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All Journal International Journal of Electrical and Computer Engineering TEKNIK INFORMATIKA Jurnal Simetris Explore: Jurnal Sistem Informasi dan Telematika (Telekomunikasi, Multimedia dan Informatika) Jurnal Pengabdian Kepada Masyarakat Sakai Sambayan WARTA KLIK (Kumpulan jurnaL Ilmu Komputer) (e-Journal) Science and Technology Indonesia JOIV : International Journal on Informatics Visualization Jurnal Komputasi Jurnal Teknoinfo Jurnal Tekno Kompak Journal of Electronics, Electromedical Engineering, and Medical Informatics Jurnal Pengabdian Kepada Masyarakat (JPKM) Tabikpun Buguh: Jurnal Pengabdian Kepada Masyarakat Jurnal Pepadun Journal of Data Science and Software Engineering Warta LPM Laporan Upaya Nyata Inovasi Ilmu Komputer (LUNIK) Integra: Journal of Integrated Mathematics and Computer Science
Favorisen R. Lumbanraja
Jurusan Ilmu Komputer, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences Other

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Journal : JOIV : International Journal on Informatics Visualization

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A New Feature Extraction Approach in Classification for Improving the Accuracy of Proteins Damayanti, -; Lumbanraja, Favorisen Rosyking; Junaidi, Akmal; Sutyarso, -; Susanto, Gregorius Nugroho; Megawaty, Dyah Ayu
JOIV : International Journal on Informatics Visualization Vol 9, No 1 (2025)
Publisher : Society of Visual Informatics

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62527/joiv.9.1.2589

Abstract

Proteins play a vital role in life as essential macromolecules, consisting of linear heteromeric biopolymers formed by amino acids covalently bonded through peptide bonds. They contribute to cell development and bolster the body's defense mechanisms. Post-translational modification processes, such as glycosylation, are necessary for proteins to function optimally. Glycosylation involves adding sugar groups to proteins, playing a critical role in various protein folding processes. Dysregulation of protein glycosylation can lead to diseases like Alzheimer's and cancer. Manual classification of glycosylated proteins is time-consuming, necessitating a faster approach. This study aims to expedite glycosylated protein classification using novel methods like AAindex, CTD, SABLE, hydrophobicity, and PseAAC for increased accuracy, comparing them with existing approaches. The dataset comprises protein sequences sourced from the openly accessible UniProt database. Results demonstrate that glycosylated protein prediction achieved 100% accuracy, surpassing previous approaches. Several features contributed to this improvement, with Hydrophobicity making a significant contribution at 24%, and PseAAC making the most significant contribution at 40% among the five extraction methods developed.
Co-Authors - Damayanti Adawiyah, Laila Admi Syarif Aflaha Asri Ahyarudin Akbar, Mohammed Raihan Akmal Junaidi Amelia Jasmine Andrian, Rico Annisa Rizqiana Ardiansyah Ardiansyah Aristoteles, Aristoteles Asmiati Asmiati Astria Hijriani Astria Hijriani Aulia Putri Ariqa Ayu Amalia Bambang Hermanto Danu Sasmita Desti Fatmalasari Destian ade anggi Sukma Dian Kurniasari Didik Kurniawan Dwi Kartini, Dwi Dwi Sakethi Dwi Sakethi, Dwi Eliza Fitri Elly Lestari Rusitati Erdi Suroso Fanni Lufiana Fanni Lufiana Febi Eka Febriansyah Hadi, Normi Abdul Hamim Sudarsono . Hdiana, Yazid Zinedine Heningtyas, Yunda Ilman, Igit Sabda Indah Pasaribu Ira Hariati Br Sitepu Irawati, Anie Rose Jihan Aferiansyah Junaidi Junaidi Junaidi Junaidi Kristina Ademariana Kurnia Muludi Kurnia Muludi Kurnia Muludi Lilies Handayani M. Juandhika Rizky Machudor Yusman Manurung, Yunita Rosalina Megawaty, Dyah Ayu Meria Nensi Muhammad Reza Faisal, Muhammad Reza Muhammad Rizki Muhaqiqin, Muhaqiqin Muliadi Mustofa Usman Nadila Rizqi Muttaqina Naurah Nazhifah Nova Ayu Lestari Siahaan Nuning Nurcahyani Nurhasanah Nurhasanah Parabi, M. Iqbal Prabowo, Rizky Pratama, Rinaldo Adi Priyambodo Priyambodo Priyambodo Priyambodo Qory Aprilarita Rahmat Safe'i Rangga Agustiantino Reza Aji Saputra RM Sulaiman Sani Rosdiana, Siti Rudy Herteno Rudy Herteno Rusitati, Elly Lestari Saragih, Triando Hamonangan Shofiana, Dewi Asiah Sholehurrohman, Ridho Sintiya Paramitha Siti Aisyah Solechah Siti Rosdiana Su'admaji, Arif Susanto, Gregorius Nugroho Sutyarso, - Syangap Diningrat Sitompul TANJUNG, AKBAR RISMAWAN Tiyara Saghira Tristiyanto Tristiyanto Wamiliana Warsono Warsono Warsono Warsono Warsono YOHANA TRI UTAMI, YOHANA TRI Zuliana Nurfadlilah