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ANALISIS MIKRO-CT SEBAGAI METODE PILIHAN TERHADAP PENELITIAN PERTUMBUHAN TULANG KRANIOFASIAL Parmasari, Wahyuni Dyah; Ardani, I Gusti Wahju; Narmada, Ida Bagus; Kuntaman, Kuntaman; Latief, Fourier Dzar Eljabbar; Bahraini, Fahrisah Nurfadeliah; Regita Cahyani, Nafansya
Prosiding Seminar Nasional COSMIC Kedokteran Vol 3 (2025): Edisi 2025
Publisher : Lembaga Penelitian Dan Pengabdian Kepada Masyarakat Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Latar Belakang: Micro-CT adalah metode pencitraan 3D yang masih jarang ditemui di Indonesia. Analisis ini bermanfaat untuk penelitian untuk mengetahui titik anatomis yang sulit ditentukan secara manual, anomali dan malformasi dari cranium serta dapat mengetahui kepadatan tulang kraniofasial. Dalam pertumbuhan tulang dapat dideteksi secara kuantitatif yaitu pengukuran antropometri, maupun kualitiatif yaitu kualitas pertumbuhan tulang. Tujuan: mengukur dimensi transfersal dan sagital dengan analisis Mikro-CT sebagai parameter pertumbuhan tulang kraniofasial. Metode: Sampel menggunakan calvaria tikus betina dewasa dengan menganalisis daerah dasar calvaria yaitu basisphenoid dan concha nasalis. Analisis sampel dilakukan dan diukur dengan Aplikasi DataViewer versi 1.6.0.0 64-bit. CTVox versi-3.3.1 64-bit digunakan untuk menampilkan visual 3D. Mesin mikro-CT yang digunakan adalah Bruker SkyScan-1173 High Energy Micro-CT. Hasil: Menentukan titik landmark terlateral dari calvaria, kemudian dihubungkan menjadi garis ukur, untuk mendapatkan jarak yang dapat diukur sebelum dan sesudah perlakuan. Didapatkan MXHR yaitu 9.366 mm dan Interinsisifus (I) dengan titik paling atas cranium yaitu 17.914 mm. Pada concha nasalis, ditentukan titik paling superfisial dan caudal kemudian diukur untuk mengetahui tinggi concha nasalis dalam kurun waktu tertentu. Kesimpulan: Mikro-CT dapat menjadi metode pilihan untuk pengukuran tulang kraniofasial dari aspek anterior-posterior maupun sagital dan dapat menyelidiki kualitas dari tulang dengan satuan grey-scale value.

Biomarkers of Suture Density and Thickness in Craniofacial Bone Growth: Micro-CT Analysis Wahyuni Dyah Parmasari; I Gusti Aju Wahju Ardani; Ida Bagus Narmada; Alexander Patera Nugraha; Ramadhan Hardani Putra; Fourier Dzar Eljabbar Latief; Fahrisah Nurfadeliah Bahraini
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 1 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i1.10178

Introduction: One of the parameters for measuring craniofacial growth is suture closure. The sutures are connected with fibrous connective tissue that grows in a few days. The objective is to analyze the gray-scale value (GV) potential by measuring the volume of interest (VOI) of the different skulls using micro-computed tomography (Micro-CT). The analysis uses certain parameters, namely density and thickness. Material and Methods: This study involves experimental mice to examine normal growth and development processes at a certain age by investigating mice’s suture maturation. If the suture closure process has been completed, it can be used as a potential standard for measuring the cessation of growth in the craniofacial area. This study examined three different skulls obtained from 15-day-old (cranium 1) baby mice, 25-day-old (cranium 2) baby mice, and 120-day-old adult mice (cranium 3). The possible GV was 0 to 255 (Micro-CT-reconstructed image dataset in 8-bit-BMP-format). There was a volumetric space that limited the analysis area of the bone tissue whose density was measured. In micro-CT-reconstructed images, VOI was determined by the region-of-interest (ROI) in the 2D image slices, which completely formed an image. The machine used was a Bruker SkyScan 1173 high energy micro-CT. Results and Discussions: The suture of Cranium 1, Cranium 2, and Cranium 3 have a relative mean density (GV) of 32,45; 29,74; and 50,1, respectively. This study also measures the geometric average measurement of bone cranium thickness with a 5x5 mm cross-section. The average thickness of cranium 1 is 0.554 mm, cranium 2 is 0.645 mm, and cranium 3 is 1.417 mm. Conclusion: Sutures cranium 1 and 2 are lower in density and thinner than cranium 3 as documented by means of Micro-CT.

