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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Biomedical Journal of Indonesia SRIWIJAYA JOURNAL OF MEDICINE Jurnal Manajemen dan Administrasi Rumah Sakit Indonesia (MARSI) Jurnal Pengabdian Masyarakat: Humanity and Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kesehatan Gigi dan Mulut (JKGM) Science and Technology: Jurnal Pengabdian Masyarakat Indonesian Journal of Pharmacology and Therapy Jurnal Pengabdian Ilmu Kesehatan Glosains: Jurnal Sains Global Indonesia
Debby Handayati Harahap
Pharmacology Faculty Of Medicine Universitas Sriwijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Antimicrobial Potential of Coleus Atropurpureus and its Metabolites Content: A Literature Review Ayu Suci Pratiwi; Debby Handayati Harahap; Erizka Rivani
Jurnal Pengabdian Ilmu Kesehatan Vol. 5 No. 3 (2025): November: Jurnal Pengabdian Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jpikes.v5i3.6006

Abstract

The increasing prevalence of multidrug-resistant bacterial infections underscores the urgent need for new antimicrobial agents, especially those derived from plant-based sources. Coleus atropurpureus, a medicinal plant used extensively in Asia and Oceania, contains various bioactive compounds, including flavonoids, terpenoids, and phenolic acids, which have demonstrated antimicrobial properties. This review examines studies published between 2015 and 2025, highlighting the antibacterial activity of ethanolic and methanolic extracts of C. atropurpureus, particularly against methicillin-resistant Staphylococcus aureus (MRSA). Phytochemical analysis reveals that these extracts exert their antimicrobial effects through multiple mechanisms, including the disruption of microbial membranes, enzyme inhibition, the induction of reactive oxygen species, and immunomodulatory actions. Furthermore, the extracts have shown synergistic effects when combined with antibiotics, suggesting their potential as adjunct therapies. The evidence gathered supports the therapeutic potential of C. atropurpureus as a natural antimicrobial agent, offering a promising alternative to conventional antibiotics in combating drug-resistant infections.
Faktor Determinan Kualitas Pelayanan Radiodiagnostik Terhadap Kepuasan Pasien Onkologi Di Rumah Sakit Mohammad Hoesin Palembang Devi, SNA Ratnasari; Uli, Hanna Marsinta; Harahap, Debby Handayati
Jurnal Manajemen dan Administrasi Rumah Sakit Indonesia (MARSI) Vol 10, No 1 (2026): Jurnal Manajemen dan Administrasi Rumah Sakit Indonesia (MARSI)
Publisher : LPPM Universitas Respati Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52643/marsi.v10i1.7535

Abstract

Latar Belakang: Salah satu upaya yang untuk meningkatkan kualitas hidup pasien adalah dengan meningkatkan mutu pelayanan bagi pasien kanker. Mutu pelayanan yang baik akan meningkatkan kepuasan pasien.Tujuan penelitian ini adalah untuk menganalisis faktor determinan kualitas pelayanan Radiodiagnostik terhadap kepuasan pasien onkologi di Rumah Sakit Mohammad Hoesin Palembang Metode: Penelitian analitik observasional dengan rancangan cross sectional telah dilakukan di Instalasi Radiologi Rumah Sakit Mohammad Hoesin Palembang sejak bulan Juni hingga November 2025. Didapatkan 293 pasien kanker yang memenuhi kriteria penelitian. Hubungan kualitas pelayanan Radiodiagnostik terhadap kepuasan pasien onkologi dianalisis menggunakan uji Uji Chi-Square/Fisher Exact dilanjutkan dengan Uji Regresi Logistik. Hasil: Terdapat hubungan antara dimensi kualitas teknik ((PR sama dengan 43,672 atau p sama dengan 0,000) atau prosedural (PR sama dengan 12,179 atau p sama dengan 0,000) atau infrastruktur (PR sama dengan 26,625 atau p sama dengan 0,000) atau interaksi (PR sama dnegan 34,380 atau p sama dengan 0,000) atau personal (PR sama dengan 18,783 atau p sama dengan 0,000) atau dan dukungan sosial (PR sama dengan 16,928 atau p sama dengan 0,000) terhadap kepuasan pasien onkologi di Rumah Sakit Mohammad Hoesin Palembang Simpulan: Dimensi kualitas interaksi, prosedural dan personal merupakan faktor determinan terhadap tingkat kepuasan pasien. Kata kunci: Determinan, Kepuasan Pasien, Kualitas Pelayanan, Onkologi, Radiodiagnostik
Correlation Between Duration of Docetaxel Administration and Epiphora Severity in Nasopharyngeal Carcinoma Patients Riani Erna; Rafika Sidharta; Denny Satria Utama; Debby Handayati Harahap
Glosains: Jurnal Sains Global Indonesia Vol. 7 No. 3 (2026): Glosains: Jurnal Sains Global Indonesia
Publisher : Sekolah Tinggi Agama Islam Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59784/glosains.v7i3.772

Abstract

Background: Docetaxel, an effective chemotherapeutic agent for various cancers, including nasopharyngeal carcinoma, is associated with epiphora as a notable adverse effect. Objective: This study aimed to investigate the correlation between the duration of docetaxel administration and the severity of epiphora, as assessed by the Munk score, in patients with nasopharyngeal carcinoma. Methods: A descriptive cross-sectional study was undertaken at the Ophthalmology Polyclinic of Dr. Mohammad Hoesin Hospital, Palembang, from January to August 2024. The study sample comprised n=25 patients who met the research criteria. Epiphora severity was measured using the Munk score. Statistical analysis was performed using Spearman’s rank correlation test. Results: The majority of patients were male (68.2%) and aged ≤50 years (77.3%). Most received an 80 mg docetaxel dose (91%) for six weeks (77.3%). Based on the Munk score, 86.4% of patients had a score of 1, and 13.6% had a score of 2. No significant associations were found between Munk score and gender (p=0.445), age (p=0.578), or docetaxel dose (p=1.000). However, the duration of docetaxel administration was significantly associated with Munk score (p=0.001) and showed a moderate positive correlation with epiphora severity (r=0.626; p=0.001). Conclusion: Patients with a Munk score of 2 received docetaxel for a longer duration. A longer duration of docetaxel administration is associated with a higher Munk score for epiphora in nasopharyngeal carcinoma patients.
Co-Authors Adnindya, Rulan Alfajri Amanda Putri, Khairunnisa Rizqika Andriani, R.A. Linda Ardesy Melizah Kurniati Aura Salsabilla Putri Ayeshah A Rosdah Ayu Suci Pratiwi Citra Tresna Murti Denny Satria Utama Devi, SNA Ratnasari Erizka Rivani Evi Lusiana Fatmawati, Fatmawati Fifa Argentina Fifa Argentina Gita Dwi Prasasty Hanna Marsinta Uli Islamia, Medina Putri Jayawarsa, A.A. Ketut Lorenza, Geofanny Mudzakky, Muhammad Yusuf Nadira Rifda Utami Nita Parisa Nugraha, M Daffa Nyiayu Fauziah Kurniawati Oktariana, Desi Rafika Sidharta Rafli, Muhammad Riani Erna Ricardo, Angelina Natalia Rukmana, Cici Chintya Aulia Sudarto Sudarto Syarinta Adenina Tahany, Hanifah Theodorus Theodorus Theodorus Veny Larasati Yudha Dwi Satrio Yuli Kurniawati