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Nelly Mayulu
Universitas Sam Ratulangi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Probiotic Lactobacillus sp. as a strategy for modulation of non-comorbid obesity: A systematic meta-analysis and GRADE assessment of randomized controlled trials Lele, Juan AJMN.; Sihaloho, Karlos B.; Vighneswara, Dewa; Rampengan , Derren DCH.; Rizqiansyah, Chrisandi Y.; Permatasari, Happy K.; Mayulu, Nelly; Tallei, Trina E.; Taslim, Nurpudji A.; Kim, Bonglee; Kezia, Immanuelle; Nurkolis, Fahrul; Syahputra, Rony A.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1562

Abstract

Given the high prevalence of obesity worldwide, effective therapeutic strategies are crucial to prevent and manage obesity-related health conditions. Existing studies indicate that Lactobacillus sp. showed beneficial effects on body weight and adiposity by modifying the gut microbiota; however, no meta-analysis has been conducted assessing the efficacy of Lactobacillus sp-based probiotics on anthropometric parameters, leptin and adiponectin levels, and gut microbiota composition. The aim of this study was to evaluate the efficacy and safety of probiotic supplementation with Lactobacillus sp. in obese individuals without comorbidities. A systematic search was conducted on November 28, 2024, using five databases: PubMed, Wiley, ScienceDirect, Epistemonikos, and Cochrane. Primary outcomes included changes in body mass index (BMI), body weight, waist and hip circumferences, visceral and subcutaneous fat areas, and total body fat content. Secondary outcomes included alterations in leptin and adiponectin levels, gut microbiota composition, and the incidence of adverse events. A total of 1,058 individuals were included across 12 clinical trials. Significant reductions were observed in BMI (mean difference (MD): -0.40 kg/m²; 95%CI: -0.48–(-0.32), p<0.00001), body weight (MD: -1.16 kg; 95%CI: -1.79–(-0.53), p=0.0003), waist circumference (MD: -1.41 cm; 95%CI: -1.75–(-1.08), p<0.00001), and hip circumference (MD: -0.85 cm; 95%CI: -1.09–(-0.61), p<0.00001) compared to controls. Additionally, compared to control group, significant reductions were observed in visceral and subcutaneous fat mass (MD: -7.35; 95%CI: -9.95–(-4.75); p<0.00001) and overall body fat (MD: -1.11; 95%CI: -1.31–(-0.91); p<0.00001). Leptin levels significantly decreased (MD: -2.11 μg/mL; 95%CI: -3.59–(-0.64), p=0.005) compared to before Lactobacillus sp. supplementation, while adiponectin levels increased (MD: 0.71 μg/mL; 95%CI: 0.22–1.20, p=0.004) following Lactobacillus sp. supplementation compared to placebo group. No significant adverse events were reported in either the intervention or control groups. In conclusion, Lactobacillus sp. probiotic supplementation may serve as an adjuvant therapy to enhance obesity management in non-comorbid obese individuals.
Co-Authors ., Mety Agnes Madianung Agow, Mersi S Aguw, Marchia Alexander S. L. Bolang Amisi, Marsella D. Angel Lolita Danari Anita Ohe S. Fatie Aprilia Lombo Bahrudin Yamin Bolang, Christy R. Brilia Ch. Kereh, Brilia Ch. Budi T. Ratag Christine Yelika Nussy Daramu, Gorby Santinus Janis Deril Gansareng Dwi Christiani Audri Rahamis Dwi Mentari Datukramat Ekaristi, Pongtuluran Erina Utami Tandirerung Franly Onibala Gigir, Mega Sari Grace Debbie Kandou Gregoria S. S. Djarkasi Gresty Masi Gustaaf A. E. Ratag Gustaaf A.E. Ratag Hesti Lestari Hesti Sulistia Ningsih Hesty R. Masela, Hesty R. Ika R.I. Permatasari Joice N. A. Engka Joice N. Engka, Joice N. Julia Rottie Juwita Mangiri, Juwita Kawengian, Shirley Everdina Susanna Kawengian, Shriley E.S. Kezia, Immanuelle Kim, Bonglee Kolantung, Priska M. Kosanto, Vincent H. Larira, Dina Mariana Lastry Glory, Lastry Lele, Juan AJMN. Lucia Cecilia Mandey Made Ardika Wanantara Maki, Olvinda Malonda, Nancy S.H Mangkat, Olivia Manuputty, Michael Marchella Sege Meriam Assa, Meriam Mokodompit, Erza P. Nancy S. H. Malonda Narasiang, Bezaliel R. Ngurah Rai, I. G.B. Nova Hellen Kapantow Novita Hasyim Nur Padhilah Domu Nurkolis, Fahrul Nurpudji A. Taslim Pasaribu, Prisniade Paulina N. Gunawan Permatasari, Happy K. Pondagitan, Alpinia Shinta Pratama, Fauzan I. Pricilia Tan, Pricilia Rambing, Chorinne J. E. Rampengan , Derren DCH. Raven G. Katiho, Raven G. Rembet, Sindi R. Rendy R. Parengkuan Rina Kundre Risa K. F. Sahalessy, Risa K. F. Rivelino Hamel Rizqiansyah, Chrisandi Y. Romario M. Anthonie Runtu, Jessica G. Sabriani Pontoh, Sabriani Salni Saharman Sanjaya, Gusti D. Setiadhi, Yudhaputra Shirley E. Kawengian, Shirley E. Shirley E. S. Kawengian Shirley Kawengian, Shirley Sihaloho, Karlos B. Sri M. Buhang Sri Utami Arifin Stephanie Ch. P. Loong Supit, Enrico D. Syahputra, Rony A. Taraming, Yasinta N. Tati Ponidjan Tatiwakeng, Rezka V. Trina E. Tallei, Trina E. Vighneswara, Dewa Vinariani Tangkilisan Vincente L. Pranata, Vincente L. Vonny N. S. Wowor Watania, Tasya Winarsi Damapolii Wiraprasidi, I P.A. Yayuk A. Lasari Yuriansya Mangkat, Yuriansya