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All Journal Pharmaciana: Jurnal Kefarmasian JPM17: Jurnal Pengabdian Masyarakat JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Warta Pengabdian Majalah Farmasetika Jurnal Layanan Masyarakat (Journal of Public Service) Berkala Ilmiah Kimia Farmasi Jurnal Masyarakat Madani Indonesia Camellia Borneo Journal of Pharmacy Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Achmad Toto Poernomo
Departemen Ilmu Kefarmasian, Fakultas Farmasi, Universitas Airlangga, Surabaya
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PENGEMBANGAN INDUSTRI KREATIF SIRUP JAMU SEHAT UNTUK PEMBERDAYAAN POSDAYA DI KABUPATEN SIDOARJO Djoko Agus Purwanto; Achmad Toto Poernomo; Febri Annuryanti
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 1 No. 1 (2017): Jurnal Layanan Masyarakat
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (317.574 KB) | DOI: 10.20473/jlm.v1i1.2017.1-5

Abstract

Indonesian people should be proud of its great natural biodiversity with precious ancestral heritages, such as Indonesian traditional medicine or Jamu. It has been intended to diversify the product of jamu that are affordable and healthy. Recently, it has been known that some luxury hotels in Indonesia creates jamu as a welcome drink, which is not only fresh but also healthful, to attract foreign customers. Empowering the community to be able making jamu syrups is importantly required for attracting many tourists to visit Indonesia. In this program, about 10 and 11 residents in the neighbourhood (RT) of 25 and 59, respectively, in Kebon Agung village, Sukodono district, Sidoarjo Regency were involved. They were trained for making jamu syrup made from lemongrass and mangosteen’s peel using health manufacturing process of traditional medicine i.e., without any chemical preserving, coloring, and taste masking agents, as well as hygienic packaging methods that can be long lasting, aesthetic appearing, and worth selling. The program consisted of training, mentoring, and lecturing to explain the making process of lemongrass and mangosteen peel syrups. The program was conducted until all participants were able to produce their own products well. The first production target was about each 200 bottles of lemongrass and mangosteen peel syrup could be sold. Bottle packaging, packaging equipment, and other supporting equipment will be delivered entirely as initial capital of POSDAYA. Hopefully, after the program is completed, the sustainability of this effort can be continued under the guidance of Universitas Airlangga. AbstrakBangsa Indonesia patut berbangga memiliki keanekaragaman hayati yang luar biasa ditambah dengan warisan nenek moyang yang berharga, salah satunya adalah jamu Saat ini, dirasakan perlu dilakukan diversifikasi pengembangan jamu sebagai minuman sehat sehingga tercipta jamu yang murah, terjangkau masyarakat, dan sehat. Ada kecenderungan beberapa hotel berbintang di Indonesia menciptakan jamu sebagai welcome drink untuk menarik pelanggan, yang tidak hanya segar tetapi juga menyehatkan. Pemberdayaan masyarakat untuk bisa membuat sirup minuman jamu yang sehat perlu lebih dikembangkan sehingga diharapkan dapat menarik wisatawan yang ingin berkunjung ke Indonesia. Dalam kegiatan ini telah dapat dilatih 10 orang warga RT 25 dan 11 orang warga RT 59 Desa Kebon Agung, Kecamatan Sukodono, Kabupaten Sidoarjo dalam pembuatan sirup sereh dan sirup kulit buah manggis dengan cara yang sehat, yaitu tanpa pengawet, tanpa pewarna, dan tanpa penambah rasa, sekaligus cara pengemasannya yang higienis sehingga dapat bertahan lama, memenuhi persyaratan estetis, dan layak jual. Metode yang digunakan adalah pelatihan, pendampingan, serta ceramah untuk menjelaskan pembuatan sirup sereh dan sirup kulit buah manggis hingga peserta mampu memproduksi sendiri dengan baik dan benar. Produksi pertama ditargetkan dapat dibuat 200 botol sirup sereh dan 200 botol sirup kulit buah manggis yang layak untuk dijual. Pembelian botol, peralatan pengemasan botol, dan alat-alat pendukung lainnya akan diserahkan seluruhnya sebagai modal awal dari POSDAYA. Harapannya setelah program selesai, keberlanjutan usaha ini dapat terus dilakukan di bawah binaan Universitas Airlangga.
Screening and Identification of Fibrinolitic Bacteria from Tempeh Muhammad Hakim Rafiga; Achmad Toto Poernomo; Sudjarwo Sudjarwo
Berkala Ilmiah Kimia Farmasi Vol. 7 No. 1 (2020): JUNI
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.965 KB) | DOI: 10.20473/bikfar.v7i1.29057

