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All Journal JURNAL KIMIA SAINS DAN APLIKASI Jurnal Pendidikan Kimia Indonesia Jurnal Entropi Biology, Medicine, & Natural Product Chemistry Jurnal Tadris Kimiya Indonesian Journal of Chemistry Chemistry Indonesian Journal of Chemical Research AR-RAZI Jurnal Ilmiah Jurnal Kartika Kimia Jambura Journal of Educational Chemistry Jambura Journal of Chemistry JCER (Journal of Chemistry Education Research) Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Acta Chimica Asiana Hydrogen: Jurnal Kependidikan Kimia Indonesian Journal of Pharmaceutical Education Indonesian Journal of Chemistry and Environment JURNAL KIMIA SAINTEK DAN PENDIDIKAN Jurnal Manusia dan Lingkungan Molekul: Jurnal Ilmiah Kimia Algoritma: Jurnal Matematika, Ilmu Pengetahuan Alam, Kebumian dan Angkasa Jurnal Sains dan Kesehatan Damhil: Jurnal Pengabdian kepada Masyarakat Jurnal Pendidikan Kimia, Fisika dan Biologi
Akram La Kilo
Universitas Negeri Gorontalo
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Education Engineering Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Studi Molecular Docking dan Prediksi ADME Senyawa Metabolit Sekunder Tumbuhan Obat Tradisional Gorontalo Terhadap Reseptor HER-2 Sebagai Antikanker Payudara Ischak, Netty Ino; Musa, Weny J.A; Aman, La Ode; Alio, La; Kilo, Akram La; Saleh, Sri Deltalia
Jambura Journal of Chemistry Vol 5, No 2 (2023): August
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jambchem.v5i2.20544

Abstract

Penelitian ini bertujuan untuk mengetahui aktivitas dan interaksi senyawa uji dari 12 tumbuhan obat tradisional Gorontalo dengan reseptor HER-2 yang merupakan protein yang terkait dengan sel kanker payudara secara in silico melalui molecular docking. Molekul dengan hasil docking terbaik akan diprediksi menggunakan program Absobsi, Distribusi, Metabolisme, dan Eliminasi (ADME) menggunakan program SwissADME secara online. Hasil validasi situs ikatan dengan menerapkan protokol penambatan ulang (redocking) menunjukkan nilai Root Mean Square Deviation konformasi ligan standar (2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridine-3-yl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5yl]ethoxy}ethanol) menggunakan Autodock Tools dengan nilai energi bebas ikatan yang terbentuk sebesar -6,32 kkal/mol. Sedangkan nilai Root Mean Square Deviation ligan standar menggunakan Autodock Vina memiliki energi bebas ikatan sebesar -11,3 kkal/mol. Hasil energi bebas ikatan ligan uji Palmarumycin CP1 sebesar -9,2 kkal/mol. Interaksi residu aktif HER-2 pada Palmarumycin CP1 dengan kontribusi terbesar terdapat pada residu Tyr 735. Hasil prediksi ADME menunjukkan bahwa hanya ada lima senyawa yang termasuk aturan Lipinski Rule of Five yaitu senyawa Tembetarine, Palmarumycin CP1, Curcumin, Cepharadione A, dan Hexahydrocurcumin. Oleh karena itu, hasil ADME menunjukkan bahwa hanya ada satu senyawa yang memenuhi aturan Lipinski Rule of Five dan sesuai dengan hasil Molecular Docking yang memiliki energi bebas ikatan sebesar -9,2 kkal/mol adalah senyawa Palmarumycin CP1.
Potential Effects of Myrmecodia Pendants (Ant Nests) on Healing Bone Injuries Najah, Adilla Syahsiyatun; Kilo, Akram La; Kadir, Ahmad
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.311-319

