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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Tumbuhan Obat Indonesia Jurnal Teknologi Informasi dan Ilmu Komputer JUITA : Jurnal Informatika Mutiara Medika: Jurnal Kedokteran dan Kesehatan Universa Medicina JSFK (Jurnal Sains Farmasi & Klinis) Molekul: Jurnal Ilmiah Kimia Journal of Electronics, Electromedical Engineering, and Medical Informatics Indonesian Journal of Electrical Engineering and Computer Science Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berita Kedokteran Masyarakat
Isnatin Miladiyah
Departemen Farmakologi, Fakultas Kedokteran, Universitas Islam Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Exploration of Xanthone Derivatives as Anti-Cancer Agents against Colorectal Cancer Miladiyah, Isnatin
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 1 (2020): June 2020
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1135.576 KB) | DOI: 10.30659/sainsmed.v11i1.7681

Abstract

Colorectal cancer currently occupies the third position of globally cancer morbidity and is the second leading cause of cancer death after lung cancer. Chemotherapy administration is still the main modality for the colorectal cancer stage I to III. Its usage is limited, since its high resistance and risk of side effects. Thus, exploration and development of novel colorectal anti-cancer drugs, including compounds derived from nature origin is needed. Xanthone becomes one natural compound which may be potentially developed as an anti-colorectal cancer due to its cytotoxic and anti-proliferative activities. The in vitro cytotoxic and anti-proliferative actions of xanthone compounds occur through a variety of mechanisms involving both apoptotic induction and inhibition of cell cycle, while in vivo may reduce the tumor size. Since colorectal cancer is frequently treated in a combination therapy, xanthone compounds have also been studied in a combination use and proven effective as co-chemotherapy with the standard chemotherapy drugs. This paper aims at providing an overview of colorectal cancer, pathology, risk factors and protective factors, as well as discussing the current therapies and potential xanthone compounds as an alternative therapy which may be developed later for the colorectal cancer
Aspirin as a Chemopreventive Agent for Cancer: a New Hope? Miladiyah, Isnatin
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 2 (2015): July-December 2015
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.847 KB) | DOI: 10.30659/sainsmed.v6i2.605

Abstract

Introduction: inflammation has been shown to play a major role in the pathogenesis of cancer. Inflammatory process activates the immune system through pro-inflammatory mediators and subsequent triggers transformation into malignant cells. Some tumors or cancers has been associated with chronic infections, such as hepatitis B and C viruses (hepatocellular carcinoma), human papilloma virus (cervical cancer), Helicobacter pylori (gastric cancer and lymphoma), and prostatitis (prostate cancer). A considerable study have investigated the benefits of aspirin for the prevention and treatment of cancer or tumors. Objectives: This paper aims to describe the relationship between inflammation and cancer incidence, so that use of aspirin as an anti-inflammatory agent is a rational choice in the treatment and prevention of cancer. Conclusion: Aspirin potential for chemoprevention of various types of cancer. Considering the high risk of side effects of aspirin, aspirin is not intended as a routine therapy to prevent the occurrence of cancer.
Do clinical decision support systems for prescribing improve patient safety? a systematic literature review Sri Kusumadewi; Isnatin Miladiyah
Indonesian Journal of Electrical Engineering and Computer Science Vol 30, No 3: June 2023
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijeecs.v30.i3.pp1748-1761

Abstract

Clinical decision support systems (CDSS) are developed independently or connected to the electronic health record (EHR) or other computerized systems. The study begins with identification by searching the literature through the Google Scholar, PubMed and ScienceDirect databases. The search results obtained 5,595 articles. Forty-two articles were obtained, which were used further. Most of the research focus is on "CDSS development and evaluation". In terms of impacts, the most common is "reduce prescribing errors". One of the biggest problems reported was the presence of "alert fatigue," which was felt to be disturbing to doctors and pharmacists. CDSS must be supported by a method that is able to indicate the presence of drug-drug interactions (DDI). The use of alerts indicating the presence of a DDI should be interpreted using clinical judgment to determine the risks and benefits of a particular drug for a specific patient. The performance of CDSS is mostly reported to have been able to reduce prescribing errors, which in turn will improve patient safety. However, increased adherence to clinical protocols has not been widely reported. Complaints that are still quite a lot reported are the presence of "alert fatigue", which can interfere with effectiveness.
Analysis of Multimodal Biosignals during Surprise Conditions Correlates with Psychological Traits Setiawan, Hendra; Miladiyah, Isnatin; Nuryadi, Satyo; Sahroni, Alvin
Journal of Electronics, Electromedical Engineering, and Medical Informatics Vol 6 No 1 (2024): January
Publisher : Department of Electromedical Engineering, POLTEKKES KEMENKES SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/jeeemi.v6i1.346

