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All Journal BALI MEDICAL JOURNAL (BMJ) E-Jurnal Medika Udayana MNJ (Malang Neurology Journal) ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Bali Medika Jurnal Journal Research of Social Science, Economics, and Management
Ni Kadek Mulyantari
Bagian SMF Patologi Klinik, Fakultas Kedokteran Universitas Udayana
Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Gambaran hasil ph dan keton pada urine puasa: Description of ph and ketones results on fast urine Parwati, Putu Ayu; Prabangkara, Ni Made Indira; Mulyantari, Ni Kadek
Bali Medika Jurnal Vol 9 No 2 (2022): Special Issue Bali Medika Jurnal Vol 9 No 2 Oktober 2022
Publisher : Stikes Wira Medika Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36376/bmj.v9i2.311

Abstract

Pemeriksaan laboratorium merupakan pemeriksaan yang sering dilakukan untuk kepentingan klinik. Beberapa pemeriksaan darah yang dilakukan di laboratorium membutuhkan persiapan pasien khusus seperti puasa 10-12 jam. Hal ini akan memberikan hasil yang akurat bagi pemeriksaan darah terkait, namun juga bisa menimbulkan hasil yang kurang akurat bagi pemeriksaan lain. Salah satu pemeriksaan yang juga sering dilakukan yaitu pemeriksaan urine lengkap. Pemeriksaan urine yang dipengaruhi oleh kondisi tubuh puasa yaitu pH dan keton urine. Tujuan penelitian ini untuk mengetahui gambaran hasil pH dan keton urine puasa. Jenis penelitian yang digunakan adalah penelitian deskriptif dengan menggunakan random sampling sebanyak 27 orang. Pemeriksaan pH dan keton urine dilakukan menggunakan carik celup. Hasil pH urine puasa yaitu 5,0 sebanyak 6 orang (22,22%); 6,0 sebanyak 18 orang (66,67%); dan 6,5 sebanyak 3 orang (11,11%). pH urine responden tergolong pH urine asam yang kemungkinan adanya hubungan dengan puasa. Urine pH asam dipengaruhi oleh beberapa faktor diantaranya yaitu kelaparan, diabetes, dehidrasi, asidosis sistemik. Hasil pemeriksaan keton urine puasa didapatkan hasil negatif sebanyak 27 orang (100%). Hasil pemeriksaan keton urine negatif karena menggunakan spesimen urine pagi yang hanya melakukan puasa selama 12 jam. Pada keadaan orang normal pemeriksaan  benda keton dalam urine negatif karena semua hasil metabolisme lemak dipecah menjadi air dan karbon dioksida. Pada kondisi puasa atau kelaparan berat dimana terdapat kekurangan karbohidrat sebagai sumber energi, maka badan akan menggunakan cadangan lemak sebagai sumber energi sehingga terjadi peningkatan keton sebagai hasil metabolisme lemak.     Laboratory examination is an examination that is often done for the benefit of the clinic. Some blood tests performed in the laboratory require special patient preparation such as fasting 10-12 hours. This will provide accurate results for related blood tests, but can also lead to less accurate results for other tests. One of the tests that is also often done is a complete urine examination. Urine examination is influenced by fasting body conditions, namely pH and urine ketones. The purpose of this study was to describe the results of fasting urine pH and ketones. The type of research used is descriptive research using random sampling as many as 27 people. Examination of urine pH and ketones was carried out using a dipstick. The results of fasting urine pH were 5.0 as many as 6 people (22.22%); 6.0 as many as 18 people (66.67%); and 6.5 as many as 3 people (11.11%). The pH of the respondent's urine is classified as acidic urine pH which may have a relationship with fasting. Urine acid pH is influenced by several factors including hunger, diabetes, dehydration, systemic acidosis. The results of the fasting urine ketone examination showed negative results as many as 27 people (100%). The results of the urine ketone examination were negative because they used a morning urine specimen that only fasted for 12 hours. In normal people, the examination of ketone bodies in the urine is negative because all the products of fat metabolism are broken down into water and carbon dioxide. In conditions of fasting or severe starvation where there is a shortage of carbohydrates as an energy source, the body will use fat reserves as an energy source, resulting in an increase in ketones as a result of fat metabolism.
Hydatidiform Mole Pregnancy with Hyperthyroidism: A Case Report Dewi, Ni Made Ratih Purnama; Gotera, Wira; Lestari, Anak Agung Wiradewi; Herawati, Sianny; Wande, I Nyoman; Mulyantari, Ni Kadek; Sudana, I Nyoman Gde; Prabawa, I Putu Yuda
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2243

