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All Journal BALI MEDICAL JOURNAL (BMJ) Jurnal Kedokteran Syiah Kuala Indonesian Journal of Tropical and Infectious Disease Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Syntax Literate: Jurnal Ilmiah Indonesia J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Biomedika dan Kesehatan Jurnal Respirasi (JR) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Abdi Insani Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Clinical Microbiology and Infectious Diseases Jurnal Widya Medika
Deby Kusumaningrum
Faculty Of Medicine, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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THE ANTI-TB DRUG SENSITIVITY OF Mycobacterium tuberculosis FROM CEREBROSPINAL FLUID AND BONE TISSUE BIOPSY SPECIMENS OF PATIENTS SUSPECTED TUBERCULOUS MENINGITIS AND SPINAL TB IN Dr SOETOMO HOSPITAL INDONESIA Mertaniasih, Ni Made; Kusumaningrum, Deby; Koendhori, Eko Budi; Harijono, Sugeng; Arky, Catur Endra; Putri, Jayanti; Urifah, Hanik
Indonesian Journal of Tropical and Infectious Disease Vol. 5 No. 3 (2014)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (152.009 KB) | DOI: 10.20473/ijtid.v5i3.236

Abstract

Tuberculous meningitis (TBM) is an infection of meningens which potentially life threatening with significant morbidity and mortality. Spinal TB has the same problem with TBM, infection in bone and joint, the delayed diagnosis worsens the prognosis. The rapid and accurate diagnosis plus promt adequate treatment is essential for the good outcome. The aim of this research is to study thefirst line drug sensitivity of Mycobacterium tuberculosis isolated from specimens of cerebrospinal fluid from suspected tuberculous meningitis patients and bone tissue biopsy from suspected spinal TB patients. The method of this research is TB Laboratory examination in Department of Clinical Microbiology – Dr. Soetomo General Hospital, Indonesia, using the gold standard liquid culture method MGIT 960 System (Becton Dickinson) and solid culture method with Lowenstein-Jensen medium. The specimens CSF from 50 TBM patients at January 2013 until May 2014. Positive isolate detection of Mycobacterium tuberculosis complex were 11 isolates (22%), which sensitivity 100% (11/11 isolates) to Rifampin (R), Pyrazinamide (Z), Ethambutol (E), and Streptomycin (S); one isolate resistant to Isoniazid, sensitivity to Isoniazid 90,90% (10/11); and received 21 specimens of bone tissue biopsy which positive 5 isolates(23%), all isolates sensitive 100% (5/5 isolates) to Rifampin and Pyrazinamide, and 1 isolates resistant to Isoniazid, Ethambutol, and Streptomycin, in which sensitivity 80% (4/5 isolates) to Isoniazid, Ethambutol, and Streptomycin. The conclusion of this research is positivity detection 22% of CSF specimens, and 23% of bone tissue biopsy were low. All isolates sensitive 100% to Rifampin and Pyrazinamide, and 80-90% sensitive to Isoniazid.
Diagnosis Based on Detection of CXCL10 in Urine as Biomarker for The Determining Diagnosis of Active Lung Tuberculosis Mertaniasih, Ni Made; Ananda, I Gede Yogi Prema; Soedarsono, Soedarsono; Kusumaningrum, Deby
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i1.22160

