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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Media Dermato-Venereologica Indonesiana
Medhi Denisa Alinda, Medhi Denisa
Department Of Dermatology And Venereology, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Teaching Hospital, Surabaya
Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Dermoscopy Supports the Diagnose of Papulosquamous Disorders Alinda, Medhi Denisa; Hutomo, Marsudi; Setyaningrum, Trisniartami
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (108.201 KB) | DOI: 10.20473/bikkk.V26.3.2014.1-7

Abstract

Background: The diagnose of papulosquamous skin disorder was established by clinical symptoms. However, some of papulosquamous manifestation are alike with each other and lead to misdiagnostic. Histopathology examination usually can help to establish diagnose but this method is invasive and time consuming. Purpose: To evaluate dermoscopic features of papulosquamous disorder. Methods: Descriptive observasional cross sectional study, total sampling in ward and out patient clinic of Dermato-venereology Department Dr. Soetomo General Hospital. Twenty four samples were included in the study, followed by the procedures from anamnesis, physical examination, dermoscopy procedures, and histopathology examination. Results: From 24 samples, 19 samples showed plaque psoriasis describing 12 ring patterns, 1 cluster pattern, 2 patchy patterns, 2 reguler patterns, and 2 unspesific patterns; 3 samples showed nummular dermatitis describing 2 cluster patterns and 1 unspesific pattern; and 2 samples showed pityriasis rosea describing 2 pheripery patterns. Conclusion: Dermoscopy can support the diagnosis of papulosquamous skin disorder especially plaque psoriasis.Key words: papulosquamous disorder, dermosocopy, histopathology examination, plaque psoriasis.
Dermoscopy Supports the Diagnose of Papulosquamous Disorders Medhi Denisa Alinda; Marsudi Hutomo; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 26 No. 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V26.3.2014.1-7

Abstract

Background: The diagnose of papulosquamous skin disorder was established by clinical symptoms. However, some of papulosquamous manifestation are alike with each other and lead to misdiagnostic. Histopathology examination usually can help to establish diagnose but this method is invasive and time consuming. Purpose: To evaluate dermoscopic features of papulosquamous disorder. Methods: Descriptive observasional cross sectional study, total sampling in ward and out patient clinic of Dermato-venereology Department Dr. Soetomo General Hospital. Twenty four samples were included in the study, followed by the procedures from anamnesis, physical examination, dermoscopy procedures, and histopathology examination. Results: From 24 samples, 19 samples showed plaque psoriasis describing 12 ring patterns, 1 cluster pattern, 2 patchy patterns, 2 reguler patterns, and 2 unspesific patterns; 3 samples showed nummular dermatitis describing 2 cluster patterns and 1 unspesific pattern; and 2 samples showed pityriasis rosea describing 2 pheripery patterns. Conclusion: Dermoscopy can support the diagnosis of papulosquamous skin disorder especially plaque psoriasis.Key words: papulosquamous disorder, dermosocopy, histopathology examination, plaque psoriasis.
Diagnosis and Management of Leprosy Medhi Denisa Alinda; Silvani Geani; Regitta Indira Agusni; Bagus Haryo Kusumaputra; Novianti Rizky Reza; Cita Rosita Sigit Prakoeswa; Muhammad Yulianto Listiawan
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 2 (2020): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.2.2020.149-157

Abstract

Background: Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which tends to attack peripheral nerves and skin. The diagnosis of leprosy is based on the presence of one of three cardinal signs. Early diagnosis of leprosy is critical and is made through clinical examination and investigation. Purpose: To discuss the diagnosis, laboratory examination, and treatment of leprosy, considering that early diagnosis and appropriate treatment are the key elements in breaking the chain of transmission and preventing leprosy patients' disabilities. Review: Leprosy is a chronic granulomatous infectious disease caused by the Mycobacterium leprae. Based on clinical appearance, histopathology findings, and immunological, leprosy is grouped into six forms using the Ridley-Jopling classification, namely Tuberculoid (TT), Borderline Tuberculoid (BT), Borderline-borderline Mid-borderline (BB), Borderline-lepromatous (BL), Subpolar Lepromatous (LLs), and Polar Lepromatous (LLp). Based on the treatment category, leprosy is grouped into paucibacillary (PB) and multibacillary (MB). Leprosy is often diagnosed clinically, and skin scraping smear remains the preferred laboratory method. The negative results of smear skin scraping may not necessarily exclude leprosy. Therefore, a higher sensitivity test might be needed to detect M. leprae. Treatment with Multi-Drug Therapy (MDT) is adjusted based on the type of leprosy, whether it belongs to the PB or MB group. Treatment of PB type, regimens are rifampicin and dapsone, while in MB type, the patients received rifampicin, dapsone, and clofazimine regimens. Conclusion: A proper diagnosis for leprosy, both through physical examination and laboratory examination, is required to determine an effective MDT treatment and break the chain of disease transmission.
Measurements and Accuracy of IgM and IgG Anti Phenolic Glycolipid-1 Levels in Blood Serum for Early Detection Mycobacterium leprae by using Enzyme-Linked Immunosorbent Assay (ELISA): A Reality of a Laboratory Abdullah, Salsabilla Putri Kinanti; Dinar Adriaty; Iswahyudi; Puput Ade Wahyuningtyas; Laura Navika Yamani; Medhi Denisa Alinda; Ratna Wahyuni; Cita Rosita Sigit Prakoeswa
Indonesian Journal of Tropical and Infectious Disease Vol. 11 No. 2 (2023)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v11i2.43481

