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All Journal CHEMICA Jurnal Teknik Kimia ALCHEMY Jurnal Penelitian Kimia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Indonesia Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal AFAMEDIS Jurnal Bakti Untuk Negeri Jurnal Komunitas Farmasi Nasional Borneo Journal of Pharmacy Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Journal of Pharmascience
Siska Musiam
Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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PERBANDINGAN PELARUT ETANOL-AIR DALAM PROSES EKSTRAKSI DAUN BAWANG DAYAK (Eleutherine palmifolia Linn) TERHADAP AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH Kumalasari, Eka; Musiam, Siska
Jurnal Insan Farmasi Indonesia Vol 2 No 1 (2019)
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i3.2290

Abstract

The immune system can be damaged by the presence of free radicals. The formation of free radicals must be prevented by antioxidants. Humanes basically do not have antioxidant reserves in their her body, so that when there is exposure to excessive the radicals then the needs body antioxidant intake from the outside. At present it is encouraged the development of antioxidants derived from plants, which are relatively easier to obtain and safe for humans consumption. Potential to antioxidant plants one of them is dayak onion leaves. Dayak onion leaves are a typical plant Borneo Central used by the Dayak tribe as medicine. To get a high active ingredient in dayak onion leaves, it is necessary to optimize the type of maceration solvent. The types of solvents used are water and ethanol. Testing of antioxidant using activities DPPH (2,2-Diphenyl-1-picrylhydrazyl) as a free radical compound. The maximum wavelength of DPPH in this study is at 519 nm. The highest IC50 value was found on dayak onion leaf extract with water solvent which was 58.62 ppm, with ethanol-water solvent of 33.71 ppm, and the smallest with ethanol solvent of 26.98 ppm. Key: antioxydan, Eleutherine palmifolia of leave, DPPH
FORMULASI DAN EVALUASI FISIK SEDIAAN MASKER CLAY KOMBINASI EKTRAK ETANOL DAUN BAWANG DAYAK DAN KULIT JERUK SIAM Musiam, Siska; Ma'ruf, Muhammad; Kumalasari, Eka
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i3.2298

Abstract

Clay masks are a popular cosmetic due to their ability to rejuvenate the skin and detoxify the face. Clay masks can be made by adding dayak onion leaves and Siamese banjar orange peel, known to be rich in natural antioxidants containing various complex secondary metabolites. The aim of this research is to formulate and evaluate a clay mask preparation made from a combination of ethanol extracts of dayak onion leaves and Siamese banjar orange peel. The samples were extracted using the maceration method with 70% ethanol as a solvent. The ethanol extracts were then formulated into clay masks using kaolin as the base material, with ratios of 1:1, 2:1, and 1:2. The organoleptic evaluation showed no changes in color, odor, or texture of the masks during storage. All formulations were homogeneous with an average pH ranging from 5.19 to 5.97. The viscosity test results ranged from 29.14 to 37.05 Pa’s, the average spreadability was 27.12-38.90 mm, and the drying time ranged from 15.21 to 17.58 minutes. It can be concluded that the ethanol extract combination of dayak onion leaves and Siamese banjar orange peel can be formulated into a stable clay mask and all formulations meet the required physical evaluation.
ANALISIS KUANTITATIF KESADAHAN TOTAL AIR MINUM ISI ULANG YANG DIJUAL DI WILAYAH KAYU TANGI KOTA BANJARMASIN Siska Musiam; Siti Darmiani; Aditya Maulana Perdana Putra
Jurnal Ilmiah Manuntung Vol 1 No 2 (2015): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v1i2.28

