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All Journal JSKK (Jurnal Sains Keolahragaan dan Kesehatan) JURNAL FARMASIMED (JFM) Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Journal of Innovative and Creativity Jurnal Kesehatan Bakti Tunas Husada Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Journal of Public Health Science (JoPHS) Galen: Jurnal Ilmu Farmasi dan Kesehatan Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Saeful Amin
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Literature Review: Analisis Khasiat Tanaman Pala (Myristica Fragnans Houtt) dalam Pengobatan Halitosis Oleh Bakteri Saeful Amin; Naila Naziba; Hayuning Putri Ambi; Salsabila Sasikirana
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i1.4475

Abstract

Halitosis, or bad breath, is a multifactorial condition that is often caused by anaerobic bacterial activity in the oral cavity, especially on the dorsum surface of the tongue. The use of natural ingredients as an alternative halitosis treatment is a concern, one of which is the nutmeg plant (Myristica fragrans), which has various active compounds such as essential oils, saponins, flavonoids, and alkaloids. This study aims to assess the potential of nutmeg plants in inhibiting the growth of bacteria that cause halitosis through a literature review of 30 national and international journals within the last five years. The results showed that nutmeg extracts, both from seeds, pulp, and leaves, have antibacterial activity against various types of halitosis-causing bacteria such as Streptococcus mutans, Staphylococcus aureus, and Escherichia coli. This activity is obtained through the mechanism of cell membrane damage and inhibition of bacterial cell wall synthesis by bioactive compounds in nutmeg plants. Therefore, nutmeg has potential as a natural antibacterial agent in the management of halitosis.
Potensi Kaempferol dan Kalkon Tergeranilasi Sebagai Kandidat Terapi Penyakit Jantung Koroner (PJK) Melalui Pendekatan Molecular Docking Saeful Amin; Tevani Almanda Ramdani; Maitsa Gita Salsabila; Teguh Nizar Zulmi
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i1.4504

Abstract

Coronary heart disease (CHD) is one of the leading causes of death worldwide due to impaired blood and oxygen supply to the heart muscle. This study aims to explore the potential of two natural compounds—kaempferol from Moringa oleifera and geranylated chalcone (GTDC) from Artocarpus altilis—as therapeutic candidates for CHD through a molecular docking approach. Medicinal chemistry analysis revealed that kaempferol exhibits significant affinity for the NF-κB protein, forming key hydrogen bonds with residues involved in the inflammatory process of atherosclerosis. Meanwhile, GTDC demonstrates strong binding to the P2Y12 receptor, which plays a crucial role in platelet aggregation, with a docking score lower than that of the natural ligand ADP. Structurally, hydroxyl group positioning and the lipophilic geranyl chain enhance both bioactivity and pharmacokinetic properties. In conclusion, a medicinal chemistry approach involving in silico docking, structure–activity relationship (SAR) analysis, and ligand optimization strategies confirms the potential of kaempferol and GTDC as promising multifunctional therapeutic agents for CHD. Further validation through in vivo studies and clinical testing is required.
Peran Kimia Medisinal dalam Pengembangan Obat Anti Sars Cov-2: Eksplorasi Senyawa Bioaktif dari Teh Hijau (Camellia Sinensis) Fitya Fithrotun Najiah; Citra Kusumaningsih; Saeful Amin; Hanifiani Kamila
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i1.4505

Abstract

COVID-19 is a viral respiratory disease that has caused a global health emergency and was declared a pandemic by the World Health Organization. The lack of certain drug molecules or treatment strategies for this disease is making it worse. Therefore, effective drug molecules are urgently needed to fight COVID-19. Specific therapies for the SARS-COV2 virus are still being developed in several countries around the world. One of the molecular targets that is thought to be specific to SARS-COV 2 is 3CLpro or the main protease of the COVID-19 virus which is an important enzyme to be able to replicate related viruses. The purpose of this study is to explore the role of medicinal chemistry in the development of anti-sars-cov 2 drugs through the exploration of bioactive compounds from natural sources, namely green tea. Green tea (Camellia sinensis) also contains eight native monomeric catechins or polyphenolic compounds. The method used was literature review with analysis of 3 selected articles from international databases such as PubMed, ScienceDirect, and Springer, as well as SINTA accredited national journals. The results showed that all test compounds except caffein had stronger binding energy than lopinavir. Epicatecin and catechin have the same binding energy value as lopinavir, which is -7.1 kcal/mol. Catechin gallate and epicatechin gallate have the strongest bond among all test compounds because they have the most negative AG, namely -9.0 and 8.2 kcal/mol.
Studi Literatur : Penambatan Senyawa Komponen Tanaman Kumis Kucing ( Orthosiphon Stamineus Benth ) Sebagai Diuretik Menggunakan Metode Docking Sefira Novi Ariyanto; Saeful Amin; Eva Sucianti; Fitria Mutiara Rohmah
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i1.4511