Abstract

Indonesia was the third most recent case of leprosy globally in 2020 with 11,173 people, after India and Brazil. Most of the leprosy manifestations are asymptomatic. This is possibly as subclinical leprosy which individuals without leprosy symptoms but have leprosy specific antibodies high levels, so it has the potential to become a transmission and disability. Therefore, an ELISA test need for early detection in preventing leprosy transmission. This study aims to measure IgM and IgG antibody levels in leprosy patients and assess the accuracy of the measurement results. This research is a cross-sectional study. Five patients' blood samples have analyzed for IgM and IgG anti-PGL-1 antibody levels by ELISA. Accuracy interpretation of this measurement based on the %CV. Antibody levels were classified based on the cut-off <605 u/ml as IgM seronegative or <630 u/ml as IgG seronegative, 605–1000 u/ml as low seropositive IgM or 630-1000 u/ml as low seropositive IgG, and >1000 u/ml as high seropositive IgM and IgG. Among five patients examined, 40% had high seropositive leprosy with anti-PGL-1 IgM and IgG antibody titers>1000 u/ml, and 60% of patients had seronegative leprosy. Accuracy in this ELISA test shows high accuracy with %CV <10% in the conversion of OD to antibody titer levels.  IgM and IgG Anti PGL-1 antibody titers by ELISA as one of the parameters in identifying patients at higher risk of leprosy. A significant portion of patients with high seropositive leprosy with high accuracy.
A Retrospective Study: Epidemiology, Onset, and Duration of Erythema Nodosum Leprosum in Surabaya, Indonesia Fransisca, Cindy; Zulkarnain, Iskandar; Ervianti, Evy; Damayanti, Damayanti; Sari, Maylita; Budiono, Budiono; Alinda, Medhi Denisa; Kusumaputra, Bagus Haryo; Prakoeswa, Cita Rosita Sigit; Listiawan, Muhammad Yulianto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 1 (2021): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.1.2021.8-12

Abstract

Background: Erythema nodosum leprosum (ENL) has a chronic and recurrent nature which could reduce patient's quality of life in addition to the onset of ENL that occurs before, during, or after multidrug treatment, further emphasizing the importance of regular control and education.Purpose:This study aimed to evaluate the epidemiology, onset, duration, and recurrence of ENL. Methods:Data from medical records were obtained for a 3-year retrospective study of multibacillary leprosy patients at the Leprosy Division of the Dermatology and Venereology Outpatient Department, Dr. Soetomo General Hospital Surabaya, with a minimum of 2–5 years follow-up period.Result:The prevalence of  ENL continued to increase almost every year especially in 2017 (32% in 2015; 32% in 2016; and 36% in 2017). ENL most often occurs during the first year of multi-drug therapy (MDT) administration followed by after the release from treatment (RFT) with the latest onset occurring 4 years after RFT. The majority of patients experienced chronic and recurrent reactions with the longest reactions lasting up to 4.5 years (55 months). Conclusion:Knowledge about the onset, duration, and recurrences of ENL are essential, and strict supervision for routine control shall be encouraged to increase the patients' compliance so as to increase their quality of life.
Epidemiology of Leprosy in Indonesia: a Retrospective Study Lubis, Ramona Sari; Anum, Qaira; Argentina, Fifa; Menaldi, Sri Linuwih; Gunawan, Hendra; Yuniati, Renni; Mulianto, Nur Rachmat; Siswati, Agnes Sri; Widasmara, Dhelya; Rusyati, Luh Made Mas; Mamuaja, Enricco Hendra; Muchtar, Vitayani; Cita Rosita Sigit Prakoeswa; Agusni, Regitta Indira; Bagus Haryo Kusumaputra; Medhi Denisa Alinda; Listiawan, Muhammad Yulianto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.29-35

