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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Tumbuhan Obat Indonesia Jurnal Teknologi Informasi dan Ilmu Komputer JUITA : Jurnal Informatika Mutiara Medika: Jurnal Kedokteran dan Kesehatan Universa Medicina JSFK (Jurnal Sains Farmasi & Klinis) Molekul: Jurnal Ilmiah Kimia Journal of Electronics, Electromedical Engineering, and Medical Informatics Indonesian Journal of Electrical Engineering and Computer Science Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berita Kedokteran Masyarakat Journal of Innovative and Creativity Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
Isnatin Miladiyah
Departemen Farmakologi, Fakultas Kedokteran, Universitas Islam Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Quantitative Structure-Activity Relationship Analysis of Xanthone Derivates as Cytotoxic Agents in Liver Cancer Cell Line HepG2 Isnatin Miladiyah; Iqmal Tahir; Jumina Jumina; Sofia Mubarika; Mustofa Mustofa
Molekul Vol 11, No 1 (2016)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (614.538 KB) | DOI: 10.20884/1.jm.2016.11.1.203

Abstract

The study of xanthone derivatives as cytotoxic agents in cancer is increasing. This study was conducted to explore the Quantitative Structure-Activity Relationship (QSAR) of xanthones as cytotoxic agents in HepG2 cells, to find compounds with better potency. The data set were taken from the previous study, involving 26 xanthone derivates and their cytotoxic activities in Inhibitory Concentration 50% (IC50). The parameters (descriptors) were obtained from quantum mechanics calculation using semiempirical AM1 method and QSAR models determined with principle component regression, with log (1/IC50) as a dependent variable and five latent variables as independent variables. From the 26 main descriptors, PCR reduced them to five latent variables (1st– 5th LV). The QSAR analysis gave the best model as follows: log (1/IC50) = 4.592 – 0.204 LV1 + 0.295 LV2 + 0.028 LV3 (n = 26, r = 0.571, SE = 0.234, Fcount/Ftable ratio = 1.165, PRESS value = 3.766). The study concluded that the descriptors contributed to anticancer activity were volume, mass, surface area, log P, dipole moment, HOMO energy, LUMO energy, and atomic net charge of some atoms. Modifications of substitution that would contribute to cytotoxic activity can be performed at phenyl ring A and C, but not at B.
AKTIVITAS HIPOGLIKEMIK SNEDDS EKSTRAK ETANOL BUAH HARENDONG (Melastoma affine D.Don) PADA IKAN ZEBRA (Danio rerio) YANG DIINDUKSI ALOKSAN Arnetta Novitalia; Isnatin Miladiyah
Jurnal Tumbuhan Obat Indonesia Vol 15 No 1 (2022): Jurnal Tumbuhan Obat Indonesia
Publisher : Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jtoi.v15i1.5313

Abstract

Diabetes melitus merupakan penyakit kronik dengan prevalensi yang tinggi di Indonesia dan diperkirakan akan terus mengalami peningkatan. Buah Harendong (Melastoma affine D.Don) mempunyai kandungan senyawa flavonoid berupa antosianin dan fenol yang berpotensi memiliki aktivitas hipoglikemik pada penderita diabetes melitus. Sediaan Self Nano-Emulsifying Drug Delivery System (SNEDDS) dapat meningkatkan ketersediaan hayati zat aktif senyawa sehingga memperbaiki efek terapetik senyawa tersebut. Tujuan penelitian ini adalah untuk mengetahui aktivitas hipoglikemik SNEDDS ekstrak etanol buah harendong pada ikan zebra. Ekstraksi buah harendong menggunakan metode maserasi dengan pelarut etanol 96%, ekstrak yang dihasilkan selanjutnya diformulasikan dalam sediaan SNEDDS dengan menambahkan kollisolv, tween 20 dan gliserin (2:6:1). Karakterisasi SNEDDS ekstrak etanol buah harendong dengan hasil ukuran partikel 77,8 nm, polydispersity index 0,123 D, zeta potensial -32,1 mV serta persen transmitan 74,567% telah memenuhi kriteria formulasi SNEDDS. Uji aktivitas hipoglikemik dengan menggunakan ikan zebra yang diinduksi aloksan 300mg selama 24 jam dan perendaman pada larutan glukosa 2% selama 7 hari. Pada penelitian ini terdapat 6 kelompok terdiri dari kelompok normal, kelompok kontrol negatif (tanpa perlakuan), kelompok kontrol positif (metformin 100 μM) dan kelompok perlakuan dengan variasi dosis kelompok H I (100 mg/2L SNEDDS), kelompok H II (200 mg/2L SNEDDS), kelompok H III ( 300 mg/2L SNEDDS). Nilai rata-rata kadar glukosa darah puasa (KGDP) kelompok normal 70,9 ± 3,7 mg/dL; kelompok kontrol negatif 208,9 ± 23,2 mg/dL; kelompok kontrol positif 68,7 ± 4,3 mg/dL; kelompok H I 100mg/2L SNEDDS 92,8 ± 8,07 mg/dL; kelompok H II 200mg/2L SNEDDS 65,2 ± 2,2 mg/dL; kelompok H III 300mg/2L SNEDDS 60,7 ± 1,8 mg/dL. Sehingga aktivitas hipoglikemik SNEDDS ekstrak etanol buah harendong terdapat pada dosis SNEDDS 200 mg/dL SNEDDS dan 300 mg/dL SNEDDS. Kata kunci: diabetes melitus, hipoglikemik, Melastoma affine D.Don, SNEDDS, ikan zebra
UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN RAMBUT AN (Nephelium lappaceum L.) PADA TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR WISTAR YANG DIINDUKSI KARAGENIN Agustina T; Isnatin Miladiyah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 5, No 1, (2013)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

