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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Lentera Pendidikan : Jurnal Ilmu Tarbiyah dan Keguruan Indonesian Journal of Cancer Chemoprevention AKSIOMA: Jurnal Program Studi Pendidikan Matematika Majalah Obat Tradisional Majalah Farmaseutik JURNAL FARMASI GALENIKA de Fermat : Jurnal Pendidikan Matematika Proximal: Jurnal Penelitian Matematika dan Pendidikan Matematika Indonesian Journal of Agrarian Law
Nur Ismiyati
Program Studi D3 Farmasi Poltekkes Bhakti Setya Indonesia Yogyakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Cytotoxic Potential of Combination of Hibiscus sabdariffa L. Extract and Cisplatin against HeLa Cervical Cancer Cell Line: A Study of Antiproliferative Activity and Apoptosis Induction Nurani, Laela Hayu; Azzahra, Fara; Utami, Dwi; Edityaningrum, Citra Ariani; Guntarti, Any; Irham, Lalu Muhammad; Daud, Intan; Khairurrizki, Amanda; Putra, Ichsan Luqmana Indra; Ismiyati, Nur; Rofida, Siti; Sugiyanto, Sugiyanto
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.92440

Abstract

Cervical cancer is one of the most prevalent cancer types, making the development of effective anticancer agents critical. Cisplatin (CIS) is a drug that has been used to treat cancer, but it also affects normal cells. Hibiscus sabdariffa L. extract (HSE), which has the potential as an anticancer agent, can be developed as a co-chemotherapy with CIS. This study aimed to determine the potential of HSE as a co-chemotherapy with CIS against HeLa cervical cancer cells and determine specific and non-specific parameters of the studied extract. Hibiscus sabdariffa L. (HS) simplicia powder was macerated with 96% ethanol. An in vitro evaluation was carried out on antiproliferative activity by calculating the doubling time. Additionally, a selectivity test was conducted to calculate combination index (CI) values based on the microtetrazolium (MTT) method. Apoptosis mechanisms were explored based on immunocytochemical methods using p53, caspase, and Bax antibodies, followed by an observation of apoptotic induction using a flow cytometer. The HSE and CIS selectivity index values obtained for Vero cells and HeLa cells were 209 and 278, respectively. The antiproliferation test results showed that the combination of HSE and CIS could better extend the doubling time of cells compared to the negative control. This combination also demonstrated a strong synergistic effect, with a CI value of 0.001. The extract as a co-chemotherapy with CIS was capable of increasing the expression of p53, caspase-3, and Bax. The flow cytometry analysis results indicated that HSE could induce apoptosis. Based on the results on the IC50 and CI value of HSE, as well as on the doubling time and apoptosis induction of HSE-influenced HeLa cells, it is concluded that HSE has the potential as a co-chemotherapy against cervical cancer.
Efek Ekstrak Etanol Daun Kemangi (Ocimum sanctum L.) Sebagai Agen Kemopreventif Pada Sel Kanker Leher Rahim Hela Melalui Aktivitas Sitotoksik Dan Induksi Apoptosis Ismiyati, Nur; Nurhaeni, Farisya
Media Farmasi: Jurnal Ilmu Farmasi Vol. 13 No. 1: Maret 2016
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v13i1.5741

Abstract

Kanker leher rahim merupakan penyebab kematian wanita akibat kanker terbesar di negara-negara berkembang. Pertumbuhan sel kanker bersifat tak terbatas karena mempunyai kemampuan untuk menghindari mekanisme apoptosis sehingga penemuan agen-agen pemacu apoptosis kini terus dikembangkan. Kemangi (Ocimum sanctum L.) dilaporkan memiliki potensi penghambatan perkembangan sel kanker melalui aktivitas sitotoksik, apoptosis, dan penghambatan angiogenesis pada sel kanker paru dan payudara. Penelitian ini bertujuan untuk mengetahui efek ekstrak etanol daun kemangi terhadap aktivitas sitotoksik dan proses pemacuan  apoptosis pada sel kanker leher rahim HeLa. Evaluasi viabilitas sel melalui nilai IC50 ditetapkan dengan MTT assay. Efek pemacuan apoptosis oleh ekstrak etanol daun kemangi terhadap sel kanker HeLa diamati dengan metode pengecatan DNA menggunakan etidium bromida-akridin oranye. Hasil penelitian ini menunjukkan ekstrak etanol daun kemangi memiliki potensi sebagai agen kemopreventif pada kanker leher rahim HeLa dengan IC50 209µg/mL. Berdasarkan hasil tersebut dapat disimpulkan penghambatan pertumbuhan sel HeLa oleh ekstrak etanol daun kemangi terjadi dengan menginduksi terjadinya apoptosis. Kata kunci : kanker leher rahim, sel HeLa, daun  kemangi, sitotoksik, apoptosis 
Affordable but Adequate? Effectiveness of Rusunawa for Low-Income Housing in Cepu Hapsari, Primerta Putri; Ishaq, Agung Bahagia; Ismiyati, Nur
Indonesian Journal of Agrarian Law Vol. 1 No. 2 (2024): July, 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jal.v1i2.31087

