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All Journal VALENSI Jurnal Penelitian Saintek SAINS DAN MATEMATIKA JURNAL KIMIA SAINS DAN APLIKASI Jurnal Ilmu Lingkungan Chem Info Alchemy Jurnal Penelitian Kimia INDONESIAN JOURNAL OF PHARMACY Indonesian Journal of Chemistry Greensphere: Journal of Environmental Chemistry

Ngadiwiyana M.Si. S.Si.

Department Of Chemistry, Faculty Of Science And Mathematics, Diponegoro University Jl. Prof. H. Soedarto SH Tembalang, Semarang 50275, Indonesia

Author-ID : 329767

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Energy Engineering Environmental Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology

Published : 49 Documents Claim Missing Document

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Application of Functionalized Multi-Walled Carbon Nanotubes for Growth Enhancement of Mustard Seed Germination Agus Subagio; Erma Prihastanti; Ngadiwiyana Ngadiwiyana
Indonesian Journal of Chemistry Vol 20, No 1 (2020)
Publisher : Universitas Gadjah Mada

Multi-walled carbon nanotubes (MWCNTs) are one of the nanomaterials that can be applied to agriculture. This work investigates the beneficial effects of MWCNT function on mustard plants. In this study, the material of MWCNTs is functionalized with nitric acid to attach the carboxylic group onto the tube wall. The functionalized MWCNTs were characterized by SEM, TEM, XRD, and FTIR. The MWCNT diameter produced ranges from 20 to 50 nm and the inner diameter is 5 to 10 nm at the pyrolysis temperature of 900 °C. It was found that crystallites of the MWCNTs have (002) and (100) directions. There is a weak peak in MWCNTs prior to the functionalization process due to the presence of metal carbide (Fe3C), which serves as an active catalyst. FTIR results clearly indicate the presence of hydroxyl and carboxylic groups. These functionalized MWCNTs were dispersed into distilled water with various concentrations at 25, 50 and 75 µg/mL. By utilizing an immersion time of 24 h, mustard (Brassica juncea) seeds were soaked in each functionalized and non-functionalized MWCNT solution. Functionalized MWCNT solution at a concentration of 50 µg/mL was found to affect the growth of mustard seeds more significantly.

Synthesis, Characterization, and Study of Proton Exchange Polymer Membrane Properties of Sulfonated Copolymer Eugenol-diallyl Phthalate Ngadiwiyana Ngadiwiyana; Nor Basid Adiwibawa Prasetya; Gunawan Gunawan; Tutuk Djoko Kusworo; Heru Susanto
Indonesian Journal of Chemistry Vol 21, No 1 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.55353

Synthesis biopolymer of sulfonated copolymer eugenol-diallyl phthalate (PEGDAF), its characterization, and study of proton exchange polymer membrane properties had been done. This synthesis was conducted by eugenol and diallyl phthalate reaction to form PEGDAF, which is sulfonated using sulfuric acid. In addition, the functional groups of the PEGDAF and its sulfonated form were analyzed using FT-IR. Furthermore, the polymer properties were determined by measuring values of sulfonation degree, cation exchange capacity, proton conductivity, and water uptake. FT-IR spectra showed that the vinyl group had been added to the process of PEGDAF formation, while spectra deconvolution was used to confirm the occurrence of sulfonation reaction. The sulfonation of PEGDAF in 2 h optimum reaction time produces a black solid with a melting point of 133 °C in 16.55% yield. The highest proton conductivity, cation exchange capacity (CEC), and water uptake were 8.334 × 10–6 S cm–1, 0.44 meq/g, and 73.0%, respectively.

Pemanjangan Sistem Terkonjugasi Sinamaldehid dan Uji Aktivitas sebagai Bahan Aktif Tabir Surya Ngadiwiyana Ngadiwiyana; Ismiyarto Ismiyarto; Khairul Anam
Jurnal Kimia Sains dan Aplikasi Vol 7, No 1 (2004): Volume 7 Issue 1 Year 2004
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Telah dilakukan pemanjangan sistem terkonjugasi sinamaldehid dengan reaksi aldol kondensasi. Penelitian ini diawali dengan mengisolasi sinamaldehid dari minyak kayu manis menggunakan pelarut natrium bisulfit. Selanjutnya sinamaldehid direaksikan dengan asetofenon melalui reaksi kondensasi. Analisis struktur senyawa hasil menggunakan spektrometer UV-Vis dan spektrometer infra merah, selanjutnya penentuan SPF dari produk yang dihasilkan dilakukan dengan mengukur absorbansinya terhadap sinar UV.Sinamaldehid didapatkan sebagai cairan jernih kekuningan dengan kemurnian 99,87% dan rendemen 82,00%. Senyawa hasil kondensasi didapatkan sebagai padatan berwarna kuning dengan titik lebur 540C, rendemen 72,21%. Analisis dengan spektometer UV-Vis memberikan serapan pada 312 nm dan 224 nm, sedangkan dengan IR mempunyai pita pada 1676,0 cm-1 (-C=O), 1604 cm-1 (–C=C-), 3028 (=C-H), dan 1575 cm- (cincin aromatis). Sinamaldehid mampu memberikan perlindungan SPF maksimum pada konsentrasi 10 g/mL, sedangkan senyawa hasil reaksi mampu memberikan perlindungan maksimum pada konsentrasi 6 g/mL.