Abstract

Tempe is a food that is well known by indonesian people. The purpose of this study was to obtain bacteria with the largest fibrinolytic activity from Tempe. This research sample was obtained from four different markets in Surabaya area. Proteolytic activity of bacteria is examined using Skim Milk Agar media. Followed by fibrinolytic examination on the fibrin plate media. Identification of bacteria is carried out by gram staining method and 16S rRNA method. The sample is prepared by mixing the sample with a normal saline solution until 10-7 dilution is obtained. Then the bacterial suspension is spread on SMA media then incubated at 37°C for 24 hours. The bacterial suspension is spread onSMA media then incubated at 37°C for 24 hours. The selection of fibrinolytic protease producing bacteria was carried out using Skim Milk Agar (SMA) and Fibrin Agar (FA) are characterized by the presence of clear zones around them. Bacteria that produce fibrinolytic activity are then cultured in the Nutrrient Agar medium. The bacteria was then tested for fibrinolytic activity on the Fibrin Plate media in incubation at 37°C for 24 hours.  Positive bacteria are calculated by measuring the diameter of clear zones. Bacteria with sample code T2.2 produce the largest fibrinolytic index. T2.2 bacteria are then microscopically characterized, macroscopically, and bacterial isolates showing fibrinolytic activities were identified using Polymerase Chain Reaction (PCR) targeting their 16S rRNA gene. T2.2 bacteria is thought to be Stenotrophomonas maltophilia with a percentage similarity 96%.
Optimasi Produksi Fibrinolitik oleh Bacillus megaterium BM 9.1 menggunakan media Limbah Pertanian sebagai sumber karbon Kiki Lestari; Achmad Toto Poernomo; Prawita A
Berkala Ilmiah Kimia Farmasi Vol. 7 No. 1 (2020): JUNI
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v7i1.29060

Abstract

The study of effect agro recidues carbon sources on fibrinolytic enzyme production by Bacillus megaterium BM 9.1 was done by using fibrin plate method. Bacillus megaterium BM 9.1 grown on agro residues medium with solid state fermentation. The fibrinolytic enzymes activity is declared by fibrinolytic index. Fibrinolytics index is the comparisson between clear zones and wall diameters. From various carbon sources tested, Bacillus megaterium BM 9.1 which is grown in banana peel, pineaple skin, corn husk, rice bran and corn cob could produce fibrinolytic enzymes. Optimum fibrinolytic activities found in a nutrient agar  and banana peel medium at fibrinolytic index 4,95 ± 0,08 (p<0,05). The comparisson fibrinolytic index  between Bacillus megaterium BM 9.1 which grown in combination nutrient agar, banana peel and nutrien agar standart is 117,%. Banana peel concentration optimation was done at concentration of 0,5 %, 1 %, 2 % and 4 % and the fibrinolytic index was found respectively according to 4,26 ± 0,11 ; 4,32 ± 0,03 ; 4,61 ± 0,03; and 4,35 ± 0,05. The optimum fibrinolytic activity was found in banana peel on consentration 2 %.
Inhibitory Activity of Fermented Milk Multi Strain Lactic Acid Bacteria Against Staphylococcus Aureus ATCC 25923 Ambarini Indah; Noor Erma Nasution; Achmad Toto Poernomo; Isnaesi Isnaeni
Berkala Ilmiah Kimia Farmasi Vol. 7 No. 1 (2020): JUNI
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (280.59 KB) | DOI: 10.20473/bikfar.v7i1.29064

