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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Biomedical Journal of Indonesia SRIWIJAYA JOURNAL OF MEDICINE Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ners Jurnal Pengabdian Masyarakat: Humanity and Medicine Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kesehatan Gigi dan Mulut (JKGM) Science and Technology: Jurnal Pengabdian Masyarakat Indonesian Journal of Pharmacology and Therapy
Debby Handayati Harahap
Pharmacology Faculty Of Medicine Universitas Sriwijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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SIDE EFFECTS OF SECOND-LINE ANTITUBERCULOSIS DRUGS IN MULTI-DRUG RESISTANCE (MDR) TUBERCULOSIS PATIENTS Tamzil, Nia Savitri; Lorenza, Geofanny; Andriani, R.A. Linda; Theodorus, Theodorus; Sudarto, Sudarto; Lusiana, Evi; Harahap, Debby Handayati; Oktariana, Desi; Prasasty, Gita Dwi
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 2 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i2.483

Abstract

Multidrug-resistant tuberculosis (MDR TB) is caused by Mycobacterium tuberculosis strains resistant to isoniazid and rifampicin—the most potent anti-TB drugs. Prolonged treatment duration and complex drug regimens often lead to poor adherence, contributing to high MDR TB incidence and low treatment success rates, particularly in Indonesia. This study analyzed drug utilization patterns in 52 MDR TB patients at Dr. Mohammad Hoesin Hospital Palembang, using total sampling based on medical records from October 2018 to December 2019. Data were analyzed descriptively with SPSS v25. The most common side effects reported were weakness, nausea, and vomiting (84.6%), followed by arthralgia, hyperuricemia, and hearing loss (42.3%). Severe side effects were more prevalent in the short-term regimen group (40.4%) compared to the long-term group (7.7%). Weakness, nausea, and vomiting were the most frequently observed side effects in MDR TB patients.
Salbutamol Usage Pattern in Asthma Patients at Merdeka Public Health Center Palembang for the Period of January 1 – December 31, 2023 Mudzakky, Muhammad Yusuf; Adenina, Syarinta; Harahap, Debby Handayati
Sriwijaya Journal of Medicine Vol. 8 No. 1 (2025): Vol 8, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i1.305

Abstract

Salbutamol is a bronchodilator commonly used in the management of asthma, both in acute and chronic cases. As part of the Short-Acting Beta-2 Agonist (SABA) class, salbutamol is effective in relieving bronchospasms. The purpose of this study was to determine the rationality of drug use at the Merdeka Community Health Center Palembang. A drug utilization study was conducted at Merdeka Public Health Center Palembang in 2024. 96 patients meeting inclusion criteria. Drug use patterns were evaluated for dose rationalization, duration, frequency, contraindications, and interactions. Data analysis was performed using univariate methods. Sociodemographic characteristics showed that women were more prevalent than men (58.3%), with the most common age groups being pre-elderly and elderly (each 36.5%). All salbutamol doses (2–4 mg per administration) were appropriate (100%), with a duration of ≤3 days for all patients. The frequency of salbutamol administration of 3–4 times daily was found in 51% of cases, in line with recommendations. A total of 74% of patients received salbutamol with appropriate consideration of contraindications, while 26% received it despite contraindications, such as hypertension or hypertensive heart disease. Drug interactions were absent in 67.7% of cases, while antagonistic interactions, primarily with amlodipine, occurred in 17.3% of cases. The use of salbutamol at Merdeka Public Health Center Palembang mostly rational to drug use guidelines. However, attention is needed for contraindications and antagonistic interactions, especially with antihypertensive drugs. These findings can serve as a reference for improving asthma management and patient safety.
Gene Polymorphism Associated With Acute Respiratory Distress Syndrome (Ards): A Literature Review Wahyuni, Ari; Hafy, Zen; Harahap, Debby Handayati; Mustofa, Syazili
Jurnal Ners Vol. 10 No. 1 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.51923

Abstract

Gene polymorphisms can influence susceptibility, severity, and prognosis of ARDS. Genetic studies in ARDS have evolved from studies focused on candidate genes to studies that rely on a hypothesis-free approach to identify novel loci associated with ARDS risk or severity. In this review we outline the role of gene polymorphisms in ARDS susceptibility, severity, and prognosis. Several academic search engines were used in the literature search, including EMBASE/Elsevier. Science Direct, PubMed Central, Google Scholar, and Cochrane Review. Two subtopics were searched using Boolean Operators with keywords (ARDS OR acute respiratory distress syndrome) and (polymorphism) AND (ARDS) OR (genetic polymorphism) AND (ARDS) OR (polymorphism in ARDS). The studies retrieved discussed the impact of gene polymorphisms associated with ARDS including genes encoding interleukin 6 (IL-6), interleukin 10 (IL-10), vascular endothelial growth factor A (VEGF), angiotensin converting enzyme (ACE), interleukin 1 receptor antagonist (IL1RN), Fms Related Receptor Tyrosine Kinase 1 (FLT1) and Inducible Factor-1α (HIF-lα). These genes support significant associations and are involved in the regulation of gene expression associated with ARDS risk. Polymorphisms of IL-6, IL-10, VEGF, ACE, IL1RN, FLT1, HIF-lα play a role in susceptibility, severity, and prognosis of ARDS.
Co-Authors Adnindya, Msy Rulan Amanda Putri, Khairunnisa Rizqika Andriani, R.A. Linda Ardesy Melizah Kurniati Ari Wahyuni Ayeshah A Rosdah Azizah, Aida Nur Citra Tresna Murti Evi Lusiana Fatmawati, Fatmawati Fifa Argentina Fifa Argentina Gita Dwi Prasasty Islami, Arya Putera Islamia, Medina Putri Jayawarsa, A.A. Ketut Larasati, Veny Lorenza, Geofanny Mudzakky, Muhammad Yusuf Nita Parisa Nugraha, M Daffa Oktariana, Desi pariyana, Pariyana Rafli, Muhammad Ricardo, Angelina Natalia Rosdah, Ayesha Augusta Rosdah, Ayeshah A. Rukmana, Cici Chintya Aulia Sudarto Sudarto Syarinta Adenina Syazili Mustofa Tahany, Hanifah Theodorus Theodorus Theodorus Yudha Dwi Satrio Yuli Kurniawati Zen Hafy