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All Journal IAES International Journal of Artificial Intelligence (IJ-AI) Jurnal Informatika Seminar Nasional Aplikasi Teknologi Informasi (SNATI) Jurnal Ilmu Komputer dan Informasi Jurnal Sains dan Seni ITS IPTEK Journal of Proceedings Series IPTEK The Journal for Technology and Science CAUCHY: Jurnal Matematika Murni dan Aplikasi Gamatika Prosiding Seminar Matematika dan Pendidikan Matematik JURNAL SOSIAL HUMANIORA (JSH) Semesta Teknika Elkawnie Register: Jurnal Ilmiah Teknologi Sistem Informasi Science and Technology Indonesia Journal of Environment and Sustainability Syntax Literate: Jurnal Ilmiah Indonesia Kinetik: Game Technology, Information System, Computer Network, Computing, Electronics, and Control BAREKENG: Jurnal Ilmu Matematika dan Terapan Limits: Journal of Mathematics and Its Applications International Journal of Computing Science and Applied Mathematics JAIM (Jurnal Abdi Masyarakat) Jurnal Teknologi Dan Sistem Informasi Bisnis Indonesian Journal of Electrical Engineering and Computer Science Majalah Ilmiah Matematika dan Statistika (MIMS) Airlangga Journal of Innovation Management Journal of Applied Data Sciences Journal of Research in Social Science and Humanities COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Jurnal Indonesia Sosial Teknologi Sewagati Limits: Journal of Mathematics and Its Applications
Mohammad Isa Irawan
Departemen Matematika Institut Teknologi Sepuluh Nopember Surabaya
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Journal : CAUCHY: Jurnal Matematika Murni dan Aplikasi

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Understanding The Mechanism of GLUT4 Translocation Involving Non-Conserved Complexes from A Modeling and Simulation T2DM Perspective Kusumastuti, Ari; Irawan, Mohammad Isa; Fahim, Kistosil
CAUCHY: Jurnal Matematika Murni dan Aplikasi Vol 10, No 1 (2025): CAUCHY: JURNAL MATEMATIKA MURNI DAN APLIKASI
Publisher : Mathematics Department, Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/cauchy.v10i1.29292

Abstract

Understanding the mechanism of Glucose Transporter 4 (GLUT4) translocation to the cell membrane is essential for describing daily glucose uptake. A normal mechanism maintains glucose homeostasis and reduces the occurrence of Type 2 Diabetes Mellitus (T2DM) and its complications. Kinetic reactions are crucial for revealing the interactions involving proteins, enzymes, and complexes within the system. We propose a system of ordinary differential equations (ODEs) to elucidate the underlying mechanism under the assumption of non-conservative complexes . The insulin signaling pathway, which includes the GLUT4 mechanism, serves as the basis for reconstructing the necessary kinetic reactions. Investigating the behaviour of the model through numerical simulations and dynamics within parameters and initial conditions from relevant researchs .
Co-Authors AA. Masroeri Abduh Riski, Abduh Adrianus Bagas Tantyo Dananjaya Ahmad Ridwan Akhmad Arif Junaidi Alan Catur Nugraha Alexander Setiawan Alvida Mustika Rukmi Alvida Mustikarukmi Amira, Siti Azza Andreas Handojo Antonio Galileo Tando Ari Kusumastuti Arie Dipareza Syafei Arifah, Enny Durratul Auliya Rahmayani Baiq Findiarin Billyan Chyntia Kumalasari Puteri Danang Wahyu Wicaksono Daniel Happy Putra Darmaji Darmaji Darmawan, Didiet Edi Satriyanto Ekky Hidma Octia Rahmah Elly Matul Imah Elnora Oktaviyani Gultom Elsen Ronando Erna Apriliani Fahim, Kistosil Fendhy Ongko Giandi, Oxsy Ginardi, Raden Venantius Hari Hadi Prasetiya Haloho, Freddi Hartanto Setiawan Hendy Hendy Hendy Hozairi Imam Mukhlash Imam Mukhlash Ira Puspitasari Ketut Buda Artana Khilmy, Akhmad Ku Khalif, Ku Muhammad Naim Mahardika, Kadek Eri Mahdiyah, Umi Mardlijah - Maulana, Muhammad Agung Adi Mey Lista Tauryawati Mohamad Muhtaromi Mohammad Hamim Zajuli Al Faroby Mohammad Iqbal Mohammad Jamhuri Mohd Aziz, Mohd Khairul Bazli Muchamad Jati Nugroho Muhammad Ahnaf Amrullah Muhammad Athoillah, Muhammad Muhammad Fakhrur Rozi Muhammad Hajarul Aswad Muhammad, Noryanti Muhammad, Noryanti binti Mujiono, Edo Priyo Utomo Putro Ni Nyoman Tri Puspaningsih Nugraha, Arma Perwira NURUL HIDAYAT Nurul Hidayat Pratama, Qoria Yudi Putri, Endah R.M. Putri, Endah Rokhmati Merdika Putris , Nadhifa Afrinia Dwi Rasyadan Taufiq Probojati Resi Arumin Sani Rita Ambarwati Rita Ambarwati Sukmono Robin Wijaya, Robin Rohwana, Ulir Ronando, Elsen Rukmini, Meme Santoso Santoso Sepriadi, Robby Setiawan, Muhammad Nanda Setumin, Samsul Shahab, Muhammad Luthfi Siti Maghfiroh Soetrisno Soetrisno Sulastri Sulastri Titin J. Ambarwati Victory Tyas Pambudi Swindiarto YAN ADITYA PRADANA Yongky Ujianto Yuda Dian Harja Zulfa Afiq Fikriya