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All Journal JSKK (Jurnal Sains Keolahragaan dan Kesehatan) JURNAL FARMASIMED (JFM) Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Journal of Innovative and Creativity Jurnal Kesehatan Bakti Tunas Husada Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Journal of Public Health Science (JoPHS) Galen: Jurnal Ilmu Farmasi dan Kesehatan Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Saeful Amin
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Tinjauan Kimia Medisinal: Hubungan Struktur-Aktivitas Senyawa Bahan Alam sebagai Kandidat Antikanker Payudara Saeful Amin; Icha Aisah Azzahra; Natasya Zakiatul Awalia Irhan; Syifa Alifia Azzahra
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 5 No. 2 (2026): Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v5i2.9344

Abstract

Breast cancer remains a major global health challenge, with treatment effectiveness often limited by drug resistance and the toxic side effects of chemotherapy on normal cells. The exploration of bioactive compounds from natural sources through a medicinal chemistry approach offers a promising alternative strategy. This study aims to examine the molecular mechanisms of action and Structure-Activity Relationships (SAR) of various natural compound scaffolds as potential breast anticancer agents. The method employed was a systematic narrative literature review of 15 recent scientific articles evaluating computational parameters, including molecular docking, as well as in vitro and in vivo activities. The results indicate that polyphenols, flavonoids such as quercetin and EGCG, and curcumin possess strong cytotoxic activity and high binding affinity toward cancer-related target macromolecules. SAR analysis demonstrates that key structural features, including the number and position of free phenolic hydroxyl groups, the presence of gallate ester groups, and conjugated diketone systems, play a crucial role in determining ligand receptor complex stability. These interactions are supported by hydrogen bonding, hydrophobic interactions, and favorable steric compatibility within receptor binding sites. Computational findings further suggest that structural optimization can enhance ligand selectivity and improve pharmacokinetic properties. This study concludes that natural phytochemical scaffolds have significant potential as lead compounds and provide a rational basis for Computer-Aided Drug Design in developing more potent, selective, multi-target, and safer breast anticancer therapies.
Kajian Kimia Medisinal Ciprofloxacin: Mekanisme Kerja, Antibakteri, dan Pola Resistensi Bakteri Saeful Amin; Fuza Khoirun Nisa; Yosi Setiawati; Muhammad Akbar Alfi Fauzan
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 2 (2025): Mei : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i2.3923

Abstract

Ciprofloxacin is a fluoroquinolone antibiotic that is widely used in the treatment of various bacterial infections. This study aims to analyze the mechanism of action of ciprofloxacin from a medicinal chemistry perspective, evaluate its antibacterial effectiveness against pathogenic bacteria, and identify the developing resistance patterns. The method used is a literature study by reviewing various relevant scientific literature. The results of the study indicate that ciprofloxacin works by inhibiting the enzymes DNA gyrase and topoisomerase IV, which play an important role in bacterial DNA replication and transcription, causing DNA fragmentation and bacterial cell death. Ciprofloxacin shows high antibacterial activity against Escherichia coli, Staphylococcus aureus, Salmonella typhi, and Vibrio cholerae. However, resistance to ciprofloxacin continues to increase, mainly due to target gene mutations, increased expression of efflux pumps, and changes in porin structure. A deep understanding of the structure-activity of ciprofloxacin is important in the development of new derivatives that are more effective and able to overcome resistance. This study provides important insights into the innovation of more robust antimicrobial drug design.
Tinjauan Kimia Medisinal Senyawa Fenol dari Ekstrak Daun dan Biji Pepaya (Carica papaya) sebagai Anti Kanker Devi Wulandari; Saeful Amin; Nida Atsila Anamareri; Atiqoh Azizah
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 2 (2025): Mei : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i2.3926

Abstract

Purpose: The aim of this study is to measure the total phenolic content in papaya (Carica papaya L.) leaf and seed extracts and to evaluate their potential as anticancer agents based on their antioxidant activity. Methodology/approach: Location & Materials: Papaya leaves and seeds were sourced from Manoko, Bandung. Extraction: The samples were washed, dried at 45°C, powdered, and extracted with 70% ethanol using the reflux method. Analysis: Total phenolic content was measured using a UV-Vis spectrophotometer at 761 nm after reacting extracts with Folin-Ciocalteu reagent and sodium carbonate. Results were compared to a gallic acid standard curve. Supporting Methods: Literature review on medicinal chemistry and anticancer drug development, as well as qualitative analysis using thin-layer chromatography (TLC) for main phenolic compounds. Results/findings: Papaya leaf and seed extracts contain significant phenolic compounds, including flavonoids and phenolic acids. These phenolics contribute to antioxidant activity, which helps protect cells from oxidative damage linked to cancer. Previous studies show papaya leaf extract can act as an immunomodulator and anticancer agent, while papaya seed contains benzyl isothiocyanate, which inhibits cancer cell growth. Limitations: The study only measures total phenolic content and does not isolate or identify individual active compounds. Anticancer activity is inferred from phenolic content and literature, not directly tested in vivo or in clinical trials. Contribution: This research provides scientific evidence that papaya leaves and seeds are promising natural sources of phenolic compounds with antioxidant and potential anticancer properties. The findings support further research in pharmacy, medicinal chemistry, and oncology, especially for developing plant-based anticancer agents.
Karakterisasi Aktivitas Antioksidan Ekstrak Etanol Bawang Lanang (Allium sativum L.) Melalui Uji DPPH Shinta Nursifa; Saeful Amin; Olivia Fauzi Syalamatul Syalamatul Putri; Firli Nimah Dinda Azqiah
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 2 (2025): Mei : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i2.3940