Abstract

Water is one of the important needs for human body. Therefore, water which consumed should be healthy and have certain quality. One of its quality parameter is total hardness. Total hardness is the hardness which caused by Ca2+ and Mg2+ ions. Hard water, or water with a high level of total hardness, if consumed in long term can lead to hyperparatyroidsm, Nephrolithiasis, and musculusweakness. The aim of this study were to determine total hardness level of refill drinking waterwhich sold in Kayutangi Banjarmasin and to compare it with the standard parameter of total hardness in Permenkes 492/Menkes/IV/2010 which is 500 mg/L in maximum. There were 16 samples in this study that taken from refill drinking water store were found accidentally. The quantitative analysis was done by complexometry titration method with Na2-EDTA as titrant and Eriochrome Black T as indicator. The results showed that the ranges of total hardness level of 16 samples that determined between 35,64 – 99,00 mg/L which is suitable with the standard based on Permenkes 492/Menkes/IV/2010
ANALISIS KUALITATIF FORMALIN PADA TAHU MENTAH YANG DIJUAL DI PASAR KALINDO, TELUK TIRAM DAN TELAWANG BANJARMASIN Novia Ariani; Maida Safutri; Siska Musiam
Jurnal Ilmiah Manuntung Vol 2 No 1 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i1.48

Abstract

Tofu is one of favourite food in Indonesia because it is containing the nutrients which body needs, such as protein. Tofu comes from processed soybeans and contains high water, so it can only save for 1 or 2 days in storage. Because of that reason several   manufacturers or dealers add additional ingredients, one of them was formaldehyde to made tofu were durable to be restored and increases consumer appeal. The aim of the study was to identifity the contain of formaldehyde at crude tofu in Kalindo, Teluk Tiram and Telawang market Banjarmasin. The investigated sample was white crude tofu were 19 samples obtained with accidental sampling. The type of research was descriptive research. Qualitative analysis of formaldehyde at crude tofu was done with conventional method by using Ag(NH3)2NO3 and KMnO4 0,1N reagents. The result of study shows that crude tofu was sold in Kalindo market 90% (9 of 10 samples) positive contain formaldehyde, 100% (4 of 4 samples) at Teluk Tiram market positive contain formaldehyde and 80% (4 of 5 samples) at Telawang market positive contain formaldehyde
PEMERIKSAAN KESEHATAN GRATIS KEPADA MASYARAKAT DESA TATAH LAYAP, KECAMATAN TATAH MAKMUR, KABUPATEN BANJAR Muhammad Ma'ruf; shafran ilahi, fitrah; Prihandiwati, Erna; Susanto, Yugo; Ariani, Novia; Musiam, Siska; Wahyuni, Amaliyah; Rizki Febrianti, Dwi; Puteri Amalia, Senya; Ayu Lestari, Desy
Jurnal Bakti untuk Negeri Vol 5 No 1 (2025): Jurnal Bakti Untuk Negeri
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/f556kt16

Abstract

Regular health check-ups play a vital role in detecting health disorders early to prevent and treat illnesses appropriately. The free health check-up program in Tatah Layap Village, Tatah Makmur Subdistrict, Banjar Regency, aims to raise community awareness about the importance of promotive and preventive measures in maintaining health. This activity includes health education through communication, information, and education (CIE) approaches, as well as direct health examinations for the community. The program was attended by 85 participants who gained valuable information and understanding of the importance of regular health check-ups. The examination results served as a guide for participants to monitor and maintain their health conditions. This program is expected to enhance community awareness about the significance of routine health check-ups as a preventive measure to reduce the risk of future illnesses
Aktivitas Anti-Inflamasi Eupatorium inulifolium dan Kalsium Karbonat Pada Tikus Jantan Dwi Rizki Febrianti; Siska Musiam
Journal of Pharmascience Vol. 7 No. 1 (2020): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8078