Abstract

Orthosiphon stamineus Benth., commonly known as kumis kucing, is a widely recognized medicinal herb in traditional medicine, particularly valued for its diuretic properties. This study aims to evaluate the potential of active compounds in O. stamineus as diuretic agents through an in silico approach using molecular docking methods. A total of 98 compounds were screened against three diuretic target receptors: 1Z9Y (furosemide receptor), 3HS4 (acetazolamide receptor), and 3VHU (spironolactone receptor). The docking results revealed that lithospermic acid I, dicaffeoyl tartaric acid, and orthosiponone C exhibited lower binding energies compared to standard ligands, indicating higher affinity and stronger molecular interaction stability. Molecular visualization showed that these compounds formed specific interactions, such as hydrogen bonds and π-π stacking, resembling the binding mechanisms of synthetic diuretics. This study highlights the significant potential of O. stamineus to be developed into a natural diuretic phytopharmaceutical. However, further validation through in vitro and in vivo studies is necessary to confirm their efficacy and safety in complex biological systems.
Prediksi Aktivitas Antikanker Babandotan dengan Pendekatan Kimia Medisinal dan Komputasi In Silico Nazwa Cahya Kamila; Saeful Amin; Ai Sriwahyuni; Azzindani Januar
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i1.4575

Abstract

This research aims to explore the potential of secondary metabolites from babandotan plant (Ageratum conyzoides L.) as breast cancer drug candidates through a medicinal chemistry approach using in silico studies. Breast cancer has the highest prevalence among women in Indonesia, with conventional treatments often causing serious side effects, prompting the search for new anticancer agents from natural sources. Babandotan plant (Ageratum conyzoides L.) has been empirically proven to have cytotoxic effects against cancer cells and possesses various pharmacological activities with anticancer potential based on its bioactive compounds such as flavonoids, terpenoids, alkaloids, and sterols.
Kajian Potensi Senyawa Aktif Bahan Alam sebagai Inhibitor Human Epidermal Growth Factor Receptor 2 (Her-2) pada Kanker Payudara : Kajian Penambatan Molekuler Saeful Amin; Anantha Puspatiara; Fina Awaliah; Widiya Zulvania
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i1.4602

Abstract

Breast cancer is the most prevalent type of cancer in women worldwide, with approximately 2.3 million new cases or 11.7% of all cancer cases. Human Epidermal Growth Factor Receptor 2 (HER-2) is one of the important therapeutic targets in breast cancer that is overexpressed in 15-25% of cases. Conventional cancer treatments such as chemotherapy often cause adverse side effects, so safer alternative therapies are needed. This study aims to assess the potential of active compounds from medicinal plants as HER-2 inhibitors through a molecular docking approach. The literature review method was used by analysing related research articles in the last five years obtained from PubMed and Google Scholar databases. The results showed that several active compounds have high potential as HER-2 inhibitors, including beta cystosterol from guava leaves (Psidium guajava L.) with a binding energy value of -12.3 kcal/mol, vitexin from dandang gendis (Clinacanthus nutans L.) with a value of -9.3 kcal/mol, and isovitexin from basil mekah (Ocimum gratissimum) with a value of -9.11 kcal/mol. These findings provide a basis for further development of natural active compounds as potential breast anticancer drug candidates with minimal side effects.
Pendekatan Kimia Medisinal dalam Optimasi Senyawa Bioaktif dari Bahan Alam sebagai Kandidat Obat Antikanker Saeful Amin; Neng Padia Amelia; Tiara Oktavia Ramadhan; Silvia Dwi Putri
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.4430