Abstract

Surprise can simultaneously represent bad or good, pleasant or unpleasant, with the same experiences since understanding how humans' physiological qualities link with their emotional or mental health is required. We conducted quantitative research to concisely correlate mental stress and emotional issues by measuring brain activity, breathing, and heart rate in real time while executing specialized audio-visual stimulation to elicit a surprise event. We evaluated the frequency and temporal domain characteristics to determine if physiological measurements matched biochemical metrics and subjective stress assessments during the elicit surprise condition experiment. We discovered that the brain is still preferable to most in recognizing a human's psychological changes over a short period of time. The temporal (T3) (r = 0.544, p = 0.005) and frontal (Fz) (r = 0.519, p = 0.008) regions were shown to correlate with salivary amylase activity. In comparison to other channels, there was a negative association between stress perception and the occipital site (O1, r = -0.618, p = 0.001). We also found that heart rate variability activity correlates with arousal perception. By looking at specific multimodal biosignals, it is possible to understand human psychological traits by recording specific physiological signals for daily mental health monitoring.
Single Channel Electrogastrogram Frequency Domain Analysis and Correspondence to Brain Activity in a Resting State Condition Sahroni, Alvin; Miladiyah, Isnatin; Adinandra, Sisdarmanto; Sofyan, Pramudya Rakhmadyansyah; Anora, Levina; Hanafi, Mhd.
Journal of Electronics, Electromedical Engineering, and Medical Informatics Vol 7 No 1 (2025): January
Publisher : Department of Electromedical Engineering, POLTEKKES KEMENKES SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/jeeemi.v7i1.590

Abstract

An electrogastrogram (EGG) is a well-known method to record gastric myoelectrical activity. However, some researchers believe that EGG measures the gastric slow wave and can be used as a surrogate for gastric motility, whereas others claim that EGG is flawed. Our proposed study broadens the scope of EGG research, particularly by offering the opportunity to observe gut-brain signaling pathways, which can enhance our understanding of brain properties and behavior in response to psychological changes. This study focuses on how to confirm single-channel EGG's setup with public datasets and previous studies and how to observe the relationship of gut-brain axis pathways. We gathered four subjects utilizing a 250 Hz bioamp to monitor brain wave activity on the head and scalp including gastric activity, and used Zenodo's EGG dataset for the confirmation phase. We placed single-channel electrodes around the stomach to investigate gastric myoelectrical activity and extracted the EGG's power spectrum using a specific band-pass filter (0.03 - 0.07 Hz). We extracted the EGG's power spectrum and dominant frequency as our main features. Regarding brain electricity activities, we applied the FIR filter to obtain each brain wave's properties. We found that each subject had different responses during pre- and postprandial, both from primary and secondary resources. We found that the increase in EGG activity caused a change in EEG properties, particularly in the alpha band (8-12 Hz). Additionally, the EEG P3 site in the parietal lobe followed the power change rates of the EGG between 0 to 0.015 of relative power. We conclude that P3 and slow-wave gastric movement from EGG correspond to each other and reflect gut-brain axis pathways. However, future studies with larger samples must strengthen our findings according to the gut-brain axis pathways in the P3 site and EGG
Pengembangan Self-Nano Emulsifying System (SNES) Ekstrak Temulawak (Curcuma xanthorrhiza): Formulasi, Karakterisasi, dan Stabilitas Fitriani, Hannie; Fitria, Annisa; Miladiyah, Isnatin; Syukri, Yandi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 8 No 3 (2021): J Sains Farm Klin 8(3), Desember 2021
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.8.3.332-339.2021