Abstract

Background: According to WHO data, the number of new cases of leprosy has decreased in 2019. However, Indonesia continues to provide a significant number of cases. According to statistics, India, Brazil, and Indonesia account for 79 percent of all instances. Purpose: This study aims to describe the profile of leprosy patients, and involves all Dermatology and Venereology Academic Hospitals in Indonesia. Methods: This study was a retrospective study of 2461 patients from Dermatology and Venereology Outpatient Clinic at 13 Academic Hospitals in Indonesia between January 2018 and December 2020. Result: Subjects in this study were dominated by males (66.8%) and aged > 14 years (95.3%). The most common type of leprosy was multibacillary (MB) (86.2%), and erythema nodosum leprosum (ENL) was the most leprosy reaction (20.3%). Majority of the subjects experienced disability in the hands (26.6%), in grade 1. Conclusion: Leprosy cases in Indonesia are mostly experienced by adult males. The most common type of leprosy is MB, with ENL being the most common leprosy reaction. Grade 1 disability is the most prevalent, therefore proper education is necessary to keep patients from progressing to grade 2 disability.
Evaluation of Histopathology Findings of Clinically Confirmed Psoriasis Vulgaris Sawitri; Fadila, Arisia; M. Yulianto Listiawan; Priangga Adi Wiratama; Dwi Murtiastutik; Evy Ervianti; Linda Astari; Damayanti; Diah Mira Indramaya; Afif Nurul Hidayati; Medhi Denisa Alinda
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 1 (2023): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.1.2023.21-26

Abstract

Background: Psoriasis vulgaris can be diagnosed clinically. A biopsy is usually used to confirm non-classic cases. The findings of the histopathology feature are not usually present, thus clinical relevance is needed to confirm the diagnosis. Purpose: To describe the histopathology findings from tissue samples of histopathologically confirmed psoriasis vulgaris reported in the Department of Pathology and Anatomy of Dr. Soetomo General Hospital. Methods: A descriptive-retrospective study of pathology-ascertained tissue samples of histopathologically confirmed psoriasis vulgaris was reported in the Department of Pathology and Anatomy from patients who were also previously diagnosed clinically with psoriasis vulgaris in the Dermatology and Venereology Outpatient Unit of Dr. Soetomo General Academic Hospital over a period of 2 years. Morphological parameters were observed after histopathology sections were stained with hematoxylin and eosin. Result: Thirty-three tissue samples were examined. Parakeratosis (86%) and hypogranulosis (70.3%) were the most observed findings. Club-shaped rete ridges, suprapapillary plate thinning, and spongiform pustules of Kogoj were the least observed findings (each by 2.7%). Three tissue samples (8.1%) showed only parakeratosis. Only 1 tissue sample (2.7%) showed 4 features (absence of the granular layer, parakeratosis, microabscess of Munro, and spongiform pustules of Kogoj). No tissue sample showed every histopathology finding of psoriasis vulgaris. Conclusion: All of the histopathology features of psoriasis vulgaris are rarely found in one tissue section. Albeit histopathology is believed to be the gold standard diagnosis of psoriasis vulgaris, relevance with clinical findings is still mandatory to support the diagnosis.
Clinical Manifestations and Distribution of Treatment for Pyoderma at a Tertiary Hospital in Surabaya, Indonesia Auliya, Arsya; Astari, Linda; Puspitasari, Dwiyanti; Alinda, Medhi Denisa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 36 No. 1 (2024): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V36.1.2024.12-19

