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All Journal Research Journal of Life Science Indonesian Journal of Human Nutrition INDONESIAN JOURNAL OF PHARMACY NurseLine Journal Media Ilmu Kesehatan Journal of Dedicators Community Science Midwifery Majalah Kesehatan Indonesia Caring : Jurnal Pengabdian Masyarakat Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Asian Journal of Health Research Jurnal Ilmiah Kesehatan Mandala Waluya Jurnal Info Kesehatan

Nurdiana Nurdiana

Department Of Pharmacology, Faculty Of Medicine, Universitas Brawijaya

Author-ID : 3097247

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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MONOSODIUM GLUTAMATE EXPOSURE AT EARLY DEVELOPMENTAL STAGE INCREASES APOPTOSIS AND STEREOTYPIC BEHAVIOR RISKS ON ZEBRAFISH (DANIO RERIO) LARVAE Nia Kurnianingsih; Juliyatin Putri Utami; Nurdiana Nurdiana; Diana Lyrawati
Indonesian Journal of Pharmacy Vol 27 No 3, 2016
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Excessive glutamate may give neurotoxic effects and contribute to Autism spectrum disorder(ASD). In this study, we investigated prolonged exposure effects of 10 µg/mL Monosodium Glutamate (MSG) on intracellular calcium level, bax, bcl-2, ratio of bax/bcl-2 genes expression, caspase-3, apoptosis of brain cells and stereotypic behavior of Zebrafish (Danio rerio) larvae at early developmental stages. Genes expression were determined by real time PCR, caspase-3 using ELISA, intracellular Ca2+ and apoptotic cells of brain using confocal microscopy, locomotor activity by using crossing lines assay whereas stereotypic behavior by circle swimming. The results indicated that MSG exposure increased brain bax and bcl-2; and caspase-3; intracellular Ca2+; and apoptosis; stereotypic behavior; and decreased locomotor activity. Termination of MSG treatments resulted in recovery of bax, bcl-2, caspase-3 basal levels and stereotypic behavior. In conclusion, MSG exposure at early embryonic stage increased brain cell damage and risk of behavior changes.

Immunomodulation Effects of Bryophyllum Pinnatum on Pregnant Pristane-Induced Lupus Mice Model Nurdiana Nurdiana; Elvira Sari Dewi; Yuni Sari; Rahmawati Wahyuni; Aminah Maya; Nursari Abdul Syukur; Mirza Zaka Pratama; Wisnu Barlianto; Umi Kalsum; Kusworini Handono
Research Journal of Life Science Vol 3, No 3 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Objective: To determine the effect of Bryophyllum pinnatum treatment in modulating immune response and the pregnancy outcomes of pregnant pristane-induced lupus mice model.Methods: Sixteen Balb/c mice were intraperitoneally injected with single 0.5 cc pristane to induce lupus manifestations. After 12 weeks of injection, mice were mated and considered as gestational day 0 (GD0). Mice were divided into 4 groups based on the dosages of Bryophyllum pinnatum: control (no treatment), B1 (10.5 mg/kg), B2 (21 mg/kg), and B3 (42 mg/kg). The treatment was given orally every day started from GD9 until 9 days. At the end of the study, blood pressure and fetal size were measured. Serum anti-dsDNA and urine albumin levels were measured by ELISA. Spleen T helper (Th) and mature B cells percentages were measured by flow cytometry.Results: Administration of Bryophyllum pinnatum reduced the percentages of Th1 (p=0.006), Th2 (p=0.005), Th17 (p=0.000), and mature B cells (p=0.007) in dose-dependent manner. B1 and B2 had significantly lower of systolic blood pressure compared to control (p=0.026 and p=0.022 respectively). Significantly lower of anti-dsDNA levels were found in B1 group compared to control (p=0.014). However, no significantly different of urine albumin levels were found between groups. Bryophyllum pinnatum also significantly increased the fetus body weight in dose-dependent manner (p=0.000).Conclusion: Treatment of Bryophyllum pinnatum could improve the pregnancy outcome and modulate the immune response in pregnant pristane-induced lupus mice. Therefore, Bryophyllum pinnatum is a potential herb which can be developed as an immunosuppressive agent in the future.