Abstract

The aim of the study was to investigate inhibitory activity of fermented milk multi strain lactic acid bacteria (LAB): Lactobacillus casei Shirota, Lactobacillus acidophilus, and Lactobacillus bulgaricus against Staphylococcus aureus ATCC 29523 at variable concentration milk using diffusion method. The multi strain culture of LAB were inoculated on skimmed and diary cow milk (DCM) at concentration of 50% and 100%; in which carbon, amino acid, fat and water concentration were different. Effect of the milk and its concentration on the inhibitory activity against the test bacteria was observed as well as decreasing milk acidity and increasing of milk viscosity after 24 hours incubation. Results showed that the performance of LAB in two kinds of milks at 50% and 100% concentrations were different. On the lower milk concentration, the acidity was lower than on the 100% milk, while on the higher milk concentration, the viscosity was bigger than on the 50% concentration. The fermented milk of L. cassei Sirota did not show inhibitory activity. The multi strain of LAB on the DCM at concentration of 50% and 100% showed antibacterial activity againts Staphylococcus aureus ATCC 25923, while the skimmedmed milk fermentation showed lower inhibitory activity on both concentrations.
Pengaruh Sumber Karbon Organik Terhadap Produksi Protease Fibrinolitik Bacillus Sphaericus BM 9.1 Dengan Solid State Fermentation (SSF) Afrilia Diana Fitri; achmad Toto Poernomo; Muhammad Faris Adrianto
Berkala Ilmiah Kimia Farmasi Vol. 7 No. 2 (2020): DESEMBER
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (567.602 KB) | DOI: 10.20473/bikfar.v7i2.29269

Abstract

Enzim fibrinolitik merupakan kelompok enzim protease serin yang mampu menghancurkan bekuan darah (fibrin) pada berbagai penyakit trombotik. Sumber enzim fibrinolitik dapat diperoleh dari mikroorganisme. Bacillus sp merupakan salah satu mikroorganisme yang berpotensi menghasilkan enzim fibrinolitik. Medium memiliki peran penting dalam menumbuhkan dan memproduksi enzim fibrinolitik. Dalam medium, sumber karbon yang cukup diperlukan untuk pertumbuhan bakteri. Dalam fermentasi mikroba, sumber karbon sangat diperlukan untuk pembentukan biomassa dan produksi energi. Media yang digunakan dalam penelitian ini adalah media Nutrient agar yang ditambahkan sumber karbon organik. Sumber karbon yang digunakan adalah glukosa, fruktosa, sukrosa, dan pati dengan konsentrasi masing-masing 1% b/v. Penambahan sumber karbon dengan konsentrasi 1% b/v pada medium menunjukkan pengaruh yang berbeda terhadap produksi enzim fibrinolitik oleh Bacillus sphaericus BM 9.1. Jadi di antara semua sumber karbon yang diuji, fruktosa menghasilkan indeks fibrinolitik tertinggi (2,86 ± 0,03). Langkah selanjutnya adalah mengoptimalkan konsentrasi sumber karbon fruktosa. Optimasi konsentrasi fruktosa diuji pada konsentrasi 1%, 2%, 3%, dan 4%. Semua konsentrasi telah diuji, konsentrasi fruktosa 1% b/v menghasilkan indeks fibrinolitik tertinggi (2,82 ± 0,04).  
Validasi Metode KLT-Densitometri Pada Penetapan Kadar (-)-Epigallocatechin Gallate (EGCG) Dalam Teh Hijau Chusnul Chatimah; Sugijanto sugianto; Achmad Toto Poernomo
Berkala Ilmiah Kimia Farmasi Vol. 7 No. 2 (2020): DESEMBER
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (463.523 KB) | DOI: 10.20473/bikfar.v7i2.29303

Abstract

Latar Belakang Daun teh (Camellia sinensis L.) memiliki banyak manfaat untuk kesehatan. Daun teh hijau mengandung banyak senyawa polifenol dalam kadar tinggi, antara lain turunan catechin epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG) dan epigallocatechin gallate (EGCG). Komponen bioaktif yang paling dominan adalah EGCG. Sebuah metode TLC-Densitometry sederhana telah dikembangkan untuk penentuan (-)-Epigallocatechin gallate dalam produk teh hijau. Metode ini menggunakan silika gel F 254 sebagai fase diam dan fase gerak kloroform-asam asetat-asam format-isopropanol (16:2:2:8). Hasil Panjang gelombang maksimum terdeteksi pada 278 nm. Respon linieritas ditemukan (-)-Epigallocatechin gallate antara 0,5043 g–2,5215 g dengan regresi persamaan Y = 5409,8 X – 569,97 (r = 0,9996; Vxo= 3,94%). Metode divalidasi untuk menentukan deteksi tiruan (0,0188 g), kuantisasi batas (0,0627µg), akurasi (91,41%), presisi untuk standar EGCG (4,47%) dan presisi metode (7,01 %). Kesimpulan hasil ini menunjukkan bahwa EGCG dalam produk teh hijau dapat dideteksi dengan metode TLC-Densitometry. Dengan menggunakan metode, konsentrasi EGCG pada produk teh hijau adalah 3,33%.  
Produksi Enzim Fibrinolitik Tempe oleh Rhizopus oryzae FNCC 6078 Alicia Sada; Noor Erma Sugianto; Achmad Toto Poernomo
Berkala Ilmiah Kimia Farmasi Vol. 8 No. 1 (2021): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (238.374 KB) | DOI: 10.20473/bikfar.v8i1.31202

