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All Journal Jurnal Kedokteran Brawijaya Padjadjaran Journal of Dentistry Manuju : Malahayati Nursing Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kedokteran Mulawarman Jurnal Medika: Karya Ilmiah Kesehatan Jurnal Pengabdian Kesehatan Masyarakat Mulawarman Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Abdillah Iskandar
Laboratorium Mikrobiologi, Fakultas Kedokteran, Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Other

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Journal : Jurnal Kedokteran Brawijaya

 1 
IDENTIFIKASI MUTASI GEN CYSTATIONINE-β SYNTHASE (CBS) DAN GEN METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) PADA PENDERITA PREMATUR INFARK MIOKARD AKUT DENGAN HIPERHOMOSISTEINEMI Muliartha, I Ketut Gede; Sargowo, Djanggan; Iskandar, Abdillah
Jurnal Kedokteran Brawijaya Vol 24, No 3 (2008)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (618.881 KB) | DOI: 10.21776/ub.jkb.2008.024.03.3

Abstract

ABSTRACT Hyperhomocysteinemia appears to be an independent risk factor for coronary heart disease. Elevated levels of  plasma  total  homocysteine  (tHcy)  was  caused  by  genetic  or  nutrient-related  disturbances  in  the transsulfuration  or  remethylation  pathways  for  homocysteine  metabolism.  This  study  observed  premature myocard  infarct  acute  patients  with  hyperhomocysteinemia.The  aim  of  the  research  was  to  determine Cystarhionine-β  Synthase  and  Methylenetetrahydrofolate  Reductase  genes  mutations  in  premature  acute myocard  infarct  patients  with  hyperhomocysteinemia.This  study  was  a  cross  sectional  study  in  premature acute myocard infarct patients. Twenty three patients were examined for plasma total homocysteine, vitamin B6, vitamin B12 folic acid and lipid profile. Total DNA isolated from patients with hyperhomocystememia and normal  folic  acid,  vitamin  B6,  vitamin  B12  levels  and  lipid  profile.  Five  patients  were  assayed  for Cystathionine-β  Synthase  and  gen  Methylenetetrahydrofolate  Reductase  genese  mutations  by  Polymerase Chain  Reactions  (PCR).  Five  from  23  patients  (  21,7%  )  plasma  total
Co-Authors Alfiani Rachmiputri Amir, Masyhudi Andre Kusuma Ruslim Andriansyah Andriansyah Annas Rabbani Arie Ibrahim Bahtiar Bahtiar Berta Ramadhani Ishaq Buchori, Muhammad Cindy Lidya Dading Satrio Setiawan Daniel, Muhammad Devi Permata Sari Djanggan Sargowo Emil Bachtiar Moerad Evi Fitriany Fanny Metungku Gresya Elizabet Manurung Hafiedz, Adzan Fajar Hary Nugroho Hastati, Sri Hoopmen, Hoopmen I Ketut Gede Muliartha Irawiraman, Hadi Iskandar Muda Iskandar Muda Khumaidi Luthfa Hubbalkhairi Ulfa Magdaleni, Agustina Rahayu Moriko Pratiningrum Muhammad Aminudin Muhammad Khairul Nuryanto Murti, Ignatia Sinta Nabiela An’nisa Putri Naila Cantika Salsabila Noviandri, Tia Purnamasari, Cicih Bhakti Rajendra, Andi Hafiz Rudi Saputra Sholichin Sholichin Sirajul Munir Sjarif Ismail Swandari Paramita Sylvana, Dini Ulyah, Rochimah Thul Verry Asfirizal Yuniati