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All Journal VALENSI Jurnal Penelitian Saintek SAINS DAN MATEMATIKA JURNAL KIMIA SAINS DAN APLIKASI Jurnal Ilmu Lingkungan Chem Info Alchemy Jurnal Penelitian Kimia INDONESIAN JOURNAL OF PHARMACY Indonesian Journal of Chemistry Greensphere: Journal of Environmental Chemistry
Ngadiwiyana M.Si. S.Si.
Department Of Chemistry, Faculty Of Science And Mathematics, Diponegoro University Jl. Prof. H. Soedarto SH Tembalang, Semarang 50275, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Energy Engineering Environmental Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology

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Reduksi Sinamaldoksim Menggunakan Sistem Katalis Zn/NH4Cl Ngadiwiyana Ngadiwiyana; Ismiyarto Ismiyarto; Purbowatiningrum Ria Sarjono
Jurnal Kimia Sains dan Aplikasi Vol 10, No 1 (2007): Volume 10 Issue 1 Year 2007
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.358 KB) | DOI: 10.14710/jksa.10.1.1-6

Abstract

Sinamaldehid merupakan komponen utama minyak kayu manis (Cinnamomum) yang dapat diisolasi menggunakan pelarut natrium bisulfit. Pemanfaatan senyawa ini masih sangat terbatas, sehingga perlu dilakukan upaya pengubahan sinamaldehid menjadi senyawa turunannya yang lebih berdaya guna. Salah satunya, sinamaldehid dapat diubah menjadi senyawa amina melalui zat antara sinamaldoksim dengan reaksi reduksi. Senyawa amina tersebut digunakan sebagai bahan untuk mensintesis senyawa turunan antibiotik C-9154.Reduksi sinamaldoksim menjadi senyawa amina dilakukan dengan cara reduksi hidrogenasi katalitik menggunakan katalis Zn/NH4Cl. Reaksi dilakukan dengan merefluks sinamaldoksim, NH4Cl(s), dan serbuk Zn dengan pelarut metanol pada temperatur refluks (58 ºC) selama 3 jam. Hasil disaring, selanjutnya filtrat hasil refluks dievaporasi. Hasil evaporasi diekstraksi dengan kloroform dan NaCl jenuh. Lapisan organik dievaporasi kembali. Hasil evaporasi dianalisis menggunakan instrumen FT-IR dan GC-MS.Hasil reduksi sinamaldoksim berupa padatan gel berwarna coklat dengan dengan berat 0,43 g dan rendemen sebesar 64,35 %. Analisis hasil menggunakan spektrometer infra merah menunjukkan serapan gugus C-N pada daerah 1330,8 cm-1. Serapan pada 3178 cm-1 menunjukkan serapan gugus N-H dari senyawa amina. Hasil analisis GC-MS menunjukkan bahwa senyawa amina yang diperoleh dari reduksi sinamaldoksim berupa sinamilamin yang merupakan senyawa amina primer (tR = 16,431 menit dengan kelimpahan 0,58 %), (N-metil-3-fenil)-2-propenamin yang merupakan senyawa amina sekunder (tR = 20,258 menit dengan kelimpahan 0,79 %) dan (N,N- dimetil-3-fenil)-2-propenamin yang merupakan senyawa amina tersier (tR = 26,666 menit dengan kelimpahan 14,79 %).
Bakteri Endofit F4 dari Daun Pepaya (Carica papaya L): Potensinya sebagai Penghasil Enzim Ekstraseluler Sarjono, Purbowatiningrum Ria; Ismiyarto, Ismiyarto; ngadiwiyana, Ngadiwiyana; Prasetya, Nor Basid Adiwibawa
Greensphere: Journal of Environmental Chemistry Vol 2, No 1 (2022): Volume 2 Issue 1 Tahun 2022
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (459.688 KB) | DOI: 10.14710/gjec.2022.14794