Sosialisasi Pemanfaatan Susu Kambing di SD Islam As-Salam Malang Fatchiyah Fatchiyah; Titin Andri Wihastuti; Nurdiana Nurdiana; Rista Nikmatu Rohmah; Lidwina Faraline Triprisila; Antonius Christianto; Akbar Farid Hasibuan
TRI DHARMA MANDIRI: Diseminasi dan Hilirisasi Riset kepada Masyarakat (Jurnal Pengabdian kepada Masyarakat) Vol 1, No 1 (2021)
Publisher : JTRIDHARMA

Sebagian besar masyarakat masih belum mengetahui manfaat yang terkandung pada susu kambing, masyarakat masih menganggap bahwa susu sapi merupakan satu-satunya sumber nutrisi hewani yang memiliki kandungan protein, gizi, dan manfaat yang sangat besar bagi kesehatan. Untuk itu perlu dilakukan sosialisasi tentang pemanfaatan susu kambing karena kurangnya pengetahuan masyarakat sehingga menyebabkan rendahnya daya beli masyarakat. Tujuan dari kegiatan ini adalah untuk menjalin rintisan kerjasama dengan sekolah sebagai salah satu tempat pemasaran produk susu kambing serta orang tua siswa-siswi dalam meningkatkan daya konsumen masyarakat terhadap susu kambing dan memberikan informasi yang berlandaskan data ilmiah tentang manfaat susu kambing. Sosialisasi dilaksanakan melalui pemaparan pemateri tentang manfaat dan pentingnya mengonsumsi susu kambing dalam kehidupan sehari-hari serta pemanfaatan susu kambing menjadi produk nutrisi sehat (susu kambing pasteurisasi). Hasil dari kegiatan sosialisasi adalah para guru dan siswa-siswi bertambah pengetahuannya tentang pentingnya mengonsumsi susu kambing sebagai pangan sehat bernutrisi dan antusias dalam membuat produk-produk sehat berbahan dasar susu kambing.

PERBEDAAN KADAR IL-6 PADA HUVECs NORMAL DENGAN HUVECs NORMAL YANG DIPAPAR PLASMA HAMIL PENDERITA PREEKLAMPSIA Budi Rahayu; Nurdiana; Siti Candra Windu Baktiyani
MEDIA ILMU KESEHATAN Vol 4 No 3 (2015): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background : Preeclampsia is a condition where the blood pressure is increasing (≥140/90 mmHg) followed by proteinuria (≥300 mg/24 hour or ≥1+ in stick test) in pregnant women after 20 weeks of pregnancy. Released placenta factor cause the damage in endothelial cells which lead to the excessive increase on pro inflammation factor interleukin 6 (IL-6). Objective: This study aimed to investigate whether level IL-6 on normal HUVECs with normal HUVECs induced by plasma from preeclamptic patients. Research Method: True experimental research using posttest only control group approach, conducted in the laboratory with invitro. HUVECs culture was divided into 5, that were normal HUVECs without treatment (K-); HUVECs preeclampsia model (K+). Measurement on the levels of IL-6 used ELISA (Enzyme-Linked Immunosorbent Assay). Result: Independent sample t-test showed that there were significant differences (p=0.000<α) on the average of IL-6 levels between the negative control group (1.64±0.12 pg/ml) and the positive control group (31.64±11.69 pg/ml). Conclusion: Adding the patient’s preeclampsia plasma into normal HUVECs can increase levels of IL-6. Keyword: Patient’s preeclampsia plasma, HUVECs, and IL-6.

ANALYSIS OF PREDICTIVE FACTORS OF MORTALITY IN HEMORRHAGIC STROKE PATIENTS AT SOEBANDI HOSPITAL JEMBER Rida Darotin; Nurdiana Nurdiana; Tina Handayani Nasution
NurseLine Journal Vol 2 No 2 (2017): November 2017
Publisher : Faculty of Nursing, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/nlj.v2i2.5938