Abstract

Tuberculosis diagnosis is an important component in decreasing TB incidence and prevalence. Because of the difficulty to collect sputum in some cases, urine specimens are used as it is easier to garner. One of the biomarkers in urine that can be used to diagnose pulmonary TB is IP-10, which can be represented by the CXCL10 gene. The study aims to determine the accuracy of diagnosis based on detection of the CXCL10 gene in urine as a biomarker for the patients with suspected pulmonary TB in Dr. Soetomo Hospital in Surabaya from November 2019 until March 2020. Thus, this is an observative laboratory research with a cross-sectional study. CXCL10 gene was examined using PCR for 36 urine samples, and then, the data, together with the medical records of clinical manifestations of pulmonary TB, GeneXpert MTB /RIF, blood count, and thorax radiograph, were processed using IBM SPSS Statistics 26. The results of the GeneXpert MTB/RIF and thorax radiograph criteria show positive results of pulmonary TB, which were 44.4% and 69.4% respectively. CXCL10 gene was not found in all urine of healthy people (negative), while 2.8% (1/36 samples) positive CXCL10 gene was found in a patient with positive GeneXpert, also with negative clinical manifestations and urine culture. In this study, the accuracy of diagnosis based on detection of the CXCL10 gene in urine for diagnosis of active pulmonary TB was 2.8%. Future research is needed to improve the methods, among them are bigger size of urine samples and clearer medical history of patients. 
Progress In Knowledge Of Microscopic Tuberculosis Diagnosis Laboratory Training Participants Silvia Sutandhio; Ni Made Mertaniasih; Eko Budi Koendhori; Deby Kusumaningrum; Titiek Sulistyowati; Lindawati Alimsardjono; Pepy Dwi Endraswari; Manik Retno Wahyunitisari; Rebekah Juniati Setiabudi
JURNAL WIDYA MEDIKA Vol. 5 No. 2 (2019)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v5i2.2202

Abstract

Indonesia is the second highest tuberculosis (TB)-burden country in the world. TB affects men and women in productive ages. Early and accurate diagnosis of TB is crucial in TB management because it allows prompt treatment with appropriate regimen. Sputum smear microscopy is the most common method used in resource-limited laboratories. The aim of this study is to assess whether adult learning method with student-centered approach can improve knowledge in laboratory techniques in microscopic TB diagnosis. It was a quasi experimental research with one group pretest and posttest design. Pretest was conducted before the training started. During the training, participants attended lectures, discussion sessions, and hands-on laboratory activities. After training, participants were asked to respond to posttest. There were 33 participants of this training (n=33). Paired t-test analysis showed significant difference between pretest and posttest scores (p=6.5x10-9). Variance between pretest scores was 4.00 and variance between posttest scores were 1.34. Pearson correlation coefficient was 0.45. Regardless their level of knowledge before training, participants could achieve relatively equivalent results after training. Significant difference between pre- and post-training test scores indicated that the learning method was effective and the training could improve participants knowledge in laboratory techniques in microscopic TB diagnosis.
Ko-infeksi asimptomatik helminthiasis pada pasien tuberkulosis paru di Surabaya kota: studi pendahuluan Rifat Nurwita Kusumaningtyas; Indah Setyawati Tantular; Deby Kusumaningrum; Rina K Kusumaratna
Jurnal Biomedika dan Kesehatan Vol 3 No 3 (2020)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2020.v3.112-118