Antibacterial and Antioxidant Activity of Endophytic Bacteria Isolated from Hibiscus tilaceus Leaves Purbowatiningrum Ria Sarjono; Aulia Anggraeni; Afiina Putri Monita; Mukhammad Asy’ari; Ismiyarto Ismiyarto; Ngadiwiyana Ngadiwiyana; Nor Basid Adiwibawa Prasetya
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 8, No. 2, November 2022
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v8i2.25686

Antibacterial is a compound that inhibits or kills bacteria, especially infectious pathogenic bacteria. Antioxidants are compounds to inhibit the activity of free radicals in the body. The leaf extract of the waru plant (Hibiscus tiliaceus) is reported to have antibacterial, antioxidant, and anti-inflammatory activity. Bioactive compounds obtained from plants generally require a lot of plant availability and large areas for growth and take a long time. One solution to solve this problem is to isolateendophytic bacteria from plants. Endophytic bacteria are bacteria that live symbiotically in the host tissue so that they can produce the same bioactive compounds as the host. In the study, several stages were carried out, including isolation of endophytic bacteria from hibiscus leaves, gram-staining of bacteria, secondary metabolites production, antibacterial activity analysis by disk method,antioxidant activity analysis by DPPH free radical scavenger method, phytochemical screening, and identification of genotypic endophytic bacteria. Isolates of endophytic bacteria from Hibiscus tiliaceus leaves were obtained in cocci. They formed gram-positive bacteria with the closest relationship with Staphylococcus warneri strainAW 25 and Staphylococcus pasteuri strainATCC 51129. Endophytic bacteria from the Hibiscus tiliaceus leaves produce secondary metabolites containing alkaloids and saponins that can inhibit the growth of Staphylococcus aureus and Salmonella typhi and can be an antioxidant agent.

Calcium Phosphate Cement Composed of Hydroxyapatite Modified Silica and Polyeugenol as a Bone Filler Material Tri Windarti; Nor Basid Adiwibawa Prasetya; Ngadiwiyana Ngadiwiyana; Limpat Nulandaya
Indonesian Journal of Chemistry Vol 23, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.80298

A composite of hydroxyapatite modified silica (HASiO2) and 10% (w/w) polyeugenol (PE) was synthesized to produce a calcium phosphate cement with antibacterial activity. The compatibility of the composite (HASiO2_PE) with bone filler requirements was determined due to its crystal, surface, antibacterial, and cytocompatibility properties. The results showed that compositing HASiO2 and PE did not affect HA's chemical dan crystal properties. The presence of PE changed HASiO2 morphology to be coarser and denser than before composited. PE tends to agglomerate but does not affect the hydrophilicity of HASiO2. The presence of PE increased the surface area and total pore volume but lowered the average pore size. Different from pure PE, the composite of HASiO2_PE that contains of 10% PE has higher antibacterial activity toward Escherichia coli than Staphylococcus aureus. The composite is biocompatible because the cytotoxicity test toward pre-osteoblast cells resulted in an IC50 of 2092 μg/mL. Thus, due to its chemical, surface, antibacterial, and cytocompatibility properties, the HASiO2_PE composite can be recommended as a bone filler material.

Antibacterial Activity of Cinnamic Acid - Chitosan Encapsulation Nur Amaliyah; Purbowatiningrum Ria Sarjono; Ngadiwiyana Ngadiwiyana; Ismiyarto Ismiyarto
Jurnal Kimia Sains dan Aplikasi Vol 21, No 1 (2018): Volume 21 Issue 1 Year 2018
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

The biggest cinnamon bark is cinnamic acid. The inhibitory activity of bacterial growth of S. aureus and E. coli and its abundance in nature becomes the superiority of cinnamic acid as antibacterial. However, the use of cinnamic acid as an antibacterial is still less than optimal because of low solubility in water. One of the latest technologies to address the problem is encapsulation in nanometer size. Encapsulation of cinnamic acid using chitosan nanoparticles as an encapsulation material was shown to increase the activity of cinnamic acid as antibacterial by protecting the active compound, as well as increasing its solubility in water through chitosan-TPP modification. Emulsion formation was performed using Corning LSE Compact at 6,000 rpm for 30 minutes. The formation of chitosan nanoparticles as encapsulation material was done using freeze dryer with freeze drying method. Chitosan was obtained from shrimp chitin with Deacetylation Degree (% DD) of 85.98%. The synthesis of chitosan nanoparticles yielded an average particle size of 330 nm with a percentage volume of 29.9% and 79.1% with an average size of 5570 nm. The morphological form of nanometer-sized chitosan was smaller and uniform than that of chitosan morphology. Encapsulation efficiency value of 67.304% makes cinnamic acid has higher activity inhibition of bacterial growth than pure cinnamic acid and chitosan nanoparticles.