Abstract

Cancer is one of the leading causes of death in the world, with the incidence rate continuing to increase every year. Conventional treatments such as chemotherapy and radiotherapy often have limitations, especially related to selectivity towards cancer cells and toxic side effects caused to normal cells. Therefore, an alternative approach that is more effective and safe is needed. One promising approach is the utilization of bioactive compounds from natural materials that are optimized through a medicinal chemistry approach. This study aims to examine the potential of natural compounds such as epigallocatechin gallate (EGCG) from green tea, berberine from Berberis vulgaris, curcumin from turmeric (Curcuma longa), and cardiotonic steroids (CTS) from Digitalis purpurea and Nerium oleander as anticancer agents, as well as their optimization strategies through structural modification, increased stability, and modern delivery technology. The method used is a systematic literature review of scientific articles from 2020 to 2025 obtained through the PubMed, ScienceDirect, and Google Scholar databases. The results of the study indicate that these compounds have various anticancer mechanisms of action, such as apoptosis induction, cell cycle inhibition, and activation of specific signaling pathways such as PI3K/Akt, MAPK, and ferroptosis. However, challenges such as low bioavailability, poor stability, and toxicity are still obstacles in their application. Through a medicinal chemistry approach, these compounds can be structurally modified or reformulated to improve their clinical effectiveness. In conclusion, the combination of natural wealth with medicinal chemistry innovation opens up great opportunities in the development of more selective, effective, and safe anticancer therapies in the future.
Eksplorasi Potensi Senyawa Alam dalam Aktivitas Antikanker Payudara: Pendekatan IN SILICO Saeful Amin; Inggit Suci Listya
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 1 (2026): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v2i1.111

Abstract

Kanker payudara menjadi salah satu penyebab utama kematian pada wanita di seluruh dunia, termasuk di Indonesia, dengan tingkat prevalensi mencapai sekitar 16,6% dari total kasus kanker baru (Marubeni, 2023). Keterbatasan efektivitas terapi konvensional akibat munculnya resistensi obat, efek samping yang berat, serta biaya pengobatan yang tinggi mendorong perlunya alternatif terapi yang lebih aman, efisien, dan terjangkau. Penelitian ini bertujuan untuk mengkaji potensi senyawa alami sebagai agen antikanker payudara melalui pendekatan in silico. Metode yang diterapkan berupa studi pustaka dengan analisis deskriptif terhadap hasil penelitian terdahulu yang menggunakan teknik molecular docking, virtual screening, dan prediksi ADMET. Hasil telaah menunjukkan bahwa beberapa senyawa alami seperti Berberine, Fisetin, Ellagic Acid, Kurkumin, Kaempferol, dan Withaferin A memiliki afinitas ikatan yang kuat (−7,0 hingga −13,7 kcal/mol) terhadap protein target kanker payudara, di antaranya EGR, BCL-2, dan PKC-α. Selain itu, simulasi dinamika molekuler mengindikasikan stabilitas kompleks yang baik serta profil farmakokinetik yang mendukung potensi bioaktifnya. Namun, isu bioavailabilitas dan validasi biologis masih menjadi tantangan utama. Secara keseluruhan, pendekatan in silico terbukti mampu mempercepat proses identifikasi kandidat obat antikanker berbasis bahan alam serta menjadi landasan bagi penelitian lanjutan secara in vitro dan in vivo.
Senyawa Aktif Kumis Kucing (Orthosiphon stamineus Benth.) : Tinjauan Farmakologi sebagai Agen Diuretik dan Antidiabetes Saeful Amin; Hasny Dwi Rahman
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 2 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i2.98

Abstract

Kumis kucing (Orthosiphon stamineus Benth.) telah lama digunakan dalam praktik pengobatan tradisional untuk gangguan ginjal dan gangguan metabolik. Artikel ini menyajikan tinjauan literatur sistematis terhadap bukti farmakologi senyawa aktif kumis kucing sebagai agen diuretik dan antidiabetik, dengan studi kepustakaan berupa penelusuran pada Google Scholar dan PubMed rentang tahun 2020–2025. Sintesis dari sembilan studi menunjukkan bahwa ekstrak dan fraksi kumis kucing kaya akan flavonoid (sinensetin, luteolin, eupatorin) serta asam fenolat (asam litospermat) yang berperan dalam peningkatan diuresis dan natriuresis pada uji hewan, penghambatan enzim α-glukosidase, hingga modulasi jalur insulin (PTP1B, GLUT4). Studi in silico mendukung adanya interaksi multi-target antara senyawa tersebut dan protein target baik di ginjal maupun pada jalur metabolik glukosa. Aktivitas antioksidan dan antiinflamasi senyawa kumis kucing memperkuat efek protektif pada ginjal dan pankreas. Hasil pada praklinis konsisten dan menjanjikan, heterogenitas metode ekstraksi, keterbatasan standardisasi, serta minimnya bukti klinis pada manusia masih membatasi penerapan klinis. Disarankan langkah lanjutan berupa standardisasi fitokimia, studi farmakokinetik/toxikologi, dan uji klinis terkontrol untuk mengonfirmasi keamanan dan efektivitas fitofarmaka berbasis O. stamineus.
Peran Kimia Medisinal dalam Penemuan Obat Baru untuk Mengatasi Resistensi Antibiotik Saeful Amin; Anwar, Reza Jakaria
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 1 (2026): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v2i1.99

