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All Journal E-Jurnal Medika Udayana The Indonesian Biomedical Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Global Pharma Technology
I Nyoman Wande
Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Udayana, RSUP Sanglah, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Correlation of Pancreatic Stone Protein (PSP) with Procalcitonin in Early-Onset Neonatal Sepsis (EONS) Patients Desak Laksmi; I Nyoman Wande; Anak Agung Ngurah Subawa; Sianny Herawati; Ni Kadek Mulyantari; Ni Nyoman Mahartini; I Made Kardana
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2425

Abstract

Sepsis is defined as a systemic condition that arises from bacterial, viral or fungal infection, associated with hemodynamic changes and clinical findings that cause high morbidity and mortality. Neonatal sepsis that occurs 72 hours after birth is called early-onset neonatal sepsis (EONS). Procalcitonin is secreted by various tissues and is a marker of the acute phase of systemic reactions. Pancreatic stone protein (PSP) is a novel marker for identifying sepsis. High PSP levels are associated with more severe sepsis conditions. This analytical observational study aimed to determine the correlation between PSP levels and procalcitonin levels in patients with EONS. The study was conducted at the Clinical Pathology Laboratory of Ngoerah Hospital, Denpasar and the Integrated Biomedical Laboratory of the Faculty of Medicine, Udayana University from May 2024 to July 2024. The subjects in this study were 48 EONS patients undergoing treatment at Ngoerah Hospital who met the inclusion criteria. The results of the Spearman correlation test revealed a moderate correlation between PSP levels and procalcitonin levels in EONS patients (r = 0.581; p <0.001). Furthermore, multivariate analysis revealed that PSP levels significantly influenced procalcitonin levels after controlling for confounding variables (B = 0.137; 95% CI 0.101-0.174; p <0.001). These findings highlight the potential of PSP as a reliable marker in diagnosing sepsis and suggest that further exploration in this area could enhance our understanding of neonatal sepsis management.
Co-Authors Ali Djamhuri Alvin Wijaya Anak Agung Ngurah Krisnanta Adnyana Anak Agung Ngurah Subawa Anak Agung Wiradewi Lestari Cokorda Istri Dewiyani Pemayun Desak Laksmi Desak Made Wihandani Endang Retnowati Ernest Jonathan Hartiono Fandy Wira Utama Fedik Abdul Ratam I Gusti Ayu Dewi Ratnayanti I Gusti Kamasan Arijana I Gusti Ngurah Mayun I Gusti Nyoman Sri Wiryawan I Gusti Putu Suka Aryana I Made Bayu Puradipa I Made Kardana I Nyoman Astika I Putu Sidhi Rastu Karyana I Wayan Gede Sutadarma I Wayan Putu Sutirta Yasa I Wayan Sugiritama I Wayan Surudarma I.A.A. Widhiartini Ida Ayu Putri Wirawati Ida Ayu Putri Wirawati Ida Ayu Trisna Wulandari Ida Bagus Putu Putrawan Juli Soemarsono Komang Okky Maharani Ciptana Putri Komang Satvika Yogiswara Komang Siska Lestari Sugitha N. K. Niti Susila, N. K. Ni Kadek Mulyantari Ni Ketut Rai Purnami Ni Made Linawati Ni Made Linda Pertiwi Ni Made Mertaniasih Ni Nyoman Lidya Trisnadewi Ni Nyoman Mahartini Ni Nyoman Mahartini Ni Nyoman Sri Budayanti Ni Putu Diah Utami Darmayanti Putu Budhiastra Putu Ria Asprila Dewi Putu Yudi Adnyani R. A.T. Kuswardhani Sherly Karolina Simanjuntak Sianny Herawati Tjokorda Gde Oka Tjokorda Gede Oka Tjokorda Istri Agung Sintya Dewi Wayan Giri Putra