Abstract

AbstractPapaya leaves are known to have antibacterial activity, so the endophytic bacteria on the papaya leaves are thought to have antibacterial activity. Previous studies have obtained 5 isolates of endophytic bacteria from papaya leaves, including F1, F2, F3, F4 and F5. Endophytic bacteria F1, F3, and F5 have known antibacterial activity, while endophytic bacteria F4 have not yet explored their activity in producing extracellular enzymes, so that in this study a qualitative test of extracellular enzymes was carried out on endophytic bacteria F4. The purpose of this study was to obtain confirmation of morphology, qualitative phytochemical data, and the ability to produce extracellular enzymes lipase, cellulase, protease and amylase from endophytic bacteria F4.The results obtained were F4 bacterial isolates white, round and smooth rounded edges which were gram positive with single cell morphology and the shape is bacillus (stems). F4 bacteria have the potential to contain amylase and protease extracellular enzymes.
Synthesis of Carboxylated Chitosan Amide Using Some Cyclic Anhydride and Their Activities as Antifungal Ismiyarto, Ismiyarto; Mumtazati, Qonita; Pandelaki, Elmi Christi Julia; Fachriyah, Enny; Ngadiwiyana, Ngadiwiyana; Sarjono, Purbowatiningrum Ria; Prasetya, Nor Basid Adiwibawa
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 2, November 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i2.35244

Abstract

Chitosan is a natural polymer that has antifungal activity. It is necessary to modify chitosan into its derivatives to increase its activity. One modification of chitosan that has the potential to be developed as an antifungal is carboxylated chitosan amide because this chitosan derivative contains a carboxylic group and is more hydrophilic. This research aims to synthesize chitosan amide carboxylate using several cyclic anhydride compounds and test its antifungal activity against Aspergillus flavus. The cyclic anhydrides used in this research are maleic anhydride and phthalic anhydride. In the initial stage of chitosan amide carboxylate synthesis, reaction optimization was carried out at varying temperatures of 25, 50, and 72oC for 7 hours. Compound characterization was carried out using FTIR and UV-Vis spectrophotometry. The disc diffusion method tested the chitosan amide carboxylate product for its antifungal activity against Aspergillus flavus. The optimal MCA (Maleoyl Chitosan Amide) product is (MCA_50), synthesized at a reaction temperature of 50oC. Under these optimal reaction conditions, PCA_50 (Pthaloyl Chitosan Amide) was successfully synthesized to produce a brownish-yellow solid with a yield of 46.1% (w/w) and a degree of substitution (DS) of 41.93%. The diameter of the inhibition zone against Aspergillus flavus for PCA_50 was 30 mm at the 12th hour of observation. The product (PCA_50) has better antifungal activity than chitosan and MCA_50.
The Effect of SiO2 Addition to the Hydroxyapatite/Curcumin Composite Properties Windarti, Tri; Prasetya, Nor Basid Adiwibawa; Ngadiwiyana, Ngadiwiyana
Indonesian Journal of Chemistry Vol 24, No 5 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.93802

Abstract

Hydroxyapatite/curcumin composites have been studied as a calcium phosphate cement candidate. In this research, the effects of adding SiO2 to the hydroxyapatite/curcumin composite on the characteristics of the cement, such as the crystal and surface properties, as well as the release behavior of curcumin in Ringer's solution media, were studied. The composite preparation with and without SiO2 was carried out using a Na2HPO4 2.5% solution. The results showed that the addition of 25% SiO2 to the hydroxyapatite/curcumin composite did not change the crystal properties of hydroxyapatite but produced a more homogenous distribution of the ingredients. The behavior of the composite in Ringer's solution also changes, which is proven by the change in the crystal growth direction and Ca/P ratio. Adding SiO2 produced a composite with a platter and larger particles, as well as a higher Ca/P ratio on the surface. The presence of SiO2 inhibited the release of curcumin in which the ratio of HA: curcumin changed from 77.7%:22.3% to 69.6%:30.4% after 5 d of immersion in Ringer's solution. Thus, besides increasing calcium phosphate deposition on the cement surface, SiO2 also prevents curcumin from being released from the composite.
Synthesis of Antibacterial Coating Film Based on Eugenol-Allyl Eugenol Copolymer with Chitosan-Gelatin Ngadiwiyana, Ngadiwiyana; Dzahabiyyah, Hana Putri; Ismiyarto, Ismiyarto; Sarjono, Purbowatiningrum Ria
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.40944

