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All Journal Health Science Journal of Indonesia Medical Journal of Indonesia The Indonesian Journal of Public Health The Indonesian Biomedical Journal Sari Pediatri Amerta Nutrition JK Unila (Jurnal Kedokteran Universitas Lampung) The Indonesian Journal of Community and Occupational Medicine eJournal Kedokteran Indonesia Occupational and Environmental Medicine Journal of Indonesia
Nuri Purwito Adi
Department Of Comunnity Medicine, Faculty Of Medicine, University Of Indonesia, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Safety and immunogenicity of the CoV2-Bio in a healthy population aged 18 years and older in Indonesia Maria, Suzy; Olfriani, Ciho; Koesnoe, Sukamto; Sekartini, Rini; Soedjatmiko; Medise, Bernie Endyarni; Yuniar, Irene; Indawati, Wahyuni; Wirahmadi, Angga; Sari, Rini Mulia; Adi, Nuri Purwito; Retnaningdyah, Windri
Medical Journal of Indonesia Vol. 34 No. 1 (2025): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247476

Abstract

BACKGROUND According to the WHO Target Product Profiles for COVID-19 Vaccines, vaccine development should be indicated for active immunization in all populations, in conjunction with other control measures to curtail the pandemic. Several RBD-based COVID-19 vaccines are being evaluated and have shown advantages. CoV2-Bio was developed based on the wild-type SARS-CoV-2 RBD amino acid sequence, representing residues of the spike protein of the Wuhan-Hu-1 isolate. This study aimed to evaluate the safety and immunogenicity of CoV2-Bio when compared to CoronaVac. METHODS This was an observer-blinded, randomized controlled prospective study of safety and immunogenicity of the CoV2-Bio in healthy adult population. A total of 54 healthy participants were randomized to receive either 3 doses of CoV2-Bio or 2 doses of CoronaVac, and 1 dose of placebo, administered 28 days apart. Participants were followed up for safety and immunogenicity. IgG antibody titers (ELISA) and neutralization assay against Wuhan and Delta strains were evaluated at baseline, Days 28, 56, and 84. We assessed seropositive rate, seroconversion, and GMT as parameters. RESULTS Both vaccines were well tolerated and induced good antibody response. The incidence rate and intensity of local and systemic adverse events did not differ between vaccine and control groups. The vaccine group showed a larger proportion of seroconversion (4-fold increase antibody) (87.5% versus 46.2%, p = 0.001) and higher GMT (305.9 AU/ml versus 102.4 AU/ml, p<0.001) when compared to control group. CONCLUSIONS 3 doses of the CoV2-Bio are safe and immunogenic in healthy adult population. 3 doses of the CoV2-Bio COVID-19 vaccine produce a better immunogenicity profile compared to CoronaVac.
Comparison of Fatigue Dimensions between Warehouse Staff and Heavy Equipment Technicians in The Mining Sector Mohammad Ikram Bahari; Dewi Friska; Dewi Yunia Fitriani; Ahmad Fuady; Nuri Purwito Adi
The Indonesian Journal of Community and Occupational Medicine Vol. 5 No. 2 (2025): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53773/ijcom.v5i2.174.49-55

Abstract

Background: Work-related fatigue is a multidimensional condition that can reduce productivity and increase the risk of workplace accidents, particularly in professions with high physical and mental demands such as heavy equipment technicians and warehouse workers in the mining sector. Both professions work under shift systems and high workloads; however, studies comparing the dimensions of fatigue between the two remain limited.Objective: To determine the proportion of fatigue levels and compare fatigue dimensions between warehouse workers and heavy equipment technicians.Methods: A descriptive-comparative cross-sectional study was conducted on 132 male workers (100 heavy equipment technicians and 32 warehouse workers) at a mining company in South Kalimantan, Indonesia. Demographic and job-related characteristics were collected. Fatigue was measured using the Swedish Occupational Fatigue Inventory (SOFI) in Indonesian, which has been validated, covering five dimensions: energy deficiency, physical exertion, physical discomfort, sleepiness, and lack of motivation. Descriptive and comparative statistical analyses were conducted.Results: Mild fatigue (among technicians and warehouse staff were 90% and 93.8% ). Moderate fatigue was experienced by 10% of technicians and 6.3% of warehouse staff. No participants experienced severe fatigue. Among heavy equipment technicians, the highest dimension was physical exertion, while the highest dimension of fatigue among warehouse staff was lack of energy. Work factors, age, work experience, and nutritional status were not significantly associated with fatigue levels.Conclusion: Mild fatigue dominates in both work groups, as this company is a supporting company for a mining company, there have never been any near misses or incidents, and has an appropriate management. For the overall fatigue dimension, heavy equipment technicians scored higher than warehouse staff. However, fatigue checks should still be carried out regularly among workers.
Adaptation of Stanford Presenteeism Scale-6 in Indonesia Tanama, Fery Alfaro; Adi, Nuri Purwito; Werdhani, Retno Asti; Herqutanto, Herqutanto
Occupational and Environmental Medicine Journal of Indonesia Vol. 2, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Presenteeism has been identified to cause productivity loss more than 50% greater than absenteeism. Currently in Indonesia there are no standardized tools to assess presenteeism among workers. Therefore, we intended to adapt and validate SPS-6 in Indonesia. Methods: This is a cross-sectional study with cross-cultural adaptation refers to the ISPOR method, with a validity and reliability statistical test. Total respondents were 112 white-collars workers. Inter-item correlation was used for validity test and Cronbach’s Alpha was used for reliability test. Results: Cross-cultural adaptation of SPS-6 has been successfully done. The most significant change occurred in the explanation of the health problem definition. All item and item’s dimension were statistically significant correlated with total score. Cronbach’s alpha of work focus dimension and psychological dimension was 0.657 and 0.646, respectively. Conclusion: The Indonesian version of the SPS-6 questionnaire was valid and reliable and could be used as an instrument to identify presenteeism for office workers (white collar workers) in Indonesia.
Program Evaluation of the Monthly Health Review Program: A Strategy to Protect High-Risk Field Workers in the Manufacturing Industry from COVID-19 Melati Yalti Kautsar Syahrial; Dewi Sumaryani Soemarko; Agus Sugiharto; Nuri Purwito Adi; Boy Subirosa Sabarguna
The Indonesian Journal of Community and Occupational Medicine Vol. 6 No. 1 (2026): ijcom
Publisher : ILUNI MKK FKUI and PRODI MKK FKUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53773/ijcom.v6i1.217.25-36

