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All Journal journal of internal medicine Jurnal Kedokteran Brawijaya Jurnal Biosains Pascasarjana Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Paediatrica Indonesiana Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology Narra J JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Jurnal Keperawatan Jurnal Penyakit Dalam Indonesia Indonesian Journal of Biomedicine and Clinical Sciences Folia Medica Indonesiana
Gatot Soegiarto
Allergy & Clinical Immunology Division, Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Correlation between interleukin-6 expression in post-mortem core liver biopsy and degree of liver injury in patients with fatal COVID-19 Maimunah, Ummi; Maharani, Andi RK.; Soegiarto, Gatot; Rahniayu, Alphania; Gunawan, Vania A.; Wiratama, Priangga A.; Djuanda, Stephanie N.; Supriadi, Supriadi; Marhana, Isnin A.; Semedi, Bambang P.; Lefi, Achmad; Kusumastuti, Etty H.; Suyanto, Edi; Lilihata, Jilientasia G.; Anggoro, Adhitri; Rinjani, Lalu GP.; Rosyid, Alfian N.; Wahyu, Dwi; Fauziah, Dyah; Rahaju, Anny S.; Kurniasari, Nila; Ariani, Grace; Nugroho, Gilang MS.; Yandi, I KR.; Nugraha, Ricardo A.
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.463

Abstract

Excessive release of interleukin-6 (IL-6) during the progression of coronavirus disease 2019 (COVID-19) induces cytokine storms, resulting in multi-organ damages including liver injury, similar in nature with mechanism of viral hepatitis. Systemic IL-6 has been associated with the incidence of liver injury among COVID-19 patients; however, studies on IL-6 expression in the liver tissue are completely lacking. The aim of this study was to measure the IL-6 expression in the liver tissues and to determine its correlation with the degree of liver injury in fatal COVID-19 patients. Through this first cross-sectional study, IL-6 expression was measured through immunohistochemical staining and the degree of liver injury was identified based on level of serum alanine aminotransferase (ALT). The Spearman correlation test was used to identify the correlation between IL-6 expression and the degree of liver injury. A total of 47 deceased COVID-19 patients were included and IL-6 expression was observed in all post-mortem liver specimens, ranging from mild to strong expression. Liver injury at various degrees (mild to severe) was found in more than half (59.5%) of the cases. The Spearman correlation analysis suggested a statistically insignificant correlation between liver IL-6 expression and the degree of liver injury (r=0.152; p=0.309). In conclusion, even IL-6 expression was observed in all post-mortem liver specimens, there was an insignificant correlation between IL-6 expression in the liver tissue with the degree of liver injury among fatal COVID-19 patients, suggesting that IL-6 was not the only main factor contributing to liver damage in COVID-19 patients.
More severe comorbidities, advanced age, and incomplete vaccination increase the risk of COVID-19 mortality Pradhevi, Lukita; Soegiarto, Gatot; Wulandari, Laksmi; Lusida, Michael AP.; Saefudin, Rendra P.; Vincent, Agustinus
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.949

