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All Journal Jurnal Farmasi Klinik Indonesia Indonesian Journal of Cancer Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Archives Pharmacia Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Jurnal Kefarmasian Indonesia

Maksum Radji

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Author-ID : 313020

Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Kejadian Demam Neutropenia pada Pasien Kanker Payudara setelah Menerima Regimen Kemoterapi TAC-G-CSF dan FAC di RSUP Dr. Hasan Sadikin Bandung Nusaibah A. Hima; Retnosari Andrajati; Maksum Radji
Indonesian Journal of Clinical Pharmacy Vol 10, No 1 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.1.1

Demam neutropenia merupakan efek samping yang sering terjadi setelah kemoterapi. Demam neutropenia dapat menyebabkan penundaan dosis kemoterapi sehingga dapat mengurangi efektivitas terapi. Kejadian demam neutropenia setelah kemoterapi dapat dicegah dengan pemberian Granulocyte-colony Stimulating Factor (G-CSF). Regimen kemoterapi yang digunakan dapat memengaruhi kejadian demam neutropenia. Selain itu, usia, stadium kanker, riwayat kemoterapi dan kadar hemoglobin sebelum kemoterapi merupakan faktor risiko demam neutropenia setelah kemoterapi. Penelitian ini bertujuan untuk mengetahui perbandingan kejadian demam neutropenia regimen Dosetaksel, Doksorubisin, Siklofosfamid (TAC) dengan profilaksis primer G-CSF dan regimen Fluorourasil, Doksorubisin, Siklofosfamid (FAC) pada pasien kanker payudara di RSUP Dr. Hasan Sadikin Bandung periode Januari 2017–Juni 2019. Desain penelitian adalah cross sectional uji dua populasi. Jumlah sampel sebanyak 61 regimen TAC-G-CSF dan 102 regimen FAC. Kejadian demam neutropenia dianalisis menggunakan Chi-Square, Kruskal Wallis dan regresi logistik. Hasil penelitian menunjukkan kejadian demam neutropenia setelah kemoterapi pada regimen TAC dengan profilaksis primer G-CSF lebih tinggi dibanding pada regimen FAC. Usia, stadium kemoterapi, riwayat kemoterapi dan kadar hemoglobin sebelum kemoterapi secara statistik tidak signifikan memengaruhi kejadian demam neutropenia setelah kemoterapi.Kata kunci: Demam neutropenia, FAC, granulocyte-colony stimulating factor (G-CSF), regimen kemoterapi, TAC The Incidence of Febrile Neutropenia in Patients with Breast Cancer after Receiving TAC-G-CSF and FAC Chemotherapy Regimen at Dr. Hasan Sadikin Hospital Bandung AbstractFebrile neutropenia is a common side effect of chemotherapy, and it reduces the effectiveness of therapy through the delay in chemo doses. Granulocyte-colony Stimulating Factor (G-CSF) is administered to prevent its incidence. The chemotherapy regimen affects the incidence of febrile neutropenia. Risk factors for febrile neutropenia include; age, stage of cancer, history of chemotherapy and pre-chemotherapy hemoglobin level. The purpose of this study was to compare the incidence of febrile neutropenia between Docetaxel, Doxorubicin, Cyclophosphamide (TAC) regimen with G-CSF primary prophylaxis and Fluorouracil, Doxorubicin, Cyclophosphamide (FAC) regimen in patients with breast cancer at Dr. Hasan Sadikin Hospital Bandung at the period of January 2017–June 2019. The cross-sectional study design of two populations was used. The sample consisted of 61 TAC and 102 FAC regimens. The Chi-Square, Kruskal Wallis, and logistic regression were used to analyze the incidence of febrile neutropenia. The results showed that the incidence of post-chemotherapy febrile neutropenia in TAC regimen with G-CSF primary prophylaxis was higher compared with FAC regimen. Furthermore, the risk factors had no statistical influence on the incidence of febrile neutropenia. Keywords: Chemotherapy regimen, FAC, febrile neutropenia, granulocyte-colony stimulating factor (G-CSF), TAC