Abstract

Ekstrak temulawak (Curcuma xanthorrhiza) yang sukar larut dalam air sudah banyak dikaji dan potensial untuk pengobatan berbagai penyakit. Pembuatan Self-Nano Emulsifying System (SNES) merupakan salah satu metode yang mampu meningkatkan kelarutan dan ketersediaan hayati suatu zat aktif obat dengan mencampurkannya ke dalam pembawa yang sesuai. Penelitian bertujuan untuk memformulasi, karakterisasi dan menguji stabilitas SNES ekstrak temulawak. Pembuatan SNES dimulai dari skrining dan optimasi pembawa ekstrak temulawak yang terdiri beberapa minyak, surfaktan dan kosurfaktan. SNES ekstrak temulawak dikarakterisasi meliputi pengukuran transmittan, ukuran partikel, indeks polidispersi (IP), potensial zeta, penentuan stabilitas termodinamika, uji ketahanan dan uji stabilitas dipercepat. Formula optimal SNES ekstrak temulawak adalah kombinasi Labrasol (20%), Tween 20 (60%), dan propilenglikol (20%), dengan drug loading ekstrak temulawak adalah 23%. Nilai parameter karakterisasi yang didapatkan adalah transmittan 100,2 ± 0,0%, ukuran partikel 13,0±1,4 nm dengan IP 0,3 ± 0,1, dan potensial zeta -42,4 ± 0,6 mV. Uji stabilitas termodinamika menunjukkan tidak terjadi pemisahan fase. Uji ketahanan menunjukkan bahwa ukuran partikel stabil selama proses pengenceran. Selain itu, SNES ekstrak temulawak stabil selama uji stabilitas dipercepat selama 3 bulan. Disimpulkan bahwa, SNES ekstrak temulawak menghasilkan sediaan yang stabil dengan drug loading yang tinggi.
Model Sistem Berbasis Pengetahuan untuk Rekomendasi Aktivitas Pensiun Prasetyo, Dono Catur; Kusumadewi, Sri; Miladiyah, Isnatin
Jurnal Teknologi Informasi dan Ilmu Komputer Vol 8 No 5: Oktober 2021
Publisher : Fakultas Ilmu Komputer, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25126/jtiik.2021854482

Abstract

Masa pensiun adalah masa yang pasti akan menghampiri setiap orang. Bila seseorang memasuki masa pensiun akan terjadi suatu perubahan yang penting dalam perkembangan hidup individu, yang ditandai dengan terjadinya perubahan keadaan seperti kehilangan finansial, kehilangan status, kehilangan teman/kenalan dan yang hilangnya kegiatan kerja yang rutin. Banyak orang yang tidak siap menghadapi pensiun, karena pensiun dianggap sebagai pemutus kegiatan rutin yang dijalananinya selama bertahun-tahun. Representasi pengetahuan sistem menggunakan kaidah produksi, proses inferensi menggunakan forward chaining dan proses perhitungan nilai kepastian menggunakan metode certainty factor. Forward chaining digunakan untuk proses pelacakan dari faktor-faktor yang telah terpilih untuk kemudian mencocokan dengan rule yang sudah ada di sistem agar dapat memberikan suatu konklusi, Setelah ditemukan rule yang cocok dari faktor-faktor yang terpilih kemudian di hitung dengan metode certainty factor untuk mengetahui tingkat keyakinan konklusi. Penggunaan dua metode ini bertujuan untuk memberikan hasil yang lebih baik dalam memberikan rekomendasi aktivitas pensiun. Hasil dari penelitian ini setelah melakukan pengujian User Acceptance Test (UAT)terhadap 30 responden pada sistem menghasilkan kesimpulan bahwa sistem ini membantu dalam memberikan rekomendasi aktivitas untuk persiapan pensiun dengan persentase 87,4%, tampilan antarmuka sistem sangat menarik dan juga informasi yang diberikan sangat jelas dengan persentase 86%, sistem yang dibangun ini mudah digunakan dengan persentase 82,6% dan sistem yang dibangun ini mudah dipelajari dengan persentase 80,6%. Hal tersebut ditunjukkan dengan nilai rata-rata persentase sebesar 80,06 %. Abstract Retirement is a period that is sure to come to everyone. When a person enters retirement, there will be an important change in the development of an individual's life, which is marked by changes in circumstances such as financial loss, loss of status, loss of friends/acquaintances, and loss of routine work activities. Many people are not ready to face retirement, because retirement is seen as a breaker in the routine that has been going on for years. The representation of system knowledge uses production principles, the inference process uses forward chaining and the process of calculating the certainty value uses the certainty factor method. Forward chaining is used for the tracking process of the factors that have been selected to then match the rules that already exist on the system to provide a conclusion, After finding a suitable rule from the selected factors then it is calculated by the certainty factor method to determine the level concluding beliefs. The use of these two methods aims to provide better results in providing recommendations for retirement activities. The results of this study after testing the User Acceptance Test (UAT) of 30 respondents on the system resulted in the conclusion that this system helps provide recommendations of activities for retirement preparation for a percentage of 87.4%, the system interface is very attractive and the information provided is very clear. With a percentage of 86%, the system built is easy to use with a percentage of 82.6%, and the system built is easy to learn with a percentage of 80.6%. This is indicated by the average percentage value of 80.06%.
Potential and toxicity effects of fish omega-3 fatty acid as a chemopreventive agent in colorectal cancer: A scoping review Syafitri, Indah; Rahmawati, Riana; Miladiyah, Isnatin
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art12

