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Laser Modalities for Keloid Management: A Narrative Review Fitria Putri; Ennesta Asri
Glosains: Jurnal Sains Global Indonesia Vol. 7 No. 4 (2026): Glosains: Jurnal Sains Global Indonesia
Publisher : Sekolah Tinggi Agama Islam Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59784/glosains.v7i4.851

Abstract

Background: Keloids are fibroproliferative scars characterized by excessive collagen deposition, high recurrence rates, and variable responses to conventional therapies. Objective: This study aims to examine the effectiveness of various laser therapy modalities in keloid management and evaluate the potential of laser therapy as an effective treatment option with minimal adverse effects. Methods: This study employed a literature review method by examining scientific publications related to the use of laser therapy for keloids. The analysis focused on the effectiveness of several laser modalities, including pulsed dye laser (PDL), neodymium-doped yttrium aluminum garnet (Nd:YAG) laser, carbon dioxide (CO₂) laser, and fractional laser therapy, in reducing keloid size and improving patient satisfaction. Results: PDL reduced keloid size by up to 72% with minimal recurrence, while Nd:YAG laser therapy reduced lesion size to approximately 10% within four weeks. CO₂ laser therapy promoted tissue remodeling through thermal effects, and fractional laser therapy achieved a 96.7% patient satisfaction rate with significant improvements in Vancouver Scar Scale scores. Overall, laser modalities demonstrated varying mechanisms of action and therapeutic effectiveness, supporting the need for individualized treatment selection. Conclusion: Laser therapy is an effective option for keloid management, reducing scar size and improving scar quality with high patient satisfaction and minimal adverse effects. However, because recurrence remains a significant challenge, a multimodal treatment approach is still recommended.
The qRT-PCR in A Nasal Swab Leprosy Patient’s at Dr. M. Djamil Padang Hospital Tutty Ariani; Ennesta Asri; Andani Eka Putra
International Journal of Science and Society Vol 6 No 3 (2024): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v6i3.1222

Abstract

Leprosy, caused by Mycobacterium leprae, in 2016, Indonesia reported 16,826 new leprosy cases, with a prevalence rate of 0.71 per 10,000 individuals and a new case detection rate of 6.5 per 10,000 individuals. This study describes the result of a quantitative real-time polymerase chain reaction (qRT-PCR) in the nasal mucosa smear of a leprosy patient at the Dermatology and Venereology Polyclinic of Dr. M. Djamil Padang Hospital. This study adopts an observational approach with a width cut design, specifically employing a cross-sectional study methodology on leprosy patient at the Dermatology and Venereology Polyclinic of Dr. M. Djamil Padang Hospital, Indonesia between February 2023 until February 2024. The qRT-PCR quantity value of nasal mucous discharge is analyzed by a real-time PCR machine. The provided data presents characteristics of a sample population (N = 36) with leprosy. The majority of the leprosy-affected individuals in this study are between 8 and 68 years old, with a median age of 34. According to the World Health Organization (WHO) classification indicates that 83.33% of cases are multibacillary (MB). A combination RLEP/ qRT-PCR assay was developed to enable laboratory-based care and follow-up of leprosy patients attending our outpatient polyclinic in M. Djamil, Padang. The assay offers a sensitive and precise method for assessing the bacterial load and viability of M. leprae from nasal swab samples. It can be used for treatment response monitoring and early diagnosis.