Pengkulturan Sampel Susu Fermentasi yang Mengandung Probiotik dan Identilikasinya dengan PCR AMARILA MALIK; INDRIANI INDRIANI; LILIANA SARAGIH; MAKSUM RADJI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 1 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Lactic Acid Bacteria (LAB) has long been used in fermented milk because its stability, unique taste and texture and also for its health benents that are provided by the probiotic. There are many fermented dairy products in the market nowadays that declared containing living culture or as probiotics. The aim of this study was to identify LAB from fermented milk product by Visual inspection on plate culture for their morphology, as well by molecular technique performing PCR and DNA sequencing methods. Morphology and growth incubation time of each isolate was observed. A pair of primer that is highly speciiic for LAB targeting the gene encoding for 168 rRNA, which represents sequences of region 677 to 693 of E. coli numbering has been used for PCR identiiication in this study. A total of nineteen isolates were obtained from 10 fermented milk samples that were grown on de Mann Rogosa Sharpe Agar (MRSA) media. Nine out of 19 isolates which represent each of the samples were selected. Genomic DNA extracted from those 9 isolates were used as template for PCR. The results showed that 8 amplicons were positively identitied as LAB, but only three identities indicated similar species as declared, while 5 others did not.

Penggunaan Obat Herbal pada Pasien Kanker Serviks MAKSUM RADJI; HENDRI ALDRAT; YAHDIANA HARAHAP; COSPHIADI IRAWAN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Herbal medicines have widely been used to treat many type of diseases despite the advance of standard or conventional therapy. In fact, many people in Indonesia use medicinal plant as their customary part of life. Therefore, it is necessary to further explore the use of herbal medicines through modern perception. ln this study we would like to know the frequency and species of herbal medicines used among cervical cancer patients in National Cancer Hospital Dharmais, Jakarta, Indonesia and also to assess the relationship between age, education, jobs, stage of cancer, and payment status of the patients. The results were 61,8% patients used herbal medicines. The herbal medicines used most were mahkota dewa (Phaleria macrocarpa Scheetf Boerl.) 35.3%, temu putih (Curcuma zedoaria Rosc.) 32.4%, and buah merah (Pandanus conoideus Lam) 17,6%. There was a significant relationship (p=0,039) between the use of herbal medicines and stage of cancer but no relationship between age, education, occupation, income and payment status with the use of herbal medicines.

Skrining Bakteriosin dari beberapa Galur Bakteri Asam Laktat Isolat Lokal Genus Streptococcus dan Weissella RAFIKA SARI; CESILIA ANITA; MAKSUM RADJI; AMARILA MALIK
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 2 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Many lactic acid bacteria (LAB) are known to produce antimicrobial peptides, termed bacteriocins. Bacteriocins are ribosomally synthesized antimicrobial peptides which kill closely related bacteria. Bacteria producing bacteriocin are also known to produce bacteriocin immunity protein (bip). This study aimed to identify bacteriocins activity in an attempt to isolate the bacteriocin and the bip. In this study, genus Streptococcus and Weissella from our LAB collection were screened on well diffusion agar for antagonism assay. Growth inhibition zone observation has been carried out by antagonism assay using Leu. mesenteroides TISTR 120, Leu. mesenteroides JCM 6124, Staphylococcus aureus FNCC 0047, Bacillus subtilis FNCC 0061, Escherichia coli FNCC 0183, Salmonella typhi FNCC 0165, Pseudomonas aeruginosa FNCC 0063, and Listeria monocytogenes FNCC 0156 as indicator strains. Protease K, catalase, and trypsin were also used following the first screening assay for confirmation test. Results showed that both Strep. macedonicus MBF10-2 and W. confusa MBF8-1 posses bacteriocin activity although both against Leu. mesenteroides only, the TISTR 120 and JCM 6124 indicator strains

Analisa Perbandingan Monoterapi dengan Dualterapi Antibiotik Empiris terhadap Outcome pada Pasien Community Acquired Pneumonia (CAP) di IGD RSUP Fatmawati Jakarta Nurraya Lukitasari; Maksum Radji; Alfina Rianti
Jurnal Sains Farmasi & Klinis Vol 6, No 2 (2019): J Sains Farm Klin 6(2), Agustus 2019
Publisher : Fakultas Farmasi Universitas Andalas

