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All Journal VALENSI Jurnal Kimia (Journal of Chemistry) Journal of Mathematical and Fundamental Sciences Jurnal Ilmiah Arena Tekstil Padjadjaran Journal of Dentistry Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia Jurnal Agrinika : Jurnal Agroteknologi dan Agribisnis Makara Journal of Science Indonesian Scholar Journal of Nursing and Midwifery Science
Euis Julaeha
Universitas Jenderal Achmad Yani
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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Formulation of Mouthwash for Gingivitis from Combination Infusion of Salam leaves (Eugenia Polyantha Wight) and Betel leaf (Piper betle. L) Putri, Megananda Hiranya; Julaeha, Euis; Herijulianti, Eliza; Nurjanah, Neneng
Padjadjaran Journal of Dentistry Vol 34, No 3 (2022): November 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol34no3.41509

Abstract

ABSTRACTIntroduction: Gingivitis is inflammation of the gingiva associated with bacterial activity in dental plaque. The combination of bay leaves and betel leaves infusion has been used as a toothbrush disinfectant. The purpose of this study was to obtain a stable and effective mouthwash formulation from the combination of both infusions to prevent and relieve gingivitis. Methods: Five mouthwash formulas were made by mixing the active ingredients which is a combination of bay leaves and betel leaves infusion, with additives. The combination namely F-I (100% : 0%); F-II (75% : 25%); F-III (50% : 50%); F-IV (25% : 75%) and F-V (0%: 100%). Antibacterial activity tests against Streptococcus mutans, Streptococcus sanguis, and Porphyromonas gingivalis and physical stability tests were carried out. Stability test was carried out by storing the formula at room temperature (280C), hot temperature (400C) and cold temperature (40C) for 3 storage cycles (6 weeks) and observing changes in the physical indicators of the solution, namely pH, specific gravity, viscosity and organoleptic conditions, namely homogeneity, clarity, color, aroma and taste at the end of every 2nd week. Results: F-I to F-V had no inhibitory activity against Streptococcus mutans and Streptococcus sanguis, but had inhibitory activity against Porphyromonas gingivalis in the range (7.19±0.48) to (8.29 ±0.82) mm (ANOVA with a significance value of 0.237 > 0.05).  The 5 formulas were more stable at cold storage, with organoleptic observations at the end of the 3rd cycle showing a slight precipitate (+), clear solution, light brown color, mint aroma and sweet taste. F-II formulas showed better physical indicators values because they were closer to the standard values. Conclusion:  The F-II formula is recommended as a mouthwash for gingivitis because significant for antibacterial effect and showed better physical indicators values as the standard values for herbal medicines.Keywords: antibacterial activity; bay leaves - betel leaves infusion; gingivitis; mouthwash formulation.
Chemical composition of Citrus spp. and oral antimicrobial effect of Citrus spp. peels essential oils against Streptococcus mutans Aripin, Dudi; Julaeha, Euis; Dardjan, Murnisari; Cahyanto, Arief
Padjadjaran Journal of Dentistry Vol 27, No 1 (2015): March 2015
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol27no1.26751

Abstract

Introduction: The essential oils of orange peels had a considerable potential to be used as an antimicrobial agent. The aim of this present study is to analized chemical composition of Citrus spp. And the oral antimicrobial effect of Citrus spp. peels essential oils against Streptococcus mutans. Methods: Five orange peels species were used in this study consist of Lime (Citrus aurantifolia), Tangerine (Citrus nobilis), Sweet Orange (Citrus sinensis), Lemon (Citrus limon), and Kaffir Lime (Citrus hystrix). The isolated essential oils were analyzed using gas chromatography-mass spectroscopy (GC-MS). The Streptococcus mutans ATCC 25175 was employed against the antimicrobial effect of samples. Results: The extraction yields of hydrodistilled-essential oils from Tangerine, Kaffir Lime, Sweet Orange, Lemon, and Lime provided the extraction yields of 4.20, 2.26, 1.97, 1.74 and 0.83% yields, respectively. Major component essential oils of Citrus spp. was D-Limonene. The highest antimicrobial activity against S. mutans was Lime peel essential oil, followed by Lemon, Kaffir Lime, and Sweet Orange or Tangerine. All samples showed antimicrobial activity against S. mutans with the variation of antimicrobial action depending on the constituent of D-Limonene, β-Pinene, and α-terpineol. Conclusion: Major component chemical composition of essential oils of Citrus spp. was D-Limonene and antimicrobial activity by Lime peel essential oil due to its proportional amount of D-limonene and β-pinene and the highest antimicrobial activity.
Formulation of mouth rinse from the essential oils of lime (Citrus aurantifolia) and its inhibitory efficacy on the growth of Streptococcus mutans – in vitro Mulyanti, Sri; Laela, Dewi Sodja; Julaeha, Euis; Suwargiani, Anne Agustina; Aripin, Dudi
Padjadjaran Journal of Dentistry Vol 32, No 1 (2020): March 2020
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol32no1.25486

