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All Journal Journal of Food and Pharmaceutical Science SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Tumbuhan Obat Indonesia Jurnal Teknologi Informasi dan Ilmu Komputer JUITA : Jurnal Informatika Mutiara Medika: Jurnal Kedokteran dan Kesehatan Universa Medicina JSFK (Jurnal Sains Farmasi & Klinis) Molekul: Jurnal Ilmiah Kimia Journal of Electronics, Electromedical Engineering, and Medical Informatics Indonesian Journal of Electrical Engineering and Computer Science Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berita Kedokteran Masyarakat Journal of Innovative and Creativity Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
Isnatin Miladiyah
Departemen Farmakologi, Fakultas Kedokteran, Universitas Islam Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Characterization of Purple Corn Anthocyanin Components and Their Pharmacokinetic Profiles through In Silico Study Chayati, Ichda; Nuryadi, Satyo; Purnomo, Hari; Miladiyah, Isnatin
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.23226

Abstract

Purple corn contains high levels of bioactive anthocyanins with potential health-promoting effects. This study aimed to quantitatively characterize the anthocyanin profile of an Indonesian purple corn variety and evaluate the pharmacokinetic properties of its major constituents using in silico modelling. The anthocyanin extract was analyzed by HPLC (high-performance liquid chromatography), and concentrations were determined using authentic standards. The pharmacokinetic parameters, including absorption, distribution, metabolism, excretion, and toxicity (ADMET), were predicted using the pkCSM platform, and drug-likeness properties were evaluated based on Lipinski’s Rule of Five. Cyanidin-3-glucoside (0.82 mg/100 g DW), peonidin-3-glucoside (0.38 mg/100 g DW), and pelargonidin-3-glucoside (0.35 mg/100 g DW) were identified as the predominant anthocyanins. In silico ADMET predictions using pkCSM revealed low intestinal absorption, moderate peripheral tissue distribution, and violations of Lipinski’s Rule of Five, indicating limited suitability as conventional oral pharmaceuticals. Nevertheless, the compounds exhibited low predicted toxicity, minimal CYP450 inhibition, and favorable excretion profiles, supporting potential safe use as nutraceuticals or functional food ingredients. This integrated approach demonstrates that experimental phytochemical profiling combined with computational pharmacokinetic analysis provides valuable insight into the properties of anthocyanins beyond standard bioavailability studies. The findings provide a foundation for future formulation strategies, such as encapsulation or delivery enhancement, to improve bioavailability and functional activity in foods or dietary supplements. Overall, anthocyanins from Indonesian purple corn are promising safe natural bioactives, warranting further experimental and translational research.
Co-Authors AGUS RIYANTO Agustina T Alvin Sahroni Aminuyati Annisa Fitria Annisa Fitria Anora, Levina Arnetta Novitalia Bayu Rizky Prabowo Eka Yuliana Farida Juliantina Rachmawaty Fitriani, Hannie Fuad Khadafianto Hanafi, Mhd. Hannie Fitriani HARI PURNOMO Hendra Setiawan Ichda Chayati Iqmal Tahir Irfan Jaen Fathani Iskandar Muda Siregar, Iskandar Muda Jumina Jumina Muflihah Rizkawati Nurhayati Nurhayati Nuryadi, Satyo Prasetyo, Dono Catur Rahmawati, Riana Riana Rahmawati Sisdarmanto Adinandra, Sisdarmanto Sofia Mubarika Haryana Sofyan, Pramudya Rakhmadyansyah Sri Kusumadewi Sufi Desrini Syaefudin Ali Akhmad, Syaefudin Ali Syafitri, Indah Trunogati, Pranandito Umatul Khoiriyah Wijaya, Diani Puspa Wiryatun Lestariana, Wiryatun Yaltafit Jeem Yandi Syukri Yeny Dyah Cahyaningrum