Stroke is a cerebrovascular disease that is often found in developed countries and currently also presents in developing countries, and one of them is in Indonesia. The high prevalence of stroke in Indonesia is affected by several risk factors such as obesity, lack of physical activity, unhealthy diet, smoking, high blood pressure, elevated blood sugar, and elevated blood lipid profile. The purpose of this study was to analyze the relationship between predictors of hemorrhagic stroke such as obesity, blood pressure, blood sugar and blood lipid profile with mortality in hemorrhagic stroke patients in RSD dr. Soebandi Jember. This research was a quantitative research with a retrospective approach. The number of samples was 101 medical record data. Univariate analysis was used to identify the description of each variable, a chi-square test was applied to analyze the correlation between variables, and the logistic regression analysis was applied to identify the most dominant factor influencing mortality of hemorrhagic stroke. The result of bivariate test showed p-value of obesity= 0,039, p-value of blood pressure= 0,478, p-value of blood sugar= 0,04, p-value of blood lipid profile= 0,026. Logistic regression obtained p-value for obesity= 0.043, OR = 2.689; p-value of blood sugar= 0,042, OR = 2,656; p-value of blood lipid profile= 0.069, OR = 3,749. There was a significant association between obesity, blood sugar, and blood lipid profile with mortality in hemorrhagic stroke patients. Obesity and blood sugar are predictors that can be used to predict mortality in hemorrhagic stroke patients, where obesity is the most dominant factor affecting mortality in hemorrhagic stroke patients.

Pendayagunaan Guru Sekolah Luar Biasa Idayu Malang dalam Deteksi Dini Gangguan Bicara dan Bahasa pada Anak Nurdiana Nurdiana; Ni Luh Putu Herli Mastuti; Astri Proborini; Yuseva Sariati
Journal of Dedicators Community Vol 5, No 2 (2021)
Publisher : Universitas Islam Nahdlatul Ulama Jepara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34001/jdc.v5i2.1418

The increase prevalence of speech and language disorders, which greatly affects the quality of life of a child. The role of educational institutions, especially teachers, is needed in early detection of these disorders. Early detection abilities must be based on the ability to understand a child's speech and language development. Community Service Activities are carried out at the Idayu 2 Malang Special School, by providing training to teachers on speech and language development and early detection methods. The method used is the provision of material followed by an examination of the students status growth ad development. There was an increase in the teacher's ability after the activity was carried out, which was marked by an increase in the average pretest and postest results: 61.15 to 86.54. On examination of the student's growth status, the nutritional status of the majority of students was found to be good nutrition (61%), but the short stature rate was also quite large (49%). The condition of children with special needs with physical limitations greatly affects their growth and development, so that the role of the environment is needed for optimal development, including parents and educational institutions.

REDUCING LUPUS PATIENTS' HOPELESSNESS THROUGH BEAUTY CLASS IN MALANG CITY IN HONOR OF WORLD LUPUS DAY Cesarius Singgih Wahono; Elvira Sari Dewi; Tri Wahyudi Iman Dantara; Perdana Aditya Rahman; Kusworini Handono; Nurdiana Nurdiana; Hani Susianti; Dian Hasanah; Choirinnisa Meilia Ayu Putri; Nora Ariyanti; Handono Kalim
Caring : Jurnal Pengabdian Masyarakat Vol 2, No 3 (2022): CARING Jurnal Pengabdian Masyarakat (Desember 2022)
Publisher : Caring : Jurnal Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.caringjpm.2022.002.03.4

Lupus is a systemic autoimmune rheumatic disease with mild to severe clinical features and can lead to hopelessness if not treated properly. The purpose of this activity is to give a beauty class and see how it affects the hopelessness of lupus patients in honor of World Lupus Day. Methods: Organizing World Lupus Day activities such as experts seminars on lupus at a glance, being friendly with lupus, and staying beautiful with lupus; a musical drama and dance performance by a lupus support group with the theme “You Are Beautiful”; and a lupus beauty class. The activity was completed in one day in May 2018 by collecting pre-test and post-test data on the incidence of hopelessness in lupus patients using the Beck Hopelessness Scale (BHS). A total of 100 lupus patients participated in the activity, and all of them underwent pre- and post-testing. The Wilcoxon Signed Rank Test with α=0.05 was used to analyze the collected data. Results: All participants expressed delight and satisfaction with their participation in this activity. The mean BHS scores before and after the beauty class were 8.62+2.68 and 6.36+1.59, respectively, with a significant difference (p=0.000). Conclusion: Beauty class is a fun way for lupus patients to feel less hopeless about their illness. Every year, an activity to commemorate World Lupus Day is required, which is beneficial for lupus patients.

