Article Per Year (5 Year)
p-Index From 2020 - 2025
1.152
P-Index
This Author published in this journals
All Journal Bioma : Berkala Ilmiah Biologi AL KAUNIYAH Journal of Mathematical and Fundamental Sciences Indonesian Journal of Biotechnology Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY Majalah Farmaseutik Jurnal Biomedika dan Kesehatan Berkala Penelitian Hayati
Woro Anindito Sri Tunjung
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Jurnal Biomedika dan Kesehatan

 1 
Gambaran Penyakit Neurodegeneratif: Huntington, Alzheimer, dan Parkinson: Sebuah Tinjauan Karlina, Ina; Andriyani, Eka Fitri Siti; Pratiwi, Arini Dian; Prasasti, Filosofia Florista Tesla Aulia; Tunjung, Woro Anindito Sri; Rohmah, Zuliyati; Nuriliani, Ardaning
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.113-123

Abstract

Neurodegenerative diseases occur due to dysfunction of the nervous system, which is accompanied by memory and movement disorders. Neurodegenerative diseases can be viewed from an etiological and pathological perspective (pathophysiological and histopathological). The most common neurodegenerative diseases are Huntington's, Alzheimer's, and Parkinson's. This review article will review the etiology and pathology of Huntington's, Alzheimer's, and Parkinson's diseases. The method used in this writing uses journals and books from Google Scholar, PubMed, ResearchGate, and the Web. The keywords used are etiology, pathology, pathophysiology, histopathology, neurodegenerative disease, Huntington's, Alzheimer's, and Parkinson's. The author limited the last 10 years of literature used. Based on a literature review, it is known that the etiology of Huntington's disease is caused by mutations in the huntingtin gene on chromosome four. The pathology of Huntington's disease is caused by unstable expansion of trinucleotide-encoded polyglutamine (CAG) repeats. One of the histopathological features of Huntington's disease can be identified from increased iron levels in the striata of the brain. The etiology of Alzheimer's disease involves interactions between genetic factors, lifestyle, environment, and the aging process. The pathology of Alzheimer's disease occurs due to the presence of apolipoprotein and its relationship to 3 mutated genes. The histopathology of Alzheimer's disease is identified by the presence of neuronal cell death, which is characterized by the shrinking of the nuclei of brain neuronal cells and the cytoplasm has a more eosinophilic color. The etiology of Parkinson's disease is progressive nerve damage to certain areas of the brain. The pathophysiology of Parkinson's disease is thought to involve a reduction in striatal dopamine, which causes an increase in inhibitory output from the globus pallidus pars interna/substantia nigra pars reticulata (Gpi/SNr), resulting in movement suppression. Histopathologically, Parkinson's disease is characterized by degeneration of neurons and neurophagia. This review concludes that Huntington's, Alzheimer's, and Parkinson's diseases can be caused by aging and genetic factors. The pathology of the disease is due to mutations, increased levels of iron, apolipoprotein, neuronal cell death, increased inhibitory output, and neuronal degeneration. The symptoms caused can be motoric, cognitive, and psychiatric.
Co-Authors Ahmad Marzuki Alfi Rizqi Amalia Alfi Rizqi Amalia Alisa Julia Nurulita Andriyani, Eka Fitri Siti Apriliyani, Tia Ardaning Nuriliani Aries Bagus Sasongko Azis, Aditya Latiful Ceria, Asy Syifa Paras Christy, Ghea Putri Dewi Yuliana Rizqi Endang Semiarti Fatonah, Vita Fhea Putri Cristy Frisca Damayanti Ghea Putri Christy Karlina, Ina Karmilah, Karmilah Lisna Hidayati Nurhidayat, Luthfi Nuryanto, Faqih Fikri Prasasti, Filosofia Florista Tesla Aulia Pratiwi Apridamayanti Pratiwi, Arini Dian Pusparini, Nur Ainun Oktavia Putu Gede Martha Setiawan R. Rumiyati Radhiyah Mardhiyah Hamid Rahmayani, Almira Rarastoeti Pratiwi Rarastoeti Pratiwi Rifqi Zahroh Janatunaim Ritmaleni, Ritmaleni Rohmah, Zuliyati Rumiyati Rumiyati Rumiyati Rumiyati Saffana, Rahmalia Diani Triono, Sugeng Tsany, Shabrina Farras Yekti Asih Purwestri