Community acquired pneumonia (CAP) adalah suatu peradangan akut pada parenkim paru yang disebabkan oleh mikroorganisme dan didapat dari masyarakat. Antibiotik adalah obat yang paling penting dalam pengobatan CAP. Namun, terapi antibiotik empiris yang optimal merupakan masalah yang sering diperdebatkan sehingga penatalaksanaan CAP masih merupakan tantangan yang besar bagi para klinisi. Penelitian ini bertujuan menganalisa perbandingan outcome terapi, efektivitas biaya dan kualitas penggunaan antibiotik empiris monoterapi terhadap dualterapi CAP secara kohort prospektif. Diperoleh hasil perbaikan klinis monoterapi dengan dualterapi tidak berbeda bermakna secara statistik (p=0,638). Namun, secara farmakoekonomi diketahui bahwa monoterapi lebih efektif dan dengan rasionalitas penggunaan yang lebih baik pula dibandingkan dualterapi.

Evaluasi Penggunaan Antibiotik Secara Kualitatif dan Analisis Efektivitas Biaya pada Pasien Pediatri di RSUP Fatmawati Jakarta Fetri Kristiani; Maksum Radji; Alfina Rianti
Jurnal Sains Farmasi & Klinis Vol 6, No 1 (2019): J Sains Farm Klin 6(1), April 2019
Publisher : Fakultas Farmasi Universitas Andalas

Peresepan antibiotika yang tidak tepat akan meningkatkan kejadian resistensi. Resistensi antimikroba telah menjadi masalah kesehatan yang mendunia dengan dampak meningkatkan morbiditas, mortalitas, dan biaya kesehatan. Penelitian ini bertujuan untuk mengetahui kualitas penggunaan antibiotik pada pasien pediatri dan pengaruh rekomedasi apoteker dalam meningkatkan kualitas penggunaan antibiotik, menurunkan lama rawat, serta biaya pengobatan. Penelitian ini menggunakan studi pra eksperimen dengan pendekatan prospektif. Data penelitian dikumpulkan dari rekam medik pasien dan dianalis dengan uji chi square serta uji korelasi. Hasil penelitian menunjukkan bahwa rekomendasi apoteker dapat menurunkan masalah ketidaktepatan dosis (29,73%) menjadi 0%), ketidaktepatan lama pemberian (51,35% menjadi 5,41%), dan ketidaktepatan pemilihan obat (18,92% menjadi 5,41%). Average Cost Effectiveness Ratio (ACER) terhadap lama rawat kelompok rekomendasi (R) adalah Rp 2.481.456 lebih rendah dibandingkan kelompok non rekomendasi (NR) adalah Rp 2.640.703, sedangkan ACER terhadap hasil terapi (sembuh) kelompok rekomendasi (R) Rp 9.369.404 lebih rendah dibandingkan kelompok non rekomendasi (NR) Rp 17.985.054. Berdasarkan hasil penelitian dapat disimpulkan bahwa penggunaan antibiotik di RSUP Fatmawati tepat dan bijak, rekomendasi apoteker dapat meningkatkan kualitas penggunaan antibiotik, menurunkan lama rawat dan biaya pengobatan.

Cinnamic Acid Derivatives as α-Glucosidase Inhibitor Agents Teni Ernawati; Maksum Radji; Muhammad Hanafi; Abdul Mun’im; Arry Yanuar
Indonesian Journal of Chemistry Vol 17, No 1 (2017)
Publisher : Universitas Gadjah Mada

This paper reviews biological activity of some cinnamic acid derivative compounds which are isolated from natural materials and synthesized from the chemical compounds as an agent of α-glucosidase inhibitors for the antidiabetic drug. Aegeline, anhydroaegeline and aeglinoside B are natural products isolated compounds that have potential as an α-glucosidase inhibitor. Meanwhile, α-glucosidase inhibitor class of derivatives of cinnamic acid synthesized compounds are p-methoxy cinnamic acid and p-methoxyethyl cinnamate. Chemically, cinnamic acid has three main functional groups: first is the substitution of the phenyl group, second is the additive reaction into the α-β unsaturated, and third is the chemical reaction with carboxylic acid functional groups. The synthesis and modification of the structure of cinnamic acid are very influential in inhibitory activity against α-glucosidase.