Lime (Citrus aurantifolia (Christm.) Swingle) Juice Potential on Preventing Lipid Profile Aberrations as Alternative to Lemon (Citrus limon (L.) Burm.f.) Juice Olivia Anggraeny; Keshya Venesa; Nadia Magdalena; Stefany Dame; Sylvia Winnie; Stephani .Nesya; Nurdiana .
Indonesian Journal of Human Nutrition Vol. 7 No. 2 (2020)
Publisher : Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijhn.2020.007.02.7

ABSTRAKHiperlipidemia merupakan penyebab dari berbagai penyakit degeneratif. Mengonsumsi air perasan lemon menjadi tren di Indonesia beberapa tahun ini. Pada penelitian ini, dilakukan perbandingan efektivitas air perasan lemon dan jeruk nipis. Tujuan dari penelitian ini adalah untuk menganalisis perbedaan profil lemak darah: kolesterol total, low density lipid (LDL), very low density lipoprotein (VLDL), dan trigliserida (TG) pada tikus yang diberi diet tinggi lemak, air perasan lemon, dan jeruk nipis. Penelitian ini menggunakan 32 tikus jantan galur Wistar yang dibagi menjadi 8 kelompok dosis perlakuan air perasan lemon dan jeruk nipis. Didapatkan hasil bahwa tidak ada perbedaan kadar LDL (P0.151; p<0.05), VLDL (P0.187; p<0.05), TG (P0.216; p<0.05), namun ditemukan perbedaan signifikan pada kadar kolesterol total (P0.003; p<0.05). Hewan coba yang diberi perlakuan jeruk nipis memiliki sebagian besar rerata kadar lemak yang tidak berbeda signifikan dengan kelompok perlakuan lemon. Meskipun demikian, kolesterol total pada kelompok jeruk nipis lebih rendah dibandingkan kelompok lemon. Konsumsi jeruk nipis tampaknya memiliki kemungkinan menjadi alternatif dari lemon yang lebih murah dan terjangkau untuk mencegah profil lemak yang buruk.Â Â Kata kunci: lemon, jeruk nipis, kolesterol total, LDL, VLDL, TGABSTRACTHyperlipidemia causes various degenerative diseases. Recently, consuming lemon juice has become a trend in Indonesia to improve blood lipid profiles. This study compared the effectiveness of lemon juice and lime juice. This study aimed to determine differences in blood lipid profile that contains total cholesterol (TC), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and triglycerides (TG) in rats given High Fat Diet (HFD), lemon juice, and lime juice. This study used 32 white male Wistar rats (Rattus norvegicus) divided into eight treatment groups of lemon and lime juice doses. The results showed no significant differences in LDL (P0.151; p<0.05), VLDL (P0.187; p<0.05), and TG (P0.216; p<0.05), but there were significant differences in total cholesterol levels (P0.003; p<0.05). The experimental animals receiving lime juice had mean scores of lipid levels that were not significantly different from those with lemon treatment. However, the total cholesterol levels among groups given lime juice showed lower levels than the control and lemon treatment groups. Lime consumption seems possible to be a cheaper and affordable alternative to lemon to prevent lipid profile aberrations.Keywords: lemon, lime, TC, LDL, VLDL, TG

Correlation between Secreted Aspartyl Protease-5 (SAP5) on Increasing Vaginal Acidity in Vulvovaginal Candidiasis Nur Sophia Matin; Regina Ayu Fristiyanti; Safrina Dewi Ratnaningrum; Nurdiana Nurdiana; Sanarto Santoso; Bambang Rahardjo
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.116