Abstract

Myrmecodia pendens is a medical plant that can have a healing effect on bone injuries. Bone injuries can occur due to many things, including injuries due to infection, non-infection, degeneration and neoplasms. Bones are the most important part of the body for the human body because the decreased bone function will affect human activities. Therefore better bone healing is needed. This review article aims to study and analyze the role of Myrmecodia pendens in the bone wound healing process. Several studies show that Myrmecodia pendens contain flavonoids, vitamins, terpenoid saponins, quones, and glycosides, as well as anti-inflammatory substances. These ingredients are markers in the healing process. Myrmecodia pendens has been proven to speed up the healing process. The conclusion shows that Myrmecodia pendens is a medicinal plant that can speed up the healing process of bone injuries.
Computational Study of Phytopharmaceutical Antidiabetes Potential of Gorontalo Traditional Medicine Plants La Kilo, Akram; Aman, La Ode; Asisah, Asisah; Ischak, Netty Ino; Paputungan, Mardjan; Alio, La
Jurnal Kartika Kimia Vol 6 No 1 (2023): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v6i1.202

Abstract

Diabetes Mellitus (DM) was a disease characterized by the occurrence of hyperglycemia. This study aimed to analyze the activity of compounds in traditional medicinal plants as potential anti-diabetic candidates using the MM method and to analyze the interactions of compounds contained in traditional medicinal plants that could be used as anti-diabetic drugs. The methods used were Molecular docking and Molecular dynamics, with the Aldose reductase 2HV5 receptor and the ligand ZST. Based on the research findings, the active compounds identified as potential anti-diabetic drugs were Calebin_A and alpha_tocotrienol. Docking method validation on Protein 2HV5 using the natural ligand ZST showed an RMSD of 0.66 Å. The best results from molecular docking were obtained with Calebin_A, which had a binding affinity of -11.3 kcal/mol, and alpha_tocotrienol, which had a binding affinity of -11.2 kcal/mol. The results of the molecular dynamics method on the best complexes were evaluated by considering the changes in system energy, system temperature, pressure, RMSD, RMSF, and binding free energy (∆G). The standard ligand ZST had a value of -30.43 kcal/mol, the test ligand calebin_A had a value of -34.48 kcal/mol, and alpha_tocotrienol had a value of -39.46 kcal/mol.
Studi Potensi Pirazolin Tersubstitusi 1-N dari Thiosemicarbazone sebagai Agen Antiamuba melalui Uji In Silico La Kilo, Akram; Aman, La Ode; Sabihi, Ismail; La Kilo, Jafar
Indonesian Journal of Chemical Research Vol 7 No 1 (2019): Edisi Bulan Juli (Edition For July)
Publisher : Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2019.7-akr

Abstract

This Research aims to study Quantitative Structure-Activity Relationship (QSAR) of pyrazoline analogues, designing the new potential compounds as antiamoebic and study the interactions between the new compunds and the drugs target by molecular docking approach. This research was a theoritical research using computational chemistry method. The object of research was 21 novel of 1-N-substituted pyrazoline analogues of thiosemicarbazones with their antiamoebic biological activity. The data of research was obtained from quantum chemistry calculation and statistically analysis using Multiple Linear Regression (MLR). The resulting QSAR equation was Log IC50 = 0.869 + (0.081 x TPSA) + (0.018 x HF) + (0.527 x E-HOMO) + (3.378 x E-LUMO) + (-16.938 x Glob) + (0.234 x LogP), with statistic parameters of n = 21; R2 = 0.933; SEE = 0.14558; FHitung/FTabel = 8.607; PRESS = 0.491. This equation was used as a basic for designing and predicting the new antiamoebic compounds of pyrazoline analogues. The design of new compound of two lead compounds with the Topliss resulted 5 of 18 new compounds having theoretical better activity than the lead compound. Molecular docking study indicated that all of the best compounds have ability to bind to drug target macromolecule.
Molecular Docking of Secondary Metabolite Compounds of Andrographis Paniculata Plant as Potential Covid-19 Drug Candidate Netty Ino Ishak; Akram La Kilo; Dandi Saputra Halidi; La Ode Aman; Jafar La Kilo; Weny J.A. Musa
Jurnal Sains dan Kesehatan Vol. 5 No. 3 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i3.1845