Abstract

ABSTRAK Tujuan dari penelitian ini adalah untuk mempelajari potensi daun Kumpai Mahung (Eupatorium inulifolium) dan kalsium karbonat sebagai anti-inflamasi, berdasarkan obat tradisional di pegunungan Dayak Meratus Indonesia. Metode yang digunakan untuk mendapatkan ekstrak adalah maserasi menggunakan pelarut metanol dengan rasio 1:10. Uji kualitatif Penapisan fitokimia fenolik dengan senyawa FeCl3 dan kuantitatif dengan spektrofotometri UV-Vis dengan kuersetin sebagai standar, panjang gelombang 418 nm konsentrasi 10-50 ppm. Ekstrak Eupatorium inulifolium dan calcium carbonat diformulasikan menjadi salep sederhana dengan penambahan vaselin album (1:3). tes anti-inflamasi menggunakan tikus jantan yang telah diinduksi oleh karagenin 3%. Hasil penelitian menunjukkan bahwa pada pengujian kualitatif dan kualitatif, adalah positif senyawa fenolik, Mengandung 3,68% flavonoid. Ekstrak Eupatorium inulifolium dan kalsium karbonat dalam salep dapat secara signifikan mengurangi edema pada kaki tikus dibandingkan dengan kontrol negatif (14,1%). Kata kunci: Edema, Salep, Anti Inflamasi  ABSTRACT The purpose of this research was to study the potential Kumpai Mahung leaf (Eupatorium inulifolium) and calcium carbonate as an anti-inflammation, based on folk medicine in Dayak meratus mountains of Indonesia. The methods used to obtain the extract is maceration using methanol solvent with the ratio of 1:10.  Qualitative test Phytochemical Screening of phenolic with FeCl3 and quantitative flavonoids compounds with spectrophotometry UV-vis with quercetin as standard, wavelength 418 nm concentration 10-50 ppm. Eupatorium inulifolium extracts and calcium carbonate are formulated into simple ointments with the addition of vaseline album (1: 3) anti-inflammation test using male mice that had been inducted by carrageenan 3%. The result showed that on qualitative and qualitative testing, is positive phenolic compounds, contains 3,68% of flavonoids. Eupatorium inulifolium extract and calcium carbonate in the ointment can significantly alleviate the edema on mice’s paw compared to a negative control (14,1%).Keywords: Rat Paw Edema, Ointment, Anti-Inflammation I.       PENDAHULUAN   Peradangan adalah salah satu tema yang paling menarik untuk dipelajari karena mencakup banyak mediator, dan ini menyebabkan banyak agen peradangan seperti antibodi monoklonal dan antagonis peradangan mulai dikembangkan dan dilaporkan ada obat lain seperti asam askorbat monosiklik, garam kalsium dan kalsium karbonat juga memiliki aspek anti-inflamasi terutama yang disebabkan sengatan serangga (Karnad, Patil dan Majagi, 2006). Peradangan memiliki beberapa respons berdasarkan penyebabnya; salah satu respons peradangan yang biasa terjadi adalah edema. Edema terjadi karena meningkatnya aliran darah lokal ke area luka, dan itu menyebabkan lebih banyak mediator kimia dan histamin dilepaskan sehingga permeabilitas kapiler meningkat (Sousa, Vieira dan Pinho, 2010). Efek dari pembengkakan ini termasuk ketidaknyamanan, rasa sakit, dan ruam (Isrofah, Sagiran, dan Afandi, 2011). Obat antiinflamasi sebagian besar bekerja dengan menurunkan permeabilitas kapiler dengan menurunkan jumlah histamin yang dilepaskan oleh basofil, menghambat fungsi fagositosis leukosit dan makrofag sehingga pembengkakan dapat mereda.Penggunaan sumber daya alam di Kalimantan Indonesia, belum dilakukan secara maksimal karena keanekaragaman
Pengaruh Metode Pengeringan Terhadap Kadar Flavonoid Ekstrak Etanolik Kulit Buah Alpukat (Persea americana Mill.) dengan Spektrofotometri UV-VIS Novia Ariani; Siska Musiam; Rakhmadhan Niah; Dwi Rizki Febrianti
Journal of Pharmascience Vol. 9 No. 1 (2022): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.10864

