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All Journal Jurnal Ilmu Pertanian Indonesia Journal of Food and Pharmaceutical Science Jurnal Farmasi Udayana Pharmaciana: Jurnal Kefarmasian Majalah Obat Tradisional JURNAL PENGABDIAN KEPADA MASYARAKAT JI-KES (Jurnal Ilmu Kesehatan) Jurnal Ilmu Kefarmasian Indonesia Borneo Journal Of Pharmascientech International Journal of Islamic and Complementary Medicine Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Journal of Food and Pharmaceutical Sciences

Kintoko, Kintoko

Universitas Ahmad Dahlan

Author-ID : 3038579

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Efek Anti Diabetes Spirulina Platensis Terhadap Analisis Kadar, Gambaran Histopatologi, Ekspresi Insulin dan Glucose Transpoter 4 Pada Tikus Putih Wistar yang Diinduksi Streptozopin Kintoko Kintoko; Rifqi Ferry Balfas; Nura Ustrina; Sitarina Widyarini; Lintang Cahya Saputri; Anandita Nurwijayanti; Fajar Slamet Riana; Neni Tri Anggraini
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Based on Basic Health Research, in Yogyakarta the incidence of diabetes mellitus based on doctor's diagnosis is 2.6% and symptoms will increase with age, but will decrease from age> 65 years. In the treatment of diabetes mellitus there are several treatments with synthetic drugs and natural ingredients for natural ingredients such as Spirulina platensis. Spirulina platensis is one of the microalgae that contains the natural spectrum of carotene and xantophyll pigment mixtures, and with fikocyanin has antioxidant activity, and Spirulina platensis can show a decrease in blood sugar. The type of research conducted is an experimental study. Spirulina platensis is made with several doses of 36 mg, 72 mg, and 144 mg. Rats were divided into 6 groups, 5 groups of streptozotosin induced at a dose of 45 mg / kgBW until the mice had DM were characterized by high KGD yield, then given spirulina suspension, measured in sugar levels on days 0-28. After that the mice in the blood and then analyzed the effect of Spirulina platensis on creatinine and urea in blood. The results were analyzed using SPSS ANOVA and Post Hoc Test methods with 95% confidence level. The results of the analysis of levels in various groups showed that in the induction of streptozotocin treated with spirulina plantesis various doses there was improvement in each analysis of the levels obtained, and also at the dose STZ+SP 36 in each analysis can improve the level of analysis. While on histopathology result and insulin expression in pancreas and histology and expression of glucose transporter 4 and histopathology on kidney and liver showed good change at various treatment dose group especially in STZ+SP 36 group. So at STZ+SP 36 dose showing the change both in this study.

EnglishPenyembuhan Luka Diabetes Krim Biosurfaktan Dialkil Alginat pada Ekspresi TNF-α TGF-β, Reepitelisasi, dan Kolagenisasi Cut Raihanah; Nurul Mahyani; Kintoko Kintoko
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Diabetic wound healing is delayed by many factors, including high TNF-α expression and low TGF-β expression which can affect the formation of new epithelial tissue and collagen as the main goal of the wound healing process. One of the diabetic wound healing agent is biosurfactant dialkyl alginate where so far its use in cream form for diabetic wound has never been reported. This study aimed to determine TNF-α, TGF-β, reepithelization and the collagenization of biosurfactant dialkyl alginate cream in diabetic biopsy wounds in STZ-induced rat. Biosurfactant dialkyl alginate was made in cream form and applied to biopsy wounds on the backs of rat twice a day for 9 days. Observation of TNF-α and TGF-β expression were performed by immunohistochemical staining, while epithelial and collagen with staining HE and Mallory. The results showed that the biosurfactant dialkyl alginate cream had an activity to decrease TNF-α expression, increase TGF-β expression and reepithelization but did not have any significant activity on collagenization. These results suggest that the biosurfactant dialkyl alginate cream can accelerate the healing of diabetic wound.

