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A retrospective clinicopathologic study of lichen planus and lichenoid lesions in the oral cavity Primasari, Ameta
Padjadjaran Journal of Dentistry Vol 21, No 3 (2009): November 2009
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.797 KB) | DOI: 10.24198/pjd.vol21no3.14108

Abstract

Lichen planus is a common oral disorder which may represent the manifestation of varies clinical presentation and microscopic findings. In this retrospective study of 86, cases of oral lichen planus (OLP) were compared with 73 cases of oral lichenoid lesions (OLL). Various clinicohistopathological features were studied. The object of this study was to compare clinical and microscopic findings in order to present evidence that supports the position of true lichen planus. Biopsy specimens were obtained from every patient. The biopsy specimens were fixed in 10 percent formalin, embedded in paraffin, sectioned at 4 microns and stained by means of routine hemotoxylin and eosin procedures. The histologic specimens were examined and evaluated without knowledge of clinical findings. The mean age at presentation of patients with OLP was 42.5 years as compared to 47.0 years for OLL. There was no significant difference between the ethnic groups, site of lesions and the distribution of the clinical presentation. Compare to histopathologic findings, there were only 55% clinical and histological agreement in this study, this because of using strict criteria for oral lichen planus there could be an over diagnosis lesions. This study showed that there were no reliable clinical and histopathological features which could differentiate OLL from OLP. The features in the OLL group were non specific. The patient’s medical history, oral habits or psychological status appeared to be able to alter the classical clinicopathological findings.
The Tooth Agenesis in Clinical Practice: A review of Case Reports Michael Dany; Ameta Primasari; Ervina Sofyanti; Sry Suryani Widjaja; Thantrira Porntaveetus
Dentika: Dental Journal Vol. 28 No. 1 (2025): Dentika: Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v28i1.20149

Abstract

Tooth agenesis (TA) relates to multiple congenital dental disorder and the most prevalent developmental disorders affecting approximately 200 million people globally. The management of TA require interdisciplinary dental approaches. Therefore, this study aimed to conduct a case report evaluation of TA based on population and ethnicity. This scoping reviews based on  Preferred Reporting Items for Systematic Reviews and Meta-Analyses, has been registered in Open Science Framework. Relevant articles were retrieved from Proquest, Science Direct, PubMed, and SpringerLink databases with keywords comprising of ‘Prevalence’ AND ‘Tooth Agenesis’ AND ‘Nonsyndromic or Syndromic’. From 2014 to 2024, there were only five non-syndromic tooth agenesis case reports were included to be reviewed. The review of multiple case reports of tooth agenesis demonstrated significant variability in clinical and radiography evaluation involving inheritance pattern. By early identification in mixed dentition, the comprehensive and individualized treatment approaches are required to address both esthetics and functional outcomes. Further population-based studies of genetic involvement in TA can contribute early detection of malocclusion.   
The Role of PAX9 and MSX1 Variants in Non-Syndromic Tooth Agenesis Finna; Ameta Primasari; Sry Suryani Widjaja; Thantrira Porntaveetus; Ervina Sofyanti
Dentika: Dental Journal Vol. 28 No. 2 (2025): Dentika: Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v28i2.20787

Abstract

Non-syndromic tooth agenesis (NSTA) is the congenital absence of teeth without systemic involvement. Genetic polymorphisms in PAX9 and MSX1 are implicated in tooth development, but results vary across populations. Therefore, this study aims to explore the role of PAX9 c.-1031G>A and MSX1 671 T>C polymorphisms with NSTA in individuals from Medan. A total of 13 NSTA patients and 26 control were genotyped using PCR-restriction fragment length polymorphism (PCR-RFLP). The results showed that the AA genotype of PAX9 was absent in NSTA cases but found in 26.92% of controls. The GG genotype was reported to be more common in 38.46% of cases, while the G allele was prevalent in 69.23%. These trends suggested a potential association, but it was not statistically significant. In this study, all patients carried the TT genotype for MSX1. These results show a possible role of PAX9 polymorphisms in NSTA susceptibility and support the need for further studies in larger populations.   Keywords: Non-Syndromic, Tooth Agenesis, PAX9, MSX1
The Potential of Salivary Lysozyme Level Examination as Caries Biomarker: A Scoping Review Albertus Luis Sandro Samosir; Ameta Primasari
Dentika: Dental Journal Vol. 28 No. 2 (2025): Dentika: Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v28i2.21593

Abstract

Salivary lysozyme is an antimicrobial enzyme naturally present in human saliva. It is widely recognized as a potential non-invasive biomarker for the early detection of dental caries, which remains a major global oral health concern. Lysozyme plays a significant role in oral immunity by degrading bacteria cell walls and maintaining microbial homeostasis. Therefore, this scoping review aimed to evaluate the potential of salivary lysozyme as a caries biomarker using PRISMA. The method was based on literature searches conducted in Scopus and PubMed databases between 2013 and 2023. The results showed that there were variations in lysozyme concentration according to caries status, where lower levels were often associated with a higher risk, but increased levels showed an active immune response to bacterial infection. Despite methodological differences among studies, there was association between salivary lysozyme concentration and caries severity, underscoring the diagnostic potential. Due to the non-invasive nature, ease of collection, and biochemical stability, salivary lysozyme examination could be applicable in both clinical and preventive settings. However, larger and standardized studies should be conducted in further studies to validate clinical reliability and diagnostic accuracy.