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Abstract

Latar BelangInflamasi merupakan respon tubuh ketika terjadi cedera. Obat antiinflamasi digunakan un~k mengontrol efek inflamasi yang membahayakan. Namun obat antiinflamasi sintetik diketahui memiliki banyak efek samping sehingga perlu dicari altematif pengobatan dengan daun rambutan yang diduga bersifat antiinflamasi.TujuanPenelitian ini bertujuan untuk mengetahui aktivitas antiinflamasi ekstrak etanol daun rambutan pada tikus putih jantan yang diinduksi karagenin.MetodePenelitian ini merupakan penelitian eksperimental mumi yang menggunakan 25 ekor tikus putih jantan umur 2-3 bulan dan bcrat 150-250 gram yang dibagi menjadi 5 kelompok, yaitu kelompok akuades, kelompok natrium diklofenak 0,9 mg/200 g BB tikus, dan tiga tingkatan dosis ekstrak etanol daun rambutan: 100 mg/kgBB, 200 mg/kgBB dan 400mg/kgBB per intraperitoneal. Tiga puluh menit setelah perlakuan tikus diinjeksi dengan karagenin 0,1 ml secara subplantar. Volume udem diukur dengan pletismometer tiap 30 menit selama 3 jam. Daya antiinflamasi diukur dengan membandingkan nilai AUCkelompok kontrol dan perlakuan.HasilBasil penelitian menunjukkan bahwa ekstrak etanol daun rambutan belum menunjukkan aktivitas antiinflamasi terhadap tikus putih jantan yang diinduksi karagenin selama 180 menit perlakuan.KesimpulanBelum cukup bukti bahwa ekstrak etanol daun rambutan memiliki aktivitas antiinflamasi dibandingkan dengan Natrium diklofenak.
Analysis of capecitabine plus oxaliplatin (xelox) combination in the management of metastatic colorectal cancer compare with fluorouracil and oxaliplatin combination (folfox) Isnatin Miladiyah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 5, (2016)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss5.art4

Abstract

Background : Combinations of Fluorouracil (FU) and biomodulator Leucovorin (LV) established as a standard regimen for therapy of colorectal cancer with metastases. To give better antitumor activity in colorectal cancer therapy, oxaliplatin is combined with FU/LV and give significant improvement. Fluorouracil can only be given by intravenous administration. This limitation raised effort to find alternative drugs that can be given orally, such as capecitabine. Capecitabine is an oral FU prodrug, with high oral bioavailability, highly accumulated in neoplastic tissue to be converted in FU, and well tolerated. Some clinical studies revealed effectivity of capecitabine plus oxaliplatin (XELOX) compared to FU/LV plus oxaliplatin (FOLFOX). Objective : This article is aimed to compare non inferiority of XELOX to FOLFOX in colorectal cancer with metastases, viewed form primary outcomes and secondary outcomes. Results : XELOX was comparable to FOLFOX with some benefitsover FOLFOX. Conclusion : XELOX could be considered as FOLFOX replacement as a standard therapyfor colorectal cancer with metastases.
Potency of xanthone derivatives as antibacterial agent against Methicillin-Resistant Staphylococcus Aureus (MRSA) Isnatin Miladiyah; Farida Juliantina Rachmawaty
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 2, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss2.art8