Abstract

The aim of this research was to investigate the interaction between secondary metabolite compounds and the Mpro receptor, which was the main protein in Covid-19. Ligand-receptor interactions were studied using the Molecular Docking method. The validation results indicated that the test ligand Andrographolide had a higher affinity value compared to the standard ligand, with a value of -6.6 kcal/mol compared to the standard ligand's -7.5 kcal/mol. Additionally, the compound 14-Acetyl-3,19-isopropylideneandrographolide, 5,4 dihydroxy-7,8,2',3'-tetramethoxyflavone-5-glucoside had an affinity of -7.5 kcal/mol, Andrographidin A had -7.6 kcal/mol, Andrographiside had -7.7 kcal/mol, Skullcapflavone I had 7.7 kcal/mol, 5-Hydroxy-7,8,2'-trimethoxyflavone-5-glucoside had -7.7 kcal/mol, Apigenin had 7.7 kcal/mol, 5-Hydroxy-7,8-dimethoxyflavone-5-glucoside had -7.8 kcal/mol, Neoandrographolide had -7.8 kcal/mol, Andropanoside had -7.9 kcal/mol, Wogonin-5 glucoside had -8.1 kcal/mol, 5,2',3'-Trihydroxy-7,8-dimethoxyflavone-3'-glucoside had -8.4 kcal/mol, and Bisandrographolide had -8.5 kcal/mol. From the molecular docking results, the secondary metabolite compounds from the Andrographis paniculata plant exhibited significant interactions surpassing the standard ligand N3. Active residue interactions observed included Phe140, Leu141, Asn142, Gly143, His163, Glu166, Gln189, and Thr190. Keywords: Andrographis paniculata; Covid-19 drug; Mpro receptor; molecular docking
Sosialisasi Dampak Penggunaan Merkuri pada Pekerja Tambang Rakyat di Desa Buladu, Kecamatan Sumalata Timur, Kabupaten Gorontalo Utara Kostiawan Sukamto; Astin Lukum; Masrid Pikoli; Akram La Kilo
Damhil: Jurnal Pengabdian kepada Masyarakat Vol 3, No 1: June 2024
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/damhil.v3i1.26821

Abstract

The awareness campaign on the impact of mercury use among artisanal miners in Buladu Village, East Sumalata District, North Gorontalo Regency, aimed to enhance knowledge about the dangers of mercury and introduce safer alternative mining methods. The event saw enthusiastic participation from 75 attendees, including miners, their families, and community representatives. The activities included pre-tests and post-tests, which showed a significant increase in participants' knowledge, with average scores rising from 45% to 85%. Interactive discussions and practical workshops revealed a high interest in understanding and adopting mercury-free mining methods. While some participants did not fully grasp the material, the majority rated the relevance of the information and the quality of the speakers as very good. Overall satisfaction was high, with 85% of participants feeling satisfied or very satisfied, and 80% expressing interest in further training. The survey also indicated a need for additional support, such as training, technical assistance, and ongoing education. Regular monitoring and the formation of working groups or cooperatives among miners are recommended to facilitate the implementation of alternative technologies and knowledge sharing. With appropriate follow-up actions, this initiative is expected to have a sustainable positive impact on the health and well-being of miners and the environmental preservation in Buladu Village.
Pelatihan Pembuatan Minuman Herbal Fungsional pada Ibu-Ibu PKK Desa Tiohu Kecamatan Asparaga Kabupaten Gorontalo Netty Ino Ischak; Akram La Kilo; Weny J.A. Musa; Siti Romla Maspeke; Ambarwati Ambarwati
Damhil: Jurnal Pengabdian kepada Masyarakat Vol 1, No 1: June 2022
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/damhil.v1i1.15653

