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All Journal Journal of Biomedicine and Translational Research Majalah Obstetri dan Ginekologi Universa Medicina Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service)
Widjiati Widjiati
Faculty Of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice Yuli Trisetiyono; Widjiati Widjiati; Syarief Thaufik Hidayat; Noor Pramono
Journal of Biomedicine and Translational Research Vol 5, No 2 (2019): December 2019
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v5i2.4716

Abstract

Background: Increased oxidative stress causes inflammation and increases angiogenesis. It presumed to promote the proliferation of endometriosis tissue. Kebar grass (Biophytum petersianum) and other herbs such as green tea and Cucumis melo, which contain high antioxidants, are expected to decrease oxidative stress, inflammation, angiogenesis, and reduced endometriosis implants.Objective: To investigate the effects of Kebar grass, green tea, and Cucumis melo to malondialdehyde serum, tumor necrosis factor alpha, and vascular endothelial growth factor expression, and the area of the endometriotic implants.Methods: Twenty-eight mice were divided into four groups, i.e., the first group of endometriosis mice was given Kebar grass extract; the second group was assigned green tea extract, the third group was given the combination of Cucumis melo extract–gliadin, and the last containing the untreated endometriosis mice as the control. Each treatment was given for 14 days. The data of MDA serum level, the area of the endometriotic implants, TNF-α, and VEGF expression were collected and analyzed.Results: The MDA serum levels of the groups treated with Kebar grass extract, green tea extract, and Cucumis melo extract – gliadin were significantly lower (p=0.001) than the control group. TNF-α expression of the groups provided with each treatment also lower than the control groups (p=0.002). However, only the administration of the Cucumis melo extract–gliadin resulted in lower VEGF expression compare with the control (p=0.017). Finally, the area of the endometriotic implants of the mice models administered with each treatment was smaller than the control group (p=0.003).Conclusion: Kebar grass as well as green tea and Cucumis melo–gliadin inhibits endometriotic implants extension by decreasing MDA serum and TNF-α expression.
The Difference of Integrin ανβ3 Expression, Leukemia Inhibitory Factors and Superoxide Dismutase Serum Concentration in the Provision of Kebar Extract (Biophytum petersianum Klotczh), Metformin, and Their Combination to Mouse models of Endometriosis Seindy Glamour; Syarief Thaufik Hidayat; Adi Setyawan Prianto; Widjiati Widjiati
Journal of Biomedicine and Translational Research Vol 4, No 1 (2018): July 2018
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (146.285 KB) | DOI: 10.14710/jbtr.v4i1.2249

Abstract

Background: In endometriosis there is a decrease in endometrial receptivity. Kebar and Metformin grasses are expected to improve the condition of endometrial receptivityObjective: To find out whether there is any effect of giving Kebar grass extract and metformin on endometrial receptivity Methods: The study was designed by using a simple experimental randomization. It was conducted in Obstetrics Gynecology Department - Faculty of Medicine Diponegoro University and Faculty of Veterinary Medicine Airlangga University. Sample calculation was employed. The study was done within five groups including control group with normal mice, group of endometriosis mouse models given placebo, group of endometriosis mouse models given Kebar grass extract, group of endometriosis mouse models given metformin, and group of endometriosis mouse models given the combination of Kebar grass – metformin extract. The examination materials of ανβ3 integrin and Leukemia Inhibitory Factors were taken from the uteri of the mice and measured by the Rammele Scale Index (Immuno Reactive Score), while the Superoxide Dismutase examination using ELISA was derived from mice serum. These examinations were performed by two veterinariansResults: The expression of ανβ3 integrin was significantly higher in the group of mouse models given Kebar grass extract as well as the combination of Kebar and metformin grass extracts (p <0.05) rather than in the group of endometriosis mouse models with no treatment, whereas LIF expression was significantly higher in the group given Kebar grass extract, metformin and combination of both extracts (p <0.05). Serum SOD levels remained the same.Conclusion: The expressions of ανβ3 Integrin and LIF are higher due to the provision of Kebar grass extract as well as the combination of Kebar grass and metformin extracts
Nicotine supplementation blocks oocyte maturation in Rattus norvegicus Meitria Syahadatina Noor; H.M Bahkriansyah; Widjiati Widjiati; Budi Santoso
Universa Medicina Vol. 32 No. 2 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.92-98