Abstract

The effectiveness of simple rental apartments (rusunawa) as a housing solution for low-income communities (MBR) is examined using the case study of the Cepu Rusunawa in Blora Regency. The housing backlog in Indonesia, which will reach 12.7 million units by 2023, with 84% of the population remaining homeless, is the background to the urgency of this research. The rapid rate of urbanization of 3% per year, with a projection that 66.6% of Indonesia's population will live in urban areas by 2035, further emphasizes the importance of vertical housing solutions. The research method employed a normative legal study approach. Data analysis was conducted through qualitative methods, utilizing legal, conceptual, and comparative perspectives for policy analysis related to the implementation of Law No. 20 of 2011 concerning Flats. The results indicate that the Cepu Rusunawa, built with an investment of IDR 15.8 billion from the state budget and inaugurated in February 2017 with 98 residential units, faces significant challenges in its management. Despite initial interest, occupancy has declined, with 30 of the 99 units vacant by 2023. Several inhibiting factors exist, including unclear management status between the central and regional governments, and the need for a comprehensive evaluation of service quality and the physical condition of the buildings. A holistic and collaborative approach from all stakeholders is needed to optimize the function of the low-cost apartments as a sustainable, affordable housing solution.
EKSPLORASI PRAKTIK BLENDED LEARNING DALAM PEMBELAJARAN MATEMATIKA UNTUK MEMPERKUAT LITERASI DAN NUMERASI SISWA SMA BALIKPAPAN Ismiyati, Nur; Intan Permatasari, Besse; Annisa, Syarifa
AKSIOMA: Jurnal Program Studi Pendidikan Matematika Vol 14, No 4 (2025)
Publisher : UNIVERSITAS MUHAMMADIYAH METRO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24127/ajpm.v14i4.14389

Abstract

Pembelajaran matematika di SMA menghadapi tantangan dalam meningkatkan pemahaman konsep serta keterampilan literasi dan numerasi. Model blended learning muncul sebagai solusi yang mengkombinasikan pembelajaran tatap muka dan daring, memungkinkan pembelajaran yang fleksibel, interaktif, dan adaptif. Model ini dapat meningkatkan motivasi belajar dan keterlibatan aktif siswa, serta memanfaatkan teknologi digital untuk mendukung proses pembelajaran yang efektif dan efisien. Di Balikpapan, penerapan blended learning sangat relevan untuk memperkuat literasi dan numerasi siswa melalui inovasi pembelajaran yang adaptif terhadap kebutuhan lokal dan perkembangan teknologi. Tujuan penelitian ini mengeksplorasi praktik blended learning dalam pembelajaran matematika untuk memperkuat literasi dan numerasi siswa SMA di Balikpapan. Metode penelitian yang digunakan dengan pendekatan kualitatif dengan jenis penelitian studi kasus eksploratif dengan pengumpulan data melalui wawancara dan dokumentasi praktik pembelajaran yang berjalan. Hasil wawancara dianalisis dengan menggunakan NVivo 15. Hasil penelitian menunjukkan bahwa penerapan blended learning secara efektif meningkatkan keterlibatan siswa, kemandirian belajar, serta kompetensi literasi dan numerasi digital melalui penggunaan berbagai platform dan media pembelajaran digital seperti GeoGebra, Kahoot, dan Google Classroom. Selain itu, inovasi dan adaptasi guru dalam mengelola pembelajaran blended learning mampu mengatasi kendala teknis dan pedagogis yang muncul selama proses belajar. Kesimpulan penelitian ini adalah blended learning merupakan strategi pembelajaran yang relevan dan efektif dalam mendukung pengembangan keterampilan abad 21, khususnya literasi dan numerasi, dengan syarat dukungan pelatihan dan infrastruktur yang memadai. Penelitian ini memberikan kontribusi penting dalam pengembangan metode pembelajaran matematika yang adaptif dan inovatif di tingkat SMA.Mathematics learning in high schools faces challenges in improving students' conceptual understanding and literacy and numeracy skills. The blended learning model emerged as a solution that combines face-to-face and online learning, enabling flexible, interactive, and adaptive learning. This model can increase student learning motivation and active engagement, while utilizing digital technology to support an effective and efficient learning process. In Balikpapan, the implementation of blended learning is highly relevant to strengthening student literacy and numeracy through learning innovations that are adaptive to local needs and technological developments. The purpose of this study was to explore blended learning practices in mathematics learning to strengthen the literacy and numeracy of high school students in Balikpapan. The research method used was a qualitative approach with an exploratory case study type. Data collection was through interviews and documentation of ongoing learning practices. Interview results were analyzed using NVivo 15. The results showed that the implementation of blended learning effectively increased student engagement, learning independence, and digital literacy and numeracy competencies through the use of various digital learning platforms and media such as GeoGebra, Kahoot, and Google Classroom. In addition, teacher innovation and adaptation in managing blended learning were able to overcome technical and pedagogical obstacles that emerged during the learning process. The conclusion of this study is that blended learning is a relevant and effective learning strategy for supporting the development of 21st-century skills, particularly literacy and numeracy, provided adequate training and infrastructure support is provided. This research makes an important contribution to the development of adaptive and innovative mathematics learning methods at the high school level.
Co-Authors Achmad Mursyidi Aditya Fitriasari Ahmad Zaky, Ahmad Ana Mardiyaningsih Annisa, Syarifa Any Guntarti Azzahra, Fara Citra Ariani Edityaningrum, Citra Daud, Intan Dyaningtyas Dewi P. Putri Dyaningtyas Dewi Putri Pamungkas Endah Puspitasari Farisya Nurhaeni Hapsari, Primerta Putri Hariyanti, Laras Ichsan Luqmana Indra Putra, Ichsan Luqmana Indra Intan Permatasari, Besse Iramie Duma Kencana Irianto Ishaq, Agung Bahagia Khairurrizki, Amanda Laela Hayu Nurani Lalu Muhammad Irham Lestari, Tri Maulidina Rahadi, Nanda Muhammad Yusron Maulana El-Yunusi Permatasari, Besse Intan Rifki Febriansah Rifki Febriansyah Sarmoko Sarmoko Siska Andrina Kusumastuti Siti Rofida Sugiyanto - Tedjo Yuwono Usman Mulbar Zaenirohmah, Rizqi Rochim