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All Journal Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Health Notions Jurnal Kajian Peradaban Islam Journal of Aquaculture and Fish Health Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Insan Farmasi Indonesia Berkala Penelitian Hayati Caring : Jurnal Pengabdian Masyarakat Jurnal Farmasi Komunitas Journal of Tropical Pharmacy and Chemistry Folia Medica Indonesiana
Budiatin, Aniek Setiya
Department Of Pharmacy Practice, Faculty Of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Genipin as a Cross-linker in a Ciprofloxacin Delivery System Containing a Bovine Hydroxyapatite-Collagen Composite for Bone Infections Nurul Fitriani; Aniek Setiya Budiatin; Esti Hendradi
Journal of Tropical Pharmacy and Chemistry Vol. 7 No. 1 (2023): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v7i1.465

Abstract

The purpose of this research was to design an implant for a ciprofloxacin-based drug delivery system by combining bovine hydroxyapatite and collagen with genipin as the crosslinking agent. The production of ciprofloxacin implants using bovine hydroxyapatite:collagen blend (70:30). In addition, this synthetic preparation was made using three various concentrations of genipin (0.6, 0.8, and 1.0%). The pellets were created by compressing the implants. The tablets are cylindrical with a diameter of 4.0 mm and a weight of 100.0 mg. Ciprofloxacin cultures were characterized for swelling rate, porosity, density, compressive strength, morphology (SEM), dose, and drug release in vitro. The addition of genipin as a crosslinking agent may maintain ciprofloxacin release consistent with in vitro therapeutic levels of ciprofloxacin. These results are supported by compressive strength data, where the addition of genipin concentrations induces higher implant stiffness and scanning electron microscopy photomicrographs reveal small pore sizes and BHA adhere to collagen fibers so that ciprofloxacin is completely dispersed in the implant after cross-linking with genipin. As a drug delivery system for osteomyelitis, it can be concluded that the use of genipin as a cross-linking agent can sustain ciprofloxacin release commensurate with in vitro therapeutic levels of ciprofloxacin for 30 days.
PENGARUH PELATIHAN TANGGAP TUBERKULOSIS DAN PENDAMPINGAN MINUM OBAT TERHADAP PENGETAHUAN KADER KESEHATAN DESA DI KECAMATAN BLUTO Rahem, Abdul; Wijaya, I Nyoman; Ifadotunnikmah, Farida; Rahmadi, Mahardian; Achmad, Gusti Noorrizka Veronika; Athiyah, Umi; Yuda, Ana; Zulkarnain, Bambang Subakti; Nugraheni, Gesnita; Ardianto, Chrismawan; Sumarno, Sumarno; Aryani, Toetik; Budiatin, Aniek Setiya; Hermansyah, Andi; Sulistyarini, Arie; Priyandani, Yuni; Sukorini, Anila Impian
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/s8534m26

Abstract

Tuberculosis (TB) is one of the leading causes of death from infectious diseases worldwide. Indonesia ranks as the country with the second-highest number of TB cases after India. TB awareness training and medication adherence support for village health cadres are strategic steps to enhance their capacity in supporting TB treatment. This study aims to analyze the impact of TB awareness training and medication adherence support on improving the knowledge of village health cadres. A pre-experimental study with a pretest-posttest design was conducted involving 50 village health cadres in Bluto Subdistrict, Sumenep Regency. Data were collected using questionnaires administered before and after the training. Analysis was performed using the Mann-Whitney test. There was a significant increase in the knowledge scores of village health cadres regarding TB (pretest: 3.50 ± 1.65; posttest: 5.64 ± 2.70; p<0.05) and anti-TB drug side effects (pretest: 7.66 ± 4.07; posttest: 15.04 ± 3.11; p<0.05). The training also successfully enhanced the cadres' understanding of TB symptoms, prevention, and treatment, including drug side effects. TB awareness training and medication adherence support significantly improved the knowledge of village health cadres, making them more competent in supporting TB control efforts at the community level.
IMPLEMENTATION OF SUPPORT GROUPS AS AN EFFORT TO IMPROVE THERAPY ADHERENCE AND BLOOD SUGAR CONTROL OF PATIENTS WITH DIABETES MELLITUS IN KEDUNG TARUKAN, TAMBAKSARI SUB-DISTRICT SURABAYA Aryani, Toetik; Budiatin, Aniek Setiya; Izza, Zamrotul; Hikmawati, Dyah; Mazidda, Sakinato
Caring: Jurnal Pengabdian Masyarakat Vol 5, No 2 (2025): CARING Jurnal Pengabdian Masyarakat (Agustus 2025)
Publisher : Caring: Jurnal Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.caringjpm.2025.005.02.3

Abstract

Abstract Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels, which over time can cause damage to the heart, blood vessels, eyes, kidneys and nerves. The purpose of this service is to provide health education about diabetes mellitus for the Kedung Tarukan community. Tambaksari sub-district, Surabaya. This service activity is carried out through observation and direct counseling methods to PKK members and local residents. The results show that counseling can increase the knowledge of each individual, pre test 46% and post test 76%.
Antibacterial-enhanced Synthetic Stainless Steel, Hydroxyapatite, and Polylactic Acid in Bioactive Screw Systems for Safe Bone Healing Prima, Eka Cahya; Melati, Putri Sekar; Arifah, Fina Nurul; Septiyanto, Arifin; Nurahman, Arip; Budiatin, Aniek Setiya; Herdianto, Nendar
Islamic Research Vol 8 No 2 (2025): Islamic Research
Publisher : Perhimpunan Intelektual Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47076/jkpis.v8i2.368

