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All Journal Majalah Kedokteran Gigi Indonesia Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science Jurnal Pengabdian UNDIKMA Strada Jurnal Ilmiah Kesehatan (SJIK)
Ira Arundina
Departemen Biologi Oral, Fakultas Kedokteran Gigi Universitas Airlangga, Surabaya, Jawa Timur, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Exercise as a method to reduce the risk of oral cancer: A narrative review Anis Irmawati; Lia Aulia Rachma; S. Sidarningsih; Muhammad Naufal Hatta; Ira Arundina; Mohammed Aljunaid
Dental Journal (Majalah Kedokteran Gigi) Vol. 55 No. 1 (2022): March 2022
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v55.i1.p56-61

Abstract

Background: Cancer is a major cause of death worldwide. One of the most common forms of cancer is oral cancer, which can occur due to exposure to carcinogenic factors, such as tobacco cigarettes, alcohol, betel-nut chewing, ultraviolet rays or human papillomavirus infection. Physical exercise is known to have many benefits and can contribute to reducing the risk of cancer, minimising the side-effects of treatment and increasing the curative effect of cancer treatment. Purpose: This study aimed to explain the role of exercise as a method to reduce oral cancer risk. Reviews: Studies examining the impact of exercise on reducing oral cancer risk are currently limited due to a lack of research on this subject. However, according to several laboratory experimental research studies on Mus musculus test subjects, moderate-intensity exercise contributes to suppressing the proliferation and development of oral squamous epithelial cells, which can subsequently become cancer cells. Exercise can also increase intracellular proteins that can induce apoptosis in cells (e.g. wild protein p53, the ratio of Bax/Bcl-2, and caspase-3), and can also decrease p53 mutant expression and transformed cells that can trigger cancer. Exercise must be optimally performed to prevent or control cancer symptoms, although the exact duration and intensity of exercise required to reduce cancer risk in humans have not been established. Conclusion: Exercise plays a role in reducing oral cancer risk by inducing apoptosis and preventing the development of transformed cells that can lead to developing cancer.
Efek pegagan (Centella asiatica L)terhadap proliferasi mesenchymal stem cell (Effect of pegagan (Centella asiatica L)to mesenchymal stem cell proliferation) Ira Arundina; Ketut Suardita
Journal of Dentomaxillofacial Science Vol. 13 No. 1 (2014): Formerly Jurnal Dentofasial ISSN 1412-8926
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v13i1.386

Abstract

Stem cells provide new hope to fasten the healing process of various oral diseases including periodontal tissue(periodontitis). At present time, there is not yet found a material that can fix the teeth perfectly. Adult stem cells frombone marrow widely used for treatment. Numbers of stem cell are limited so growth factor is necessary to promoteproliferation of stem cells. Growth factor that has been used is expensive and difficult to get. Because of theseconstraints, it is necessary to develop alternative uses of medicinal plants as growth factor that accelerates woundhealing process. This study is aimed to proven what extent the potential Pegagan (Centella asiatica L) as a naturalgrowth factors to stem cells. The ability of proliferation and osteogenic differentiation in mesenchymal stem cells(MSC)was analyzed by adding terpenoid fraction of Centella asiatica. MTT assay data showed that the addition ofPegagan on cultured MSCs can increase stem cell proliferation. Pegagan increases the ability of MSC proliferationand differentiate into osteoblasts It is concluded that pegagan increase the ability of MSC proliferation anddifferentiate into osteoblasts.
Ujitoksisitasakut ekstrakbatangpisangambon(Musa paradisiacavar sapientum) terhadap hati mencit (Mus musculus) dengan parameter LD (Acute toxicity test of ambonese banana (Musa paradisiaca var sapientum) stem extract in liver of mice (Mus musculus) with LD 50 parameters 50 Hendrik Setia Budi; Ira Arundina; Retno Indrawati; Leonita Widyana Mahardikasari
Journal of Dentomaxillofacial Science Vol. 13 No. 2 (2014): Formerly Jurnal Dentofasial ISSN 1412-8926
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v13i2.394

