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All Journal Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Health Notions Journal of Aquaculture and Fish Health Jurnal Layanan Masyarakat (Journal of Public Service) Berkala Penelitian Hayati Jurnal Farmasi Komunitas Journal of Tropical Pharmacy and Chemistry
Budiatin, Aniek Setiya
Department Of Pharmacy Practice, Faculty Of Pharmacy, University Of Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Genipin as a Cross-linker in a Ciprofloxacin Delivery System Containing a Bovine Hydroxyapatite-Collagen Composite for Bone Infections Nurul Fitriani; Aniek Setiya Budiatin; Esti Hendradi
Journal of Tropical Pharmacy and Chemistry Vol. 7 No. 1 (2023): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v7i1.465

Abstract

The purpose of this research was to design an implant for a ciprofloxacin-based drug delivery system by combining bovine hydroxyapatite and collagen with genipin as the crosslinking agent. The production of ciprofloxacin implants using bovine hydroxyapatite:collagen blend (70:30). In addition, this synthetic preparation was made using three various concentrations of genipin (0.6, 0.8, and 1.0%). The pellets were created by compressing the implants. The tablets are cylindrical with a diameter of 4.0 mm and a weight of 100.0 mg. Ciprofloxacin cultures were characterized for swelling rate, porosity, density, compressive strength, morphology (SEM), dose, and drug release in vitro. The addition of genipin as a crosslinking agent may maintain ciprofloxacin release consistent with in vitro therapeutic levels of ciprofloxacin. These results are supported by compressive strength data, where the addition of genipin concentrations induces higher implant stiffness and scanning electron microscopy photomicrographs reveal small pore sizes and BHA adhere to collagen fibers so that ciprofloxacin is completely dispersed in the implant after cross-linking with genipin. As a drug delivery system for osteomyelitis, it can be concluded that the use of genipin as a cross-linking agent can sustain ciprofloxacin release commensurate with in vitro therapeutic levels of ciprofloxacin for 30 days.
Co-Authors Alya Naura Yolanda Baiq Risky Wahyu Lisnasari Bambang Subakti Zulkarnain Cantika Suci Adlina Lasandara Cecilia Yohana Selviana Chrismawan Ardianto Dewi Wara Shinta Didik Hasmono Esti Hendradi Fadilla Sukraina I Gede Rekyadji Arimbawa ismailia Wienda Yasmin Pratama Putri Isna Asidah Junaidi Khotib Khoirotin Nisak Khoirotin Nisak Laksmi Sulmartiwi Latif Azizah Mahardian Rahmadi Melania Aneswari Muhammad Rahmad Royan Muhammad Taher Nikolas Yakub Nurul Fitriani Nurul Fitriani Oktantia Frenny Anggani Rayya Zhafira Rio Marcellino Rita Mela Kurnia Weno Saputri Rizqa Maghfira Rozalina Loebis, Rozalina Samirah Samirah Toetik Aryani Tri Yoga Wicaksono Winda Fatma Sari Yusuf Alif Pratama Zainul Amiruddin Zakaria Zamrotul Izzah Zamrotul Izzah