Abstract

Antibiotic resistance is increasing worldwide and becoming a serious problem for the treatment of patients and also affecting their economy. One instance of bacteria that is resistant to the antibiotic is Methicillin- Resistant Staphylococcus aureus (MRSA). MRSA infections are fatal and even deadly. Some MRSA strain has shown resistance towards currently available antibacterial agents. To overcome this, we need new compound alternatives. One of the compounds currently being developed is xanthone derivatives. Xanthones can be found in many kinds of plants, including Garcinia mangostana , in which the active compounds are mangostanin and ±-mangostin. Xanthones is effective against several types of Grampositive and Gram-negative bacterias, including Staphylococcus species. Some studies have shown that xanthone derivatives are effective against Staphylococcus aureus, including MRSA. One of the proposed mechanisms of xanthone's antibacterial activity is the involvement of the bacteria's cytoplasmic membrane. Xanthone amphiphilic compounds are capable of disrupting bacterial membrane through a mechanism called interfacial activity models. Xanthone can also act as the antioxidant and by inducing the release of lipoteichoic acid (LTA) from the cell wall of MRSA. LTA is the main constituent of the cell wall of Gram-positive bacteria, which are covalently bonded to the outside of peptidoglycan. This structure is important for cell division and bacterial osmotic protection. Thus, it is believed that the mechanism of action of xanthones involved damaging bacterial cell membrane.
Uji Daya Antioksidan Ekstrak Air Biji Kedelai Kuning (Glycine max (L) Merill) Dibandingkan Vitamin E pada Tikus Putih (Rattus norvegicus) Jantan yang Diinduksi CCI4 Eka Yuliana; isnatin miladiyah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 2, No 5, (2010)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

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Abstract

The production of free radiacals (oxidants) that are not in balance with antioxidant activity can cause cell damage. The need for antioxidant is absolutely necessary not only endogenous but also exogenous. Yellow soybean is one ofthe plants that have antioxidant activity, which can reduce the effects of free radicals while vitamin E is a powerful antioxidant which is used. This study aims to determine antioxidant activity of water extract in the soybean seed yellow (Glycine max (L) Merill) compared the decreased content of vitamin E on malondialdehyde (MDA) in the rat (Rattus norvegicus) male induced by CCL4. This study is an experimental research laboratory with a pretest-posttest control group. 25 male rats (Rattus norvegicus) were divided into 5 treatment groups. Group I (positive control vitamin E), group II, III, and IV were given water extract of yellow soybean (Glycine max (L) Merill) with a concentration of 2.5%, respectively, 10%, and 40%. Group Vis a negative control distilled water. Treatment was given for 5 days. On 6th day, all groups treated with CCL4 0.2 ml/200 g 88. Antioxidant activity measured by the decrease in serum MDA levels before and after treatment. Statistical analysis using One Way ANOVA. In One Way Anova test p value = 0.196 (p> 0.05), which showed no significant difference (not significant) toward the mean decrease in rat blood serum MDA in all groups Water extract of yellow soybean (Glycine max (L) Merill) a difference between the antioxidant actiVity compared vitamm E as an antioxidant in white rats (Rattus novergicus) male Wistar strain which has been induced CCL4 but this difference was not statistically significantly.
Toksidinamik Antibiotika Golongan Aminoglikosida isnatin miladiyah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 2, No 5, (2010)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

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Abstract

The aminoglycosides are the mainstay in the treatment of serious gram-negative systemic mfections. These are the broad spectrum antibiotics, and could be used for many infections of body systems. A disadvantage of theaminoglycosides is their association with nephrotoxicity, ototoxicity, and neurotoxicity, all are associated with elevated serum levels. This article is carried out to give informations about mechanisms of toxicities and their pathology, which is highlighted on aspects of biochemistry, functional, and structural.
Cytotoxicity of ethanolic extract of fruit shells and seeds of Nyamplung (Calophyllum inophyllum L.) on WiDr colorectal cancer cells Irfan Jaen Fathani; Isnatin Miladiyah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art10

