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Pengaruh Ekstrak Virgin Olive Oil (EVOO) terhadap Ekspresi Nuclear Factor Kappa Beta (NF-kB) pada Tikus Rattus Novergicus Model Preeklamsia Dwi Norma Retnaningrum; Wenny Rahmawati
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.46795

Abstract

Preeclampsia is a serious condition that threatens the safety of pregnant women worldwide. This condition causes high blood pressure and organ dysfunction in pregnant women who have reached 20 weeks of gestation. One of the main causes of preeclampsia is cellular damage due to free radicals and inflammation in the body, which can be detected through increased levels of NF-kB protein that triggers inflammation. This research examines the benefits of extra virgin olive oil (EVOO) in addressing this problem. Extra virgin olive oil was chosen because it is rich in polyphenol compounds that can fight free radicals and reduce inflammation. The researchers wanted to prove whether giving extra virgin olive oil could reduce NF-kB protein levels in the placenta of experimental rats experiencing preeclampsia-like conditions. The study was conducted by comparing five groups of pregnant rats: a group without treatment, a group induced to develop preeclampsia, and three groups given extra virgin olive oil at different doses (0.5 mL, 1 mL, and 2 mL per day). The research results showed that extra virgin olive oil administration was proven effective in reducing NF-kB protein levels in rat placenta, and the higher the dose given, the better the results. These findings provide hope that extra virgin olive oil can be a safe and natural complementary treatment option to help reduce inflammation in pregnant women with preeclampsia. This research paves the way for utilizing natural ingredients in preventing and managing preeclampsia, which ultimately can help save the lives of mothers and babies.
The Effect of Modified Supplementary Feeding with Mung Bean Porridge Enriched with Ginger and Lemongrass (PMT Burjo Jase) on Weight Gain in Toddlers Satriani, Desak; Amalia, Waifti; Rahmawati, Wenny
Media Husada Journal of Midwifery Science Vol. 4 No. 1 (2026): Januari
Publisher : LPPM Widyagama Husada Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33475/mhjms.v4i2.39

Abstract

Nutrition is important for supporting the growth and development of toddlers. Providing supplementary foods made from local ingredients is one strategy for addressing nutritional problems in toddlers and preventing stunting. The purpose of this study was to determine the effect of modifying the provision of supplementary foods consisting of mung bean porridge with ginger and lemongrass on weight gain in toddlers at the Adenium RW 14 Posyandu in Sumberporong Village. The research design used a Quassy Experimental Design with a one-group pretest and posttest design. The research population consisted of 23 toddlers. Sampling was conducted using purposive sampling. The researcher required inclusion and exclusion criteria. The research was conducted over 14 days. The research instruments used were digital scales, KIA books, questionnaires, and observation sheets. The analysis used was univariate and bivariate using the Wilcoxon test. Based on the statistical test results, the significance value was 0.000, which was not greater than 0.05, meaning that there was an effect of modifying the provision of mung bean porridge with ginger and lemongrass as supplementary food on increasing the weight of toddlers at the Posyandu. The results of the study showed that the average weight gain of toddlers was 0.33 kg. It can be concluded that there is an effect of supplementary feeding on toddlers in the form of modified supplementary feeding of mung bean porridge with ginger and lemongrass. It is recommended that village midwives create various programs to improve the nutritional status of toddlers and add references to the PMT menu.