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All Journal Jurnal Farmasi Klinik Indonesia Indonesian Journal of Cancer JFIOnline Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Jurnal Kefarmasian Indonesia
Maksum Radji
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Pendekatan Farmakogenomik Dalam Pengembangan Obat Baru Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 2, No. 1
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Abstract

The human population is heterogeneous and consists of populations of immense ethnic diversity. There are considerable allelic differences between human popula-tions as well as individuals within each ethnic group as a result of molecular hetero-geneity of the genome. This, in turn, is responsible for differential allelic expression of genes endowing them with polymorphic characters. The molecular diversity within genes is responsible amongst others, of disease resistance or susceptibility or for that matter drug response. Pharmacogenomics is the key to the understanding of differ-ential drug response in different patients in relation to genetic constitution. The revelation of such information at the molecular level would assist the pharmaceuti-cal industry to address a therapy directed to each individual. The objective of this article is to understand the nuances of the genetic repertoire and correlate it with disease gene identification, genes that have been or can be used as drug targets, identify candidate genes for drug development and recent trends in drug discovery.
Peranan Bioteknologi Dan Mikroba Endofit Dalam Pengembangan Obat Herbal Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 2, No. 3
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Plants have been the chief source of compounds of medicine for thousand of years. Plants are also the source of many medicines for the majority of the worldÂ’s population. The role of biotechnology is very important for multiplying, conserving the spesies, and enhancing the production of secondary metabolites. Endophytes are microbes that inhabit plants are currently considered to be a wellspring of novel secondary metabolites offering the potensial for medical and industrial exploitation. Natural products from various endophytic microbes have been investigated. Some examples of natural products observed from endophytic microbes are antibiotics, antiviral compounds, anticancers, antimalarial compounds, antioxidants, antidiabetics, and immunosuppressive compounds.
Avian Influenza A (H5N1) : Patogenesis, Pencegahan Dan Penyebaran Pada Manusia Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 3, No. 2
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Avian influenza A (H5N1), or highly pathogenic avian influenza (HPAI), has become the worldÂ’s attention because of possibility of global pandemic. This review describes the features of human infection, pathogenesis, transmission, and clinical management of avian influenza A (H5N1).
Uji Efektivitas Antimikroba Beberapa Merek Dagang Pembersih Tangan Antiseptik Radji, Maksum; Suryadi, Herman; Ariyanti, Dessy
Majalah Ilmu Kefarmasian Vol. 4, No. 1
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Abstract

In Modern life, peoples are more conscious to keep their healthy. One of the way to keep our body healthy is by keeping our hand clean. Washing hands with soap and water, sometimes is unpractical since it need water to rinse off the soap. Prod-uct innovation has been developed to overcome the unpractical side, which is called antiseptic hand wash or hand sanitizer. This study has been done to evaluate the antimicrobial activity of some hand sanitizer products marketed in Jakarta. The re-sult showed that alcohol-based hand sanitizer and triclosan-based hand sanitizer used in this experiment were significantly reduce bacterial counts on hands, but not all of the samples are effective in reducing fungal counts on hands.
Uji Aktivitas Antimikroba dan Uji Sitotoksik Ekstrak Etanol Akar Tanaman Akar Kucing (Acalypha indica Linn), Daging Buah Mahkota Dewa (Phaleria macrocarpa (Sheff) Boerl) dan Sari Buah Merah (Pandanus conoideus Lam) Radji, Maksum; Sari, Ratna Chandra; Sumiati, Atiek
Majalah Ilmu Kefarmasian Vol. 5, No. 1
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The antimicrobial activity and cytotoxic effect of ethanol extract of Acalypha indica Linn, Phaleria macrocarpa (Sheff) Boerl and Pandanus conoideus Lam, had been carried out. The results of the research showed that those ethanol extracts had antimi-crobial activities against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosae ATCC 27853 and Candida albicans. The determi-nation of cytotoxic effects of those ethanol extracts by brine shrimp lethality test (BSLT) using Artemia salina Leach showed that LC50 of Acalypha indica Linn, Phaleria macrocarpa (Sheff) Boerl and Pandanus conoideus Lam were 1,279 ug/ml, 0.123 ug/ml and 0.054 ug/ml respectively.
Pemeriksaan Bakteriologis Air Minum Isi Ulang Di Beberapa Depo Air Minum Isi Ulang Di Daerah Lenteng Agung dan Srengseng Sawah Jakarta Selatan Radji, Maksum; Oktavia, Heria; Suryadi, Herman
Majalah Ilmu Kefarmasian Vol. 5, No. 2
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Recently, refilled drinking water stores are flourishing in the some cities of Indonesia. This research tries to find out the quality of refilled drinking water at some shop in Jagakarsa, South Jakarta. The samples of refilled drinking water were taken from thir-teen shops around Lenteng Agung and Srengseng Sawah, Jagakarsa area. The bacte-riological test of refilled drinking water was to detect the availability of Coliform bacteria and identification of some bacterial pathogens such as Escherichia coli, Sal-monella, Staphylococcus aureus, Clostridium perfringens and Pseudomonas aeruginosa. It had been concluded that two of thirteen samples of refilled drinking water had the total number of bacteria above of the limit number according to the standard about the quality and requirement of drinking water. Four of the thirteen samples contain Sta-phylococcus aureus and none of the samples contain Escherichia coli, Salmonella, Clostridium perfringens and Pseudomonas aeruginosa.
Vaksin DNA: Vaksin Generasi Keempat Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 6, No. 1
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Abstract