Abstract

Purpose: This study aimed to evaluate the antioxidant activity and identify secondary metabolite compounds of the ethanol extract from lanang onion bulbs (Allium sativum L.) against DPPH free radicals. Methodology/approach: Extraction was performed by maceration using 95% ethanol, followed by fractionation with n-hexane, ethyl acetate, and water. Antioxidant activity was tested qualitatively by thin-layer chromatography (TLC) and quantitatively by the DPPH method using a UV-Vis spectrophotometer. Phytochemical screening was carried out to identify bioactive compound content. Results/findings: The ethanol extract and ethyl acetate fraction exhibited strong antioxidant activity with IC₅₀ values of 13.85 ppm and 7.27 ppm, respectively. Phytochemical tests revealed the presence of flavonoids, saponins, alkaloids, tannins, steroids, and triterpenoids in each fraction. Limitations: This study was limited to in vitro testing and did not include comprehensive toxicity or in vivo analysis. Contribution: This research contributes to the development of natural antioxidants in pharmacology, phytochemistry, traditional medicine, and functional food industries. The results are useful for researchers, academics, and herbal or health-related industries.
Peran Senyawa Bioaktif Tumbuhan untuk Penyakit Degeneratif : Tinjauan Kimia Medisinal Agis Difa Maharan; Saeful Amin; Nova Noor Fauzan; Nova Sopiyanti
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 2 (2025): Mei : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i2.3959

Abstract

Degenerative diseases, such as Alzheimer's, diabetes mellitus, and cancer, are global health challenges whose prevalence increases with increasing life expectancy. Phytochemicals, bioactive compounds found in plants, have shown potential in preventing and inhibiting the development of these diseases. Compounds such as flavonoids, polyphenols, and glucosinolates have antioxidant, anti-inflammatory, and neuroprotective activities that can protect these body cells from oxidative damage and chronic inflammation. This study suggests that consuming phytochemical-rich foods, such as cruciferous vegetables, pigmented fruits, and certain spices, contributes to a reduced risk of degenerative diseases.
Kimia Medisinal dan Masa Depan Pengobatan Desinta Nurohman Husen; Saeful Amin; Karina Budi Arti; Maesaroh Maesaroh
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 2 (2025): Mei : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i2.3989

Abstract

This study aims to review the latest developments in medicinal chemistry and its prospects in the development of future treatments. Through a comprehensive literature study approach, this study analyzes the latest innovations in drug design and development, including the use of computational technology, nanotechnology, and biological target-based approaches. The results show that the integration of artificial intelligence and machine learning technologies with conventional medicinal chemistry techniques has opened a new paradigm in more efficient and precise drug discovery. Personalization of treatment based on patient genetic profiles, development of new antibiotics to overcome antimicrobial resistance, and nanomaterial-based therapies are important trends in contemporary medicinal chemistry applications. This study concludes that the future of medicine will be greatly influenced by advances in medicinal chemistry, with the main challenges being safety, regulation, and accessibility.More intensive multidisciplinary collaboration is needed between chemists, biologists, pharmacologists, clinical medicine, and informatics to optimize the potential of medicinal chemistry in the future medicine revolution.
Tinjauan Kimia Medisinal dalam Pengembangan Obat Berbasis Flavonoid: Studi Literatur Saeful Amin; Wulandari, Ratna
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 5 No. 1 (2026): Januari: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v5i1.5538