Abstract

The development of coating film materials based on biopolymers and active antibacterial compounds has attracted attention in the food industries. Food packaging biopolymers can be increased antibacterial properties by adding compound modification of natural ingredients such as eugenol-allyl eugenol copolymer (PEAE). The aims of this study were to synthesize a coating film based on chitosan-gelatin with PEAE and test its antibacterial properties. PEAE synthesis was carried out by polymelirization reaction with the (BF3O(C2H5)2) as catalyst and characterized by FTIR, molecular weight, and solubility. Synthesis of chitosan-gelatin coating films with variations in PEAE concentration of 1.25%, 2.5%, and 3.75% and characterization includes FTIR, SEM, TS, E%, and contact angle. Antibacterial activity is carried out by the turbidimetry method. PEAE was synthesized with the results in the form of brown solids with 94.91% yield, molecular weight of 9,553.98 da, and the melting point of 95-98 °C. Chitosan-Gelatin films with the addition of PEAE produce a thin yellowish film, with a sequential decreased tensile strength, and the percentage value of extension increases with the increase in PEAE concentration. The best antibacterial activity in the film PEAE 2.5, with the percentage of inhibition of Staphylococcus aureus and Escherichia coli of 99.71% and 98.39% respectively.
Improved Thermal Stability of Silica Nanofluids Using Anionic Surfactants for Enhanced Oil Recovery Applications Rowi, Khasan; Ngadiwiyana, Ngadiwiyana; Subagio, Agus
Jurnal Kimia Sains dan Aplikasi Vol 28, No 5 (2025): Volume 28 Issue 5 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.5.244-251

Abstract

Silica nanoparticles have shown great potential in the oil and gas industry sector, especially in applications for enhanced oil recovery. Silica nanofluids are widely used in EOR applications because they are inexpensive, easy to synthesize, environmentally friendly, can be surface modified, and provide high oil recovery rates. However, silica nanofluids have drawbacks in thermal stability and salinity at high temperatures, adversely affecting their application in oil reservoirs. In this paper, the effects of a surfactant sulfonate compound (SPU11) and a co-surfactant sulfosuccinate compound (SPU22) on the thermal stability of silica nanofluids at temperatures ranging from 60 to 100°C were investigated. Next, the silica nanofluids were analyzed for particle size using a particle size analyzer (PSA), wettability using a sessile drop contact angle, and oil recovery capacity using a core flooding test. The results showed that the silica nanofluid with 0.3% SPU11 and 0.3% SPU22 surfactant showed good thermal stability below 80°C for 3 months in 3 wt% brine; PSA analysis showed that the aggregate diameter was 52.86 nm; wettability analysis showed that the silica nanofluid had a contact angle of 60.8° to 36.6° and the core flooding results of silica nanofluid showed an oil in place recovery (OOIP) of 9.7%.
Antioxidant and antibacterial activities of alkaloids from endophytic bacterium Pseudomonas hibiscicola Wk isolated from waru (Hibiscus tiliaceus) leaves Sarjono, Purbowatiningrum Ria; Laksmitasari, Nuraini Dwi; Asy'ari, Mukhammad; Ngadiwiyana, Ngadiwiyana; Ismiyarto, Ismiyarto; Fachriyah, Enny
Jurnal Penelitian Saintek Vol 30, No 1 (2025)
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jps.v30i1.77501