Abstract

Numerous studies have stated that comorbidities are risk factors for coronavirus disease 2019 (COVID-19) mortality, but few have considered the severity or stage of these comorbidities. The aim of this study was to determine the association between the severity of comorbidity, age, and number of COVID-19 vaccinations with COVID-19 mortality. This case-control study was conducted from July 2021 until December 2022 at the Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. The patients were divided into non-survived patients (case group) and survived patients (control group). The inclusion criteria for cases were adult patients hospitalized with confirmed COVID-19, based on reverse transcriptase-polymerase chain reaction (RT-PCR) testing of nasopharyngeal swabs. Using total sampling, 1,046 confirmed COVID-19 patients, which consisted of 450 (43%) non-survived patients and 596 (57%) survived patients, were included. The most common comorbidity was diabetes mellitus (DM) (82.7%), chronic kidney disease (CKD) (43%), hypertension (25.7%), and obesity (23.6%). Our multivariate analysis indicated that older age (aOR: 1.03; 95%CI: 1.02–1.04, p<0.001), male sex (aOR: 1.29; 95%CI: 1.11–2.00, p=0.007), severe COVID-19 at first admission (aOR: 3.13; 95%CI: 2.08–4.73, p<0.001), having pneumonia (aOR: 1.99; 95%CI: 1.21–3.33, p=0.005), poorly controlled DM with HbA1c≥9% (aOR: 2.90; 95%CI: 1.72–4.89, p<0.001), severe obesity with body mass index (BMI)≥30 (OR: 2.90; 95%CI: 1.72–4.89, p<0.001), hypertension stage 2 (aOR: 1.99; 95%CI: 1.12–3.53, p=0.019) or stage 3 (aOR: 6.59; 95%CI: 2.39–18.17, p<0.001), CKD stage 3 (aOR: 2.50; 95%CI: 1.36–4.59, p=0.003), stage 4 (aOR: 5.47; 95%CI: 2.18–13.69, p<0.001) or stage 5 (aOR: 1.71; 95%CI: 1.04–2.81, p=0.036), and having chronic lung disease (aOR: 3.08; 95%CI: 1.22–7.77, p=0.017) significantly increased the risk of COVID-19 mortality. In contrast, COVID-19 vaccination reduced the risk of COVID-19-associated death. This study highlights that more severe comorbidities, advanced age, and incomplete vaccination were associated with COVID-19 mortality.
Co-Authors Aldise Mareta, Aldise Alpha Fardah Athiyyah Alphania Rahniayu Anang Endaryanto Anggoro, Adhitri Ari Baskoro Ariani, Grace Atmaja, Peter Yustian Azwin Mengindra Putera Bayu Dharma S Budi Utomo Camilia Metadea Aji Savitri Chairul Effendi Chandra, Christopher Marcellino Cita Rosita Sigit Prakoeswa Damayanti, Luki Agustina Deasy Fetarayani Delvac Oceandy Dewajani Purnomosari, Dewajani Dewajani Purnomosari3 Dian Ristanti Djoko Poetranto, Djoko Djuanda, Stephanie N. DYAH FAUZIAH, DYAH Edi Suyanto Edith Frederika, Edith Fahmita, Karin Dhia Far-Far, Imanuel Gunawan, Vania A. Handoko Hariyono Hariftyani, Arisvia Sukma Hendra Ikhwan Gautama Hermina Novida, Hermina INGRID SURYANTI SURONO Isyroqiyyah, Nur Moya Isyroqiyyah, Nur Moya Konthen, Putu Gedhe Kristyono, Irwan Kurnia, David Kusumastuti, Etty H. Laksmi Wulandari Lefi, Achmad Lilihata, Jilientasia G. Lucia Landia Setyowati, Lucia Landia Lusida, Michael AP. Maharani, Andi RK. Mahdi, Bagus Aulia Marhana, Isnin A. Masaoki Yamaoka, Masaoki Muhammad Amin Mukti Fahimi Nila Kurniasari Noer Halimatus Syakdiyah Nugraha, Ricardo A. Nugroho, Gilang MS. Nugroho, Puguh Setyo Pradhevi, Lukita Rahaju, Anny S. Reinaldi Rachmadhianto Resti Yudhawati Retno Asih Setyoningrum Rinjani, Lalu GP. Ristanti, Dian Rosyid, Alfian N. S.Pd. M Kes I Ketut Sudiana . Saefudin, Rendra P. Semedi, Bambang P. Setiawati, Yuani Setyobudi, Assyadilla Kirana soedarto soedarto, soedarto Supriadi Supriadi Suwandi Tri Hartini Yuliawati Ummi Maimunah Vincent, Agustinus Wahyu, Dwi Wiratama, Priangga A. Yandi, I KR. Yetti Hernaningsih Yosephi, Valensa Yuani Setiawati Yudianto, Valentino Ryu