Abstract

Tiohu is a village located in the Asparaga sub-district, Gorontalo Regency, in this village there are various types of herbal plants that are efficacious as traditional medicines. Temulawak, ginger, and turmeric are spices that are beneficial for health and can be made into instant powder ingredients that are brewed into functional drinks such as immune boosters and appetite enhancers. natural ones. This service program aims to hone the community's creativity in utilizing herbal plants to sell value products to help the family's economic source through the creative economy. This service is part of the KKNT-MBKM program, Department of Chemistry, State University of Gorontalo. The method used in this activity is to conduct training and practice herbal processing plants into instant drinks in the form of functional drink powders.
Investigating Pt/Pumice catalyst for efficient 3-methyl-1-butanol conversion Paputungan, Mardjan; La Kilo, Akram
Acta Chimica Asiana Vol. 7 No. 2 (2024)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v7i2.162

Abstract

The objective of this study was to obtain a modified Pt/pumice catalyst to support the conversion reaction of 3-methyl-1-butanol under specific reaction conditions. To achieve this objective, the first step involved preparing modified pumice catalyst pellets by impregnating them with Pt metal followed by activation at a temperature of 500 °C. The second step involved characterizing the Pt/pumice catalyst, including the surface distribution of Pt metal using SEM. The third step involved conducting the catalyst activity test against 3-methyl-1-butanol in a reactor (furnace) at temperatures ranging from 400 to 500°C with a flow system for the feed. The fourth step involved analyzing the conversion results using GC-MS chromatograms. The research results showed that the Si/Al ratio in the modified Pt/Pumice catalyst using a PtCl4 solution with a concentration of 0.0321 M for impregnation was 4:1, compared to 4.8:1 for Pt/Zeolite and 3.2:1 for Pt/ABP. The modified catalyst activity test for 3-methyl-1-butanol showed the following conversion results: Pt/Pumice 27.63%, Pt/Zeolite 23.85%, Pt/Black Pumice 14.81%, and for platinum catalyst, the conversion was 22.35%. These results indicated that the highest conversion was observed in the treated sample A-3 under the reaction condition of 450°C. The conversion products analyzed using GC-MS showed the presence of three molecules: 3-methylbutanal, 2-methylbutanal, and anhydrous isobutanoate.
ANALYSIS OF HAZARDOUS COMPOUNDS IN REFILLABLE ROLL-ON PERFUMES CIRCULATING IN GORONTALO CITY USING GC-MS Ibrahim, Indriyanti; Isa, Ishak; Rumape, Opir; Aman, La Ode; Kunusa, Wiwin Rewini; Kilo, Jafar La; La Kilo, Akram
JURNAL KIMIA SAINTEK DAN PENDIDIKAN Vol. 8 No. 1 (2024): JURNAL KIMIA SAINTEK DAN PENDIDIKAN
Publisher : Program Studi Kimia - Universitas Sari Mutiara Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/kimia.v8i1.5101

Abstract

This study aims to analyze the potentially hazardous compounds in refillable roll-on perfumes. The analytical method employed was GC-MS. The results from GC-MS analysis revealed hazardous compounds including Alpha-Pinene with concentrations in samples A-E = 0.0048 ppm, 0.0035 ppm, 0.0105 ppm, 0.0038 ppm, 0.0034 ppm; Dipropylene glycol with concentrations in samples A-E = 0.0322 ppm, 0.0162 ppm, 0.0692 ppm, 0.0493 ppm, 0.0465 ppm; Limonene with concentrations in samples A-E = 0.0705 ppm, 0.0373 ppm, 0.0222 ppm, 0.1462 ppm; Linalool with concentrations in samples A-E = 0.0092 ppm, 0.0568 ppm, 0.0146 ppm, 0.1298 ppm, 0.1233 ppm; Linalyl Acetate with concentrations in samples A-E = 0.1207 ppm, 0.0719 ppm, 0.0413 ppm, 0.1418 ppm, 0.1285 ppm. The levels of these compounds in the samples are below exposure thresholds, suggesting their current use is considered safe. However, stringent government oversight is necessary for refillable perfume products available in Gorontalo City.
Analysis of Hazardous Compounds in Refillable Roll-On Perfumes Circulating in Gorontalo City Using GC-MS Ibrahim, Indriyanti; Isa, Ishak; Rumape, Opir; Aman, La Ode; Kunusa, Wiwin Rewini; La Kilo, Jafar; La Kilo, Akram
Indonesian Journal of Chemistry and Environment Vol 7, No 2 (2024): DECEMBER 2024
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/ijoce.v7i2.74796