Abstract

Colorectal cancer (CRC), a malignancy that affects the colon and rectum, is influenced by gene mutations, epigenetic changes, local inflammation, and lifestyle risk factors. New cases of CRC globally account for 10%, with mortality at 9.4%, while Indonesia occupies the top four incidence and mortality cases. A family history of CRC requires preventive measures, including consuming functional foods to maintain the colon microenvironment. This article aims to review the potency and toxicity effects of omega-3 fish fatty acids as a chemopreventive agent against CRC. The data sources were original articles about omega-3 fish fatty acids as CRC chemopreventive agents, published in 2012-2022 and in English or Indonesian. Databases used are Ovid, ScienceDirect, ProQuest, PubMed, Springer Link, EBSCO, and Google Scholar using Boolean search. The selection of studies followed the PRISMA-ScR method. Of the nine articles selected, fish omega-3 fatty acids had the potential as a chemopreventive agent against CRC, with several variations in daily dose ranges accompanied by a good lifestyle. Oral omega-3 fish supplementation gave benefits in the range of 96 mg–2,000 mg of eicosapentaenoic acid (EPA) and between 360 mg–1,000 mg of docosahexaenoic acid (DHA), with a daily intake varying between 0–14 grams/day. One study reported a toxic effect of fish omega-3 fatty acids, which raised the risk of post-operative infection after parenteral (intravenous) administration. There are no reported side effects across eight studies following oral preparation administration. The omega-3 fish fatty acid shows potential as a chemopreventive therapy for CRC; further studies are required to explore the parenteral administration-associated toxic effects.  
Co-Authors AGUS RIYANTO Agustina T Alvin Sahroni Aminuyati Annisa Fitria Annisa Fitria Anora, Levina Arnetta Novitalia Bayu Rizky Prabowo Eka Yuliana Farida Juliantina Rachmawaty Fitriani, Hannie Hanafi, Mhd. Hannie Fitriani Hendra Setiawan Iqmal Tahir Irfan Jaen Fathani Iskandar Muda Siregar, Iskandar Muda Jumina Jumina Nurhayati Nurhayati Nuryadi, Satyo Prasetyo, Dono Catur Rahmawati, Riana Sisdarmanto Adinandra, Sisdarmanto Sofia Mubarika Haryana Sofyan, Pramudya Rakhmadyansyah Sri Kusumadewi Syafitri, Indah Trunogati, Pranandito Wiryatun Lestariana, Wiryatun Yandi Syukri