Sintesis Turunan Azomethin Sebagai Zat Aktif Inhibitor Korosi pada Logam Menggunakan Bahan Dasar Piperonal dan 2-Aminopiridin Intan Endah Rachmawati; Ngadiwiyana Ngadiwiyana; Ismiyarto Ismiyarto
Jurnal Kimia Sains dan Aplikasi Vol 20, No 3 (2017): Volume 20 Issue 3 Year 2017
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Sintesis senyawa turunan azomethin dilakukan melalui reaksi kondensasi antara piperonal dan 2-aminopiridin dengan variasi pelarut toluen, benzen, etanol selama 3 jam. Karakterisasi produk sintesis melalui uji titik leleh dan diidentifikasi menggunakan spektroskopi UV-Vis, FTIR dan LC-MS. Dilakukan pengujian antikorosi pada logam besi untuk mengetahui aktivitas inhibitor korosi menggunakan metode weight loss. Identifikasi menggunakan spektroskopi UV-Vis muncul pada serapan 233 nm dan pada FTIR pada bilangan gelombang 1604,77 cm-1 yang merupakan gugus C=N, serta menggunakan LC-MS diketahui bahwa senyawa mempunyai berat molekul 226,26 gram/mol identik senyawa N-(benzo[d][1,3]dioxol-5-ylmethylene)pyridin-2-amine. Laju korosi senyawa turunan azomethin pada konsentrasi 1% sebesar 1,2 mg cm-2 hari -1 dengan perendaman selama 4 jam.

Synthesis of Nano Chitosan as Carrier Material of Cinnamon’s Active Component Ngadiwiyana Ngadiwiyana; Enny Fachriyah; Purbowatiningrum Ria Sarjono; Nor Basid Adiwibawa Prasetya; Ismiyarto Ismiyarto; Agus Subagio
Jurnal Kimia Sains dan Aplikasi Vol 21, No 2 (2018): Volume 21 Issue 2 Year 2018
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Development and innovation to improve the efficacy of active ingredients of a plant can be done by using nanoparticle encapsulation of chitosan, which has dual function of protecting natural extracts degradation and delivering natural extracts to the target site. Chitosan is a natural polymer that is nontoxic, mucoadhesive, biodegradable, and biocompatible. This polymer also has a low level of immunogenicity and can be prepared into nanoparticles in mild conditions that make it suitable for natural extracts delivery systems. This paper reported synthesis of chitosan nanoparticles for cinnamon’s natural extract delivery. Chitosan synthesis was carried out by chitin deacetylation isolated from shrimp shells. Chitosan characterization was done by measuring deacetylation degree by FTIR. Chitosan nanoparticles were prepared by ionic gelation method using tripolyphosphate as crosslinker. Morphology and particle size of nano chitosan were characterized using a scanning electron microscope (SEM) and a transmission electron microscope (TEM). The result found that the yield of deproteinated chitin was 62.60%. Further process of demineralization resulted a yield of 52.60%, then depigmentation with a yield of 75.56%, and deacetylation with a yield of 79.02%. FTIR analysis showed that deacetylation degree of chitin into chitosan was found of 87.78%. Characterization by SEM found that nano chitosan has a particle size of 87 nm. While TEM images showed that the nano chitosan has a uniform shape and a lower physical aggregation.

Oksidasi 3-(3,4-dimetoksifenil)-propanol dengan Menggunakan Oksidator Piridinium Klorokromat (PCC) Ngadiwiyana Ngadiwiyana; Ismiyarto Ismiyarto; Ayu Ratri Kartika Iriany
Jurnal Kimia Sains dan Aplikasi Vol 10, No 3 (2007): Volume 10 Issue 3 Year 2007
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