Abstract

The sap of ambonese banana (Musa paradisiaca var sapientum) contain flavonoids, saponins, tannins which have beenwidely used by people in Trunyan Bali as traditional medicine on wound healing, and it has been reported as apotential wound healing after tooth extraction. The aim of this research was to determine the level of safety of usingherbal medicine, ambonese banana stem extract on histopatology liver of mice with LDparameters. This experimentalstudy was performed bythe post test only controlled group design. The sample were 28 mice (Mus musculus) randomlydivided into 4 groups. K group as control group was given aquadest. P1, P2, and P3, as treatment groups were givenambonese banana stem extract with dose 0.42g/20gbw, 2.1g/20gbw, 4.2g/20gbw. The extract was given per-oral withsonde on the first day. On day 3, the mice were terminated, and the livers were microscopically histopathological observed. The observed at 3th50 day, there were no deaths in every groups of mice (K, P1, P2, and P3) on the third day observation. Kruskal Wallis test showed there was not significant difference in histopathological appearance on liverof mice (p=0.771). It wasconcluded that the maximumsafety dose that can still be administered is 0.42g/20gbw followingthe LDparameter. Theacute toxicity test of ambonese banana stem extract did not show necrosis on liver but it showedthe highest simple degeneration than all groups which were given 0.42g/20gbw dose.
Changes in osteoblast and osteoclast cell count after moringa oleifera leaf extract administration during orthodontic tooth movement Rika D. Syarif; Tuti Kusumaningsih; Ira Arundina
Journal of Dentomaxillofacial Science Vol. 5 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v5i2.1081

Abstract

Objective: The aim of this study was to analyze the effect of moringa leaf extract administration at 5%, 10%, and 20% concentration toward osteoblast and osteoclast cell count in tension area of Cavia cobaya tooth movement. Matrial and Methods: This study was an experimental research with post test only control group design conducted on Cavia Cobaya. The samples were divided into 4 groups, namely control group (given orthodontic forces), P1 group (given orthodontic forces and Moringa oleifera extract at 5% concentration), P2 group (given orthodontic forces and Moringa oleifera extract at 10% concentration) and P3 group (given orthodontic forces and Moringa oleifera extract at 20% concentration). The samples were sacrificed in day 15 and the tissue were collected for histological examination to examine osteoblast and osteoclast cell count.Results: The Anova test showed a significant difference of osteoblast and osteoclast cell count among groups (p<0.05).Conclusion: Moringa leaves extract administration at 20% concentration for 7 days shows higher number of osteoblast and osteoclast compared to control group, 5% and 10% extract group.
Mutant p53 Expression Of Oral Transformed Epithelium Cell In Rats Injected By Benzo[A]Pyrene Sawitri Dwi indah Pertami; I Ketut Sudiana; Theresia Indah Budhy; Retno Palupi; Ira Arundina
STRADA : Jurnal Ilmiah Kesehatan Vol. 9 No. 1 (2020): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v9i1.234

Abstract

Benzopyrene is a polycyclic aromatic hydrocarbons (PAHs) compound that can cause transformation of normal cells into malignant in order to its genotoxic,mutagenic,and carsinogenic ability. DNA mutation in tumor suppressor genes p53 make cells immortal which results in cell transformation and develops into malignancies. This study consist of five groups including the control group (without benzopyrene injection) and 4 treatment groups injected with benzopyrene each for 4 weeks (P1), 6 weeks (P2), 8 weeks (P3) and 10 weeks (P4). Therefore, the mutant p53 expression was calculated and analyzed statistically with the One Way Anova Test. There was signifficance difference in mutant p53 expression of oral transformed epithelium cell injected by benzopyrene (p=0.000) and the highest expression was at 10th week. It can be concluded that the mutant P53 expression of oral transformed epithelium cells in rats was increased after injected by benzopyrene
Effectiveness of gold sea cucumber (Stichopus hermanii) extracts in accelerating the healing process of oral traumatic ulcer in rats Damaiyanti, Dian Widya; Soesilowati, Pratiwi; Arundina, Ira; Sari, Rima Parwati
Padjadjaran Journal of Dentistry Vol 31, No 3 (2019): November 2019
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol31no3.22555

