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All Journal Jurnal Farmasi Klinik Indonesia Indonesian Journal of Cancer JFIOnline Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Jurnal Kefarmasian Indonesia
Maksum Radji
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Seleksi Galur-Galur Leuconostoc yang Mempunyai Aktivitas Bakteriostatin Terhadap Berbagai Bakteri Indikator Retnaningsih, Agustina; Malik, Amarila; Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 9, No. 2
Publisher : UI Scholars Hub

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Lactid Acid Bacteria (LAB) are known to produce bacteriocins which have antimicrobial activity, and possessed to be developed as antibiotic complement. This study aimed to characterize bacteriocins activity from Leuconostoc strains isolated previously from local sources, and to optimize pH and incubation temperature as well. A well diffusion agar assay for zone inhibition method and bacteriocin potency assay performing minimum inhibition concentration (MIC) have been done. Bacterial indicators used in this study are Leu. mesenteroides TISTR 120, and JCM 6124, Staphylococcus aureus FNCC 0047, Listeria monocytogenes FNCC 0156, Escherichia coli FNCC 0183, Pseudomonas aeruginosa FNCC 0063, Salmonella typhi FNCC 0165 and Bacillus subtilis FNCC 0061. Catalase, Trypsin and Protease K were also used for confirmation test. Results revealed that both Leu. mesenteroides MBF2-5 and MBF7-17 possessed bacteriocin activity although against Leu. mesenteroides TISTR 120 and JCM 6124 indicators strains. The optimum pH for bacteriocin potency assay for both Leuconostoc strains MBF2-5 and MBF7-17 was pH 6, whereas the optimum incubation temperature was 32 oc with MIC value of 90% and 80%, respectively.
The Effectiveness of Clinical Pharmacist Intervention in Reducing Drug Related Problems of Childhood Acute Lymphoblastic Leukemia Patient in Tangerang District General Hospital, Indonesia Budiastuti, Rizky Farmasita; Radji, Maksum; Purnamasari, Rini
Pharmaceutical Sciences and Research Vol. 6, No. 1
Publisher : UI Scholars Hub

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This study aimed to evaluate the clinical pharmacist interventions in reducing drug-related problems (DRPs) in childhood acute lymphoblastic leukemia (ALL) patients in the Tangerang District General Hospital, Banten, Indonesia. This study used a prospective analysis of patients with a pre-post design between January-March 2017. The Pharmaceutical Care Network Europe (PCNE) (V6.2) pre-post study system was used to identify the DRPs of 138 patients. The Pharmacist interventions were addressed to physicians, patients, and other health professions to determine the effectiveness of pharmacist interventions before and after the intervention. The number of identified DRPs was 177 problems and the identified types of DRP was 164 types. The pharmacist interventions significantly decreased the DRPs from 177 to 10 DRPs (p < 0.05) and type of DRPs from 164 to 10 types of DRPs (p < 0.05). Risk factors for nutritional status, type of ALL, comorbidities, number of drug items, and type of treatments did not significantly affect (p > 0.05) to the decreased of the number and type of DRPs. Clinical pharmacist interventions able to reduce the number and type of DRPs and can improve treatment outcomes in childhood ALL.
Potensi Pemanfaatan Nigella sativa L. sebagaiImunomodulator dan Antiinflamasi Sulistiawati, Farida; Radji, Maksum
Pharmaceutical Sciences and Research Vol. 1, No. 2
Publisher : UI Scholars Hub

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Nigella sativa L. has long been used as an herbal medicine in some countries, particularly in the Middle East and in other Asian countries, including in Indonesia. One component is a protein compound extracted from black cumin oil residues, known to have efficacy to enhance the immune system and as an anti-inflammatory. As the compound will be degraded when administered orally, the research on its delivery systems, is interesting to be developed. This article will review about the prospects of their utilization and strategy formulation that preparation can be delivered orally.
DETEKSI CEPAT BAKTERI Escherichia coli DALAM SAMPEL AIR DENGAN METODE POLYMERASE CHAIN REACTION MENGGUNAKAN PRIMER 16E1 DAN 16E2 Radji, Maksum; Puspaningrum, Anglia; Sumiati, Atiek
Makara Journal of Science Vol. 14, No. 1
Publisher : UI Scholars Hub

