Article Per Year (5 Year)
p-Index From 2021 - 2026
1.819
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Biomedical Journal of Indonesia SRIWIJAYA JOURNAL OF MEDICINE Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Manajemen dan Administrasi Rumah Sakit Indonesia (MARSI) Interdental Jurnal Kedokteran Gigi (IJKG) Jurnal Pengabdian Masyarakat: Humanity and Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kesehatan Gigi dan Mulut (JKGM) Science and Technology: Jurnal Pengabdian Masyarakat Indonesian Journal of Pharmacology and Therapy Jurnal Pengabdian Ilmu Kesehatan
Debby Handayati Harahap
Pharmacology Faculty Of Medicine Universitas Sriwijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

Published : 15 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 15 Documents
Search

 1   2 
SIDE EFFECTS OF SECOND-LINE ANTITUBERCULOSIS DRUGS IN MULTI-DRUG RESISTANCE (MDR) TUBERCULOSIS PATIENTS Tamzil, Nia Savitri; Lorenza, Geofanny; Andriani, R.A. Linda; Theodorus, Theodorus; Sudarto, Sudarto; Lusiana, Evi; Harahap, Debby Handayati; Oktariana, Desi; Prasasty, Gita Dwi
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 2 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i2.483

Abstract

Multidrug-resistant tuberculosis (MDR TB) is caused by Mycobacterium tuberculosis strains resistant to isoniazid and rifampicin—the most potent anti-TB drugs. Prolonged treatment duration and complex drug regimens often lead to poor adherence, contributing to high MDR TB incidence and low treatment success rates, particularly in Indonesia. This study analyzed drug utilization patterns in 52 MDR TB patients at Dr. Mohammad Hoesin Hospital Palembang, using total sampling based on medical records from October 2018 to December 2019. Data were analyzed descriptively with SPSS v25. The most common side effects reported were weakness, nausea, and vomiting (84.6%), followed by arthralgia, hyperuricemia, and hearing loss (42.3%). Severe side effects were more prevalent in the short-term regimen group (40.4%) compared to the long-term group (7.7%). Weakness, nausea, and vomiting were the most frequently observed side effects in MDR TB patients.
Salbutamol Usage Pattern in Asthma Patients at Merdeka Public Health Center Palembang for the Period of January 1 – December 31, 2023 Mudzakky, Muhammad Yusuf; Adenina, Syarinta; Harahap, Debby Handayati
Sriwijaya Journal of Medicine Vol. 8 No. 1 (2025): Vol 8, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i1.305

Abstract

Salbutamol is a bronchodilator commonly used in the management of asthma, both in acute and chronic cases. As part of the Short-Acting Beta-2 Agonist (SABA) class, salbutamol is effective in relieving bronchospasms. The purpose of this study was to determine the rationality of drug use at the Merdeka Community Health Center Palembang. A drug utilization study was conducted at Merdeka Public Health Center Palembang in 2024. 96 patients meeting inclusion criteria. Drug use patterns were evaluated for dose rationalization, duration, frequency, contraindications, and interactions. Data analysis was performed using univariate methods. Sociodemographic characteristics showed that women were more prevalent than men (58.3%), with the most common age groups being pre-elderly and elderly (each 36.5%). All salbutamol doses (2–4 mg per administration) were appropriate (100%), with a duration of ≤3 days for all patients. The frequency of salbutamol administration of 3–4 times daily was found in 51% of cases, in line with recommendations. A total of 74% of patients received salbutamol with appropriate consideration of contraindications, while 26% received it despite contraindications, such as hypertension or hypertensive heart disease. Drug interactions were absent in 67.7% of cases, while antagonistic interactions, primarily with amlodipine, occurred in 17.3% of cases. The use of salbutamol at Merdeka Public Health Center Palembang mostly rational to drug use guidelines. However, attention is needed for contraindications and antagonistic interactions, especially with antihypertensive drugs. These findings can serve as a reference for improving asthma management and patient safety.
Rat Models of Periodontitis: A Focused Review on Ligature, Bacterial Inoculation, and LPS-Induced Approaches Astarini, Afifah; Harahap, Debby Handayati; Rosdah, Ayeshah
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 3 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i3.12391

Abstract

Introduction: Periodontitis is a common chronic inflammatory disease that leads to progressive destruction of the gingiva, periodontal ligament, and alveolar bone. This is due to a dysbiotic oral microbiome that triggers an exaggerated host immune response. Preclinical rat models are indispensable in periodontal research, allowing for controlled investigations of disease mechanisms and therapeutic interventions. Review: This review examines three widely used rat models of experimental periodontitis, including ligature-induced, oral bacterial inoculation, and lipopolysaccharide (LPS) injection. The ligature-induced model is favored for its rapid and reproducible induction of localized inflammation and bone loss, although mechanical trauma may confound the microbial effects. Oral inoculation with pathogens such as Porphyromonas gingivalis simulates natural infections and chronic progression, offering greater biological relevance. The LPS model provides a controlled inflammatory stimulus that facilitates the study of host immune pathways and cytokine expression; however, it lacks microbial complexity. Recent studies have explored the combination of ligature and LPS methods to synergistically intensify inflammation and bone loss, thereby improving model robustness for therapeutic evaluation. Conclusion: Each animal model offers specific benefits for studying periodontitis development and treatment. Although these models have certain limitations, ongoing improvements in research methods will increase their relevance to human health. Advances in technology, imaging, and microbiological techniques are expected to improve the accuracy and usefulness of these models. These developments will enhance our understanding of the disease and contribute to the discovery of more effective and targeted treatment options for periodontitis.
Antimicrobial Potential of Coleus Atropurpureus and its Metabolites Content: A Literature Review Ayu Suci Pratiwi; Debby Handayati Harahap; Erizka Rivani
Jurnal Pengabdian Ilmu Kesehatan Vol. 5 No. 3 (2025): November: Jurnal Pengabdian Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jpikes.v5i3.6006