Abstract

BACKGROUNDIndonesia has the third largest tobacco consumption in the world after China and India. Nicotine as the main component of cigarette smoke has negative effects on the reproductive system, such as oocyte maturation, ovulation, and fertilization, and increasing the diploidy of oocytes. The goal of this researchwas to evaluate the effect of nicotine on oocyte maturation in Rattus norvegicus.METHODSThis was an experimental study with post test only control group design. The subjects were 40 rats selected homogenously and randomly. They were divided into a control group (receiving carboxy-methyl-cellulose sodium and 3 treatment groups (I-III) receiving nicotine subcutaneously for 7 days at dosages of 21 mg/ kgBW, 41 kg/kgBW and 84/kgBW, respectively. The observations comprised oocyte maturation stage, viz. germinal vesicle (GV), germinal vesicle breakdown (GVBD), metaphase I and metaphase II. Data were analyzed by one-way Anova with á=0.05, followed by Tukey’s HSD test.RESULTSOne-way Anova showed significant differences in oocyte  maturation in all groups. Tukey’s HSD test showed that for GV, the differing groups were control and I, control and II, I and III. For GVBD, the differing groups were control and I, I andII, I and III. For metaphase I, the differing groups were control with I, II, and III, I and II, I and III. For metaphase II, the differing groups were control versus I, II, and III, I and II, I and III.CONCLUSIONLow dose of nicotine is capable of affecting oocyte maturation in Rattus norvegicus.
EFEK IBUPROFEN ORAL TERHADAP PERUBAHAN BERAT BADAN PADA MENCIT BETINA Anindya Marcha Angelina Djianto; Tri Hartini Yuliawati; Sri Ratna Dwiningsih; Widjiati Widjiati
Majalah Biomorfologi Vol. 29 No. 2 (2019): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (121.518 KB) | DOI: 10.20473/mbiom.v29i2.2019.27-31

Abstract

Background: Ibuprofen is one of the most used non-steroidal anti-inflammatory drugs (NSAID) due to its ease of access without the need of prescription. However, ibuprofen may cause side effects associated with gastrointestinal mucosal injury. The discomfort caused when eating may cause nausea and loss of appetite which leads to weight loss. Objective: This study was done to prove changes in body weight after treatment of oral ibuprofen using mice as test subjects. Material and method: This study used pre-test post-test control group design. 33 female BALB/c mice were grouped into 3 groups (P1, P2, P3). P1 is a control group which was given aquadest as placebo, P2 was given 52 mg/kg body weight of oral ibuprofen and P3 was given 104 mg/kg body weight of oral ibuprofen. Treatment lasted for 15 days. Results were analyzed using Kruskal-Wallis test and Mann-Whitney U test in IBM SPSS Statistics 22. Result: 80% of the mice had their body weights decreased with an average decrease of 0.91 g (±2.26) in group P1, average decrease of 2.2 g (±2.15) in P2, and average decreased of 4.11 g (±2.62) in P3. Statistical analysis showed that body weight changes of group P3 has significant difference (p = 0.009) compared to P1 and P2. Conclusion: It can be concluded that 104 mg/kg dose of oral ibuprofen caused a decrease in body weight of female mice.
PENINGKATAN PRODUKTIVITAS SAPI RAKYAT, PEMBUATAN YOGURT, PERMEN SUSU DAN MENINGKATKAN KESEHATAN MASYARAKAT DI KECAMATAN PACET KABUPATEN MOJOKERTO Widjiati Widjiati; Trilas Sardjito; Nenny Harijani
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 1 No. 1 (2017): Jurnal Layanan Masyarakat
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3510.568 KB) | DOI: 10.20473/jlm.v1i1.2017.40-45

