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All Journal Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Indonesian Journal of Dental Medicine Sinnun Maxillofacial Journal
Fatma Yasmin Mahdani
Department Of Oral Medicine, Faculty Of Dental Medicine, Universitas Airlangga
Dentistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Indonesian Journal of Dental Medicine

 1 
Current Approaches of Salivary Glands Regeneration for Management of Xerostomia and Hyposalivation: A Narrative Review Mahdani, Fatma Yasmin; Ayuningtyas, Nurina Febriyanti
Indonesian Journal of Dental Medicine Vol. 6 No. 1 (2023): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v6i1.2023.43-46

Abstract

Background: The salivary glands are the organs that produce saliva and have a role keeping the oral cavity moist and lubricated. Salivary glands regeneration is important for developing treatments on management of xerostomia and hyposalivation because of the irreversible damage of salivary glands. Common causes include aging, polypharmacy, autoimmune disease, including Sjogren's syndrome, and head and neck radiation, in which xerostomia and hyposalivation having a substantial impact on patient health and wellbeing. Purpose: to describe current approach of salivary glands regeneration for management of xerostomia and hyposalivation through narrative review. Review(s): A literature search using Science Direct and PubMed yielded results between 1973 and 2022, and the results were evaluated to identify the most promising approaches and for future research. The keywords of the search strategy were "salivary gland regeneration” and "xerostomia” or "hyposalivation”. Current studies have revealed potential targets in the development of salivary gland regeneration for the management of xerostomia and hyposalivation. Stem cells therapy aims to repair damaged at the cellular level, especially stimulating acini cells, multiplying and differentiating to replace dead or damaged acini cells. Bioengineering is through isolated acini cells cultured on many modified cell line and administration of bioactive compounds. Gene therapy aims to rebuild functional water channels and neutralization of inflammatory mediators. Conclusion: Several approaches of salivary glands regeneration that can be taken are stem cells therapy, bioengineering, and gene transfer.
Knowledge of xerostomia in the elderly in Rejosari Village, Lamongan Regency, East Java Sukmawati, Natasya Fauzia; Ratna Fitri, Adinda; Radithia, Desiana; Parmadiati, Adiastuti Endah; Ayuningtyas, Nurina Febriyanti; Mahdani, Fatma Yasmin
Indonesian Journal of Dental Medicine Vol. 8 No. 1 (2025): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v8i1.2025.19-24

Abstract

Background: Xerostomia, or dry mouth, is a subjective sensation often linked to hyposalivation, affecting oral and overall health. With a global prevalence of 5.5% to 46%, it is more common in the elderly due to factors like polypharmacy, systemic diseases, and age-related salivary gland changes. Xerostomia impacts daily activities such as speaking, chewing, and swallowing, reducing quality of life. Rejosari Village in Lamongan Regency, East Java, has a high elderly population and a well-established healthcare center for seniors (Posyandu Lansia), making it an ideal setting for studying awareness and knowledge of xerostomia. Purpose: To describe the level of knowledge of xerostomia among elderly people in Rejosari Village, Lamongan Regency, East Java. Methods: This descriptive observational study utilized an online questionnaire distributed via Google Forms. Participants were selected through consecutive sampling, focusing on elderly individuals who met the inclusion criteria. Of the 75 respondents who completed the questionnaire, 70 were included in the final analysis. Data were analyzed descriptively, categorizing knowledge levels into high, moderate, and low. Results: Among the 70 eligible respondents, 70.00% exhibited a high level of knowledge about xerostomia. Meanwhile, 22.86% were classified as having moderate knowledge, and 7.14% had low knowledge levels. These findings indicate that most elderly residents in Rejosari Village are well-informed about xerostomia, although knowledge gaps persist among certain groups. Conclusion: The elderly’s knowledge about xerostomia in Rejosari Village, Lamongan Regency, East Java is dominated in the high knowledge category.
White sponge nevus as a hereditary disease: A brief narrative review Mahdani, Fatma Yasmin; Puspasari, Karlina; Manuaba, Ida Bagus Pramana Putra; Putri, Salsabila Fitriana; Ayunnisa, Naqiya; Ernawati, Diah Savitri; Hendarti, Hening Tuti
Indonesian Journal of Dental Medicine Vol. 8 No. 1 (2025): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v8i1.2025.49-52

Abstract

Background: White sponge nevus (WSN) is an autosomal dominant hereditary genetic disorder characterized by thickened keratin in the oral mucosa that appears folded, wavy, spongy, thick, and rough. WSN do not have the potential to become malignant, but an accurate diagnosis is still needed to prevent unnecessary treatment and reduce potential remissions and exacerbations due to infection. Purpose: to provide a detailed description of white sponge nevus as a hereditary disease by means of narrative review. Review: A literature search using ScienceDirect and PubMed yielded results between 2012 and 2024. The keywords of the search strategy were “hereditary disease” and “white sponge nevus” or “Cannon’s disease” or “white folded gingivostomatitis” or “leukokeratosis.”. White sponge nevus (WSN) was first discovered by Hyde in 1909 and usually occurs in children and people under 20 years old. The main etiology of WSN is an autosomal dominant hereditary genetic disorder; KRT4 and KRT13 are specific keratin encoders that cause WSN, and there are predisposing factors such as bacterial infection, smoking, and alcohol consumption. Conclusion: In determining the diagnosis of WSN, it is necessary to carry out blood tests, subjective examinations, objective examinations, and supporting examinations in the form of exfoliative cytology and biopsies. As well as the need for comprehensive treatment, even though the prognosis of this disorder is good.
Co-Authors Adiastuti Endah Parmadiati Ari Hapsari Tri Wardani Ayunnisa, Naqiya Desiana Radithia, Desiana Desvia Nuzela Qurzani Hariyadi Dewi, Gremita Kusuma Diah Savitri Ernawati Femilian, Afryla Hening Tuti Hendarti Intan Nirwana, Intan Jenny Sunariani Kuntardjo, Yuhanna Manuaba, Ida Bagus Pramana Putra Nurina Febriyanti Ayuningtyas Pasaribu, Togu Andrie Simon Pramitha, Selviana Rizky Pratiwi, Aulya Setyo Puspasari, Karlina Puspitasari, Yeni Putri, Salsabila Fitriana Rajah, Karthiyayinee Alagir Ratna Fitri, Adinda Reiska Kumala Bakti Saka Winias Sismiyanti, Rossy Sukmawati, Natasya Fauzia Surboyo, Meircurius Dwi Condro Winda Dwi Malinda Masuku