Abstract

The increasing prevalence of multidrug-resistant bacterial infections underscores the urgent need for new antimicrobial agents, especially those derived from plant-based sources. Coleus atropurpureus, a medicinal plant used extensively in Asia and Oceania, contains various bioactive compounds, including flavonoids, terpenoids, and phenolic acids, which have demonstrated antimicrobial properties. This review examines studies published between 2015 and 2025, highlighting the antibacterial activity of ethanolic and methanolic extracts of C. atropurpureus, particularly against methicillin-resistant Staphylococcus aureus (MRSA). Phytochemical analysis reveals that these extracts exert their antimicrobial effects through multiple mechanisms, including the disruption of microbial membranes, enzyme inhibition, the induction of reactive oxygen species, and immunomodulatory actions. Furthermore, the extracts have shown synergistic effects when combined with antibiotics, suggesting their potential as adjunct therapies. The evidence gathered supports the therapeutic potential of C. atropurpureus as a natural antimicrobial agent, offering a promising alternative to conventional antibiotics in combating drug-resistant infections.
Faktor Determinan Kualitas Pelayanan Radiodiagnostik Terhadap Kepuasan Pasien Onkologi Di Rumah Sakit Mohammad Hoesin Palembang Devi, SNA Ratnasari; Uli, Hanna Marsinta; Harahap, Debby Handayati
Jurnal Manajemen dan Administrasi Rumah Sakit Indonesia (MARSI) Vol 10, No 1 (2026): Jurnal Manajemen dan Administrasi Rumah Sakit (MARSI)
Publisher : LPPM Universitas Respati Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52643/marsi.v10i1.7535

Abstract

Latar Belakang: Salah satu upaya yang untuk meningkatkan kualitas hidup pasien adalah dengan meningkatkan mutu pelayanan bagi pasien kanker. Mutu pelayanan yang baik akan meningkatkan kepuasan pasien.Tujuan penelitian ini adalah untuk menganalisis faktor determinan kualitas pelayanan Radiodiagnostik terhadap kepuasan pasien onkologi di Rumah Sakit Mohammad Hoesin Palembang Metode: Penelitian analitik observasional dengan rancangan cross sectional telah dilakukan di Instalasi Radiologi Rumah Sakit Mohammad Hoesin Palembang sejak bulan Juni hingga November 2025. Didapatkan 293 pasien kanker yang memenuhi kriteria penelitian. Hubungan kualitas pelayanan Radiodiagnostik terhadap kepuasan pasien onkologi dianalisis menggunakan uji Uji Chi-Square/Fisher Exact dilanjutkan dengan Uji Regresi Logistik. Hasil: Terdapat hubungan antara dimensi kualitas teknik ((PR sama dengan 43,672 atau p sama dengan 0,000) atau prosedural (PR sama dengan 12,179 atau p sama dengan 0,000) atau infrastruktur (PR sama dengan 26,625 atau p sama dengan 0,000) atau interaksi (PR sama dnegan 34,380 atau p sama dengan 0,000) atau personal (PR sama dengan 18,783 atau p sama dengan 0,000) atau dan dukungan sosial (PR sama dengan 16,928 atau p sama dengan 0,000) terhadap kepuasan pasien onkologi di Rumah Sakit Mohammad Hoesin Palembang Simpulan: Dimensi kualitas interaksi, prosedural dan personal merupakan faktor determinan terhadap tingkat kepuasan pasien. Kata kunci: Determinan, Kepuasan Pasien, Kualitas Pelayanan, Onkologi, Radiodiagnostik
Co-Authors Adnindya, Msy Rulan Amanda Putri, Khairunnisa Rizqika Andriani, R.A. Linda Ardesy Melizah Kurniati Astarini, Afifah Ayeshah A Rosdah Ayu Suci Pratiwi Azizah, Aida Nur Citra Tresna Murti Devi, SNA Ratnasari Erizka Rivani Evi Lusiana Fatmawati, Fatmawati Fifa Argentina Fifa Argentina Gita Dwi Prasasty Hanna Marsinta Uli Islami, Arya Putera Islamia, Medina Putri Jayawarsa, A.A. Ketut Larasati, Veny Lorenza, Geofanny Mudzakky, Muhammad Yusuf Nita Parisa Nugraha, M Daffa Oktariana, Desi pariyana, Pariyana Rafli, Muhammad Ricardo, Angelina Natalia Rosdah, Ayesha Augusta Rosdah, Ayeshah Rukmana, Cici Chintya Aulia Sudarto Sudarto Syarinta Adenina Tahany, Hanifah Theodorus Theodorus Theodorus Yudha Dwi Satrio Yuli Kurniawati