Abstract

Mojokerto Regency is a region with a good economic level. The regency has fertile land and well-preserved Majapahit Kingdom remains. In addition, it has dairy cattle farm located around Pacet Sub-district. Milk produced from this area can support economy in East Java. However, there is no increased milk sale price of dairy processing to be food with high sale price. Dairy cattle community have not been touched by technology of dairy processing to produce high sale priced food such as yoghurt, ice-cream, or dairy candies. Therefore, science and technology are needed by the community in this area to increase their productivity and income in order to create independent economy. The social service is aimed to assist the community in order to increase their income by mastering science and technology in the form of increasing the sale price of milk and creating independent economy by increasing dairy cattle productivity and giving added value of milk to be processed food such as dairy candies or yoghurt. The social service is integrated, in order to give science and technology to the community, to motivate the students and community to keep their health and to take care of their teeth. The target of the activity is to lessen the community’s burden by improving management of cattle caring and dairy cattle productivity, making processed products from milk with higher economic value, creating small scaled industry, and improving public health. The activities conducted were as follows giving trainings to make yoghurt, dairy candies or herbs, giving cattle health service to increase cattle productivity by undergoing cattle fertility examination, treating infertile cattle, doing artificial insemination to cattle in their estrous cycle, giving vitamin to increase cattle appetite, improving cattle feed quality by giving trainings to process cattle feed. Briefing and service on health was given to educate the community in order to live healthily by keeping health and taking care of teeth.The conclusion drawn from the activity conducted in Pacet Sub-district Mojokerto is training on how to make yoghurt and dairy candies is able to give added value for the community in Pacet Sub-district. Many cases on cattle reproductive disorder in Pacet Sub-district are identified, and measurement on Elementary school children’s growth is needed to monitor nutritional status of the children. AbstrakKabupaten Mojokerto merupakan daerah dengan tingkat ekonomi yang baik. Kabupaten ini memiliki lahan subur dan Kerajaan Majapahit yang terpelihara dengan baik. Selain itu, ia memiliki peternakan sapi perah yang terletak di sekitar Kecamatan Pacet. Susu yang dihasilkan dari daerah ini bisa menunjang perekonomian di Jawa Timur. Namun, tidak ada kenaikan harga jual susu olahan susu menjadi makanan dengan harga jual tinggi. Komunitas sapi perah belum tersentuh oleh teknologi pengolahan susu untuk menghasilkan makanan dengan harga jual tinggi seperti yoghurt, es krim, atau permen susu. Oleh karena itu, sains dan teknologi sangat dibutuhkan oleh masyarakat di daerah ini untuk meningkatkan produktivitas dan pendapatannya agar tercipta perekonomian mandiri. Pelayanan sosial ini bertujuan untuk membantu masyarakat dalam rangka meningkatkan pendapatan mereka dengan menguasai sains dan teknologi dalam bentuk kenaikan harga jual susu dan menciptakan ekonomi mandiri dengan meningkatkan produktivitas sapi perah dan memberi nilai tambah susu untuk diolah makanannya. seperti permen susu atau yoghurt. Pelayanan sosial terintegrasi, untuk memberi sains dan teknologi kepada masyarakat, untuk memotivasi siswa dan masyarakat agar tetap menjaga kesehatan dan merawat giginya. Sasaran kegiatan ini adalah mengurangi beban masyarakat dengan meningkatkan pengelolaan produktivitas sapi dan produktivitas sapi perah, membuat produk olahan dari susu dengan nilai ekonomi lebih tinggi, menciptakan industri skala kecil, dan meningkatkan kesehatan masyarakat. Kegiatan yang dilakukan adalah sebagai berikut memberikan pelatihan untuk membuat yoghurt, permen susu atau herbal, memberikan layanan kesehatan sapi untuk meningkatkan produktivitas ternak dengan menjalani pemeriksaan kesuburan ternak, mengobati ternak yang tidak subur, melakukan inseminasi buatan pada ternak dalam siklus estrus mereka, memberi vitamin untuk meningkatkan ternak. nafsu makan, meningkatkan kualitas pakan ternak dengan memberikan pelatihan untuk mengolah pakan ternak. Briefing dan pelayanan kesehatan diberikan untuk mendidik masyarakat agar dapat hidup sehat dengan menjaga kesehatan dan merawat gigi. Kesimpulan yang diambil dari kegiatan yang dilakukan di Kecamatan Pacet Mojokerto adalah pelatihan bagaimana membuat yoghurt dan permen susu mampu memberi nilai tambah bagi masyarakat di Kecamatan Pacet. Banyak kasus gangguan reproduksi ternak di Kecamatan Pacet diidentifikasi, dan pengukuran pertumbuhan anak sekolah dasar diperlukan untuk memantau status gizi anak-anak. 
The Suppression Effect of Kebar Extract on Endometriosis Lesion MDA and TNF -a Independent to VEGF A Study in Endometriosis Mice Mode: Efek Supresi Ekstrak Kebar terhadap Lesi Endometriosis, MDA dan TNF-a, tidak Bergantung pada VEGF: Studi pada Model Tikus Endometriosis Yuli Trisetiyono; Noor Pramono; Syarief T. Hidayat; Widjiati Widjiati
Indonesian Journal of Obstetrics and Gynecology Volume 8 No. 1 January 2020
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (620.248 KB) | DOI: 10.32771/inajog.v8i1.1070