3-(3,4-dimetoksfenil)-propanol mudah dioksidasi menjadi bentuk aldehida-nya menggunakan piridinium klorokromat (PCC) tanpa menimbulkan oksidasi lebih lanjut membentuk asam karboksilat. PCC telah disintesis dengan mereaksikan reacting HCl dan CrO3, diikuti dengan penambahan piridin dalam larutan pada suhu 0oC dan hasilnya 85%. Sedangkan, reaksi oksidasi dari 3-(3,4-dimetoksfenil)-propanol dengan PCC sebagai oksidator dilakukan dalam diklorometan selama 3 jam dan direfluks pada suhu 30oC dan rasio mol alkohol:PCC adalah 1:2. Produk oksidasi diekstraksi menggunakan dietileter dan diuapkan, menghasilkan 71,3% dari produk oksidasi dengan indeks refraksi sebesar 1,57. Data FT-IR menunjukkan adanya penyerapan yang kuat pada gugus karbonil (C=O) pada bilangan gelombang 1724,2 cm-1 dan penyerapan CH aldehida pada 2723,3 cm-1, diperkuat oleh data GC-MS di tR = 20.797 menit yang menunjukkan ion molekuler pada m/e = 194 dan puncak dasar pada m/e = 151 yang mewakili struktur 3-(3,4-dimetoksfenil)-propanal

Synthesis and Antibacterial Testing of Imina Derivative Compounds from Piperonal and Anilin Dimas Syamsudin; Ismiyarto Ismiyarto; Ngadiwiyana Ngadiwiyana
Jurnal Kimia Sains dan Aplikasi Vol 21, No 1 (2018): Volume 21 Issue 1 Year 2018
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Synthesis of Imine derivates used as antibacterial activity has been done. Synthesis was conducted by condensation reaction between piperonal and aniline. The product synthesis was characterized by melting point, LC-MS, FTIR and 1H-NMR, then application of the product as antibacterial towards bacteria Staphylococcus aureus and Escherichia coli. The product of synthesis was pale-brown solid, and had melting point at 56-61 0C. Identification by LC-MS showed the compound molecular weight was 225.30 gram/mol, identification by FTIR showed a compound contained imine C=N at 1620.21 cm-1, C-H aromatic at 1581.63 cm-1, Csp3-H at 2962.37 cm-1 from CH2, and C-O at 1265.30 cm-1, Identification by 1H-NMR showed a compound had a singlet peak at δ=6 ppm that proton was from the CH2, multiplet peak at δ=6.9-7.7 ppm proton from two aromatics and singlet peak at δ=8.4 ppm from proton imine. The minimum inhibitory concentration of the product towards Staphylococcus aureus and Escherichia coli was 1 mg/mL with diameter inhibition zone 2 mm and 3 mm. From these data it could be concluded that the compound 3,4- methlenedioxybenzilyimine was formed and it had ability as an antibacterial agent.

Co-Authors . Widayat A.A. Ketut Agung Cahyawan W Adityo Anggadita Afiina Putri Monita Agus Subagio Agus Subagio Ahmad Fathoni Amalia Fitriyan Fajriyah Anjar Jatika Ardhita Niken Destiana Arnelli Arnelli Asy'ari, Mukhammad Asy’ari, Mukhammad Aulia Anggraeni Ayu Ratri Kartika Iriany Bambang Cahyono Bayu Refindra Fitriadi Chairil Anwar Choirunnisa, Nur Fadilla Damar Nurwahyu Bima Dian Amalia Dimas Syamsudin Dra. Dewi Kusrini M.Si Dzahabiyyah, Hana Putri Enny Fachriyah Enny Fachriyah Erma Prihastanti Fannie Kurniasari Femmy Nurul Akbar Gunawan Gunawan Hanna Niela Diana Hardjono Sastrohamidjojo Hendra Dwipa Rifky Mahardika Heru Susanto Huda, Muhammad Badrul Ina Noprastika Intan Endah Rachmawati Ismiyarta Ismiyarta Ismiyarto Ismitarto Ismiyarto Ismiyarto Ismiyarto Ismiyarto Jumina Jumina Khairul Anami Khasan Rowi Laksmitasari, Nuraini Dwi Limpat Nulandaya Liswinda Zafirah Rahmatia Marcelinus Christwardana Mukhammad Asy’ari Mumtazati, Qonita Nies S. Mulyani Nies Suci Mulyani Niken Windi Saputri Noor Basid Adiwibawa Prasetya Nor Basid Adiwibawa Prasetya Nor Basid Adiwibawa Prasetya Nor Basid Adiwibawa Prasetya Nor Basid AP Nor Basyid A. Prasetya Nur Amaliyah Nurlina Priastuti Pandelaki, Elmi Christi Julia Purbowatiningrum Ria Sarjono Rani Mustika Retno Dwi Soelistyowati Rinaryadi, Kemilau Permata Hati Salsabila, Salsabila Sesika Novari Suyanti Suyanti Tri Windarti Triwijayanti, Yunita Tutuk Djoko Kusworo Yosie Andriani

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