setiawan Ulya Felasufah Umroh Mahmudah Umroh Mahmudah Yance Anas Yuni Antika

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