Abstract

This study aims to investigate the antioxidant and antibacterial activity from alkaloid extract. Alkaloid compounds were isolated from the endophytic bacteria Pseudomonas hibiscicola Wk, which was obtained from Hibiscus leaves. The alkaloid compounds were characterized using thin layer chromatography. The isolated alkaloid compounds were tested for total phenol content, and antioxidant activity. The phytochemical analysis of the alkaloid compounds from the endophytic bacteria Pseudomonas hibiscicola Wk showed a positive result for alkaloids, confirmed by an Rf value of 0.8125 which is similar to the Rf value of alkaloids from the periwinkle plant, namely vindoline (Rf = 0.85). Alkaloid compounds from the endophytic bacteria Pseudomonas hibiscicola Wk had the highest total phenol content of 2.390 mg gallic acid/gram sample at a concentration of 10.000 mg/L. These results indicate that the alkaloid compounds obtained contain phenol groups. The IC50 value obtained from the isolated alkaloid compound was 99.70 mg/L, demonstrating strong antioxidant capacity, and has the ability to inhibit the growth of E.coli and S.aureus bacterial.
Isolation of Endophytic Pseudomonas Strains from Papaya Leaves and Their Extracellular Enzyme Production and Antioxidant Profile Sarjono, Purbowatiningrum Ria; Choirunnisa, Nur Fadilla; Triwijayanti, Yunita; Salsabila, Salsabila; Asy’ari, Mukhammad; Ngadiwiyana, Ngadiwiyana; Ismiyarto, Ismiyarto; Prasetya, Nor Basid Adiwibowo; Andriani, Yosie
Jurnal Kimia Valensi Vol. 11 No. 1 (2025): Jurnal Kimia VALENSI
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i1.40921

Abstract

Endophytic bacteria, symbiotic microorganisms residing in plant tissues, produce bioactive compounds similar to host plants, such as antioxidants. These antioxidants are crucial in combating free radicals linked to degenerative diseases. This study isolates and characterizes two endophytic bacterial strains from papaya leaves, exploring their enzymatic and antioxidant activities. Two isolates of endophytic bacteria from papaya leaves were obtained, F1-A and F1-B. F1-A endophytic bacteria are types of monobacilli, Gram-positive bacteria. F1-B endophytic bacteria are types of Bacilli. Using 16S rRNA analysis, both isolates were predicted to belong to the Pseudomonas bacterial strain. Research on optimizing their growth under various temperatures and pH conditions showed that both isolates grow best at 37°C. F1-B provides a better opportunity as a source of industrial enzymes because it can excrete amylase, urease, cellulose, and protease enzymes compared to F1-A, which can only produce amylase and protease enzymes. Nevertheless, F1-A can act as a potent antioxidant with an IC50 of 34.18 ppm compared to F1-B, which has an IC50 value of 292.31 ppm. The IC50 value of the F1-A isolate was not much different from the IC50 of quercetin, which was 12.50 ppm. The ability of F1-A as an antioxidant is also influenced by the results of phytochemical screening, which can contain more secondary metabolites than F1-B. These results highlight the potential of Pseudomonas strains as sources of industrial enzymes and natural antioxidants, warranting further investigation.
Synthesis and Antibacterial Activity of Chitosan-Cinamaldehyde/AgNp Schiff Base Composite Huda, Muhammad Badrul; Rinaryadi, Kemilau Permata Hati; Ngadiwiyana, Ngadiwiyana; Christwardana, Marcelinus; Sarjono, Purbowatiningrum Ria; Ismiyarto, Ismiyarto
Jurnal Kimia Valensi Vol. 11 No. 1 (2025): Jurnal Kimia VALENSI
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i1.45121