Anatomical Landmarks and Measurements of Craniofacial Structures: A Micro-CT Analysis Parmasari, Wahyuni Dyah; Ardani, I Gusti Aju Wahju; Narmada, Ida Bagus; Nugraha, Alexander Patera; Putra, Ramadhan Hardani; Latief, Fourier Dzar Eljabbar; Bahraini, Fahrisah Nurfadeliah
Odonto : Dental Journal Vol 12, No 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.29-43

In this study, an adult rat's calvaria was used to examine craniofacial anatomical landmarks of maxilla and mandible using Micro-Computed Tomography (micro-CT) as the marker of craniofacial growth and development in rat. It is used to assist research, translating landmark points for diagnosis. Landmarks on the rat’s calvaria were determined to set the measurements of two specified points. One of the ways to validate craniofacial growth and development is to look at the differences between craniofacial before and after a specified period or treatment. With micro-CT analysis, the researchers are more precise in determining the difficult points in the cranium.The sample analysis was carried out and measured by DataViewer version 1.6.0.0 64-bit Application. CTVox version-3.3.1 64-bit is used to display 3D visuals. Reconstruction results after adjusting the data range were 30-255 (the color range 0-255). The machine used was Bruker SkyScan-1173 High Energy Micro-CT. Findings anatomical landmarks for the examples, the maxilla determined I for the point on premaxilla between jawbone and lingual surface of upper incisors. In the mandible, I’ for the most anterior edge of the alveolar bone on the convexity of the lower incisor. The unevenness of the cranium made manual measurements difficult and not possible. However, this micro-CT method makes the landmark point determination more detailed and dependable. This makes geometric measurements of craniofacial more reliable. Micro-CT analysis is a more dependable method to determine anatomical landmarks and measure craniofacial structures as the marker of craniofacial growth and development in rat.

Anatomical Landmarks and Measurements of Craniofacial Structures: A Micro-CT Analysis Parmasari, Wahyuni Dyah; Ardani, I Gusti Aju Wahju; Narmada, Ida Bagus; Nugraha, Alexander Patera; Putra, Ramadhan Hardani; Latief, Fourier Dzar Eljabbar; Bahraini, Fahrisah Nurfadeliah
Odonto : Dental Journal Vol 12, No 1 (2025): April 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.1.29-43

In this study, an adult rat's calvaria was used to examine craniofacial anatomical landmarks of maxilla and mandible using Micro-Computed Tomography (micro-CT) as the marker of craniofacial growth and development in rat. It is used to assist research, translating landmark points for diagnosis. Landmarks on the rat’s calvaria were determined to set the measurements of two specified points. One of the ways to validate craniofacial growth and development is to look at the differences between craniofacial before and after a specified period or treatment. With micro-CT analysis, the researchers are more precise in determining the difficult points in the cranium.The sample analysis was carried out and measured by DataViewer version 1.6.0.0 64-bit Application. CTVox version-3.3.1 64-bit is used to display 3D visuals. Reconstruction results after adjusting the data range were 30-255 (the color range 0-255). The machine used was Bruker SkyScan-1173 High Energy Micro-CT. Findings anatomical landmarks for the examples, the maxilla determined I for the point on premaxilla between jawbone and lingual surface of upper incisors. In the mandible, I’ for the most anterior edge of the alveolar bone on the convexity of the lower incisor. The unevenness of the cranium made manual measurements difficult and not possible. However, this micro-CT method makes the landmark point determination more detailed and dependable. This makes geometric measurements of craniofacial more reliable. Micro-CT analysis is a more dependable method to determine anatomical landmarks and measure craniofacial structures as the marker of craniofacial growth and development in rat.