Abstract

ackground Rhizopus oryzae FNCC 6078 had been evaluated producing fibrinolytic enzyme under solid state fermentation. Soybean had been used to produce fibrinolytic enzyme through fermentation in tempeh. The main purpose of this study was to reveal optimum condition for fermentation. The parameters of the condition were inoculum volume, incubation period and temperature. Optimum condition was defined by maximum fibrinolytic activity. Methode Fibrinolytic activity was measured using spectrophotometry at 274 nm. Result optimum condition for producing fibrinolytic enzyme was 1,5 mL volume of inoculum of Rhizopus oryzae suspension in 25%T, 42 hours for incubation period and 35oC temperature incubation.
Physicochemical Properties and Antioxidant Activity of Three Types of Monofloral Honey from Indonesia Sulistyianingsih; Achmad Toto Poernomo; Riesta Primaharinastiti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 3 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i32022.290-297

Abstract

Background: In addition to minerals, honey contains carbohydrates (glucose and fructose), protein, amino acids, water, enzymes, ash, vitamins, and other substances. Compounds of honey can affect the chemical properties of honey. Knowing the physicochemical properties of honey is very important because physicochemical properties affect the quality of honey. One of the biological activities of honey is an antioxidant. Antioxidants can interfere with oxidative processes, prevent disease, and play an important role in the body's defence system. Objective: to determine and compare physicochemical properties (color, viscosity, ash content, water content, reducing sugar (glucose), total phenolic compound, HMF) and antioxidant activities of monofloral honey samples from Indonesia. Methods: The color of honey are categorized using the Pfund scale. Viscosity measurement is carried out using a Brookfield viscometer. The water content is carried out using a refractometer. Phenolic content and antioxidant activities analysis were carried out by UV-VIS spectrophotometer. Results: The results show that rambutan honey from Malang has the highest physicochemical properties and antioxidant activity, which had an amber color, water content of 21.7% b/b, acidity 20.7 mL NaOH/Kg, viscosity of 33.08 poise, ash content of 0.17% b/b, reducing sugar 69.38%b/b, total phenolics content 533.7 mg GAE/Kg sample and IC50 0.111 µg/mL. Conclusion: The quality of honey varies from region to region. The best honey (according to SNI) is rambutan honey from Malang.
Study of Growth Curve of Lactobacillus plantarum FNCC 0026 and Its Antibacterial Activity Safarini Marwah; Achmad Toto Poernomo; Esti Hendradi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 1 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i12023.38-43

Abstract

Background: Lactobacillus plantarum is one of the lactic acid bacteria (LAB) with strong antibacterial activity. However, these bacteria show different growth for each strain. The turbidimetric bacterial growth curve approach is the most accurate, fastest, and most reproducible method for obtaining an overview of the bacterial life cycle. In addition, we also examined the antibacterial activity of each observation of the growth curve. Objective: The aim of the study was to determine the optimal incubation time with the highest biomass concentration and antibacterial activity of the Lactobacillus plantarum FNCC 0026. Method: Observations of optical density (OD) values "‹"‹were performed simultaneously on 10 points of Lactobacillus plantarum FNCC 0026 and performed every 12 hours. Antibacterial activity tested against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 8739. Result: The Lactobacillus plantarum FNCC 0026 fermentation broth showed the highest OD value and antibacterial activity after 30 hours of incubation. The maximum diameter of the inhibition zone against Staphylococcus aureus ATCC 25923 and Escherichia coli 25923 were 17.08 ± 0.51 mm and 16.83 ± 0.54 mm. Conclusion: The results showed that the antibacterial activity had a linear relationship with the concentration of bacteria. In the Lactobacillus plantarum FNCC 0026, the optimum cultivation time is in the lag phase (24 – 30 hours).
Growth Inhibitory Effects of Red and Yellow Passion Fruits against MRSA and ESBL-producing Bacteria Aprelita Nurelli Dwiana; Achmad Toto Poernomo; Iif Hanifa Nurrosyidah; Isnaeni; Dian Rahmawaty; Idha Kusumawati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 1 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i12023.86-91