Introduction: Vulvovaginal candidiasis (VVC) is an infection of the vaginal mucosa that extends to the vulva due to excessive growth of Candida albicans, causing a progressive decrease of Lactobacillus spp., as the main of normal flora. Decrease in the number of Lactobacillus spp. causes a reduction of lactic acid production that it was causing increasing vaginal pH. The increase in pH is due to the progressive growth of C. albicans colonies in the vaginal mucosa. In addition, the mechanism of candidiasis is also influenced by the secretion of virulence factors by C. albicans. Secreted Aspartyl Protease-5 (SAP5) is the dominant virulence factor that plays a role in changing the morphology of yeast cells into hyphae. This study aims to identify the correlation between SAP5 levels and vaginal pH. Material and Methods: This research was conducted in vivo using a sample of Rattus norvegicus with a posttest randomized experimental group design approach. This study has two groups, i.e., Negative Control (NC) and Positive Control group (PC). SAP5 and pH samples were taken from vaginal fluids and then measured using ELISA and a digital pH meter. The statistical analysis used was Pearson Correlation to analyze the correlation between SAP5 and pH levels. Results: There was a strong correlation (R=0.846) that means the increase of SAP5 is related to the increase of vaginal acidity in the PC group. Conclusion: The increase in SAP5 levels is directly followed by an increase in the pH value of vaginal fluids,

Effect of infused lemon water (citrus limon) on Newborn Baby Weight (BBL) in pregnant rats (rattus norvegicus) exposed to electric cigarette vapor Rahmawati Nurul Fadilah; Nurdiana Nurdiana; Ni Luh Putu Herli Mastuti
Science Midwifery Vol 12 No 3 (2024): August: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i3.1637

The electric cigarettes are said safe for health, in fact there are toxic substances, carcinogens, and unstable nicotine, it is suspected to cause low birth weight in pregnant women who are exposed to electric cigarette. Nicotine in electric cigarette is free radicals, so to ward off free radicals is required antioxidant. Infused lemon contains antioxidants that are higher than lime and are believed to resist free radicals from electric cigarettes. The purpose of research to determine the influence of infused lemon water in preventing low birth weight in pregnant rats (Rattus novergicus) exposed by electric cigarettes. The study used 30 pregnant rats, divided into 5 groups; Negative control (KN), positive control (KP), Treatment (P1), Treatment (P2), Treatment (P3). Using electric cigarette liquid 9 mg, and the difference in the weight of lemon in the making of infused water (P (1): 25g, P (2): 50g, P (3): 100g lemon + 100ml water). The treatment is given on day 1 ovulation to day 18, sacrificed on the 19th day ovulation then calculated the average weight of the baby. The average weight baby KN: 5.502g, KP: 2.821g, P (1): 4.301g, P (2): 4.888g, P (3): 5.435g. The result of One-way ANOVA indicates there is a significant difference in the treatment group with the value P=0,000 (P<0.05). The KP group differs significantly from KN. Group P (1,2,3) is significantly different from KP. The KN group is significantly different from P (1), but does not differ significantly from P (2, 3). The group P (1) differs significantly with P (3). Infused lemon juice can prevent the occurrence of low birth weight in the child of the pregnant rats that’s exposed by electric cigarettes especially in group P (3).

Co-Authors Akbar Farid Hasibuan Anisa Setyowati Antonius Christianto Astri Proborini Bambang Rahardjo Budi Rahayu Choirinnisa Meilia Ayu Putri Darotin, Rida Dewi Azar Nuria Wardani Dian Hasanah Diana Lyrawati Elvira Sari Dewi fatchiyah . Handono Kalim Hani Susianti Hikmawan Wahyu Sulistomo Ihda Dian Kusuma Ita Sulistiani Kalsumy, Umi Keshya Venesa Kharisma Ciptaning Gusti Kusworini Handono Kusworini Handono Laras Indah Sari Lidwina Faraline Triprisila Melani Chysti Situmorang Nadia Magdalena Ni Luh Putu Herli Mastuti Nia Kurnianingsih Nora Ariyanti Nur Sophia Matin Nurdin Nurdin Nursari Abdul Syukur Olivia Anggraeny Perdana Aditya Rahman Pratama, Mirza Zaka Ra. Aminah Maya Rahmawati Nurul Fadilah Rahmawati Wahyuni Regina Ayu Fristiyanti Rista Nikmatu Rohmah Safrina Dewi Ratnaningrum Sanarto Santoso Siti Candra Windu Baktiyani Stefany Dame Stephani .Nesya Subandi Subandi Subandi Subandi Sylvia Winnie Tina Handayani Nasution Titin Andri Wihastuti Tri Wahyudi Iman Dantara Utami, Juliyatin Putri Wahono, Cesarius Singgih Wisnu Barlianto Yati Sri Hayati Yuni Sari Yuseva Sariati

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