Abstract

This study aims to analyze the potential hazardous compounds in refillable roll-on perfumes. The analytical method employed was GC-MS. The results from GC-MS analysis revealed hazardous compounds including Alpha-Pinene with concentrations in samples A-E = 0.0048 ppm, 0.0035 ppm, 0.0105 ppm, 0.0038 ppm, 0.0034 ppm; Dipropylene glycol with concentrations in samples A-E = 0.0322 ppm, 0.0162 ppm, 0.0692 ppm, 0.0493 ppm, 0.0465 ppm; Limonene with concentrations in samples A-E = 0.0705 ppm, 0.0373 ppm, 0.0222 ppm, 0.1462 ppm; Linalool with concentrations in samples A-E = 0.0092 ppm, 0.0568 ppm, 0.0146 ppm, 0.1298 ppm, 0.1233 ppm; Linalyl Acetate with concentrations in samples A-E = 0.1207 ppm, 0.0719 ppm, 0.0413 ppm, 0.1418 ppm, 0.1285 ppm. The levels of these compounds in the samples are below exposure thresholds, suggesting their current use is considered safe. However, stringent government oversight is necessary for refillable perfume products available in Gorontalo City.
Co-Authors Abdul Wahab Pahrun Ahmad Kadir Kilo Ahmat Sudir Umar Alberto Costanzo Alberto Costanzo Alfikry Gonibala Ambarwati Ambarwati Anita Muhammad Arsyad, Muhammad Arif M. Arviani Arviani Asisah, Asisah Astin Lukum Astin Lukum Bait, Dewimuliawati J. Bambang Prijamboedi Botutihe, Deasy N. Bumulo, Nuraini Christopel, Nelpiani Christopel, Nelpiani D. Mazza D. Mazza, D. Dandi Saputra Halidi Daniele Mazza Daniele Mazza Deasy N Botutihe Deasy Natalia Botutihe Dewi Budi Purwati Djafar, Yuliyanti Wahab Eka Anggraini Odja Erga Kurniawati Erni Mohamad Fatma Tahir Hardianti Daing Hendri Iyabu Hidanurhayati, Hidanurhayati Ibrahim, Indriyanti Ika Riyana Tungkagi Ishak Isa Ismunandar Ismunandar Jafar La Kilo Julhim S Tangio Julhim S. Tangio Kadir Kilo, Ahmad Kadir, Ahmad Kamumu, Isal Kostiawan Sukamto Kostiawan Sukamto, Kostiawan Kusrini Kusrini La Alio La Ode Aman Lukman A. R. Laliyo Lukman A.R. Laliyo Maksum, M. Junaidi Mangara Sihaloho Mardjan Paputungan Masrid Pikoli Masrid Pikoli Mian Kau Monoarfa, Zunarti P Muhamad Abdulkadir Martoprawiro Muhammad Taufiq Nur Najah, Adilla Syahsiyatun Nelpiani Christopel Netty Ino Ischak Netty Ino Ischak Nita Suleman Nur Fadillah Pulukadang Nurhayati Bialangi Opir Rumape Patilima, Rusmiyati Ramona Nintias R. Abas Regina Olii Reski Rahmatia Idris Rusmiyati Patilima Sabihi, Ismail Saleh, Sri Deltalia Salman, Lismawati Saprini Hamdiani Sarmini A Iladat Siti Romla Maspeke Sri Revayana Kupang Sri Wanti Sappe Subawa, Kadek Suleman Duengo Suryanto Suryanto Sutra S Hadis Tahir, Wawan Triwahyuni S. Umamah Weny J.A. Musa Weny J.A. Musa Windi Dilapanga Wiwin Rewini Kunusa Wiwiyani Wiwiyani Yuszda K Salimi Zaenul Wathoni