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Rapid Detection of Escherichia coli in Water Samples by Polymerase Chain Reaction Using 16E1 and 16E2 Primers. The detection of Escherichia coli in various water samples by Polymerase Chain Reaction method using 16E1 and 16E2 primers has been carried out. It was found that four out of ten samples were detected Escherichia coli and revealed the presence of the amplified product of the size 584 base pairs. Confirmation test of PCR result was also done using the conventional culturing method. The results of this study showed that the PCR assay was specific and faster than the conventional culturing method for detection of Escherichia coli.
ISOLASI DAN SKRINING MOLEKULER BAKTERI ASAM LAKTAT PEMBAWA GEN GLUKANSUKRASE DARI MAKANAN DAN MINUMAN MENGANDUNG GULA Malik, Amarila; Hermawati, Ajitya Kurnia; Hestiningtyas, Mahardhika; Radji, Maksum
Makara Journal of Science Vol. 14, No. 1
Publisher : UI Scholars Hub

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Isolation and Molecular Screening of Glucansucrase Gene Harboring-Lactic Acid Bacteria. Exopolysaccharides (EPS) have been possessed to be used in pharmaceutical, cosmetic and food industries. Lactic acid bacteria (LAB) produce a wide variety of exopolysaccharides and carries sucrase genes glucansucrase/glucosyltransferase (gtf) and fructansucrase/fructosyltransferases (ftf) for EPS production. In this study, the isolation and screening of EPS producing-LAB (EPS-LAB) were carried out on modified de Mann-Rogosa-Sharpe (MRS) agar medium supplemented with 10% of sucrose on LAB isolated from various unique sugar containing-foods and -beverages originated from local sources. Besides obtaining EPS-LAB, this study aimed to screen for gtf gene as well as to molecular identify strains by using PCR technique. Degenerate primer pairs DegFor and DegRev which targeted the conserved region of gtf genes catalytic domain were used, whereas LABfw and LABrv were used to molecular identify strains using 16S rRNA gene. An approximately 660 base pairs (bp) amplicons which targeted gtf gene were obtained from 13 out of 16 srains chosen. Result from PCR of 16S rRNA gene identification on gtf positive strains revealed that all strains were molecular identified as LAB after DNA sequencing analysis by using blastn. A rare EPS-producing LAB were obtain i.e. Weissella. Strains obtained in this study are potential sources for exploring novel sucrase gene/s and obtain unique EPS polymer product/s.
Evaluasi Penggunaan Antibiotik dengan Metode Gyssens pada Pasien Stroke Rawat Inap di RSUD Koja secara Retrospektif (Periode KJS dan BPJS) Sitompul, Fransiska; Radji, Maksum; Bahtiar, Anton
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 1, FEBRUARI 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i1.2915

Abstract

Stroke is a major cause of mortality and morbidity worldwide. Patients with stroke are susceptible to medical complications, especially infections. This study aim to evaluate antibiotic by stroke inpatients hospitalized in RSUD Koja (KJS and BPJS period) with Gyssens methods. The study design is a retrospective cross-sectional. The sample is consisted of 112 medical records from KJS period (July 2013-December 2013) and 74 medical records from BPJS period (January 2014-June 2014) taken by total sampling. The use of antibiotic were analyzed using Chi Square and logistic regression multivariate. The percentage of antibiotic use was 23,11%, mostly were ceftriaxon 33,3%, ceftizozim 7,6% and amoxicillin – clavulanic acid 7,6%. Length of stay more than 7 days was 77,96%. The most common route of antibiotic administration was parenteral (68,67%). Patients that were given antibiotics were,among others,diagnosal by bronchopneumonia (29,33%), pulmonary tuberculosis and 17,6% and urinary tract infection (8,7%). The clinical outcome showed that 69,3% of 186 patients were recovered after antibiotic were given to treat their infections. Gyssen evaluation method showed that rational antibiotic used on KJS period was 77,4% and BPJS periods was 81,3%. There were correlations between rational use at antibiotic and the route of administration, between clinical outcome anduse at diagnosis and route of administration. The conclusion of this study according to Gyssen method is the rational antibiotic influence the clinical outcome (p < 0,05)
Qualitative Evaluation of Antibiotics Use for Ventilator Associated Pneummonia (VAP) Patient in ICU Dharmais Cancer Hospital Using Gyssens Method Ramadhanti, Shahyawidya; Radji, Maksum; Andalusia, Rizka
Indonesian Journal of Clinical Pharmacy Vol 12, No 1 (2023)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2023.12.1.42