Abstract

Background: The Indonesian government has issued guidelines for companies during the COVID-19 pandemic to monitor high-riskemployees due to the severe complications associated with COVID-19. The study aims to identify the cause of program issues and determinepotential improvements to achieve the program’s target of a monthly health review, protecting high-risk field workers in the manufacturingindustry from COVID-19.Methods: A mixed-methods approach combining quantitative and qualitative data was employed, utilizing the Problem-Solving Cycle.Quantitative data were obtained from document reviews, which revealed the characteristics of the Implementers (n=5) and program participants(n=58). Qualitative data are collected through in-depth interviews with policy stakeholders, program implementers, and program participantsto identify the causes of program problems. These problems are then prioritized as main issues using the USG method, and alternative solutionsare discussed. The selected solutions are evaluated based on their effectiveness and efficiency using the Reinke method.Results: On average, 89.58% of participants attended the program throughout the past two years, and only 59.98% of individuals had ahealth condition under control. The interviews revealed that the absence of a Standard Operating Procedure (SOP) was the primary cause ofthe failure to achieve the attendance and under control health condition targets, which were also impacted by a lack of coordination. Nonadherence to medication contributes to discordant comorbidities.Conclusion: Creating an SOP with a relevant target program is the primary solution, and internal meetings to create a monthly schedule.Additionally, the company doctor and program implementers regularly educate program participants to raise awareness of the benefits oftaking the medication regularly.
Co-Authors Agus Sugiharto Agus Sugiharto Ahmad Fuady Amilya Agustina Andi Wijaya Ardi Artanto Aria Kekalih Arriz Akbar Sukadi Astrid Sulistomo Bernie Endyarni Medise Betharia Sonata Butarbutar Boy Hidayat Boy Subirosa Sabarguna Cinthya Yuanita Dewi Friska Dewi S. Soemarko Dewi Sumaryani Soemarko Dewi Yunia Fitria Dewi Yunia Fitriani Dewi Yunia Fitriani Dina Tri Amalia Endang Mariani Rahayu Fredy Christianto Gratcia Ayundini herlinah herlinah Herqutanto - Indah S. Widyahening Irawan Yusuf Irene Yuniar, Irene Iwan Sugiarta Iwan Susilo Joko Johan, Anita Kiminori Odagami Kusuma Dewi, Dian L. Meily Kurniawidjaja Levina Chandra Khoe Lim Jen Fuk Marsen Isbayu Putra Marsen Isbayu Putra Melati Yalti Kautsar Syahrial Mohammad Ikram Bahari Muchtaruddin Mansyur Muhammad Ikhsan Mokoagow Muhammad Ilyas Muhammad Ilyas Muhammad Ilyas Muhammad Soffiudin Mulyana Mulyana Mulyana Mulyana Olfriani, Ciho Parmitasari Puji Lestari, Shanti Retnaningdyah, Windri Retno Asti Werdhani Rini Mulia Sari Rini Sekartini S. Soemarko, Dewi Soedjatmiko Sukamto Koesnoe Suzy Maria Tanama, Fery Alfaro Tomohisa Nagata Tukimun, Suci Tria Meirisa Umi Fahmida Vani Nur Pratami W. Roestam, Ambar Wahyuni Indawati, Wahyuni Wibowo, Suryo Wirahmadi, Angga Yessi Kualasari Yunianti Lafau