Abstract

Background: Colorectal cancer is the 3rd most common type of cancer in the world with unsatisfactory therapeutic effectiveness. One of the efforts being made to overcome this problem is by extracting various new chemotherapy agents, including herbal plants. The Nyamplung plant (Calophyllum inophyllum L.) is reported to contain calophyllolide, triterpene, coumarin, saponin, biflavonoids, benzophenones and neoflavanoids which are potential anticancer agents. Objective: This study aims to determine the cytotoxic activity of ethanolic extract of fruit shells and seeds of Nyamplung (Calophyllum inophyllum L.) on WiDr colorectal cancer cells and their selectivity on normal cells (Vero).Methods: The fruit and seeds of Nyamplung were extracted by maceration with 70% ethanol solvent. The cytotoxic test was carried out by the 3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide (MTT) method, with doxorubicin as a positive control. Data analyzed using Microsoft Excel software using linear regression analysis. The IC50 value and selectivity index were used as indicator of toxicity selectivity.Results: The IC50 value of the ethanolic extract of Nyamplung fruit shells on WiDr was 42.47 µg/ml with a selectivity index of 1.50. Meanwhile, the IC50 value of ethanolic extract of Nyamplung seeds was 1,030.41 µg/ml with a selectivity index of 67,982,414.71. Doxorubicin as a positive control obtained IC50 value on WiDr cells of 3.49 µg/ml with a selectivity index of 764.41.Conclusion: The ethanolic extract of Nyamplung seeds was not cytotoxic against WiDr colorectal cancer cells, while the ethanolic extract of Nyamplung fruit sell was moderate cytotoxic with low selectivity index.
Hubungan antara pendekatan belajar dan prestasi akademik pada sistem pembelajaran "problem based learning" Farida Juliantina Rachmawaty, Isnatin Miladiyah dan Shofyatul Yumna Triyana
Berita Kedokteran Masyarakat (BKM) Vol 21, No 1 (2005)
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.3684

Abstract

Background: Recently Problem-based Learning (PBL) in higher education is highlighted, especially in the medical education. PIK is considered as a better alternative. This method encourages students to be self-directed learners and having learning skills to become lifelong learners. A doctor must base their acts on the highest performances, thus lifelong learning is needed. Objective: This study were aimed at examining learning approaches of students of Faculty of Medicine, Islamic University of Indonesia and to approve the relationship between learnig approaches and academic achievement in PIK method. Methods: Subjects participating in this study were students of first level of Faculty of Medicine Islamic University of Indonesia, and this was a cross-sectional study. Learning approaches was obtained by questionnaire as primary data, and academic achievement used GPA as secondary data. Data were analyzed with SPSS 11 on computer programme using Spearman correlation and discriminating power test using Mann-Whitney test. Results: The results showed that Surface Approach had inverse correlation with academic achievement of students
Therapeutic Drug Monitoring (TDM) in The Use of Aspirin as Antirheumatoid Drugs Miladiyah, Isnatin
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (305.137 KB) | DOI: 10.30659/sainsmed.v4i2.378

Abstract

Therapeutic drug monitoring (TDM) is used in drug therapy for selected drugs with narrow therapeutic index, or a broad range of kinetics variation, or drugs with strong correlation between plasma concentration and clinical effects or toxicity. Aspirin is one of the widely used old generation drugs, with a broad range of activity spectrum: analgesic, antipyretic, anti‐inflammatory, and antiplatelet. As anti‐inflammatory drug, aspirin directed as therapy for many of chronic inflammation, such as rheumatoid arthritis. As an antirheumatic agent, aspirin shows a wide variation in the pharmacokinetic of aspirin metabolism, and has a narrow therapeutic index because it effectives at concentration of 10‐30 mg/dl, but at more than 40 mg/dl intoxication occurs (metabolic acidosis, hyperpnea, and death). Those are why aspirin use as antirheumatic agent need therapeutic drug monitoring, so that doctors can guarantee that plasma aspirin concentration is in the therapeutic range, to achieve optimilization of therapy with minimal side effects. This article reveals about use of aspirin as antirheumatoid drugs and why therapeutic drug monitoring is needed in aspirin use (Sains Medika, 4(2):210‐226).
Co-Authors AGUS RIYANTO Agustina T Alvin Sahroni Aminuyati Annisa Fitria Annisa Fitria Anora, Levina Arnetta Novitalia Bayu Rizky Prabowo Eka Yuliana Farida Juliantina Rachmawaty Fitriani, Hannie Fuad Khadafianto Hanafi, Mhd. Hannie Fitriani Hendra Setiawan Iqmal Tahir Irfan Jaen Fathani Iskandar Muda Siregar, Iskandar Muda Jumina Jumina Muflihah rizkawati Nurhayati Nurhayati Nuryadi, Satyo Prasetyo, Dono Catur Rahmawati, Riana Riana Rahmawati Sisdarmanto Adinandra, Sisdarmanto Sofia Mubarika Haryana Sofyan, Pramudya Rakhmadyansyah Sri Kusumadewi Sufi Desrini Syaefudin Ali Akhmad, Syaefudin Ali Syafitri, Indah Trunogati, Pranandito Umatul Khoiriyah Wijaya, Diani Puspa Wiryatun Lestariana, Wiryatun Yaltafit Jeem Yandi Syukri Yeny Dyah Cahyaningrum