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All Journal Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Jurnal Matematika & Sains Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Acta Pharmaceutica Indonesia JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) ALCHEMY Jurnal Penelitian Kimia JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Majalah Farmasetika Jurnal Ilmiah Farmasi Farmasyifa Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Riset Farmasi Pharmaceutical Sciences and Research (PSR) Bandung Conference Series: Pharmacy Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi
Sani Ega Priani
Universitas Islam Bandung
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Journal : Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)

 1 
Development of Nanocapsules Containing Cytotoxic Agents- A Review: Kajian Literatur Pengembangan Sediaan Nanokapsul Mengandung Agen Sitotoksik Priani, Sani Ega; Setianty, Tia Nur; Aryani, Ratih; Fitrianingsih, Sri Peni; Syafnir, Livia
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 2 (2021): (October 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i2.15578

Abstract

Background: The incidence and mortality of cancer are rapidly growing worldwide. Modification on drug delivery systems based on nanotechnology was applied to improve the effectiveness and safety of treatment. Nanoencapsulation, a part of nanotechnology, was known can be involved in cytotoxic agents. Objective: This research was conducted to determine the type of polymers for nanoencapsulation of cytotoxic agents and analyze the effect of nanoencapsulation on the cytotoxic activity. Methods: The study was performed by systematic literature review using selected articles from reputable databases that meet the inclusion and exclusion criteria. Results: The results show that many cytotoxic agents have been developed in nanocapsules systems due to their low water solubility, chemical instability, and low bioavailability. The nanoencapsulation process was carried out using synthetic or natural polymers such as polylactic-co-glycolic acid (PLGA), PEGylated PLGA, polycaprolactone (PCL), chitosan-sodium tripolyphosphate, chitosan-sodium alginate, heparin-poly(l-lysine), and polymethyl methacrylate (PMMA). Those polymers are widely used for nanoencapsulation related to their biocompatible, biodegradable, non-toxic, and providing the desired coating properties. The nanoencapsulation on cytotoxic agents significantly increases the in vitro cytotoxicity, marked by the decrease of IC50 value in the range 1.4-15.4 folds compared to pure drugs. The increase in cytotoxicity could be caused by particle size reduction, modification of particle surface properties, and enhancement of drug stability. Conclusion: It can be concluded that nanoencapsulation can be applied for cytotoxic agents to increase their activity using the appropriate coating polymer.
Co-Authors Ainul Fatihah Halim Aisyah Nurul Fitri Aisyah, Nurul Siti Almirah Azis Amila Gadri Anan Suparman Anan Suparman Anan Suparnan Anindi Febrilia Annisa Khansa Pratiwi Aprian Dwiatama Arini Gania Shapira Aulia Fikri Hidayat Clarisa Ananda Putri Putri Darijanto, Sasanti Tarini Debby Prihasti Ayustine Delfiana Aura Efrida Desti Puspa Rahayu Dina Mulyanti Dina Mulyanti Dina Mulyanti Dina Mulyanti Dinda Ayu Fauziyah Dinnanda Yussepina Wulansari Dinnanda Yussepina Wulansari Dona Indriastuti Dwiatama, Aprian Dyah Ayu Nurismawati Efrida, Delfiana Aura Eka Darma, Gita Cahya Faqih Radina Fetri Lestari Fetri Lestari Fida Surtiniyati Shofia Fitri Mellyna Cantika Fitrianti Darusman Frida Anggita Amalia G.C. Eka Darma Gita Cahya Eka Darma Gita Cahya Eka Darma Halim, Ainul Fatihah Hanifa Rahma Hanifa Rahma Hasna Syakira Fauziah Hilmi Fauzan Nurhakim Indah Ayu Lestari Indra T Maulana Indra Topik Maulana Iwo, Maria Immaculata Jahra Farhanuddin Lanny Mulqie Linda Nur'Aini Livia Syafnir Maria Immaculata Iwo Maria Immaculata Iwo Melati Sasabila Mentari Luthfika Dewi Mentari Luthfika Dewi Mira Nurseha Muhammad Taufik Septian Mulkiya, Kiki Nadya Lutfiah Nashita Rafawziya Nazela Constantia Hilyatul Aulia Neneng Alifia Nur Fauziah Nurrayyan Nurrayyan Nurrayyan, Nurrayyan Nurul Siti Aisyah Pedriantini Iqlima Subekti Putri, Clarisa Ananda Radina, Faqih Rafanisa Apriansah Rafika Susun Nursunda Raisha Az Zahra Ratih Aryani Ratih Aryani Ratih Aryani Ratih Aryani, Ratih Ratri Putri Chairunnisa Restianti Mutiara Reyhan G Reza A K Rizki Anggara Permana Rizza F. Nurasyfa Robby Prayitno Saadiya Noerman Salsabilla Wijaya Salwa Fajriati Maulida Mudakir Sasanti Tarini Darijanto Sasanti Tarini Darijanto, Sasanti Tarini Setianty, Tia Nur Shelma Azhari Abdilla Sifa Tamhaz Siti Anggina Ismiyati Solihat Soewondo, Budi Prabowo Somantri, Sri Yulianingsih Sri P. Fitraningsih Sri Peni Fitrianingsih Sri Yulianingsih Somantri Syafira Nissa Fahira Syafnir, Livia Syifa Siti Fatimah Azzahro Tati Kurniati Taufik Muhammad Fakih Tri Suciati Vina Azzahra Siti Nurhedian Widad Aghnia Shalannandia Wijaya, Salsabilla Wulan Kartika Dewi Yasmin Ramadania Burhanudin Zainab Zahira Azzahra Zalfa Ainun Rozak