Abstract

Chitosan is a material that has antibacterial properties. Chitosan was modified with cinnamaldehyde to form chitosan Schiff base, which acts as a capping agent in the synthesis of silver nanoparticles. The Schiff base product was modified again into a silver nanoparticle Schiff base composite to improve its ability as a capping agent and improve its antibacterial properties. This study aims to synthesize a chitosan-cinnamaldehyde/AgNP Schiff base composite (CCSB/AgNP) as an active ingredient with excellent antibacterial properties. The first stage was the synthesis of a chitosan-cinnamaldehyde Schiff base. In the second stage, the synthesis of the chitosan/AgNP composite was carried out by adding STPP with sonication and a water bath. The third stage involved synthesizing of the CCSB/AgNP composite using the same method as the second stage employing both heating and non-heating as well as sonication and non-sonication. The product was characterized using a UV-Vis spectrophotometer, FT-IR, SEM-EDX, mapping, and AAS. Antibacterial tests were performed on the synthesized product using the Total Plate Count (TPC) method. Chitosan has a molecular weight of 338080 g/mol and a degree of deacetylation of 65.09%. The Schiff base product of chitosan-cinnamaldehyde is a brownish-yellow solid with a yield of 76.9% (w/w) and a degree of substitution of 87.02%. The presence of Ag was confirmed by EDX mapping, which revealed mass percentages of 0.26%, 1.00%, and 3.97% for C/AgNP-1, C/AgNP-2, and CCSB/AgNP-2, respectively. The chitosan/AgNP product has a yield of 97% (w/w) and an SPR effect at 439 nm. The synthesis of CCSB/AgNP obtained a dark green solid with a yield of 87% (w/w) and an SPR effect at 433 nm. The antibacterial activity test yielded the highest percentage reduction in the number of bacteria in CCSB/AgNP at 3 days of observation at 95.1%, and 7 days at 94.1%. 
Co-Authors . Widayat A.A. Ketut Agung Cahyawan W Adityo Anggadita Afiina Putri Monita Agus Subagio Agus Subagio Ahmad Fathoni Amalia Fitriyan Fajriyah Anjar Jatika Ardhita Niken Destiana Arnelli Arnelli Asy'ari, Mukhammad Asy’ari, Mukhammad Aulia Anggraeni Ayu Ratri Kartika Iriany Bambang Cahyono Bayu Refindra Fitriadi Chairil Anwar Choirunnisa, Nur Fadilla Damar Nurwahyu Bima Dian Amalia Dimas Syamsudin Dra. Dewi Kusrini M.Si Dzahabiyyah, Hana Putri Enny Fachriyah Enny Fachriyah Erma Prihastanti Fannie Kurniasari Femmy Nurul Akbar Gunawan Gunawan Hanna Niela Diana Hardjono Sastrohamidjojo Hendra Dwipa Rifky Mahardika Heru Susanto Huda, Muhammad Badrul Ina Noprastika Intan Endah Rachmawati Ismiyarta Ismiyarta Ismiyarto Ismitarto Ismiyarto Ismiyarto Ismiyarto Ismiyarto Jumina Jumina Khairul Anami Khasan Rowi Laksmitasari, Nuraini Dwi Limpat Nulandaya Liswinda Zafirah Rahmatia Marcelinus Christwardana Mukhammad Asy’ari Mumtazati, Qonita Nies S. Mulyani Nies Suci Mulyani Niken Windi Saputri Noor Basid Adiwibawa Prasetya Nor Basid Adiwibawa Prasetya Nor Basid Adiwibawa Prasetya Nor Basid Adiwibawa Prasetya Nor Basid AP Nor Basyid A. Prasetya Nur Amaliyah Nurlina Priastuti Pandelaki, Elmi Christi Julia Purbowatiningrum Ria Sarjono Rani Mustika Retno Dwi Soelistyowati Rinaryadi, Kemilau Permata Hati Salsabila, Salsabila Sesika Novari Suyanti Suyanti Tri Windarti Triwijayanti, Yunita Tutuk Djoko Kusworo Yosie Andriani