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All Journal E-Jurnal Medika Udayana Jurnal Kedokteran Diponegoro WMJ (Warmadewa Medical Journal) Molecular and Cellular Biomedical Sciences (MCBS) J-Dinamika: Jurnal Pengabdian Kepada Masyarakat INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Pengabdian Masyarakat (ABDIRA) Indonesian Journal of Cancer Makara Journal of Science Ahmad Dahlan Medical Journal Folia Medica Indonesiana Jurnal Implementa Husada (JIH)
Putri, Rachma Greta Perdana
Department Of Histology, Faculty Of Medicine, Universitas Ahmad Dahlan, Yogyakarta, Indonesia
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Gastrointestinal Involvement in The Confirmed Covid-19 Patients Rachma Greta Perdana Putri
WMJ (Warmadewa Medical Journal) Vol 6 No 1 (2021): Mei 2021
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.6.1.2630.7-12

Abstract

The current pandemic of Coronavirus disease 2019, or known as COVID-19, has been claimed as Public Health Emergency of International Concern by WHO on 30 January 2020. According to WHO, there 47.362.304 confirmed cases and 1.211.986 deaths reported due to COVID-19 and still counting. This article investigates the involvement of gastrointestinal symptoms in COVID-19 related to the pathogenesis, transmission, and severity of the disease. The data was collected by keyword searching through EBSCO, PubMed, Google scholar, and additional references from retrieved articles. This article analyzes studies investigating gastrointestinal symptoms in Covid-19. The studies found gastrointestinal symptoms in COVID-19 confirmed patients such as abdominal pain, diarrhea, nausea, vomiting, constipation, and melena. Two studies showed that COVID-19 patients with gastrointestinal symptoms tended to have more severe disease. ACE2, as the receptor of S protein, was found abundantly in intestinal enterocytes besides in the respiratory system. Enterocyte abnormality induces decreased absorption of NA+, water, and mucosal disaccharides. It leads to increased undigested mono and disaccharides, carbohydrates, fats, and protein into the colon. As a result, the colon is unable to absorb sufficient water, leading to diarrhea. Gastrointestinal symptoms are commonly found in patients with COVID‐19, and the trend is increasing in the later stage of the epidemic. SARS‐CoV‐2 enters gastrointestinal epithelial cells and the feces of COVID‐19 patients are potentially infectious. The virus also found in wastewater system and may cause water pollution. Hence, further studies investigating gastrointestinal symptoms and possibility of fecal oral transmission should be conducted.
MiR-141-3p Relative Expression Level from FFPE Samples as Biomarker of Prostate Adenocarcinoma Carcinogenesis in Yogyakarta, Indonesia Sari Eka Pratiwi; Sri Nuryani Wahyuningrum; Rachmagreta Perdana Putri; Danarto Danarto; Didik Setyo Heriyanto; Nur Arfian; Sofia Mubarika Haryana; Indwiani Astuti
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 4 No 1 (2022): The future of diagnostic laboratory testing
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v4i1.2355

Abstract

Globally, prostate cancer (PCA) is the second leading cause of male cancer-associated mortality. Micro-RNAs (miRNAs) are small non-coding RNAs considered promising biomarkers for diagnosis, prognosis, and treatment options. A miR-141 expression is frequently dysregulated and influences the development and progression of PCA. This study aimed to identify miR-141 expression level as a marker to differentiate PCA from another prostate anomaly, especially in Yogyakarta. Formalin-fixed paraffin-embedded (FFPE) tissues for each three groups: benign prostatic hyperplasia/BPH, high-grade prostatic intraepithelial neoplasia/HGPIN, and PCA (n=7/group) were stored in a commercial clinical laboratory in Yogyakarta. The total RNA was extracted from FFPE sections using miRNeasy FFPE kit, followed by the quantification of miR-141-3p expression level by RT-PCR. The result showed that miR-141 relative expression level on PCA was higher than other groups and significantly different (P<0.05, Kruskal Wallis test). The mean of the miR-141 relative expression level of BPH, HGPIN, and PCA were 1.04±0.87, 6.44±7.8, and 7.06±8.83, respectively. The relative expression level of miR-141 can potentially be a prognostic biomarker in PCA and could differentiate aggressiveness in prostate anomaly, especially BPH, HGPIN, and PCA.
Pengaruh Pengetahuan dan Aspek-Aspek Personal terhadap Kesediaan Vaksinasi Human Papillomavirus pada Siswi SMA Negeri 1 Klaten Asarizq Fatihah Rasjava; Dewi Yuniasih; Rachma Greta Perdana Putri; Leonny Dwi Rizkita
JURNAL IMPLEMENTA HUSADA Vol 6, No 2 (2025)
Publisher : UMSU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jih.v6i2.23840