Abstract

Background: The pathogenesis of endometriosis remains unclear, and involves multifactorial etiologies. The increase in oxidative stress is known to be associated with this disease. Oxidative stress increases angiogenesis and supports the proliferation of endometriosis tissue in the peritoneal cavity. Kebar grass, a medicinal plant, is expected to increase antioxidant defense resulting in decreased oxidative stress, inflammation, angiogenesis, and reduced endometrial tissue implants. Objective: To investigate the effects of Kebar grass extract administration to MDA serum levels, TNF-a and VEGF expression, and the extension of the endometriotic lesions in mice model. Methods: This study was experimentally designed. It was conducted in the Department of Obstetrics Gynecology, Faculty of Medicine Diponegoro, University and Faculty of Veterinary Medicine, Airlangga University. Twenty-one mice were divided into three groups: the first group is control of 7 untreated endometriosis mice model, the second group consisted of 7 mice injected with leuprolide acetate 1mg/kgBB single dose, and the last group consisted of 7 mice fed with Kebar grass extract 3mg/day for 14 days. MDA serum level was measured by spectrophotometry, TNF-a and VEGF expression by IHC using Rammele Scale Index (ImmunoReactive Score), whereas the extension of the endometriotic lesions was measured using computerize tracing. Results: Both Kebar grass extract and leuprolide acetate administration significantly decrease MDA serum levels in endometriosis mice model, compare with the control group, (0.09±0.02 nmol, 0.11±0.07 nmol, and 0.30±0.06 nmol, respectively; p=0.001). TNF-α expression of the group treated with Kebar grass extract was lower than leuprolide acetate and control group (2.43±1.521 %, 4.86±0.458 %, and 7.26±2.898 %, respectively; p=0.002). However, there was no significant difference in VEGF expression among study groups (4.34±2.40 %, 5.11±1.95 %, and 7.40±3.49 % respectively; p=0.116). Finally, the extension of the endometriotic lesions of the mouse models administered with Kebar grass extract and leuprolide acetate was smaller than the control group (0 mm2, 4.54±7.75 mm2, and 34.80±13.09 mm2 respectively; p=0.005). Conclusion: Kebar grass extract has the effect of decreasing MDA serum levels and reducing TNF-α expression, resulted in smaller endometriotic lesions in mice, even though it does not affect VEGF expression. Keywords: malondialdehyde, tumour necrosis factor alpha, vascular endothelial growth factor, endometriotic lesion, kebar grass extract, endometriosis mouse
PERBEDAAN PENGARUH PAPARAN MUSIK MOZART, BEETHOVEN, DAN CHOPIN SELAMA KEBUNTINGAN TERHADAP KEPADATAN DENDRIT DI CEREBELLUM Rattus norvegicus BARU LAHIR Ancha Ayu Amishinta; Hermanto Tri Joewono; widjiati Widjiati
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 10 No 2 (2018): SEPTEMBER
Publisher : NHM PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia is categorized as middle humandevelopment index. One of the causes is the fluentignorance of brain growth and development during1000 days of life period. This period is the bestopportunity to give proper stimulations to increase themaximal brain growth and development. Exposure toclassical music such as Mozart, Beethoven, andChopin music can increase the wave of brain activity.During pregnancy, Mozart music is proven to increasethe dendritic density. Analyzing the difference ofdendritic density of cerebrum and cerebellum ofnewborn baby of Rattus norvegicus that are exposedto the Mozart, Beethoven, and Chopin music, and thatis not exposed to music during pregnancy. Laboratoryexperimental research, posttest-only control groupdesign. Subjects were female pregnant Rattusnorvegicus, grouped into 4 random groups: 1 controlgroup and 3 treatments groups; with 6 samples each.Subjects were super ovulated, and 65 dB intensity ofmusic was played for an hour at 20.00-21.00 on thesubjects on 10th day of pregnancy. On 20th day ofpregnancy, the mothers were dissected usingcaesarean section. 2 heaviest newborn babies ofRattus norvegicus were taken, and their brain tissueswere taken as samples. The dendritic density ofcerebrum and cerebellum were observed using GolgiCox method of silver impregnationprocedure.Statistical test concluded there weresignificant differences of dendritic density of cerebrumand cerebellum of newborn babies of Rattusnorvegicus among the exposure to Mozart,Beethoven, and Chopin music, and without theexposure to music with value of p=0,004 (<0,05) incerebrum and p=0,003 (<0,05) in cerebellum. Thedendritic density of cerebrum and cerebellum ofnewborn babies of Rattus norvegicus that wereexposed to Mozart music during pregnancy werehigher than that are exposed to Beethoven andChopin music and that were not exposed to music. Itis recommended for the next research to do furtherresearch to prove the dendritic density caused by themusical stimulation during pregnancy when Rattusnorvegicus grows up.
PERBEDAAN PENGARUH PAPARAN MUSIK MOZART, BEETHOVEN, DAN CHOPIN SELAMA KEBUNTINGAN TERHADAP INDEKS APOPTOSIS SEL NEURON DI CEREBELLUM Rattus norvegicus BARU LAHIR Dessy Hidayati Fajrin; Hermanto Tri Joewono; widjiati Widjiati
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 10 No 2 (2018): SEPTEMBER
Publisher : NHM PRESS

