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Diah - Kusumawaty
Universitas Pendidikan Indonesia
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Modifikasi Permukaan Lipid Nanopartikel Berbasis Tanaman Untuk Terapi Kanker Dan Inflamasi: Tinjauan Naratif Terstuktur RINI FAUZIAH; Diah Kusumawaty
Jurnal Biologi dan Pembelajarannya (JB&P) Vol 13 No 2 (2026): OKTOBER 2026
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/jbp.v13i2.29115

Abstract

Plant-derived lipid nanoparticles (PDLNPs) have been widely developed as nanomedicine platforms for cancer and inflammatory therapies due to their high biocompatibility, good stability, and specific targeting ability. This study aimed to analyze the effect of surface modification on the physicochemical characteristics, cellular uptake, and therapeutic effectiveness of PDLNPs through the Structured Narrative Review approach. The results showed that unmodified PDLNPs generally exhibited exosome-like spherical morphology, stable particle size, and negative zeta potential that supported colloidal stability. Surface modification using TPGS-RNP and iRGD was proven to improve encapsulation efficiency, mucosal penetration, target tissue retention, and cellular uptake through receptor-mediated endocytosis mechanisms. In addition, natural lipids such as MGDG and plant bioactive compounds also played important roles in targeting and inducing apoptosis in cancer cells. Overall, surface modification enhanced the anticancer and anti-inflammatory effectiveness of PDLNPs, indicating their potential as a more effective and specific plant-based drug delivery system.
Co-Authors Abd. Rasyid Syamsuri Abdullah Rasyad Achmad Dinoto Afifi Mutiarani Aisyah Belva Any Aryani Astry Agusthina Muchtar Azzahra, Waliyyatu Azzania Fibriani Dennisa Ameria Sendjaya Diah Puspita Sari Diah Puspita Sari Diah Puspitasari Dian Din Yati Diana Rochintaniawati Diana Rochintaniawaty Didik Priyandoko Dina Mariana Dzikrina, Hanina Ekajaya, Renandy Kristianlie Eliya Mei Sisri Fadillah, Nuke Siti Fadya Oktavia Geovanni Pratama Putri Gusni Nugraha As-Syiba Hanif Syafrian Purnama Hanina Dzikrina Irna Riski Kardila Jayah, Johan Susanto Kartika Khadafiah Mutia Wiandari Khansa Biantari Alika Kirey Qanita Kusdianti Kusdianti Kusdianti Kusdianti Kusumawardhani, Meirina Kartika Lulu Desia Mutiani Rahmayuni Mr Kusnadi Naneu Nurfarida Nurjamil, Aris Muhamad Nurul faridah Nurul Faridah, Nurul Nurul Ilma Apriliani Nuryani Rustaman Restu Utari Dewina RINI FAUZIAH Salma Annisa Nur Alifah Salsabila Shafa Saidah Saputro, William Junino Shafira Lestari Shintya Yuniar Siti Awalia Nur Fadillah Siti Nabila Siti Sriyati SONY SUHANDONO Suroso Adi Yudianto Surtikanti Hertien Koosbandiah, Surtikanti Sururi, Zaki Fahreza Topik Hidayat TRINA EKAWATI TALLEI Try Kurniawan Visi Tinta Manik Wahyu Surakusumah Wahyuni Sultan Wijanarka Wijanarka Yayan Sanjaya