Abstract

Buah alpukat (Persea americana Mill.) merupakan salah satu tanaman yang memiliki khasiat sebagai obat. Bagian yang sering dimanfaatkan adalah daging buah sedangkan kulit buah belum banyak dimanfaatkan. Kulit buah alpukat berpotensi untuk dikembangkan sebagai antioksidan dengan kandungan senyawa aktif flavonoid. Proses pengolahan simplisia sangat penting terutama pada tahap pengeringan. Tahap pengeringan bertujuan untuk memperoleh simplisia yang tidak mudah rusak selama penyimpanan dalam waktu lama dan menjamin kandungan senyawa aktif yang memiliki khasiat obat. Penelitian ini bertujuan untuk mengetahui pengaruh metode pengeringan terhadap kadar flavonoid ekstrak kulit buah alpukat. Jenis penelitian ini eksperimental. Teknik pengambilan sampel adalah Random Sampling. Metode pengeringan yang digunakan dengan penjemuran dengan sinar matahari dan menggunakan oven. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 96%. Metode analisis senyawa dilakukan dengan spektrofotometer Uv-Visible. Perbandingan dua metode pengeringan dianalisis dengan statistik Independent T-Test. Hasil penelitian menunjukkan Kadar flavonoid kulit buah alpukat yang dikeringkan dengan oven sebesar 13,14% sedangkan yang dikeringkan dengan sinar matahari ditutup kain hitam sebesar 5,58%. Dari hasil kadar dapat disimpulkan bahwa metode pengeringan kulit buah alpukat dengan oven lebih efektif dalam menghasilkan ekstrak yang memiliki kandungan kadar flavonoid Kata Kunci: Flavonoid, Metode Pengeringan, Persea americana Mill., Spektrofotometri  Avocado (Persea americana Mill.) is a plant that has medicinal properties. The part that is often used is the flesh of the fruit, while the skin of the fruit has not been widely used. Avocado skin has which the potential to be developed as an antioxidant with the active compound being flavonoids. The processing of raw materials is very important, especially at the drying stage. The drying stage aims to obtain raw materials that is not easily damaged during long storage and ensures the content of active compounds that have medicinal properties. This study aims to determine the effect of the drying method on flavonoid levels of avocado peel extract. This type of research is experimental. The sampling technique was random sampling. Methods of the drying used is in the sun drying and using an oven. Extraction was carried out by maceration method using ethanol 96% solvent. The method of compound analysis was carried out with a Uv-Visible spectrophotometer. The comparison of the two drying methods was analyzed using the Independent T-Test statistic. The results showed that the flavonoid content of oven-dried avocado peels was 13.14%, while those dried in the sun covered with a black cloth were 5.58%. From the results, it can be concluded that the oven-drying method of avocado peel is more effective in producing extracts that contain higher levels of flavonoids than the sun drying method.
Hand Sanitizer Ekstrak Daun Pucuk Idat (Cratoxylum glaucum) sebagai Antibakteri Staphylococcus aureus dan Escherichia coli Putri, Megawati Ayu; Saputra, Marhan Ebit; Amanah, Ike Nur; Musiam, Siska; Fabiani, Verry Andre
ALCHEMY Jurnal Penelitian Kimia Vol 16, No 2 (2020): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.16.2.32208.227-231