Quality of Life and Adherence to Imatinib Mesylate Therapy in Chronic Myeloid Leukemia Patients at Dharmais Cancer Hospital Jakarta Nisha Virginia; Maksum Radji; Lucia Rizka Andalucia
Indonesian Journal of Cancer Vol 15, No 3 (2021): September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Quality of life and adherence to long-term imatinib mesylate (IM) therapy is a major factor in achieving therapeutic effects in patients with chronic myeloid leukemia (CML). However, the data of the quality of life and adherence level is inconsistent in various studies and is also not fully understood yet in Indonesia. Methods: This is an observational study (single-centered) using a cross-sectional design. CML patients older than 18 years old with National Health Insurance (JKN) at the Dharmais Cancer Hospital (RSKD) Jakarta who used IM for at least one month were tested using the Medication Adherence Questionnaire (MAQ) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) from March to April 2020.Result: A total of 50 CML patients were included in the study (male: female ratio = 1.08: 1), had a good median score of global health status/QoL, and had a good function and symptom scales, except for the fatigue symptom scale (median: 33.33; 25th percentile - 75th percentile: 11.11– 44.44). The patient adherence rate was dominated by adherent patients (20/50; 40.0%). Comparative analysis revealed that the scale of QoL (p = 0.028) and fatigue (p = 0.094) variables showed statistically significant differences between adherent and non-adherent subjects.Conclusions: This study showed that two-fifth of patients were considered to be non-adherent. Adherent patients were known to have higher QoL than non-adherent patients. Meanwhile, patients with severe symptoms of fatigue were found to be non-adherent to IM therapy.

Evaluasi Penggunaan Antibiotika Profilaksis di Ruang Bedah Rumah Sakit Kanker Dharmais Jakarta dan Hubungannya dengan Kejadian Infeksi Daerah Operasi Lydia Septa Desiyana; Ajoedi Soemardi; Maksum Radji
Indonesian Journal of Cancer Vol 2, No 4 (2008): Oct - Dec 2008
Publisher : National Cancer Center - Dharmais Cancer Hospital

Infeksi daerah operasi (IDO) merupakan salah satu infeksi nosokomial yang menyebabkan morbiditas, mortalitas dan peningkatan biaya perawatan. Faktor resiko terjadinya IDO dapat berasal dari pasien sendiri, lingkungan, operasi dan perawatan pasca operasi. Penggunaan antibiotika profilaksis merupakan salah satu cara menurunkan kejadian IDO.Dilakukan penelitian di ruang bedah RS. Kanker "Dharmais" dengan metode cross-sectional dan prospektif. Metode pengambilan sampel yang dilakukan adalah total sampling. Data dari seluruh pasien yang menjalani operasi pada 10 April -9 Mei 2008 diambil, kemudian dilakukan pemantauan kejadian IDO sampai dengan 30 hari pasca operasi.Dari 150 pasien yang menjalani operasi, sejumlah 131 pasien yang dapat dipantau hingga 30 hari pasca operasi. Antibiotika profilaksis digunakan pada 111 dari 131 operasi yang dilakukan (84,73%). Antibiotika yang paling banyak digunakan adalah sefalosporin generasi III, yaitu ceftriaxone (52,25%). 84,68% pasien menerima antibiotika profilaksis tidak tepat waktu dan 81,98% menerima antibiotika profilaksis > 24 jam. IDO terjadi pada 3 dari 131 (2,29%) pasien tersebut. Hasil analisa multivariat menunjukkan lama rawat sebelum operasi merupakan faktor risiko yang berpengaruh terhadap kejadian IDO pada penelitian ini (p = 0,031, OR = 3,259).Antibiotikan profilaksis yang paling banyak digunakan di instalasi bedah RS. Kanker "Dharmais" adalah ceftriaxone, waktu pemberiannya sebagian besar tidak tepat dan digunakan lebih dari 24 jam. Ceftriaxone merupakan antibiotika spektrum luas yang mempunyai efekstivitas terhadap gram positif dan negatif.Penilaian kesesuaian pemilihan jenis antibiotika profilaksis dilakukan dengan menggunakan data sensitivitas ruangan tahun 2007 dengan hasil bahwa antibiotika profilaksis yang digunakan masih sensitif terhadap bakteri yang ada diruangan ICU, kelas II dan kelas III. Kejadian IDO di RS. Kanker "Dharmais" adalah 2,29%. Hasil analisa bivariat dengan chi-square menunjukkan bahwa sifat operasi, durasi operasi dan lama rawat sebelum operasi mempunyai hubungan bermakna dengan kejadian IDO (p < 0,05). Sementara itu hasil analisa multivariate menunjukkan jumlah hari rawat sebelum operasi merupakan faktor risiko terjadinya IDO.Kata kunci: antibiotika profilaksis, infeksi luka operasi, operasi.