Abstract

Introduction: Essentials oil of lime (Citrus aurantifolia) peel has high activity in inhibiting the growth of Streptococcus mutans bacteria. The objective of this research was to determine the formulation of mouth rinse from the essential oils of lime (C. aurantifolia) with the highest inhibitory and on the growth of S. mutans. Methods: This research was an experimental in-vitro study. The sample used was the lime (C. aurantifolia) peel waste peel using hydrodistillation technique; testing of the essential oil quality was performed using 100°C distilled water for 3 hours; organoleptic test and physical mouth rinse formula test was also conducted. Mouth rinse formulations were made from the essential oils in the concentrations of 1, 2, 4, 8, 10, and 20%. Mouth rinse activity was tested with optical density. Minimum inhibitory concentration was determined with microdilution. Results: Essential oil mouth rinse formulation showed antibacterial activity at the concentrations of 2, 4, 8, 10, and 20% (formulations I-IV); the recommended mouth rinse concentration was 4% (formulation III) due to its highest antibacterial. Formulation IV showed the highest minimum inhibitory concentration value of 5.2 mg/mL (0.52%) and the safe minimum bactericidal concentration of 0.4 mg/mL (1.04). Conclusion: Mouth rinse formulation from essential oils of lime (C. aurantifolia) peel begins to show inhibition of the growth of S. mutans bacteria at the concentration of 2% essential oils (formulation II), with inhibition against the growth of S. mutans is 7.08. The formula shows a minimum inhibitory concentration (MIC) value and a minimum bactericidal concentration (MBC) of 5.2 mg/mL (0.52%) and 10.4 mg/mL (1.04), respectively.
The antibacterial effect of β-pinene derived from Citrus aurantifolia peel against oral Streptococcus mutans ATCC 25175 Julaeha, Euis; Herlina, Tati; Nurzaman, Mohamad; Mayanti, Tri; Kurnia, Dikdik; Sari, Elizabeth Fitriana
Padjadjaran Journal of Dentistry Vol 33, No 1 (2021): March 2021
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no1.29200

Abstract

Introduction: Streptococcus mutans has been known to play a major role in dental caries development. This tooth decay is the most common oral disease affecting people in the world. Hence, discovering the new herbal antibacterial agent seems to become more promising yet challenging. One of natural antibacterial source is the peel of Citrus aurantifolia, as it may contain antibacterial active compounds against pathogenic oral microbes. This study was aimed to isolate antibacterial compound from essential oil of Citrus aurantifolia and to analyse its antibacterial activity against oral Streptococcus mutans ATCC 25175. Methods: Type of research was laboratory experimental. The essential oil was isolated from peel of Citrus aurantifolia by hydro-distillation technique and further isolation of antibacterial compounds was conducted by combination column chromatography using organic solvent, and the structure was determined by UV-Vis, infrared (IR), 1D NMR of 1H-, 13C-NMR and DEPT 135° in CDCl3 spectrometers methods. The antibacterial activity was tested against Streptococcus mutans ATCC 25175 using the Kirby-Bauer method. Results: 0.75% yield was obtained from the essential oil of peel Citrus aurantifolia and after purification, an antibacterial compound was identified as β-pinene with the molecular formula C10H16. Furthermore, the β-pinene from peel of Citrus aurantifolia exerted inhibition growth against Streptococcus mutans at concentration of 2000, 1000, and 500 ppm by showing respectively, inhibition values of 13.0, 11.9, and 11.6 mm on paper disk. Conclusion: In the present study, the essential oil of Citrus aurantifolia peel is proven to contain prospective antibacterial compound (β-pinene) that potentially can be used as natural antibacterial alternative choice to manage oral disease associated with Streptococcus mutans infection.
Studi In Silico Aktivitas Senyawa Steroid Terhadap Antikanker Payudara Menggunakan Estrogen Alfa (ER-α) Nurlelasari, Nurlelasari; Widyana, Almas; Julaeha, Euis; Hardianto, Ari; Huspa, Desi Harneti Putri; Maharani, Rani; Mayanti, Tri; Darwati, Darwati; Hanafi, Muhammad; Supratman, Unang
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 1 (2023): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.1.62384.44-52