Abstract

Introduction: Gold sea cucumber (Stichopus hermanii) is a marine organism that contains omega-3 and glycosaminoglycan for enhancing collagen needed in the healing process. This study was aimed to determine the effectiveness of gold sea cucumber extracts in accelerating the healing process of oral traumatic ulcer in Wistar rats, in terms of the correlation between collagen type I expression, ulcer diameter, and body weight loss. Methods: Twenty Wistar rats (Rattus norvegicus) was divided into four groups and treated with gold sea cucumber extracts with the concentration of 80%, 40%, and 20% in the form of 0.1 ml gel daily. The negative control group received no treatment. Ulceration of the lower lip of labial mucosa was induced by a burnisher. The animals were observed for 7 days, during which they were weighed and the ulcers diameter was measured. The rats were then sacrificed after 7 days of treatment. Histometric analysis of collagen type I expression was also performed. Data obtained were analysed for differences between the group with one-way ANOVA test and the correlation was analysed with the Pearson test. Results: The significant differences (p < 0.05) between treatment groups was found in the ulcer diameters and the collagen type I expression. The most decreased ulcer diameter and the highest collagen type I expression detected in the group of treatment with a concentration of 80% — no significant differences found in the weight loss between-groups (p > 0.05). Strong correlation was also found between the expression of collagen type I and diameter of ulcer (Pearson correlation = 0.599, p = 0.05), however, no correlation found between weight loss with the expression of collagen type I (Pearson correlation = -0.102, p = 0.66), and the ulcer diameter (Pearson correlation = 0.022, p = 0.92). Conclusion: Gold sea cucumber had a potential benefit to be used as a traumatic ulcer healing medicament. Water extract of gold sea cucumber able to accelerate traumatic ulcer healing by enhancing the production of collagen type I and reduce the diameter of ulcer. There is a strong correlation between collagen type 1 expression and diameter of ulcer, and a weak correlation found between body weight loss and collagen type I expression, also with reducing ulcer diameter.Keywords: Gold sea cucumber, Stichopus hermanii, healing process, traumatic ulcer.
Pengolahan Air Bersih Berbasis Kebutuhan Rumah Tangga dalam Upaya Meningkatkan Kesehatan Masyarakat di Desa Kandat Kabupaten Kediri Ira Arundina; Theresia Indah Budhy S; Roni Handayani; Septyana Eka Rahmawati
Jurnal Pengabdian UNDIKMA Vol. 3 No. 1 (2022): May
Publisher : LPPM Universitas Pendidikan Mandalika (UNDIKMA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/jpu.v3i1.4943

Abstract

The purpose of this community service activity is to increase awareness of Kandat Village residents through counseling about clean water treatment for household needs. This service method used a hybrid method, namely offline and online. The results of the service show that the community is aware of the need for clean water for health and daily needs. Utilization of infrastructure to facilitate clean water treatment is indicated by the construction of reservoirs. The achievement of fulfilling clean water is expected to have a positive impact, especially preventing the spread of the Covid-19 pandemic by using clean water to implement health protocols.
Co-Authors Agung Sosiawan Anis Irmawati Damaiyanti, Dian Widya Dania Maharani Dian W Damaiyanti Ester Arijani Rachmat Hendrik Setia Budi Imelda Kristina Sutrisno Ketut Suardita, Ketut Leonita Widyana Mahardikasari Lia Aulia Rachma Meircurius Dwi C.S Mohammed Aljunaid Muhammad Luthfi Muhammad Naufal Hatta Nita Naomi Nizamiar Hamni Pratiwi Soesilawati Rahmawati, Septyana Eka Regina Purnama Dewi Iskandar Retno Indrawati Roestamadji Retno Palupi Retno Pudji Rahayu Rika D. Syarif Rima Parwati Sari, Rima Parwati Roni Handayani S.Pd. M Kes I Ketut Sudiana . Sawitri Dwi Indah Pertami Sidarningsih Sidarningsih, Sidarningsih Soesilowati, Pratiwi Surboyo, Meircurius Dwi Condro Tantiana Tantiana Theresia Indah Budhy Sulisetyawati Tuti Kusumaningsih Yoes Prijatna Dachlan Yuliati