Abstract

BACKGROUNDPulmonary tuberculosis (TB) is a leading cause of morbidity and mortality, and East Java province is the second largest contributor of co-infection in Indonesia. Asymptomatic helminth infection among pulmonary tuberculosis patients causes another public health problem. Few data relate to helminth infection based on clinical and immunological outcomes of pulmonary TB in highly endemic areas. METHODSThis study was designed as a preliminary study and aimed to determine helminth co-infection among TB patients with a macroscopic assessment. This cross-sectional study was conducted in June-August 2017. RESULTSAmong 16 treated active TB patients from TB cohort data of Tanakali Kedinding health center found that 56% were stool smear-positive for Trichuris trichiura eggs, but had no clinical symptoms. CONCLUSIONWhether or not the helminth infection may have an impact on the diagnosis and treatment of active TB remains to be further investigated. Co-infection could be inhibited by the host immune response and improve the prognosis of TB treatment.
Peningkatan Kapasitas Kader Desa dan Staf Laboratorium untuk Optimalisasi Deteksi Dini Tuberkulosis di Kabupaten Sampang Kadariswantiningsih, Ika; Mertaniasih, Ni Made; Kusumaningrum, Deby; Endraswari, Pepy Dwi; Koendhori, Eko Budi; Setiawan, Andy; Lestari, Aprilia Dwi; Yudayanti, Elprania Credo; Juita, Liza Puspa Senja Asmara; Yitijuatni
J-Dinamika : Jurnal Pengabdian Masyarakat Vol 10 No 1 (2025): April
Publisher : Politeknik Negeri Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia menghadapi tantangan besar dalam deteksi dini Tuberkulosis, terutama di wilayah dengan tingkat deteksi rendah seperti Kabupaten Sampang. Keterbatasan pengetahuan kader desa dan staf laboratorium menjadi hambatan utama dalam meningkatkan deteksi dini TB. Program pelatihan ini bertujuan untuk meningkatkan kapasitas kader desa dan staf laboratorium melalui pelatihan terstruktur untuk mendukung deteksi dini Tuberkulosis yang lebih efektif. Pelatihan dilakukan dalam dua sesi paralel, yaitu untuk 15 kader desa dan 10 staf laboratorium. Kader desa diberikan pelatihan melalui ceramah dan diskusi kelompok terfokus tentang identifikasi gejala Tuberkulosis dan protokol rujukan. Staf laboratorium dilatih dengan metode ceramah dan praktikum tentang teknik diagnostik menggunakan tes cepat molekuler Tuberkulosis dan pemeriksaan diagnosis mikroskopis Tuberkulosis. Evaluasi pre dan post pelatihan menunjukkan peningkatan signifikan dalam pengetahuan dan keterampilan kader desa serta staf laboratorium. Kader desa mampu mengenali gejala TB lebih dini dan melakukan rujukan yang tepat, sementara staf laboratorium menunjukkan peningkatan keterampilan dalam teknik diagnostik yang lebih akurat. Program ini membuktikan bahwa pemberdayaan komunitas dan pelatihan teknis mampu meningkatkan deteksi dini TB. Model ini dapat diadopsi di wilayah lain yang menghadapi tantangan serupa untuk mendukung eliminasi TB pada tahun 2030.
PEMBERDAYAAN STAF TEKNISI LABORATORIUM FASYANKES DAN KADER KESEHATAN DI KABUPATEN PAMEKASAN UNTUK PENINGKATAN PERAN PADA TEMUAN DAN DIAGNOSIS PENYAKIT TUBERKULOSIS PARU Mertaniasih, Ni Made; Kusumaningrum, Deby; Endraswari , Pepy Dwi; Koendhori, Eko Budi
Jurnal Abdi Insani Vol 12 No 7 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i7.2314

Abstract

Tuberkulosis (TB) merupakan masalah kesehatan global yang masih menjadi prioritas utama dalam upaya penanggulangan penyakit. Tingginya angka kesakitan dan kematian akibat TB memerlukan langkah-langkah strategis, terutama dalam hal deteksi dini dan pengobatan yang tepat. Diagnosis dini TB paru yang akurat dan cepat sangat bergantung pada deteksi bakteri patogen dalam dahak pasien, yang selanjutnya menentukan strategi pengobatan yang sesuai. Tes Cepat Molekuler (TCM) digunakan untuk diagnosis awal, sedangkan pemantauan hasil pengobatan dilakukan melalui pemeriksaan mikroskopis bakteri tahan asam (BTA). Tujuan kegiatan Pengmas adalah meningkatkan pemahaman dan keterampilan staf teknisi laboratorium dalam mendiagnosis TB sesuai dengan standar kompetensi.  Serta memperkuat peran kader kesehatan dalam penanggulangan TB di masyarakat. Tim Dosen Departemen Mikrobiologi Kedokteran Fakultas Kedokteran Universitas Airlangga bersama mahasiswa dan alumni Program Studi Spesialis Mikrobiologi Klinik melaksanakan kegiatan ceramah mengenai TB paru, meliputi aspek diagnosis, pengobatan, dan pencegahan penularan kepada 17 kader kesehatan serta pelatihan pemeriksaan mikroskopis BTA bagi  16 staf teknisi laboratorium dari berbagai fasilitas kesehatan masyarakat dan RSUD di Kabupaten Pamekasan. Evaluasi pasca pelatihan menunjukkan peningkatan yang signifikan dalam pemahaman dan keterampilan para kader kesehatan terkait temuan kasus TB di masyarakat, diagnostik, serta upaya pencegahan penularan. Seluruh staf laboratorium mengalami peningkatan kompetensi dalam pemeriksaan BTA, termasuk pembuatan dan pembacaan sediaan sesuai standar nasional (IUATLD). Kegiatan pengabdian kepada masyarakat oleh tim akademisi efektif dalam pemberdayaan kader kesehatan sebagai ujung tombak deteksi dini TB serta meningkatkan keterampilan diagnosis mikroskopis staf laboratorium. Pelatihan ini berkontribusi pada peningkatan kualitas diagnosis dan pengobatan TB.
Pola Kuman Serta Kepekaan Antibiotik pada Pasien Sepsis di Ruang Rawat Inap Penyakit Dalam RSUD dr. Soetomo Surabaya Nabila, Nabila; Bramantono, Bramantono; Kusumaningrum, Deby; Widodo, Agung Dwi Wahyu
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i8.17294