Artificial Intelligence in Forensic Odontology: Advancing Accuracy in Victim Identification and Crime Solving Fauziah, Yessy Andriani; Narmada, Ida Bagus; Yudianto, Ahmad; Darmadi, Eveline Yulia
Journal of Syiah Kuala Dentistry Society Vol 10, No 1 (2025): June
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v10i1.48129

Background: Forensic odontology plays a pivotal role in human identification, particularly in criminal investigations and mass disaster scenarios. Traditionally, this field has relied on manual techniques, which are often limited by human error, subjectivity, and time constraints. Recent advances in artificial intelligence (AI) offer new solutions to overcome these challenges. Objective: This review aims to explore and synthesize the current knowledge regarding the integration of AI in forensic odontology, focusing on its role in victim identification, bite mark analysis, and age and sex estimation. Method: A narrative literature review was conducted using electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar. Articles published between 2015 and 2023 were retrieved using relevant keywords such as artificial intelligence, forensic odontology, victim identification, bite mark analysis, and age estimation. Inclusion criteria encompassed original research, systematic reviews, and high-quality narrative reviews in English discussing AI or machine learning applications in forensic dentistry. Exclusion criteria were non-English publications, unrelated studies, and papers lacking methodological clarity. Results: The integration of AI, particularly machine learning and neural networks, has significantly improved the accuracy and efficiency of forensic odontology procedures. AI systems demonstrate superior performance in dental image recognition, bite mark pattern analysis, and age/sex prediction compared to conventional methods. These tools facilitate rapid data processing and reduce examiner bias, making them especially valuable in time-sensitive situations like disaster victim identification. Furthermore, AI contributes to more reliable and consistent forensic evidence in legal settings. Conclusion: AI is revolutionizing forensic odontology by enhancing precision, objectivity, and speed in identification processes. Despite its advantages, ethical concerns regarding data privacy and the need for standardization remain critical. Continued interdisciplinary research and validation are essential to ensure the responsible and effective adoption of AI in forensic science.

The Indonesian Orthodontists’ Perceptions about malocclusion and postural in Diagnosis: Survey analytic of Malocclusion and posture Sofyanti, Ervina; Manurung, Prans Samuel Antony; Purbiati, Maria; Farmasyanti, Cendrawasih Andusyana; Mardiati, Endah; Narmada, Ida Bagus; Alhasyimi, Ananto Ali
Indonesian Journal of Medical Anthropology Vol. 6 No. 2 (2025): Indonesian Journal of Medical Anthropology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijma.v6i2.22433

The relationship between dental occlusion and posture remain controversial due to the lack of clear cause-and-effect evidence. Scientifically validated and reliable evidence can shape individuals' perceptions and influence their decisions regarding orthodontic treatment. This study aimed to conduct a survey to assess Indonesian orthodontists' perceptions regarding the relationship between malocclusion and posture (both oral and body posture) based on gender and years of professional experience. An online survey was conducted involving orthodontists who attended the Orthodontic Meeting in November based on a 7-item Likert scale modified questionnaire. Levene's test was performed continued with a prerequisite for the Multivariate Analysis of Variance test (p<0.05). The perceptions of 214 active members of the Indonesian Orthodontist Association showed a positive agreement regarding the relationship between malocclusion and posture (both oral and body). There was no significant interaction between gender and perception (p=0.417), nor between years of professional experience as an orthodontist and perception (p=0.182) regarding the relationship between malocclusion and posture. Since this survey-based analytical study found no interaction between gender and years of professional experience in orthodontists' agreement on the premise, these findings should be considered when updating the standard operating procedures curriculum for orthodontic diagnosis and multidisciplinary orthodontic approaches. Keyword: Perception, Orthodontist, Malocclusion, Posture

