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All Journal Journal of Health Sciences E-Prodenta Journal of Dentistry Conservative Dentistry Journal Denta: Jurnal Kedokteran Gigi Cendekia: Jurnal Ilmu Sosial, Bahasa dan Pendidikan Jurnal Ekonomi Bisnis, Manajemen dan Akuntansi (JEBMAK) Jurnal Pendidikan dan Pengabdian Masyarakat Fonologi: Jurnal Ilmuan Bahasa dan Sastra Inggris
Dwi Andriani
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Arts Humanities Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Social Sciences Other

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Effectivity of Stichopus hermanii Supplementation to Prevent Oral Candidiasis on Rats Paramita Devi Oktaviani; Endah Wahjuningsih; Dwi Andriani
Denta Journal Kedokteran Gigi Vol 12 No 1 (2018): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Candida albicans is normal flora of oral cavity that can be pathogenic due to predisposition influence so that trigger Oral candidiasis. Stichopus hermanii suspected as an Oral candidiasis therapy because it contain antioxidant compound, antitumor and antifungi. Objective: Analyzing the effectiveness of Stichopus hermanii supplementation as a protective effect of oral candidiasis in Rats exposure to smoke. Materials and Methods: This experiment is post test only group control design using 35 male rats divided into 5 groups(X). X1 (negative control), X2 (positive control), X3 (Stichopus hermanii powder 0,0225mg/kgBB), X4 (Stichopus hermanii powder 0,045mg/kgBB), X5 (Stichopus hermanii powder 0,09mg/kgBB). Candida albicans induced into the mouth by an oral swab using cotton bud 3 times a week for 8 weeks. Smoke exposure as a predisposition factor be given 3 bars per day for 8 weeks. The rats being killed and tongue biopsies measure the thickness of tongue epithelium. The obtained data analyzation using One Way ANOVA and LSD test. Result: There is a significant difference (p<0.05) between X1 and X2, X1 and X3, X1 and X4, X1 and X5, X2 and X3, X2 and X4, X2 and X5, X3 and X5. Conclusion: Adduction of Stichopus hermanii capable of reducing risk of Oral candidiasis. Supplementation of Stichopus hermanii powder 0,09mg/kgBB is the most effective reduce thickness of the tongue epithelium in the group that exposure to smoke and induced of Candida albicans.
The Effect of Acanthus Ilicifilius Extract On Anticandida Albicans Antibody in Wistar Rats with Oral Candidiasis Immunosupressed Model Dwi Andriani; Dwi Setianingtyas; Nafi’ah
Denta Journal Kedokteran Gigi Vol 11 No 1 (2017): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Candida albicans (C.Albicans) causes oral candidiasis. Candida adhesion proteins stimulate the immune system to eliminate C.albicans chloroform extract of acanthus leaves ilicifolius have inhibitory against C.Albicans. Purpose: To proved the potential Acanthus ilicifolius (A.ilicifolius) extract to inhibit the growth of C.Albicans in rats with oral candidiasis. Materials and Methods: This study was true experimental with post test only control group design. Wistar rats were used and imunosupressed with dexamethasone and ditetrasiklin peroral after that induced by C.albicans 6x108 on the tongue of rats for14 days. Divided into five groups, healthy (G1), candidiasis (G2), treatment group 1 (G3): candidiasis + nystatin, Treatment 2 (G4): candidiasis+extract A.Ilicifollius 8%, and Treatment 3 (G5) : candidiasis+extract A.Ilicifollius 16%. The rats was treated for 14 days after induction of candida. A.Ilicifollius chloroform extraction method was maceration. Samples was processed immunohistochemistry staining methods and added antibody anticandida albicans (IgG mouse). Observed the results using microscope (magnification 400x). Data were analyzed with the Kruskal-Wallis and Mann Whitney. Results: There was significant differences between G1 with G2, G3, G4, G5 (p˂0,05). There was significant difference between G2 to G3, G4 and G5 (p˂0,05). There was no significant difference between G3, G4, and G5 (p˃0,05). Conclusion. A.ilicifollius extract have potential to inhibit the growth of Candida albicans in rats with oral candidiasis.
Co-Authors ADITYA PRATAMA Agni Febrina Pargaputri Arief Hadziq Fikri Diana Soesilo Diana Soesilo, Diana Dwi Setianingtyas Effendi Effendi Eka Agustina Endah Wahjuningsih Eric Priyo Prasetyo Fahita Al Afiyah Ghora Setyawan Intan Novita Sari Isidora Karsini Mefina Kuntjoro Nafi’ah Paramita Devi Oktaviani Pargaputri, Agni Febrina Prabanita, Amellindha Salsabilah Ratna Ariesta Dwi Andriani Siti Anisatur Rofiqah Sularsih Syamsulina Revianti Syarifah Fatimatuzzahra Yuli Andriani