Abstract

Pendahuluan: Kanker serviks, merupakan keganasan yang disebabkan oleh infeksi Human Papillomavirus (HPV), merupakan salah satu kanker yang paling umum di dunia, termasuk di Indonesia. Pencegahan yang dapat dilakukan berupa vaksinasi HPV dan deteksi dini. Penelitian ini bertujuan untuk mengeksplorasi dampak penyuluhan kesehatan dalam meningkatkan pengetahuan dan kesediaan siswi SMA N 1 Klaten untuk menerima vaksin HPV.Metode: Penelitian ini menggunakan pre-eksperimental dengan desain One-Group Pretest-Posttest dilakukan pada 83 siswi SMA Negeri 1 Klaten. Data dikumpulkan melalui kuesioner pretest dan posttest yang mengukur pengetahuan tentang HPV, kanker serviks, dan vaksinasi HPV. Analisis data menggunakan uji Wilcoxon dan uji bivariat untuk melihat hubungan antara faktor-faktor pribadi dan kesediaan vaksinasi.Hasil dan Pembahasan: Hasil menunjukkan peningkatan pengetahuan yang signifikan setelah penyuluhan, dengan 98,8% responden memiliki tingkat pengetahuan yang baik terkait HPV dan kanker serviks. Namun, analisis bivariat menunjukkan bahwa tingkat pengetahuan tidak memiliki hubungan signifikan dengan kesediaan vaksinasi. Kepercayaan terhadap vaksinasi HPV memiliki pengaruh yang signifikan terhadap kesediaan, sementara usia, motivasi, dan paparan informasi tidak menunjukkan hubungan yang signifikan.Kesimpulan: Penyuluhan kesehatan efektif dalam meningkatkan pengetahuan tentang vaksin HPV, namun faktor kepercayaan lebih berpengaruh pada kesediaan vaksinasi daripada pengetahuan itu sendiri.
Co-Authors Alim, Ahmad Muttaqin Amanatus Sholikhah Andrianto Selohandono Annisa Annisa Annisa Annisa Ario Tejosukmono Ario Tejosukmono Ario Tejosukmono Arliono, Tri Yunanto Asarizq Fatihah Rasjava Danarto Danarto Danarto Danarto Danian, Muhamad Dewi Yuniasih Dewi Yuniasih Dewi Yuniasih Dewinta, Mustika Cahya Nirmala Didik Setyo Heriyanto Dwi Utami Emelia, Dwi Ditha Eureka Raihan Asqy Dendy Fadhila, Rais Fardhiasih Dwi Astuti Heriyanto, Mochammad Junaidy Hutomo, Muhammad Agita Ihsana, Nuni Imam Masduki Indarto, Bayu Praditya Indwiani Astuti Indwiani Astuti Intan Dyah Prawesti Irfan Rahmatullah Katrina Rizky Salsabila Khoiru Nisa, Afifah Leonny Dwi Rizkita Leonny Dwi Rizkita Maulana Faris Ikhzul Haq Moch. Junaidy Heriyanto Muhammad Agita Hutomo Muhammad Farid Muhammad Faris Nafiuzzaqi murdiyanto, joko Novi Wijayanti Sukirto Nur Arfian Nurcholid Umam Kurniawan Nurul Qomariyah Oktomi Wijaya Pamungkasih, Wahyu Prameswari, Adilla Soraya Prisilla Maya Heni Pratiwi Purwanto, Barkah Djaka Putra, Fadly Muhammad Bima Putri Dangga, Vathana Az Zahra Rahmatullah, Irfan Reza, Anggit Rokhmah, Budi Nur Rosyida Awalia Safitri Sari Eka Pratiwi Septian Emma Dwi Shafa Zahra Salsabila Sofia Mubarika Haryana Solikhah Solikhah Sompokan, Ruendhita Azzahra Sari Sri Nuryani Wahyuningrum Sri Nuryani Wahyuningrum Sukirto, Novi Wijayanti Tianotak, Muhammad Tri Yoga Tiara Ismirahmadani Tira Alfiani Laariya Ulfa, MH Muflihatul Wijaya, Adi Indra Wildan Fandi Farihan Yuni Herliyanti Yuniasih, Dewi