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Abstract

The efforts that can be done to improvebrain cells in the prenatal period is the provision ofnutrients and good stimulation. Exposure to classicalmusic such as Mozart, Beethoven, and Chopinmusic can increase the wave of brain activity. Duringpregnancy, Mozart music is proven to decrease theapoptosis of neuronal.Analyzing the difference of apoptosisneuronal of cerebrum and cerebellum of newbornbaby of Rattus norvegicus that are exposed to theMozart, Beethoven, and Chopin music, and that isnot exposed to music during pregnancy.Laboratory experimental research, posttestonly control group design. Subjects were femalepregnant Rattus norvegicus, grouped into 4 randomgroups: 1 control group and 3 treatments groups;with 6 samples each. Subjects were super ovulated,and 65 dB intensity of music is played for an hour at20.00-21.00 on the subjects on 10th day ofpregnancy. On 20th day of pregnancy, the motherswas dissected using SC technique. 2 heaviestnewborn babies of Rattus norvegicus were taken.Statistical test concluded there wassignificant differences of apoptosis neuronal ofcerebellum of newborn babies of Rattus norvegicusamong the exposure to Mozart, Beethoven, andChopin music, and without the exposure to musicwith value of p=0,033 in cerebellum.In conclution, the exposure of Mozart’smusic during pregnancy perform expression ofBDNF cerebellum in the offspring-rat was higherthan exposed Beethoven’s music, Chopin and notexposed to music.
PERBEDAAN PENGARUH PAPARAN MUSIK MOZART, BEETHOVEN DAN CHOPIN SELAMA KEBUNTINGAN TERHADAP JUMLAH SEL NEURON DI CEREBELLUM Rattus norvegicus BARU LAHIR Herlina Alvianti N; Hermanto Tri Joewono; widjiati Widjiati
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 10 No 2 (2018): SEPTEMBER
Publisher : NHM PRESS

