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All Journal Bioma : Berkala Ilmiah Biologi AL KAUNIYAH Journal of Mathematical and Fundamental Sciences Indonesian Journal of Biotechnology Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY Majalah Farmaseutik Jurnal Biomedika dan Kesehatan Berkala Penelitian Hayati
Woro Anindito Sri Tunjung
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Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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Efficacy of Salak Seed and Pomelo Peel Extracts on HeLa Cell Apoptosis and Proliferation Azis, Aditya Latiful; Ceria, Asy Syifa Paras; Tsany, Shabrina Farras; Saffana, Rahmalia Diani; Nuryanto, Faqih Fikri; Tunjung, Woro Anindito Sri
Al-Kauniyah: Jurnal Biologi Vol. 18 No. 2 (2025): AL-KAUNIYAH JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v18i2.41782

Abstract

The development of adjuvant therapies is vital for reducing cancer recurrence and minimizing the adverse effects of conventional treatments. Salak seeds (Salacca zalacca) and pomelo peels (Citrus maxima) are rich in bioactive compounds such as terpenoids, flavonoids, lycopene, and polyphenols, making them promising candidates for adjuvant cancer therapy. This study evaluated the anticancer effects of their individual and combined extracts. Bioactive compounds in salak seed (S) and pomelo peel (J) extracts were identified using gas chromatography-mass spectrometry (GC-MS) and analyzed in silico to assess their binding affinities to key target proteins: COX-2 (anti-inflammatory), caspase-3 (apoptosis induction), and PI3K (cell proliferation). The extracts were tested in vitro on cervical cancer HeLa cells at varying treatment groups: S; J; 1S3J; 1S1J; and 3S1J. Assays evaluated anti-inflammatory activity, cytotoxicity, cell migration inhibition, and apoptosis induction. Both in silico and in vitro analyses consistently demonstrated that the extracts significantly reduced cell viability exhibited anti-inflammatory effects, inhibited cell proliferation, and enhanced apoptosis. Among the tested treatments, the 1S1J combination showed the most pronounced effects across all parameters, highlighting its synergistic interaction, and superior therapeutic potential. These findings position the 1S1J combination as an optimal candidate for adjuvant cervical cancer therapy, warranting further investigation.
Co-Authors Ahmad Marzuki Alfi Rizqi Amalia Alfi Rizqi Amalia Alisa Julia Nurulita Andriyani, Eka Fitri Siti Apriliyani, Tia Ardaning Nuriliani Aries Bagus Sasongko Azis, Aditya Latiful Ceria, Asy Syifa Paras Christy, Ghea Putri Dewi Yuliana Rizqi Endang Semiarti Fatonah, Vita Fhea Putri Cristy Frisca Damayanti Ghea Putri Christy Karlina, Ina Karmilah, Karmilah Lisna Hidayati Nurhidayat, Luthfi Nuryanto, Faqih Fikri Prasasti, Filosofia Florista Tesla Aulia Pratiwi Apridamayanti Pratiwi, Arini Dian Pusparini, Nur Ainun Oktavia Putu Gede Martha Setiawan R. Rumiyati Radhiyah Mardhiyah Hamid Rahmayani, Almira Rarastoeti Pratiwi Rarastoeti Pratiwi Rifqi Zahroh Janatunaim Ritmaleni, Ritmaleni Rohmah, Zuliyati Rumiyati Rumiyati Rumiyati Rumiyati Saffana, Rahmalia Diani Triono, Sugeng Tsany, Shabrina Farras Yekti Asih Purwestri