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All Journal Indonesian Journal of Pharmaceutical Science and Technology Pharmacon INDONESIAN JOURNAL OF PHARMACY Pharmascience JURNAL BIOLOGI INDONESIA JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmaseutik JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Farmasi Journal of Fundamental and Applied Pharmaceutical Science Molekul: Jurnal Ilmiah Kimia
Arief Nurrochmad
Departement of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy University of Gadjah Mada, Yogyakarta Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : Jurnal Farmasi

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Aktivitas Hepatoprotektif Ekstrak Kunyit (Curcuma domestica Val.) dan Ekstrak Meniran (Phyllantus niruri Linn.) Pada Tikus yang Diinduksi Parasetamol Kajian Histopatologi Liver Novianto, Agil; Nurrochmad, Arief; Puspitasari, Ika
Jurnal Farmasi (Journal of Pharmacy) Vol. 3 No. 1 (2014): Jurnal Farmasi (Journal of Pharmacy), October 2014
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Curcuma domestica and Phyllanthus niruri was two plants which has been shown to have an effect hepatoprotective. This research was conducted to determine mechanism study of hepatoprotective combination of Curcuma domestica and Phyllanthus niruri extract to animals induced by paracetamol. Animals devide into 8 groups in random order of 5 each rats. Normal groups were give aquadest, negative groups (Paracetamol) were give CMC Na 0,5 %, positive goups were give silimarin with dose 100 mg/kg, Curcuma domestica groups with a dose of 100 mg/kg, Phyllanthus niruri groups with 200 mg/kg BW as well as a combination of I-III with Curcuma domestica and Phyllanthus niruri extract comparison of each of 75: 50; 50: 100; and 25: 150 mg/kg in BW. Test preparations are given for 7 days. On day 7, all groups except normal induced with paracetamol single dose2.5 g/kg for peroral 30 minutes after administering the test preparations. Hepatoprotective activity were analyzed using liver histopathology. The results showed that the combination I can inhibited liver necrosis and gives better hepatoprotective activity comparable with single dose with optimal Curcuma domestica and Phyllanthus niruri extract dose of 75 and 50 mg/kg.
PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN SIRIH MERAH (Piper Crocatum Ruiz & Pav) TERHADAP EKSPRESI GLUKOSA TRANSPORTER 2 PADA HATI DAN PANKREAS YANG DIINDUKSI STREPTOZOTOCIN-NIKOTINAMIDA Wisnu Kusuma, Eka; Herowati, Rina; Nurrochmad, Arief
Jurnal Farmasi (Journal of Pharmacy) Vol. 6 No. 1 (2017): Jurnal Farmasi (Journal of Pharmacy), October 2017
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Diabetes mellitus is a metabolic disease characterized by hyperglycemia, decreased expression of GLUT-2 in pancreatic, and increased expression of GLUT-2 in liver. Red betel leaf seed is useful for treatment of diabetes. This study aims to determine the effect of antihyperglycemic, increased expression of GLUT-2 in pancreas, and decrease in liver of the red betel leaf ethanol extract in STZ-NA induced rats. This research used 25 male white wistar rats, which randomly divided into five groups, normal control, negative control, positive control, EEDSM dose of 50 mg/kg bw and 100 mg/kg bw. Induced STZ-NA days 0, measured glucose levels next day 5 and treated were for 14 days. Measured parameters were GLUT-2 expression in pancreas and liver. The results showed that EEDSM for 14 days qualitatively able to increase the expression of GLUT-2 in pancreatic cells with those in the normal control, negative control, positive control, EEDSM 50 mg/kg bw, and 100 mg/kg bw respectively to 100%, 32,31%, 67,67%, 52,73% and 60,01%. EEDSM qualitatively able to reduce the expression of GLUT-2 in liver cells with those in the normal control, negative control, positive control, EEDSM 50 mg/kg bw, and 100 mg/kg bw respectively to 13,21%, 100%, 52,05%, 87,08%, dan 78, 09%.
Co-Authors Abdul Rohman Agil Novianto, Agil Agung Endro Nugroho Alexxander, . Alexxander, . Andi Suhendi Anggraeni, Nuniek Arief Rahman Hakim Baiq Maylinda Gemantari Dina, Shela Puzi Dirman, Arifin Djoko Wahyono Edy Meiyanto Endang Lukitaningsih Fita Rahmawati Hanafi, Arif Riswahyudi Harjaningsih, Woro Ida Ayu Putu Sri Widnyani Ika Puspitasari Imono Argo Donatus, Imono Argo Laras Widawaty Putri Manggo, Tasya Faradillah Marbun, Prajona Mukrinin, Walit Uhkri Nanang Fakhrudin, Nanang Napitupulu, Elfrida Nurlely Nurlely Puji Astuti Rahma, Nazulanita Rahmawati, Adillah Retno Murwanti Romadhonsyah, Fitra Sitarina Widyarini Subagus Wahyuono Tiaravista, Amanda Gita Titik Nuryastuti Tri Murti Andayani Wahyuddin, Munifah Wahyudi, Danang Tri Wirasti, Wirasti Wisnu Kusuma, Eka Yundari, Yundari