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Abstract

Efforts could be made to improve humanresources that have intelligence required apositive relationship between health and goodeducation quality, one of the efforts to improvehuman resources requires good brain qualitysince the phase of conception. Classical musichas been shown to boost brain function andhuman intellectual optimally believed to have thebest stimulating effect on babies. Cellularexposure to Mozart affects the number of moreneuronal cells. Analyze the number of cerebrumand cerebellum neuronal cells of newborn Rattusnorvegicus between the exposed to Mozart music,Beethoven, Chopin and not exposed to musicduring pregnancy. This research was anexperimental research with posttest only controlgroup design. The sample was divided into fourgroups randomly, non-exposed, Mozart musicexposure group, Beethoven music exposuregroup, Chopin music exposure group, exposed for1 hour during the night after Rattus norvegicuswas pregnant on day-10 with an intensity of 65 dBand a distance of 37 cm from the rat cage. On the20th day of the pregnant mother of Rattusnorvegicus was sacrificed and selected two ofRattus norvegicus's babies with the greatestweight and then the brains of Rattus norvegicus'sbabies were decapitated and brain dissection tocount the number of neuronal cells withHemotoxyln-Eosin staining. The statistical resultsshowed that the number of neurons of cerebellumcells in the Mozart group differed significantly fromBeethoven, Chopin and not exposed to music withp <0.05. The number of neuronal cells ofcerebellum of the newborn Rattus norvegicus whoexposed to Mozart music during pregnancyproved higher than that exposed to Beethovenmusic, Chopin and not exposed to music.
PERBEDAAN PENGARUH PAPARAN MUSIK MOZART, BEETHOVEN DAN CHOPIN SELAMA KEBUNTINGAN TERHADAP EKSPRESI BRAIN DERIVED NEUROTROPHIC FACTOR DI CREBELLUM RATTUS NORVEGICUS BARU LAHIR Pitria Permatasari; Hermanto Tri Joewono; widjiati Widjiati
JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan P-ISSN : 1979-3340 e-ISSN : 2685-7987 Vol 10 No 2 (2018): SEPTEMBER
Publisher : NHM PRESS

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Abstract

r 2015 was ranked 113 out of 188 countries.Education would be needed to raise HDI’s rank. Oneprinciple component of education is the quality of thebrain. BDNF expression in the brain was affected bymany stimuli. Mozart classical music had aneurobiological effect which had ability to increaseBDNF. Whereas, other classical musics such asBeethoven and Chopin had never been studied. Thisstudy aims to cerebellum’s BDNF expression in theoffspring of Rattus norvegicus that ere exposed tothe Mozart , Beethoven, Chopin during pregnancy.The method used is pure laboratoryexperiment with posttest only control group design.The variables measured were BDNF expression inthe brain. The samples were divided into 4 groups ofeach 6 rats.The results showed that significantdifferences in BDNF expressions between controlgroup and Mozart (p=0,023; p<0,05), betweenMozart group and Chopin (p=0,003). There were nostatistically detected differences between controlgroup and Beethoven (p=0,256), control group andChopin (p=0,684), Mozart group and Beethoven(p=0,092) and Beethoven group and Chopin(p=0,292). Based on the above results it can beconcluded that the exposure of Mozart’s musicduring pregnancy had a higher expression of BDNFin the offspring-rat’s cerebellum compare to thosewhich exposed by Beethoven and Chopin’s music.
Co-Authors Adi Setyawan Prianto Agustina Hidayati Agustina, Widayati Alfiah Hayati Ancha Ayu Amishinta Anindya Marcha Angelina Djianto Anwar Fauzi Aty Widyawaruyanti Azami D Azinar Boedi Setiawan Budi I Santoso Budi Prasetyo Budi Santoso Desak Ketut Ayu Aryani Dessy Hidayati Fajrin Eighty M Kurniawati Fedik A Rantam Fitria Desky Gatut Hardianto, Gatut H.M Bahkriansyah Hari Paraton Harry Mangasi Binsar Panjaitan Hendy Hendarto Herlina Alvianti N Hermanto T Joewono Hermanto Tri Joewono Masyitah Hamidah Meitria Syahadatina Noor Nasrul Wahdi Nenny Harijani Noor Pramono Noor Pramono Nur AR Widiatmoko Nyna Puspa Ningrum Pitria Permatasari Ratriana Via Parasti Raudatul Hikmah Seindy Glamour Sri Ratna Dwiningsih Syarief T. Hidayat Syarief Thaufik Hidayat Tri Hartini Yuliawati Tri HS Hadi Trilas Sardjito Yuli Trisetiyono