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All Journal Jurnal Ilmu Dasar e-Journal Pustaka Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Program Kreativitas Mahasiswa - Penelitian Indonesian Journal of Pharmaceutical Science and Technology STOMATOGNATIC- Jurnal Kedokteran Gigi Journal of Agromedicine and Medical Sciences Global Medical and Health Communication CHEMPUBLISH JOURNAL Jurnal Bioteknologi & Biosains Indonesia (JBBI) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Journal of Tropical Ethnobiology BERNAS: Jurnal Pengabdian Kepada Masyarakat Borneo Journal of Pharmacy Journal of Bio-molecule Research And Engineering Journal of Agropharmacy Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Evi Umayah Ulfa
Fakultas Farmasi Universitas Jember
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : CHEMPUBLISH JOURNAL

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Artikel Uji toksisitas akut oral xilooligosakarida dari hidrolisis xilan jerami menggunakan enzim rekombinan Endo-β-1,4-D-Xylanase : Studi Toksisitas Xilooligosakarida Vergian, Putra; stri Ratnadewi, Anak Agung I; Riandy, Cahyaningtyas Tetta; Rukmana, Riesma; Ulfa, Evi Umayah; Siswoyo, Tri Agus; Syafriadi, Mei
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.49759

Abstract

Xylooligosaccharides (XOS) are recognized as prebiotics that stimulate the proliferation of probiotic bacteria and enhance short-chain fatty acid (SCFA) production. Compared to other prebiotics, XOS offer notable advantages, including thermal stability and tolerance to a broad pH range. Building on these attributes, this study aimed to evaluate the potential toxicity of XOS derived from rice straw xylan hydrolyzed using recombinant endo-β-1,4-D-xylanase expressed in Saccharomyces cerevisiae. Acute oral toxicity was assessed in male Wistar rats at a single dose of 2000 mg/kg body weight, with observations conducted over a 14-day period. Parameters evaluated included body weight, clinical signs, hematological and biochemical indices, as well as macroscopic and histopathological alterations. Signs of toxicity were observed as changes in stool consistency within the first 4 to 24 hours, while mortality occurred in three male rats. Although body weight showed a tendency to increase, particularly in males, the estimated LD₅₀ value ranged between >500 and 2000 mg/kg body weight, classifying XOS as moderately toxic. Moreover, histopathological examination revealed pathological alterations in the kidneys and liver, while serum biochemical analysis indicated metabolic changes that remained within normal limits. Overall, these findings suggest that XOS possess promising prebiotic potential; however, further studies are required to confirm their long-term safety for application in food products.
Co-Authors Agustina, Bayu Agustina, Bayu Ajeng Maharani Sri Pananjung Ajeng Maharani Sri Pananjung, Ajeng Maharani Ameliana, Lidya Arafika, Whendy Waliya Auralia Putri Pratama Bagus Setya Rintyarna Bambang Sri Kaloko Bambang WIJIANTO Baroroh, Rizqy Kiromin Debi Listiayana Dedi Irawanto Desi Sandra Sari Dhani Wijaya, Dhani Diana Holidah Dianasari, Dewi Dwi Nurahmanto Ema Rachmawati Ema Rachmawati Endah Puspitasari Esti Utarti ESTIKA YUNINDARWATI Fahrauk Faramayuda, Fahrauk Ferani Cendrianti Gazzali, Amirah Mohd Harinditha Pramana Putra Hidayatul Ulyah Imtiyaz, Andi Hilman Indah Yulia Ningsih Izzay Afkarina Jacinda Na’ilahafitra Kartika Senjarini Lestyo Wulandari Lina Winarti Liza Pratiwi M Mirza Nuryady, M Mirza Maharany, Dinda Mei Syafriadi Mochammad Amrun Hidayat Mufidah, Fania Mufti Ni Nyoman Tri Puspaningsih Novanda asri I, Novanda asri Nuri . Pananjung A.S, Pananjung Paramayuda, Farukh Pratama P., M. Reynaldi Archan Putri Eka Maryani Ramadhan, Andika Dewi Riandy, Cahyaningtyas Tetta Rini Riyanti Rismatul Khoiroh Rizki Rica Rachim Fadilah Putri Rohmah, Etik Ainun Rukmana, Riesma Sattya Arimurti Shinta Cholifatu Rohma stri Ratnadewi, Anak Agung I Tri Agus Siswoyo Umar Dian Prambudi Kusuma Vergian, Putra Viddy Agustian Rosyidi Windi Eka Yulia Retnani Yuniar Wahyu Rahmawati Yuniatin Hasanah Yunita Armiyanti