Abstract

Resistensi antibiotik merupakan salah satu ancaman kesehatan global yang semakin meningkat akibat penggunaan antibiotik yang tidak tepat, baik pada manusia maupun hewan. Kondisi ini menurunkan efektivitas terapi penyakit infeksi dan berpotensi menimbulkan krisis kesehatan di masa depan. Oleh karena itu, penemuan antibiotik baru dengan pendekatan modern menjadi sangat penting. Penelitian ini bertujuan untuk mengeksplorasi peran kimia medisinal dalam penemuan obat baru yang mampu mengatasi resistensi antibiotik melalui integrasi metode in vitro dan in silico. Metode penelitian dilakukan dengan studi literatur menggunakan database Google Scholar dan ScienceDirect tahun 2020–2025 dengan kata kunci “resistensi antibiotik”, “antimikroba”, dan “kimia medisinal”. Dari hasil telaah, diperoleh berbagai studi yang menunjukkan efektivitas pendekatan kombinasi, antara lain uji aktivitas antibakteri senyawa alami dan sintetik, farmakokinetik, serta pemodelan komputasi seperti QSAR, molecular docking, dan algoritma berbasis AI. Hasilnya, beberapa senyawa potensial ditemukan, seperti NG1 dan DN1 hasil desain AI, seftarolin fosamil yang aktif terhadap MRSA, senyawa endofit maupun laut dengan aktivitas antibakteri signifikan, serta flavonoid modifikasi dengan afinitas tinggi terhadap target enzim. Kesimpulannya, integrasi pendekatan in vitro dan in silico terbukti efektif mempercepat penemuan antibiotik baru, menekan biaya penelitian, serta membuka peluang besar dalam menghadirkan terapi inovatif untuk menghadapi krisis resistensi antibiotik.
Co-Authors Adi Budi Ramadhan, Adi Budi Ramadhan Agis Difa Maharan Ahmad, Zahratunnisa Ai Nuraisah Ai Sriwahyuni Alfi Nurul Aini Aliya Fayyaza Khairun Nisa Amir Mursadad Anantha Puspatiara Andri Prasetiyo Anwar, Reza Jakaria Atiqoh Azizah Azriel Pratama, Arryza Azzindani Januar Cheriel Dhiya Nazwa Alivia Desinta Nurohman Husen Devi Wulandari Dhearlyn Astania Oxtavia Amir Dinda Nurhayati Famili Dini Aryani Esti Mumpuni Eva Sucianti Fina Awaliah Firli Nimah Dinda Azqiah Fitria Mutiara Rohmah Fitya Fithrotun Najiah Fuza Khoirun Nisa Galih Hamdani Riansyah Gani Gusdayan Hanif Azhar Zaidaan Hanifiani Kamila Hasny Dwi Rahman Hayuning Putri Ambi Hendra Komara Hidayah, Nauval Aqil Icha Aisah Azzahra Inggit Suci Listya Intan Permatasari Jayanty, Rizka Sri Karina Budi Arti Lidiasari, Alda Lidiasari Maesaroh Maesaroh Maitsa Gita Salsabila Muhammad Akbar Alfi Fauzan Naila Naziba Nandita Marsya Putri Utami Natasya Zakiatul Awalia Irhan Nazmi Tri Harja Nazwa Cahya Kamila Neng Mirna Wati Dewi Neng Padia Amelia Nida Atsila Anamareri Nova Noor Fauzan Nova Sopiyanti Nurlichan, Suci Rahayu Oktaviani, Rissa Aenur Olivia Fauzi Syalamatul Syalamatul Putri Putri Nasywa Nabilah Ma’rifatillah Putri, Amyla Putri Nurul Nazmi Ratna Wulandari Rayhanah Firdaus Kusmawan restu rianingsih Sabrina Putri Mutiara Fajrin Salla Sabillah Salsabila Sasikirana Sefira Novi Ariyanto Sekar Harsti Rahmadhani Setiawati, Dede Evita Shilvia Siti Nurohmah Shinta Nursifa Silvia Dwi Putri Siti Maryam Slamet Ibrahim - Solihah, Adilla Nurafdilla Suci Mega Rahmi Suryaman, Novita Deris Syifa Alifia Azzahra Teguh Nizar Zulmi Tevani Almanda Ramdani Tiara Oktavia Ramadhan Tsani, Ghani Angga Widiya Zulvania Yosi Setiawati