Abstract

Background: Red passion fruit (Passiflora edulis Sims) and yellow passion fruit (Passiflora edulis f. flavicarpa) are native Indonesian fruits with numerous health benefits. This study used de Man, Rogosa, and Sharpe (MRS) medium for fermentation. Probiotics are beneficial microorganisms obtained from fermented food or drink (Hamid et al., 2020). Probiotics and lactic acid bacteria, which are known to have various benefits, particularly as antibacterial, are among the active components identified in passion fruit pulp. Objective: This study examinedthe antibacterial activity of red and yellow passion fruits. Methods: Freshly collected passion fruit pulps were fermented in MRS medium in a shaker incubator for 48 hours at 24°C. The filtrates from the fermented broth were tested against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL)-producing bacteria. The analyses applied the streak plate method and the total plate count method. Results: The Minimum Inhibitory Concentrations (MICs) of red passion fruit ferment filtrate against MRSA 10 and MRSA 11 were 50% and 60%, respectively, and of yellow passion fruit ferment filtrate against MRSA 10 and MRSA 11 were both 30%. Meanwhile, the MICs of red passion fruit ferment filtrates were 35% against ESBL 41 and ESBL 43 and 25% against ESBL 45 and ESBL 47, whereas the MICs of yellow passion fruit (Passiflora edulis f. favicarpa) ferment filtrates were 25% against ESBL 41 and ESBL 43, and 12.5% against ESBL 45 and ESBL 47. Red passion fruit (Passiflora edulis Sims) and yellow passion fruit (Passiflora edulis f. flavicarpa) ferment filtrates became growth inhibitors against the clinical isolates of MRSA and ESBL-producing bacteria with an optimal fermentation time of 24 hours and an optimal concentration of 75%. Conclusion: The results of this study found that the fermented filtrates of red and yellow passion fruits in MRS media could be developed as an antibacterial against MRSA and ESBL-producing bacteria.
Co-Authors Achmad Burhanudin Adristy Ratna Kusumo Afrilia Diana Fitri Alfi Khatib Alicia Sada Ambarini Indah Aprelita Nurelli Dwiana Asri Darmawati Aty Widyawaruyanti Ayu Chandra Dewi Bambang Tri Purwanto Burhanudin, Achmad Chusnul Chatimah Dian Rahmawaty Digdo Suryagama Diyah, Nuzul Wahyuning Djoko Agus Djoko Agus Purwanto Esti Hendradi Febri Annuryanti Hadi Poerwono Haryanto, Isnaeni Yudi Hidayati, Shabrina Wahyu Idha Kusumawati Ifah Yulistyani Isnaeni Isnaeni Isnaeni Isnaeni Isnaeni Isnaeni Isnaeni Yudi Haryanto Juni Ekowati Kholis Amalia Nofianti Kiki Lestari Lailatul Nuraini Lusiana, Rebhika M. Faris Adrianto Melanny Ika Sulistyowaty Muhammad Faris Adrianto Muhammad Hakim Rafiga Nindya Pramesti Wardani Nindya Pramesti Wardani Noor Erma Nasution Noor Erma Sugianto Nurrosyidah, Iif Hanifa Paramita, Diajeng Putri Prawita A Rebhika Lusiana Riesta Primaharinastiti Riesta Primaharinastiti, Riesta Safarini Marwah Setyawati, Eni Sonia Khoirun Nisa Sudjarwo Sudjarwo Sudjarwo Sudjarwo Sugijanto sugianto Sulistyianingsih Sulistyowati, Melanny Ika Syahrani, Achmad Tutiek Purwanti Wiwied Ekasari Zahratus Silmi Aliyah