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Meika Syahbana Rusli
Program Studi Teknik Industri Pertanian, Fakultas Teknologi Pertanian, IPB University Kampus IPB Dramaga PO Box 220, Bogor 16680, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Social Sciences Transportation Other

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REKAYASA PROSES SINTESIS PIPERONAL DARI KULIT LAWANG (Cinnamomum culilawan Blume) SEBAGAI PREKURSOR OBAT KANKER Imanuel Berly Delvis Kapelle; Tun Tedja Irawadi; Meika Syahbana Rusli; Djumali Mangunwidjaja; Zainal Alim Mas'ud
Jurnal Penelitian Hasil Hutan Vol. 34 No. 3 (2016): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2016.34.3.217-229

Abstract

Piperonal as a precursor of cancer drug (Curcumin analogues) can be synthesized from extract of lawang’s bark (Cinnamomum culilawan Blume) with multiple stages, among others: isolation of essential oils, isolation safrole, safrole isomerization, and synthesis of piperonal. Essential oils were isolated from the bark of lawang (the water content of 46.2%) using a water distillation system with 1/3 volume of high boiler for five hours. Isolation of safrole from lawang bark oils was performed using NaOH solution and purified using reduced pressure distillation system at a temperature of 90-123°C / 1 mmHg. The safrole isomerization was undergone using alkali catalyst (KOH) without solvent at a temperature of 120°C for 8 hours. Oxidation of isosafrol was performed using KMnO in acidic conditions using a KTF 4 tween 80 at a temperature below 30°C, and purified using silica gel. Results of isolation yield 0.94% with 14 components were determined through GC-MS, including 67.35% eugenol, safrole 13.96%, 12.61% methyl eugenol, 4-terpineol sineol 1.79% and 1.55%. The isolated safrole yield of 17.21% with purity testing and identification using FTIR, HNMR and GCMS confirmed the product was safrole. The isomerization obtained yield of 77.56% with GC analysis indicated compounds of cis-isosafrole and trans-isosafrole. The results of oxidation obtained yield of 65.63% with a purity of 100% by GCMS and the H-NMR indicated the product is piperonal.
Co-Authors . Risfaheri Ade Kurniawan Adhitio Satyo Bayangkari Karno Anas Miftah Fauzi Andriani, Woro Anggi Firdaus Agumsah Ani Suryani Ani Suryani Annisa Putri Annisa Rahma Budiani Arief Riyanto Arum Nur Fitrah Asron Ferdian Falaah, Asron Ferdian Athin Nuryanti B. S. Kusmuljono Benedicta Evienia Prabawanti Dianta Mustofa K. Djumali Mangunwidjaja Djumali Mangunwidjaja Djumali Mangunwidjaja Djumali Mangunwidjaja Djumali Mangunwidjaja Dwi Purnomo Dwi Purnomo Dwi Setyaningsih Edi Mulyon Egi Agustian Eriyatno . Erliza Noor Ermawaty - Maradhy Faqihudin Faqihudin Faqihudin Gilang Ramadhan Hani Handayani, Hani Hari Setiapraja Hendrastuti Hendrastuti I Gusti Wayan Murjana Yasa Johny Wahyuadi Soedarsono Joko Santoso Kapelle, Imanuel B. D. M. Fedi Alfiadi Sondita Maspanger, Dadi Rosadi Nada Kamilia Nia Yuningsih Ningrum, Sari Sekar Nur Fatiha Fiprina Nur Hidayati Nurmalia Muliati Obie Farobie Retno Sri Endah Lestari Retno Sri Endah Lestari Rista Fitria Rizal Syarief Rizal Syarief Rizal Syarief Nazriel Rosniyati Suwarda Rudy Yulianto Rudy Yulianto Rudy Yulianto Rurin Wahyu Listriana Sally Wiedjarnarko Sherly Hanifarianty, Sherly Suci Wulandari Sukardi Sukardi Sukardi, Sukardi Surjono Hadi Sutjahjo Suryani, Ani Tentri Yera Idqa Ridmaningrum Tun Tedja Irawadi Tun Tedja Irawadi Tuti Tutuarim Wati Hermawati Widi Hastomo Widiatmaka Yusron Rivai Zainal Alim Mas'ud Zainal Alim Mas'ud Zainal Alim Mas'ud