Pendekatan Farmakogenomik Dalam Pengembangan Obat Baru Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 2, No. 1
Publisher : UI Scholars Hub

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The human population is heterogeneous and consists of populations of immense ethnic diversity. There are considerable allelic differences between human popula-tions as well as individuals within each ethnic group as a result of molecular hetero-geneity of the genome. This, in turn, is responsible for differential allelic expression of genes endowing them with polymorphic characters. The molecular diversity within genes is responsible amongst others, of disease resistance or susceptibility or for that matter drug response. Pharmacogenomics is the key to the understanding of differ-ential drug response in different patients in relation to genetic constitution. The revelation of such information at the molecular level would assist the pharmaceuti-cal industry to address a therapy directed to each individual. The objective of this article is to understand the nuances of the genetic repertoire and correlate it with disease gene identification, genes that have been or can be used as drug targets, identify candidate genes for drug development and recent trends in drug discovery.

Co-Authors A., Nurgani A., Nurgani Abdul Mun’im Abna, Inherni Marti Afrilia, Salsa Aintania, Rasyya Ajitya Kurnia Hermawati Ajoedi Soemardi Ajoedi Soemardi, Ajoedi Aldrat, Hendri Aldrat, Hendri Alfina Rianti Alfina Rianti Amalia, Yayu AMARILA MALIK Amarila Malik Anglia Puspaningrum Anton Bahtiar Aprilita Rina Yanti Arry Yanuar ASTAWA YASA, Kadek Urip Atiek Soemiati Atiek Sumiati Atiek Sumiati, Atiek Ayuningtyas, Yessy Tri Belladona, Ladisa Virgiane Budi, Erwanto Budi, Erwanto CESILIA ANITA Cosphiadi Irawan Dessy Ariyanti Farida Fakhrunnisa Farida Sulistiawati Farida Sulistiawati, Farida Farmasita Budiastuti, Rizky Fetri Kristiani Hartanto, Virgo Budi HENDRI ALDRAT Heria Oktavia, Heria Herman Suryadi Hermawati, Ajitya Kurnia Hestiningtyas, Mahardhika INDRIANI INDRIANI LILIANA SARAGIH Lucia Rizka Andalucia Lydia Septa Desiyana Lydia Septa Desiyana, Lydia Septa Mahardhika Hestiningtyas Mentari, Claudia Muhammad Hanafi Nisha Virginia Nugraheni, Femi Arifah Nugraheni, Femi Arifah Nuning Indani, Nuning Nurraya Lukitasari Nusaibah A. Hima Puspaningrum, Anglia Putri, Andi Rani Anggraini RAFIKA SARI Ramadhanti, Shahyawidya Ratna Chandra Sari Retnaningsih, Agustina Retnosari Andrajati Retnosari Andrajati Rini Purnamasari, Rini Rizka Andalusia Siti Fauziyah Siti Maisaroh SITI MARIAM Sitompul, Fransiska Syarafina, Nihla Nurin Teni Ernawati Vardhani, Afifah Kusuma Yahdiana Harahap YAHDIANA HARAHAP

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