Abstract

Hyperthyroidism is a condition with excess biosynthesis and hormone secretion by the thyroid gland. One of the secondary causes of hyperthyroidism is hydatidiform mole pregnancy, which is included in Gestational Trophoblastic Disease (GTD). Hyperthyroidism in hydatidiform mole pregnancies occurs due to increased beta-Human Chorionic Gonadotropin (beta-hCG).  Increasing beta-hCG level affects stimulation of the thyroid gland, increasing thyroid hormone levels in the serum, which causes thyrotoxicosis. This case is such a rare case. A 22-years-old female, G1P0A0, came complaining of amenorrhea accompanied by vaginal bleeding with abdominal pain, nausea, vomiting and palpitations.accompanied by vaginal bleeding with abdominal pain, nausea, vomiting and palpitations. Physical examination showed tachycardia with a pulse rate of 120 beats per minute. Ultrasound examination of the abdomen showed an anteflexed uterus with a honeycomb appearance. Based on a series of tests, the patient has a hydatidiform mole pregnancy with a risk of impending thyroid storm, indicated by TSH suppression with increased fT4. Beta-hCG can cause hyperthyroidism through cross-reaction with TSH receptors. In patients with hyperthyroidism due to GTD, it is not characterized by the characteristic features often found in Graves' disease. Evacuation with curettage and medication was performed to reduce thyroid hormone and serum beta-hCG levels. Hyperthyroidism is an abnormality that can be found in hydatidiform mole pregnancies. It is important to carry out early detection by examining thyroid function in GTD, proper management, and regular monitoring of thyroid function and beta-hCG in pregnant female to provide comprehensive management and prevent complications that can be caused by hyperthyroidism.      
Mapping of Donor Blood Antigens and Development of Panel Cell Reagents in Bali Province Mulyantari, Ni Kadek; Lestari, Anak Agung Wiradewi; Herawati, Sianny
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2351

Abstract

Examination of other blood groups' antigens, such as Rhesus (d, C, c, E, e), Kell, Duffy, Kidd, and others, is not routinely carried out in blood services. This study aimed to determine the type of blood group antigen and the composition of the antigens of panel cell reagents for antibody screening and identification in Bali. The subjects were 120 voluntary donors who regularly donate blood. Blood group antigen examination was carried out with a column agglutination test. The antigen mapping was analyzed to determine the possible development of panel cell reagents. Among 120 research subjects, 76.67% were male. Rhesus antigen mapping showed 73.3% DCe phenotype, 3.33% DcE, 3.33% Dce, 19.17% DCE. MNS system, 22.5% M-N+, 35.83% M+N+, 85% S-s+, 14.17% S+s+ and 0.83% S+s-. For the Kell system, no donor with phenotype K+k-, 5.83% K+k+, 94.17% K-k+. No donor with Kpa antigen and 100% with Kpb antigen. Based on Duffy system, 74.17% Fy (a+b), 23.33% Fy(a+b+), 1.7% Fy(a-b+), 0.8% Fy(a-b-). For Kidd system 36.67% Jk(a+b-), 45.83% Jk(a+b+), 17.5% (Jk(a-b+) and no donor with Jk(a-b-). The screening analysis of donor antigens allows the development of panel cell reagents using two types of panel cells. Most donors have a Rhesus DCe phenotype with other dominant antigens, M+N+, S-s+, K-k+, Kpb, Fy(a+b-), and Jk(a+b+). The development of panel cell reagents can be done with the antigen composition of R1R1 (D, C, e, M, S, k, Kpb, Fya, Jka) and R2R2 (D, c, E, M, N, s, K,k, Kpb, Fya, Fyb, Jka, Jkb).  
Correlation of Pancreatic Stone Protein (PSP) with Procalcitonin in Early-Onset Neonatal Sepsis (EONS) Patients Desak Laksmi; I Nyoman Wande; Anak Agung Ngurah Subawa; Sianny Herawati; Ni Kadek Mulyantari; Ni Nyoman Mahartini; I Made Kardana
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2425