Abstract

Sepsis adalah disfungsi organ yang mengancam jiwa yang disebabkan oleh disregulasi respon host terhadap infeksi. Penatalaksanaan sepsis salah satunya adalah pemberian antibiotik spesifik, namun pengobatan awal adalah pemberian antibiotik spektrum luas sebelum ada hasil kultur. Penggunaan antibiotik yang tidak tepat pada pasien septik dapat menyebabkan resistensi bakteri dan memperburuk kondisi pasien. Tujuan penelitian ini adalah mempelajari pola sensitivitas bakteri dan antibiotik pada pasien sepsis di RSUD Dr. Soetomo Surabaya Metode. Penelitian deskriptif retrospektif ini dilakukan di RSUD Dr. Soetomo pada bulan Januari sampai dengan Desember 2019. Sampel penelitian ini adalah seluruh data rekam medis pasien sepsis yang memiliki hasil kultur darah bakteri positif di Laboratorium Mikrobiologi Klinik RSUD Dr. Soetomo Surabaya di Hasil 2019. Hasil penelitian menunjukkan bahwa dari 722 sampel darah, termasuk 124 (17,2%) sampel dengan hasil kultur positif. Pasien termuda berusia 16 tahun dan tertua berusia 97 tahun. Hasil ini juga menunjukkan bahwa sebagian besar pasien sepsis adalah perempuan. Bakteri yang paling banyak ditemukan adalah Staphylococcus spp. 80,4%. Bakteri gram positif (Staphylococcus spp.) sensitif terhadap linezolid, vankomisin, teicoplanin Kesimpulan. Bakteri yang paling banyak ditemukan adalah Staphylococcus spp, sedangkan antibiotik yang paling sensitif terhadap Staphylococcu spp gram positif adalah antibiotik linezolid, vankomisin, dan teicoplanin.
Co-Authors A. M. Widya Agnes Dwi Sis Perwitasari, Agnes Dwi Sis Agung Dwi Wahyu Widodo Alimsardjono, Lindawati Ananda, I Gede Yogi Prema Andy Setiawan Arifa Mustika Bakhtiar, Arief Bramantono Bramantono, Bramantono Catur Endra Arky, Catur Endra Eko B. Koendhori Eko Budi Koendhori, Eko Budi Firsta Wahono Febrianto Firsta Wahono Febrianto Hanik Urifah, Hanik Heronimus Hansen Kaware Indah Setyawati Tantular, Indah Setyawati Jayanti Putri, Jayanti Juita, Liza Puspa Senja Asmara Kadariswantiningsih, Ika Kuntaman Kuntaman L. Alimsardjono Lestari, Aprilia Dwi ManikRetno Wahyunitisari Muhammad Hanun Mahyuddin N. D. Kurniati Nabila, Nabila Naritha Ni Made Mertaniasih Nurul Wiqoyah, Nurul Nuswantoro, Djohar P. N. Endraputra Pepy Dwi Endraswari, Pepy Dwi Prabowo, Gwenny Ichsan Rebekah Setiabudi, Rebekah Retno Asih Setyoningrum Rifat Nurwita Kusumaningtyas Rina K Kusumaratna S. R. S. Oktaviani S. Soedarsono Shofia Ihtasya Silvia Sutandhio Soedarsono Soedarsono Sugeng Harijono, Sugeng Titiek Sulistyowati Titiek Sulistyowati Wayan Tunas Artama Yitijuatni Yudayanti, Elprania Credo