Tingkat Pengetahuan Ustadz /Ustadzah pada Pola Makan Sehat Santri/Santriwati di Lingkungan Pondok Pesantren Narmada, Ida Bagus; Alfiandini, Ratna Nurlia; Putranto, Ananda Firman
Jurnal Promotif Preventif Vol 7 No 6 (2024): Desember 2024: JURNAL PROMOTIF PREVENTIF
Publisher : Fakultas Kesehatan Masyarakat Universitas Pancasakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47650/jpp.v7i6.1587

Di lingkungan pesantren, terdapat sejumlah permasalahan khusus terkait status gizi para santri sehingga diperlukan penguatan peran pos kesehatan, seperti di Pondok Pesantren Tahfidz Al-Qur’an Karangmojo, untuk mendukung upaya pencegahan dan penurunan angka permasalahan gizi pada remaja. Ustadz dan Ustadzah, sebagai pembimbing, akan bertugas mendukung Poskestren Sehingga perlu diketahui tingkat pengetahuan ustadz dan ustadzah terkait pemberian gizi pada santri dan santriwati. Penelitian ini menggunakan studi deksriptif untuk mengetahui tingkat pengetahuan ustadz dan ustadzah. Populasi penelitian mencakup seluruh ustadz dan ustadzah Pondok Tahfidz Al-Qur’an Karangmojo, Kabupaten Ponorogo berjumlah sebelas orang. Sedangkan sampel penelitian adalah seluruh anggota populasi dengan teknik pengambilan sampel adalah Total Sampling. Instrumen penelitian yang digunakan berupa tes kuesioner tertutup. Kuesioner yang digunakan menggunakan skala Likert yang memiliki 4 pilihan jawaban, antara lain, sangat setuju, setuju, tidak setuju dan sangat tidak setuju. Kriteria penilaian berdasarkan skala Likert, dengan “Sangat Setuju” = 4 poin, “Setuju” = 3 poin, “Tidak Setuju” = 2 poin, “Sangat Tidak Setuju” = 1 poin. Hasil menunjukkan bahwa 47% besar ustadz dan ustadzah berusia 26-35 tahun dengan Pendidikan terakhir mayoritas adalah S1 (59%). Hasil menunjukkan bahwa tingkat pengetahuan ustadz dan ustadzah sangat baik dalam pembiasaan pola makan sehat bagi santri dan santriwati.

NFkB and MMP-13 expression in condylar cartilage of temporomandibular joint with occlusal disharmony in vivo Suhartini; Narmada, Ida Bagus; Hamzah, Zahreni; Joewarini, Endang
Dental Journal (Majalah Kedokteran Gigi) Vol. 57 No. 1 (2024): March
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i1.p22-27

Background: Temporomandibular disorder (TMD) is a collection of symptoms that causes pain and disturbs a person's life quality. One of the trigger factors is mechanical overloading. Mechanical overloading in occlusal disharmony conditions will lead to an inflammatory reaction in the temporomandibular joint (TMJ). This condition will induce nuclear factor Kappa Beta (NFkB) activation to transcribe proinflammatory cytokines and matrix metalloproteinase-13 (MMP13) and will also degrade condylar cartilage as a major factor in strengthening the TMJ. Purpose: The aim of this study was to analyze the expression of NFkB and MMP13 in the condylar cartilage of TMJ with occlusal disharmony. Methods: This research was an experimental study with post-test-only control group design. Twenty Rats (Rattus norvegicus) were divided into four groups: One control group without any intervention and three experimental groups. Occlusal-reducing intervention was due on the right molar of the experimental groups, which were divided into the 7th, 14th, and 21st days. Immunohistochemical staining was performed to determine the expression of NFkB and MMP13 in the condylar cartilage. The data were analyzed by using the Welch test and independent t-test. Results: There were significant differences in NFkB and MMP13 expression between the control and experiment experimental groups (p<0.05). NFkB expression increased on the 7th, 14th, and 21st days of observation. The MMP13 expression showed a significant difference between the control and experimental groups (p<0.05). Conclusion: Occlusal disharmony increases NFkB and MMP13 expression and could affect TMJ integrity and induce TMD. These findings are important for describing the mechanism of TMJ damage and developing potential alternative therapies to prevent further TMD.

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