Abstract

Daun pucuk idat merupakan tanaman lokal Bangka Belitung yang memiliki aktivitas antibakteri terhadap Staphylococcus aureus dan Escherichia coli.Sebagai upaya pemanfaatan potensi lokal maka dibuat suatu produk sediaan gel hand sanitizer yang praktis dan ekonomis. Ekstrak daun pucuk idat diperoleh dengan metode maserasi menggunakan pelarut aseton. Ekstrak yang dihasilkan diformulasikan dalam berbagai konsentrasi ekstrak daun pucuk idat (40%, 60%, 80%, dan 100%) dengan penambahan carboxymethyl cellulose sodium (CMC-Na) 0,25 g, gliserin 1 mL, propilenglikol 0,5 mL serta akuades        10 mL. Setiap formulasi gel handsanitizer dilakukan pengujian stabilitas fisik meliputi uji organoleptis, uji homogenitas, uji daya sebar, uji pH, uji iritasi kulit serta uji aktivitas antibakteri.  Hasil uji organoleptik menunjukkan bahwa semua konsentrasi hand sanitizer berbentuk gel, berwarna kuning muda, berbau dan homogen. Uji pH dan daya sebar gel hand sanitizer telah memenuhi ketentuan SNI No. 06-2588. Pengujian iritasi kulit tidak menimbulkan kemerahan, gatal-gatal dan tidak mengakibatkan kulit menjadi kasar pada punggung tangan sukarelawan. Berdasarkan uji sifat fisik gel hand sanitizer yang dihasilkan memiliki sifat fisik yang serupa dengan gel hand sanitizer komersial. Hasil uji antibakteri hand sanitizer ekstrak daun pucuk idat terhadap E. coli dengan konsentrasi ekstrak daun pucuk idat 40%, 60%, 80%, dan 100% diperoleh diameter zona hambat berturut-turut sebesar 11,5 mm, 17,4 mm, 19,3 mm dan 19,3 mm, sedangkan pada bakteri S. aureus diperoleh diameter zona hambat berturut-turut sebesar 17,1 mm, 24,2 mm, 27,4 mm, dan  18 mm. Hasil uji antibakteri menunjukkan bahwa sediaan gel hand sanitizer ekstrak aseton daun pucuk idat memiliki aktivitas antibakteri terhadap bakteri E. coli dan S. aureus.Hand Sanitizer of Leaves Extract of Cratoxylum glaucum as Antibacterial of Staphylococcus aureus and Escherichia coli. Cratoxylum glaucum leaves is local plants of Bangka Belitung which have antibacterial activity against S. aureus and E. coli. As an effort to explore local potential, a practical and economical gel hand sanitizer product was prepared. Cratoxylum glaucum leaves extract was obtained by maceration method using acetone. The extract was formulated in various concentrations of Cratoxylum glaucum leaf extract (40%, 60%, 80%, and 100%) with the addition of 0.25 g carboxymethyl cellulose sodium (CMC-Na), 1 mL glycerin, 0.5 mL propylene glycol and 10 mL distilled water. Each concentration of the hand sanitizer gel was tested for physical stability including organoleptic, homogenity, spreadability, pH, skin irritation and antibacterial activity test. The organoleptic test results showed that all concentrations of hand sanitizers formed gel with light yellow color, smelly odor and homogeneous form. The analysis of pH and spreadability of hand sanitizer gel has fulfilled SNI No. 06-2588. The skin irritation testing does not cause redness, itching, and rough skin on the back of volunteer hands. Based on the physical properties test, the resulting hand sanitizer gel has physical properties similar to commercial hand sanitizer gel. The results of the antibacterial test of hand sanitizer against E. coli with Cratoxylum glaucum leaf extract concentrations of 40%, 60%, 80%, and 100% obtained the diameter inhibitory zones of 11.5 mm, 17.4 mm, 19.3 mm, and 19.3 mm, respectively. Meanwhile, the results of the antibacterial test of hand sanitizer against S. aureus bacteria with concentration of 40%, 60%, 80%, and 100% shows that the inhibition zone diameters were 17.1 mm, 24.2 mm, 27.4 mm, and 18 mm, respectively. The antibacterial test results shows that the gel hand sanitizer prepared has antibacterial activity against E. coli and S. aureus bacteria.
Co-Authors Agus Ariyanto Aisyah Aisyah Aisyah, Noor Amanah, Ike Nur Anna Khumaira Sari Ariani, Novia Ariani, Novia Ayu Lestari, Desy Ayuchecaria, Noverda Dani Kurniawan Darmiani, Siti Eka Kumalasari Eka Kumalasari Eka Kumalasari Eka Kumalasari Erna Prihandiwati Febrianti, Dwi Rizki Fitria Ulfah Hamidah, Marina Imam Agus Faisal Indah Fitri Ramadhani Maida Safutri Marina Hamidah Maya Armianti Muhammad Ma'ruf Muhammad Ma'ruf Nazulla Mudjib Nararia Nida Munirah Novia Ariani Prasdianto Prasdianto Prihandiwati, Erna Puteri Amalia, Senya Putra, Aditya Maulana Perdana Putri, Megawati Ayu Rakhmadhan Niah Ratu Mouly Noor Renny Renny Riza Alfian Rizki Febrianti, Dwi Saftia Aryzki Safutri, Maida Saputra, Marhan Ebit Sari, Ratih Pratiwi shafran ilahi, fitrah Siti Darmiani Susanto, Yugo Verry Andre Fabiani Wahyuni, Amaliyah