Abstract

Flavonoids are natural polyphenols that are abundantly found in a wide variety of fruits, vegetables, seeds, and medicinal plants, and are known for their wide-ranging antioxidant, anticancer, anti-inflammatory, and antidiabetic effects. This comprehensive review outlines the important role of medicinal chemistry in the development of flavonoid-based therapeutics, with a particular focus on classification, structure activity relationships (SAR), mechanisms of action, and various strategies to improve bioavailability. Literature from PubMed, Scopus, and Google Scholar indicates that structural features such as hydroxyl group number and position, the C2=C3 double bond, and modifications like methylation, glycosylation, or prenylation strongly influence biological activity and pharmacokinetics. Clinical use is limited by poor solubility, rapid metabolism, and low stability. Chemical modification and advanced delivery systems including liposomes, nanoparticles, nanocrystals, micelles, and natural carriers can enhance solubility and plasma concentration. Combining medicinal chemistry with modern formulation technologies may enable flavonoids to become safe and effective therapeutic agents.
Literature Review: Potensi Monascus Purpureus sebagai Agen Antikolesterol Alami Saeful Amin; Hanif Azhar Zaidaan; Rayhanah Firdaus Kusmawan
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 5 No. 1 (2026): Januari: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v5i1.5617

Abstract

Monascus purpureus, also known as red yeast rice, is a red mold widely used in traditional Asian food fermentation, particularly in Indonesia and China. One of its main bioactive compounds is monacolin K, a substance structurally identical to lovastatin, a well-known cholesterol-lowering statin drug. Monacolin K works by inhibiting the HMG-CoA reductase enzyme, a key enzyme in the biosynthesis of cholesterol in the liver. Various modern studies have demonstrated that Monascus purpureus consumption can significantly reduce total cholesterol, low-density lipoprotein (LDL), and triglyceride levels, while increasing high-density lipoprotein (HDL) levels, with relatively minimal side effects compared to synthetic statins. In addition, the natural pigments produced by Monascus purpureus, such as monascin and ankaflavin, exhibit strong antioxidant and anti-inflammatory activities that help protect vascular endothelial cells from oxidative stress and inflammation—two major factors contributing to atherosclerosis. The combination of M. purpureus extracts with probiotics or other natural ingredients, such as garlic or fermented soy products, has also been shown to produce synergistic effects in improving lipid metabolism and promoting cardiovascular health. With its potent bioactive components and high safety profile, Monascus purpureus holds great potential to be developed as a natural anticholesterol agent for the prevention and management of dyslipidemia in a sustainable and effective manner.
Co-Authors Adi Budi Ramadhan, Adi Budi Ramadhan Agis Difa Maharan Ahmad, Zahratunnisa Ai Nuraisah Ai Sriwahyuni Alfi Nurul Aini Aliya Fayyaza Khairun Nisa Amir Mursadad Anantha Puspatiara Andri Prasetiyo Anwar, Reza Jakaria Atiqoh Azizah Azriel Pratama, Arryza Azzindani Januar Cheriel Dhiya Nazwa Alivia Desinta Nurohman Husen Devi Wulandari Dhearlyn Astania Oxtavia Amir Dinda Nurhayati Famili Dini Aryani Esti Mumpuni Eva Sucianti Fina Awaliah Firli Nimah Dinda Azqiah Fitria Mutiara Rohmah Fitya Fithrotun Najiah Fuza Khoirun Nisa Galih Hamdani Riansyah Gani Gusdayan Hanif Azhar Zaidaan Hanifiani Kamila Hasny Dwi Rahman Hayuning Putri Ambi Hendra Komara Hidayah, Nauval Aqil Icha Aisah Azzahra Inggit Suci Listya Intan Permatasari Jayanty, Rizka Sri Karina Budi Arti Lidiasari, Alda Lidiasari Maesaroh Maesaroh Maitsa Gita Salsabila Muhammad Akbar Alfi Fauzan Naila Naziba Nandita Marsya Putri Utami Natasya Zakiatul Awalia Irhan Nazmi Tri Harja Nazwa Cahya Kamila Neng Mirna Wati Dewi Neng Padia Amelia Nida Atsila Anamareri Nova Noor Fauzan Nova Sopiyanti Nurlichan, Suci Rahayu Oktaviani, Rissa Aenur Olivia Fauzi Syalamatul Syalamatul Putri Putri Nasywa Nabilah Ma’rifatillah Putri, Amyla Putri Nurul Nazmi Ratna Wulandari Rayhanah Firdaus Kusmawan restu rianingsih Sabrina Putri Mutiara Fajrin Salla Sabillah Salsabila Sasikirana Sefira Novi Ariyanto Sekar Harsti Rahmadhani Setiawati, Dede Evita Shilvia Siti Nurohmah Shinta Nursifa Silvia Dwi Putri Siti Maryam Slamet Ibrahim - Solihah, Adilla Nurafdilla Suci Mega Rahmi Suryaman, Novita Deris Syifa Alifia Azzahra Teguh Nizar Zulmi Tevani Almanda Ramdani Tiara Oktavia Ramadhan Tsani, Ghani Angga Widiya Zulvania Yosi Setiawati