Abstract

Bone fractures are rising worldwide due to aging populations and increased trauma, creating demand for implants that overcome infection, delayed healing, and poor osteointegration. Multifunctional biomaterials, especially PLA–HA Bioxcrew systems, offer integrated mechanical support with antibacterial, anti-inflammatory, and osteogenic functions while remaining biocompatible. Implant-associated infections driven by Staphylococcus aureus and Gram-negative bacteria persist because of biofilm formation and chronic inflammation. Bioxcrew advancements address these barriers through metal-ion doping, nanoscale surface engineering, and incorporation of antimicrobial agents into biodegradable polymer matrices, enabling controlled ion release, immune modulation, stem-cell recruitment, and improved bone regeneration. Stainless steel provides strength, hydroxyapatite enhances biological integration, and PLA enables safe degradation and localized drug delivery, making their hybridization ideal for next-generation implants. Using a narrative–integrative review of peer-reviewed literature from 2018 to 2025, this study synthesizes trends in antibacterial strategies and regenerative performance. Findings show that hybrid Bioxcrew platforms significantly reduce infection risk and enhance functional bone healing.
Acceleration of Bone Fracture Healing through the Use of Natural Bovine Hydroxyapatite Implant on Bone Defect Animal Model Khotib, Junaidi; Lasandara, Cantika SC; Samirah, Samirah; Budiatin, Aniek S
Folia Medica Indonesiana Vol. 55, No. 3
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bone is an important organ for supports the body that stores reserve of calcium, phosphorus, and other minerals. In fracture conditions where bleeding, soft tissue edema, nerve damage, and blood vessels around the bone damage happen, they can cause the mobilization of these minerals in the surrounding tissue. One of the efforts made in the treatment of these fractures is reconnection, in which it works by filling of bone defect with a matrix and administration of anti-infection. Biomaterial filling in defective bone is thought to accelerate the healing process of bone fracture and prevent osteomyelitis. For this reason, this study evaluates the acceleration of bone fracture healing using natural hydroxyapatite (NHA) bone filler in rabbits with bone defect model. Fracture modeling was performed by surgical technique and drilling of bones with a 4.2 mm diameter to form a defect in the rabbit femur. Bone implant contained bovine hydroxyapatite-gelatin-glutaraldehyde (BHA implant) or bovine hydroxyapatite-gelatin-glutaraldehyde-gentamicin (BHA-GEN implant) that was inserted in bone defects. 27 rabbits were divided into 3 groups: the control group who had bone defect, the bone defect group was given BHA implant and the bone defect group was given BHA-GEN implant. Observation of osteoclast, osteoblast, osteocyte, BALP level, and bone morphological integrity was carried out on the 14th, 28th, and 42nd days after surgery. Histological observation of rabbit femur showed a significant difference on the number of osteoclast, osteoblast and osteocyte in all three groups. The BALP level also showed a significant difference in the group given the natural BHA bone implant compared to the control group on day 14 (p = 0.0361). Based on the result of the X-ray, there was also a better integration of rabbit femur bone in groups with the use of BHA or BHA-GEN bone implant. Thus, it can be concluded that the use of a natural BHA implant can accelerate the process of bone repair in the fracture of rabbit femur. In addition, BHA implants were compatible as a matrix for supporting the bone cell growth.
Co-Authors Abdul Rahem, Abdul Alya Naura Yolanda Ana Yuda Arie Sulistyarini Arifah, Fina Nurul Baiq Risky Wahyu Lisnasari Bambang Subakti Zulkarnain Cantika Suci Adlina Lasandara Cecilia Yohana Selviana Chrismawan Ardianto Chrismawan Ardianto Dewi Wara Shinta Didik Hasmono Eka Cahya Prima Esti Hendradi Fadilla Sukraina Farida Ifadotunnikmah Gesnita Nugraheni Gusti Noorrizka Veronika Ahmad Herdianto, Nendar Hermansyah, Andi I Gede Rekyadji Arimbawa I NYOMAN WIJAYA ismailia Wienda Yasmin Pratama Putri Isna Asidah Izza, Zamrotul Junaidi Khotib Khoirotin Nisak Khoirotin Nisak Laksmi Sulmartiwi Lasandara, Cantika SC Latif Azizah Mahardian Rahmadi Mazidda, Sakinato Melania Aneswari Melati, Putri Sekar Muhammad Rahmad Royan Muhammad Taher Nikolas Yakub Nurahman, Arip Nurul Fitriani Nurul Fitriani Oktantia Frenny Anggani Rayya Zhafira Rio Marcellino Rita Mela Kurnia Weno Saputri Rizqa Maghfira Rozalina Loebis, Rozalina Samirah Samirah, Samirah Septiyanto, Arifin Sukorini, Anila Impian Sumarno . Toetik Aryani Tri Yoga Wicaksono Umi Athiyah Winda Fatma Sari Yuni Priyandani Yusuf Alif Pratama Zainul Amiruddin Zakaria Zamrotul Izzah