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All Journal JURNAL PESISIR DAN LAUT TROPIS Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Majalah Info Sains Journal of Pharmaceutical and Sciences.
Royke R. Palandi
Universitas Kristen Indonesia Tomohon
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Activity of Caulerpa racemosa Against Helicobacter pylori Bacteria Kalangi, Jekki J. F.; Lengkey, Yessie K.; Potalangi, Nerni O.; Tulandi, Selvana S.; Palandi, Reky R.; Karauwan, Ferdy A.
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.498

Abstract

Sea grapes (Caulerpa racemosa) contain various secondary metabolites with bioactive compounds that function as antibacterial agents. This study aimed to evaluate the antibacterial activity of ethanol extract from sea grapes (Caulerpa racemosa) against Helicobacter pylori. The method used was the agar diffusion technique with paper discs at four different extract concentrations: 500 µg, 600 µg, 700 µg, and 800 µg per disc. Extraction was carried out through maceration using 96% ethanol as the solvent, and antibacterial activity was assessed based on the formation of inhibition zones around the discs. The results showed that all extract concentrations exhibited very strong inhibitory effects on the growth of H. pylori, with inhibition zones of 27.23 mm, 28.51 mm, 29.91 mm, and 31.51 mm, respectively. The higher the extract concentration, the larger the inhibition zone formed. Based on antibacterial activity categorization, Caulerpa racemosa extract demonstrates potential as a strong antibacterial agent against Helicobacter pylori.
Antibacterial Activity Test of Scleria sumatrensis Leaf Extract against Staphylococcus aureus in Vitro Pareta, Douglas N.; Palandi, Reky R.; Tulandi, Selvana S.; Turang, Juliani R.; Runtu, Alter Y.
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 8 No. 1 (2025): April 2025
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v8i1.506

Abstract

Staphylococcus aureus bacteria is one of the important pathogens that can cause various types of infections, ranging from mild ones such as folliculitis and impetigo to life-threatening conditions such as nosocomial pneumonia, osteomyelitis, endocarditis, sepsis, and toxic shock syndrome. Due to its ability to develop resistance to antibiotics, new alternative treatments are needed, one of which is from natural ingredients. In this study, the antibacterial activity of Scleria sumatrensis extract was tested against Staphylococcus aureus with a concentration variation of 100 - 500 µg / disc. The results showed that at a concentration of 100 ?g / disc, the extract provided antibacterial activity in the moderate category, while at a concentration of 200 to 500 ?g / disc, the activity produced was included in the strong category. These findings indicate that Scleria sumatrensis extract has the potential as a natural antibacterial agent against Staphylococcus aureus, so it is worthy of further development as an alternative therapy for infections caused by S. aureus bacteria.
Co-Authors Adolfina Sumangando Alfiano H. Mbaubedari Anti, Reski Asmiati Mulkin Ayu Brenda Sumariangen Billy T. Wagey Charly J. Watung Douglas N. Pareta Felicia T. Rawung Friska Mery Montolalu Gideon A. R. Tiwow Goni, Jenelitha S. Hanna M. Rumagit, Hanna M. Hariyadi, Hariyadi Hellen Matindas Hindang Kaempe Ingriani Tan Djindadi Irma Dawi Jabes Wolter Kanter Jeane Mongi Jeike Adondis Kalangi, Jekki J. F. Karauwan, Ferdy Lengkey, Yessie Marlein M.C. Laloan Marshella Mokoagouw Marzilano M. R. Rumagit Meifi Kaparang Melisa Paat Mita Sindy Tumiir Moningka, Asriani S. Nerni Potolangi Nickson J. Kawung Olvie Datu Paat, Vlagia Indira Pakingki, Priska Pelealu, Nancy C. Raden Mohamad Herdian Bhakti Randy Tampa'i Randy Tampa’i Rece Maliada Rian Kapantow Riski Tjuana Rizald M. Rompas Rocky Ardiles Lawere Runtu, Alter Y. Sambou, Christel N. Sarah Sambow Silvana L. Tumbel Sonny Untu Susan Claudia Mende Tombuku, Joke Luis Tulandi, Selvana Stien Turang, Juliani R. Vania V. Liling Wantah, Kezia T. Wilmar Maarisit Yappy F. Saroinsong