Vaccines have been developed for a range of different infectious diseases. The complex-ity of microbial infections requires novel approaches to vaccine design. The first-generation of vaccines were live attenuated pathogens. Because of safety concerns, the second-generation of vaccines, chemically or physically inactivated pathogens were later developed. Purified or synthetic proteins represent a third generation, and recent advances in molecular biology and genetic engineering have led to the development of the fourth vaccine generation, which includes DNA and virus vector-based vaccines. This review discusses on the genetic elements and construction of DNA vaccines, comparison of DNA vaccines and conventional vaccines, the benefits and limitations of DNA vaccines, and the advances of genetic vaccine development over the last decade.
Vaksin Kanker Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 6, No. 3
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Abstract

Cancer vaccines are medicines that work by stimulating or restoring the immune system’s ability to fight cancers and disease. There are two types of cancer vaccines, prophylactic cancer vaccines, which are intended to prevent cancer from developing in healthy people, and treatment cancer vaccines, which are intended to treat already existing cancers by strengthening the body’s natural defenses against cancer. This article discusses about cancer vaccines including the role of microbes that are respon-sible of human tumor, the mode of action of cancer vaccines and the efficacy of human papillomavirus (HPV) vaccines in preventing various benign and malignant condi-tions, including cervical cancers caused by HPV.
Pemberian Vaksin Melalui Tanaman Transgenik Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 1, No. 1
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Vaccines have played an important role in preventive medicine since Edward Jenner discovered that cowpox induced protection against human smallpox. Until recently, a vaccination has meant a needle in the arm. However, with the increasing need for inexpensive, easily administered vaccines, along with the improvements in genetic engineering, the concept of edible vaccines is fast becoming reality. This is especially important in developing countries, where it is estimated that three to five million children die each year from common diseases, which could have easily been prevented with the proper vaccination. Compared to traditional lab-synthesized vaccines, plants are capable of producing proteins at lower cost, and need not be isolated for injection. Plant-based vaccines are also safer than traditional vaccines because they use selected sub-units of the disease rather the attenuated whole disease-causing organism.
Uji Mutagenisitas dan Anti Kanker Ekstrak Aseton Dan N-Heksana Dari Kulit Batang Sesoot (Garcinia picrorrhiza Miq.) Radji, Maksum; Sumiati, Atiek; Indani, Nuning
Majalah Ilmu Kefarmasian Vol. 1, No. 2
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Mutagenicity and anti-mutagenicity of the acetone and n-hexane extracts of Garcinia picrorrhiza Miq.bark have been studied by Ames method using Salmonella typhimurium TA 97, TA 98 TA 100, TA 102, dan Escherichia coli WP2. The results showed that the two extracts had a positive effect. It can be concluded that the acetone and n-hexane extracts of Garcinia picrorrhiza Miq. bark have anticancer activity.
Co-Authors A., Nurgani A., Nurgani Afrilia, Salsa Aintania, Rasyya Ajitya Kurnia Hermawati Ajoedi Soemardi Ajoedi Soemardi, Ajoedi Aldrat, Hendri Aldrat, Hendri Amalia, Yayu Amarila Malik Anglia Puspaningrum Anton Bahtiar Aprilita Rina Yanti Atiek Soemiati Atiek Sumiati Atiek Sumiati, Atiek Ayuningtyas, Yessy Tri Belladona, Ladisa Virgiane Budi, Erwanto Budi, Erwanto Cosphiadi Irawan Dessy Ariyanti Farida Sulistiawati Farida Sulistiawati, Farida Farmasita Budiastuti, Rizky Hartanto, Virgo Budi Heria Oktavia, Heria Herman Suryadi Hermawati, Ajitya Kurnia Hestiningtyas, Mahardhika Lydia Septa Desiyana Lydia Septa Desiyana, Lydia Septa Mahardhika Hestiningtyas Mentari, Claudia Nugraheni, Femi Arifah Nugraheni, Femi Arifah Nuning Indani, Nuning Puspaningrum, Anglia Putri, Andi Rani Anggraini Ramadhanti, Shahyawidya Ratna Chandra Sari Retnaningsih, Agustina Rini Purnamasari, Rini Rizka Andalusia Siti Fauziyah Siti Maisaroh SITI MARIAM Sitompul, Fransiska Syarafina, Nihla Nurin Vardhani, Afifah Kusuma Yahdiana Harahap