Abstract

Ventilator-associated pneumonia (VAP) is a pulmonary infection that occurs after more than 48 hours of mechanical ventilation or endotracheal intubation. VAP is the most common nosocomial infection in ICU (Intensive Care Unit), and of course the use of antibiotics will affect the treatment of the infection. This study aims to evaluate the quality of antibiotic use for VAP treatment in ICU Dharmais Cancer Hospital using Gyssens method, evaluate the different outcomes of antibiotic therapy that are rational and irrational according to the Gyssens method, and evaluating the distribution of rational (category 0) and irrational (category 1-5) antibiotic use. This prospective study was carried out from February to May 2017 with descriptive analyses. Antibiotic uses were documented prospectively by a pharmacist and analysis by using Gyssens method. Pharmacist was used total sampling method, which is included all adult VAP patients in ICU. A total of 29 patients (18,24%) were reviewed from 159 patients. The most dominant antibiotic use for VAP empiric treatment was meropenem and the most dominant antibiotic use for VAP definitive treatment was levofloxacin. Factors affecting the quality of antibiotic use include type of the therapy, number of antibiotics used by patient and length of stay (P>0,05). Factors affecting the therapy outcome of VAP patient was time of antibiotic use (P<0.05). The relationship between outcome therapy and quality of antibiotic use based on Gyssens method shows on category 0 which died 64,3%, category 2 died 66,7% and the category 4 died 75%. The relationship between outcome therapy and quality of antibiotic use based on Gyssens method shows more irrational use of antibiotics then the therapy outcome is not getting better.
SOCIAL PHARMACY INITIATION TO IMPROVE QUALITY OF LIFE AND HEALTH EDUCATION IN FISHERMAN VILLAGE KAMAL MUARA Vardhani, Afifah Kusuma; Radji, Maksum; Syarafina, Nihla Nurin; Maisaroh, Siti; Amalia, Yayu; Ayuningtyas, Yessy Tri; Belladona, Ladisa Virgiane; Aintania, Rasyya; Putri, Andi Rani Anggraini; Mentari, Claudia; Afrilia, Salsa; Hartanto, Virgo Budi
Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Vol. 9 No. 1 (2025): MARET
Publisher : LPPM Univ. Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/abdidos.v9i1.2565

Abstract

Kamal Muara Sub-district, Penjaringan District, located in the coastal area of ​​North Jakarta, is a community with a heterogeneous population in terms of ethnicity, culture, and occupation. Most of the residents work as fishermen and factory workers. Various health and environmental issues such as low awareness of personal hygiene and healthy eating habits were problems faced by coastal residents. This activity aims to provide health education, improve nutrition, and raise environmental awareness through a social pharmacy practice program. The methods used in this program are observation and field practice. The students participated in activities such as education on safe drug use, healthy exercise sessions, creative healthy fish cooking, recycling workshops, proper handwashing and tooth brushing techniques, and environmental cleaning. The results of this study show that awareness and knowledge of the importance of health in the community increased through a series of educational programs. The program also successfully promoted collaboration and mutual cooperation among residents with significant support from community leaders and academia. The positive impact of this program is expected to last and become part of the daily habits of the community.
Co-Authors A., Nurgani A., Nurgani Afrilia, Salsa Aintania, Rasyya Ajitya Kurnia Hermawati Ajoedi Soemardi Ajoedi Soemardi, Ajoedi Aldrat, Hendri Aldrat, Hendri Amalia, Yayu Amarila Malik Anglia Puspaningrum Anton Bahtiar Aprilita Rina Yanti Atiek Soemiati Atiek Sumiati Atiek Sumiati, Atiek Ayuningtyas, Yessy Tri Belladona, Ladisa Virgiane Budi, Erwanto Budi, Erwanto Cosphiadi Irawan Dessy Ariyanti Farida Sulistiawati Farida Sulistiawati, Farida Farmasita Budiastuti, Rizky Hartanto, Virgo Budi Heria Oktavia, Heria Herman Suryadi Hermawati, Ajitya Kurnia Hestiningtyas, Mahardhika Lydia Septa Desiyana Lydia Septa Desiyana, Lydia Septa Mahardhika Hestiningtyas Mentari, Claudia Nugraheni, Femi Arifah Nugraheni, Femi Arifah Nuning Indani, Nuning Puspaningrum, Anglia Putri, Andi Rani Anggraini Ramadhanti, Shahyawidya Ratna Chandra Sari Retnaningsih, Agustina Rini Purnamasari, Rini Rizka Andalusia Siti Fauziyah Siti Maisaroh SITI MARIAM Sitompul, Fransiska Syarafina, Nihla Nurin Vardhani, Afifah Kusuma Yahdiana Harahap