Aktivitas Antibiotik Isolat Bakteri Kp13 dan Analisa Kebocoran Sel Bakteri Escherichia coli Alfian Syarifuddin; Nanik Sulistyani; Kintoko Kintoko
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

A bacterium is one of microorganisms that can produce secondary metabolite, such as antibiotic. KP13 isolate is a bacterium isolated from Melaleucaleuca dendron L rhizosphere. The aim of this study is to know the eff ect of the most active fraction antibacterium of KP13 isolate toward Escherichia coli bacterium and the ability to caused cell leakage. Extraction of antibiotic was conducted by ethyl acetate. Extract is fractioned with a n-heksan-etilacetate solvent gradient another uses a solvent methanol. Each fraction is done by KLT and grouped based on RF value. A fraction group is compare by inhibition eff ectiveness. Then, the Minimum Inhibitory Concentration (MIC) from the most active group is tested. Cell leakage analysis was performed using UV spectrophotometry to detect the release of nucleic acid and protein. Atomic Absorption Spectrophotometry (AAS) was used to detect ion release of K+ and Ca2+ from. cell of bacteria. The results showed that the most active fraction against Escherichia coli was the fraction number 1 with MIC value of 5% and inhibition zone of 7.33±0.58 mm.

Optimalisasi Produksi Fikosianin pada Sianobakteria Laut BTM 11 dan Uji Aktivitas Antioksidannya Baso Didik Hikmawan; Swastika Praharyawan; Kintoko Kintoko
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1198

Phycocyanin (PC)-producing cyanobacteria has shown many pharmaceutical applications, the main one is the antioxidant properties. Biosynthesis of PC-producing cyanobacteria is affected by many factors like nitrogen availability and light intensity during cultivation. This study aims to analyze the optimum concentration of nitrogen and light intensity during the cultivation of PC biosynthesis of marine cyanobacteria BTM 11 and identify its antioxidant properties This study was an experimental laboratory method and the PC level was determined through the variation of sodium nitrate (NaNO3) as a source of nitrogen dissolved in media and using different light intensities. The most optimum nitrogen and light intensity values of PC were measured by its antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical capture method. Data was analyzed by one-way ANOVA and the post-hoc Duncan to see whether p<0.05. The result showed that there was a significant difference in the PC level that was cultivated with the variation of NaNO3 concentrations. The highest PC level was observed in media containing 525 mg of NaNO3 and the optimum light intensity of 4500 lux. The result of the antioxidant activity assay showed that the BTM11’s PC’s antioxidant activity had its IC50 at 91.89 μg/mL and the IC50 of ascorbic acid was 2.39 μg/mL

Co-Authors Adhi Gunawan Alfian Syarifuddin Anandita Nurwijayanti Andhini Noor Chandra, Meta Any Guntarti Astri Desmayanti Astri Desmayanti Astri Desmayanti Aulia Rahman Ayu Shabrina Baso Didik Hikmawan Citra Ariani Citra Ariani Edityaningrum, Citra Cut Raihanah Dyah Aryani Perwitasari Eka Fitri Susiani Eka Siswanto Syamsul Elfasyari, Trie Yuni Endang Darmawan Epi Taufik Ersi Arviana Ihsan Fajar Slamet Riana Feby Zulien Hanifah Karimatulhajj Hardi Astuti Witasari Hardi Astuti Witasari Hayatus Sa’adah Khoiriyah Isni Leswara, Dianita Febrina Lintang Cahya Saputri Lusi Mardika Ariyanti Meta Damaharyuningtyas Nadiya Utari Nanik Sulistyani Nazziyah, Salmaa Sayyidah Neni Tri Anggraini Nining Sugihartini Nur Idha Sri Budiarti Nura Ustrina Nurkhasanah Nurkhasanah Nurul Mahyani Puspawan Hariadi Putra, Teguh Adiyas Rifqi Ferry Balfas Rukaya, Benazir Evita Salsabila Ramadhan Sapto Yuliani Septian Emma Dwi Jatmika Sitarina Widyarini Supomo Supomo Suwijiyo Pramono Swastika Praharyawan Tsania Taskia Nabila Warsi Warsi Widiyastuti, Lina Yuda Fajar Pratama

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