Abstract

Sepsis is defined as a systemic condition that arises from bacterial, viral or fungal infection, associated with hemodynamic changes and clinical findings that cause high morbidity and mortality. Neonatal sepsis that occurs 72 hours after birth is called early-onset neonatal sepsis (EONS). Procalcitonin is secreted by various tissues and is a marker of the acute phase of systemic reactions. Pancreatic stone protein (PSP) is a novel marker for identifying sepsis. High PSP levels are associated with more severe sepsis conditions. This analytical observational study aimed to determine the correlation between PSP levels and procalcitonin levels in patients with EONS. The study was conducted at the Clinical Pathology Laboratory of Ngoerah Hospital, Denpasar and the Integrated Biomedical Laboratory of the Faculty of Medicine, Udayana University from May 2024 to July 2024. The subjects in this study were 48 EONS patients undergoing treatment at Ngoerah Hospital who met the inclusion criteria. The results of the Spearman correlation test revealed a moderate correlation between PSP levels and procalcitonin levels in EONS patients (r = 0.581; p <0.001). Furthermore, multivariate analysis revealed that PSP levels significantly influenced procalcitonin levels after controlling for confounding variables (B = 0.137; 95% CI 0.101-0.174; p <0.001). These findings highlight the potential of PSP as a reliable marker in diagnosing sepsis and suggest that further exploration in this area could enhance our understanding of neonatal sepsis management.
Co-Authors Anak Agung Ayu Lydia Prawita Anak Agung Ayu Lydia Prawita Anak Agung Ngurah Subawa Anak Agung Wiradewi Lestari aryati . Bagus Dwiki Arya Dharma Betti Bettavia Hartama Pardosi Daniel H. Susanto Desak Laksmi Dewi, Ni Made Ratih Purnama Ekarini Katharina Yunarti Nabu Ekarini Katharina Yunarti Nabu Ekarini Katharina Yunarti Nabu Endang Retnowati Evert Solomon Pangkahila Fatqur Rochman Gde Dicky Arimbawa I Gede Juliarta I Gusti Agung Ngurah Radhitya Wijaya Radhitya Wijaya I Made Kardana I Nyoman Hariyasa Sanjaya I Nyoman Wande I Nyoman Wande I Putu Eka Widyadharma I Putu Yuda Prabawa I Wayan Putu Sutirta Yasa Lestari, AA. Wiradewi Luh Putu Citta Saraswati M.Y. Probohoesodo Made Minarti Witarini Dewi Mahardika, Ketut Indah Karina Nasronudin Nasronudin Ni Ketut Puspa Sari Ni Komang Krisnawati Ni Komang Krisnawati Ni Made Linda Pertiwi Ni Nyoman Mahartini Ni Nyoman Mahartini Nugraha, Ketut Yoga Wira Nyoman Pramudita Parwati, Putu Ayu Prabangkara, Ni Made Indira Prabawa, I Putu Yuda pradnya wibawa, komang budhi Puspa Sari, Ni Ketut Putu Mita Wulandari Ryan S. Mulyana Ryan Saktika Mulyana Sianny Herawati Sianny Herawati Sri Wijayanti, Ida Ayu Sudana, I Nyoman Gde Sudewa Djelantik Swari, Kadek Gyna Yadnya Teguh Triyono Tertia, Clarissa Tjokorda Gede Oka Tresna Erawan, I Gusti Ngurah Agung Usi Sukorini Wikananda, Made Argyanta Wira Gotera Zulaikha Binti Osman