Abstract

Background: Pyoderma is a skin disease caused by infection with Gram-positive bacteria. In Indonesia, this disease has a high prevalence due to inadequate sanitation, climate condition, humidity, and high population density. Patients with pyoderma present in diverse range of symptoms, in the form of clinical manifestation or systemic symptoms. Inadequate management of pyoderma can lead to an escalation in morbidity rates. Therefore, it is important to conducting comprehensive research about clinical profile of pyoderma patients. Purpose: To describe the profile of pyoderma patients in Dermatology and Venereology Outpatient Unit of Dr. Soetomo General Acdemic Hospital Surabaya in January 2016 to December 2018. Methods: This study is a retrospective descriptive analysis using secondary data derived from medical records at Dermatology and Venereology Outpatient Unit of Dr. Soetomo General Academic Hospital Surabaya. Result: The analysis of pyoderma patient at Dermatology and Venereology Outpatient Unit of Dr. Soetomo General Academic Hospital Surabaya in January 2016 to December 2018 reveals a total of 407 patients, predominantly male and the most age category were toddlers. Most clinical diagnosis were furuncles and carbuncles. Among the clinical manifestations, macula was the most frequent primary skin lesion, while erosion predominated among secondary lesions. The most commonly administered therapies were systemic and topical antibiotics. Conclusion: In the period from January 2016 to December 2018, clinical manifestations of pyoderma patients at the Dermatology and Venereology Outpatient Unit of Dr. Soeto...
PERKEMBANGAN GLOBAL PENELITIAN DERMATOLOGI ANAK DALAM DUA DEKADE TERAKHIR: Perkembangan Global Penelitian Dermatologi Anak Kinanti, Hapsari; Agusni, Regitta Indira; Nurasrifah, Dewi; Widia, Yuri; Reza, Novianti Rizky; Alinda, Medhi Denisa; Damayanti, Damayanti; Hidayati, Afif Nurul
Media Dermato-Venereologica Indonesiana Vol 52 No 3 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i3.456

Abstract

Pendahuluan: Penelitian di bidang dermatologi anak terus berkembang sejak tahun 1986. Jumlah penelitian yang terus meningkat menimbulkan tantangan bagi tenaga kesehatan dalam mengikuti dan memahami seluruh perkembangan ilmu pengetahuan. Penelitian ini bertujuan menyajikan perkembangan terkini dalam bidang dermatologi anak yang dapat digunakan sebagai dasar untuk menentukan arah penelitian lebih lanjut. Metode: Kajian bibliometrik menggunakan data dari Scopus dianalisis menggunakan Biblioshiny dan VOSviewer untuk memberikan gambaran mengenai produktivitas dan tren topik penelitian. Hasil: Dalam dua dekade terakhir, terdapat peningkatan jumlah produksi artikel mengenai dermatologi anak setiap tahunnya. Negara yang paling produktif menghasilkan artikel didominasi oleh negara maju. Dua topik yang paling banyak diteliti adalah dermatitis atopik dan psoriasis, aspek keamanan terapi biologis, dan terapi target agar dapat digunakan pada populasi anak sedini mungkin. Penanganan hemangioma infantil dan erupsi obat pada anak menggunakan agen sistemik dan biologis sedang gencar diteliti pada dekade terakhir. Teledermatologi dan artificial intelligence menjadi gambaran pelayanan dermatologi anak di masa yang akan datang. Hal ini menunjukkan bahwa penelitian di bidang dermatologi anak masih terus berkembang. Kesimpulan: Diperlukan kolaborasi antara peneliti di negara berkembang dan negara maju untuk memperluas subjek penelitian dan menciptakan hasil penelitian dengan dampak yang lebih besar. 
Co-Authors Abdullah, Salsabilla Putri Kinanti Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Agnes Sri Siswati Anum, Qaira Auliya, Arsya Bagus Haryo Kusumaputra Bagus Haryo Kusumaputra Bagus Haryo Kusumaputra, Bagus Haryo Budiono Budiono Cindy Fransisca, Cindy Cita Rosita Sigit Prakoeswa Damayanti Damayanti Damayanti Dhelya Widasmara Diah Mira Indramaya DINAR ADRIATY Dwi Murtiastutik Dwiyanti Puspitasari, Dwiyanti Evy Ervianti Fadila, Arisia Fifa Argentina Iswahyudi Jayawarsa, A.A. Ketut Kinanti, Hapsari Laura Navika Yamani Linda Astari, Linda Lubis, Ramona Sari Luh Made Mas Rusyati M. Yulianto Listiawan Mamuaja, Enricco Hendra Marsudi Hutomo Marsudi Hutomo, Marsudi Maylita Sari, Maylita Muchtar, Vitayani Mulianto, Nur Rachmat Novianti Rizky Reza Nurasrifah, Dewi Priangga Adi Wiratama Puput Ade Wahyuningtyas Ratna Wahyuni Regitta Indira Agusni Renni Yuniati Reza, Novianti Rizky Sawitri Silvani Geani Sri L. Menaldi Tengku Riza Zarzani N Trisniartami Setyaningrum Yuri Widia, Yuri