Abstract

Kanker payudara merupakan penyebab kedua terbanyak kematian pada wanita akibat kanker setelah kanker paru-paru di seluruh dunia. Steroid merupakan kelompok senyawa aktif yang diantaranya berhasil diisolasi dari genus Chisocheton yang dilaporkan memiliki aktivitas melawan sel kanker payudara MCF-7. Tujuan penelitian ini adalah untuk mengetahui interaksi senyawa steroid terhadap estrogen alfa (ER-α) melalui metode in silico, yaitu penambatan molekul. Pemodelan struktur tiga dimensi (3D) senyawa steroid dilakukan dengan memperhatikan keadaan terprotonasinya pada pH 7,4. Metode in silico divalidasi melalui penambatan ulang struktur kristal ER-α, hingga diperoleh nilai RMSD < 2 Å, dengan program AutoDock 4.2.6. Dengan program yang sama, senyawa-senyawa steroid ditapis dengan metode penambatan molekul. Hasil penapisan menghasilkan nilai energi bebas dari kedua senyawa steroid yaitu -10,08 kkal/mol (7α-hidroksi-β-sitosterol) dan -10,75 kkal/mol (stigmast-5-en-3β-ol), yang nilainya lebih baik dari estradiol (-9,62 kkal/mol), sebagai ligan alami ER-α. Kedua senyawa ini berpotensi untuk menginhibisi estrogen alfa, dimana senyawa stigmast-5-en-3β-ol memiliki potensi yang lebih besar karena nilai energi bebasnya lebih rendah. Hal ini menandakan bahwa modifikasi struktur senyawa mampu mengubah nilai energi ikatan dan interaksi antara ligan dan reseptor.In Silico Study of Steroid Compound Activity Against Breast Cancer Using Estrogen Alpha (ER-α). Breast cancer is the second worldwide leading cause of cancer death in women after lung cancer. Steroids are a group of active compounds isolated from the Chisocheton genus that has activity against MCF-7 breast cancer cells. This study aimed to determine the interaction activity of steroid compounds against alpha estrogen receptor (ER-α) through in silico method specifically mlecular docking. The modeling of the three-dimensional structure (3D) of steroid compounds was performed by considering their protonation states at pH 7.4. The in silico method was validated by redocking the crystal structure of ER-α until obtaining an RMSD value < 2 Å, using the AutoDock 4.2.6 program. Steroids compounds were screened with the same program namely the molecular docking method. Screening results show that the free energy values of the steroid compounds were -10.08 kcal/mol (7α-hydroxy-β-sitosterol) and -10.75 kcal/mol (stigmast-5-en-3β-ol), which are stronger than estradiol (-9.62 kcal/mol) as native ligand of ER-α. Both of these compounds can inhibit the alpha estrogen receptor, in which the stigmast-5-en-3β-ol compound has a greater potential because of its lower free energy value. This finding indicates that modification of the compound's structure could change the binding energy value and interaction between ligands and receptors.
Co-Authors Achmad Zainuddin Ade Kania Ningsih, Ade Kania Ajeng Diantini, Ajeng Anne Agustina Suwargiani Ari Hardianto Arif Rahman Hakim Cahyanto, Arief Darwati Darwati Desi Harneti Putri Huspa Dikdik Kurnia Dudi Aripin Elizabeth Fitriana Sari Faizal Hermanto Hadi Kuncoro Herijulianti, Eliza Iman Permana Maksum Kindi Farabi Laela, Dewi Sodja Laode Rijai Lilis Siti Aisyah, Lilis Siti Megananda Hiranya Putri Mohamad Nurzaman Muhammad Hanafi Mulyawan, Agus Surya Murnisari Dardjan, Murnisari Neneng Nurjanah Nurcahyanti, Ois Nurlelasari Nurlelasari Permadi, Nandang Rani Maharani Shabarni Gaffar Sri Mulyanti Sugiyana, Doni Tati Herlina Tri Mayanti Tri Reksa Saputra, Tri Reksa Unang Supratman Wahyudi, Tatang Wibisono, Aditya Seiza Widyana, Almas Yenny Febriani Yun, Yenny Febriani Yoshihito Shiono Yudi Rosandi Yulisar, Riza