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All Journal Majalah Kedokteran Bandung Media Penelitian dan Pengembangan Kesehatan Global Medical and Health Communication The Indonesian Biomedical Journal Indonesian Journal of Obstetrics & Gynecology Science The Southeast Asian Journal of Midwifery Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care) Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Benny Hasan Purwara
Department Of Obstetric And Gynecology, Faculty Of Medicine, Universitas Padjadjaran, Bandung
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : The Indonesian Biomedical Journal

 1 
Correlation of Maternal Serum Hepcidin, Soluble Transferrin Receptor (sTfR) and Cholecalciferol with Third Trimester Anemia: Findings from A Nested Case-control Study on A Pregnancy Cohort Raden Tina Dewi Judistiani; Sefty Mariany Samosir; Setyorini Irianti; Benny Hasan Purwara; Budi Setiabudiawan; Johannes Cornelius Mose; Budi Handono
The Indonesian Biomedical Journal Vol 12, No 4 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i4.1252

Abstract

BACKGROUND: Cholecalciferol, hepcidin, and soluble transferrin receptor (sTfR) interaction play an essential role in iron hemostasis. Anemia in pregnancy contributes to morbidity and mortality both for the mother and baby. In this study, we assessed the correlation between hepcidin, sTfR and cholecalciferol in third trimester maternal anemia. We aimed to find the cut-off for hepcidin and sTfR.METHODS: A case-control study involving 56 pregnant women in each anemia and healthy group was nested on a previous larger cohort study in Indonesia. Serum hepcidin, sTfR and cholecalciferol level were measured by enzyme-linked immunosorbent assay (ELISA) method.RESULTS: Serum hepcidin and sTfR level were significantly higher in case group, while serum cholecalciferol level has no difference between the two groups. New cut-off points were found for hepcidin (<15.93 ng/mL) and sTfR level (>2234.45 ng/mL). Low level of hepcidin (OR=5.32) and high level of sTfR (OR=8.28) increase the risk of anemia. High level of sTfR (adjusted OR=4.725; CI 95%=1.730-12.904; p=0.02) was the most important factor contributes to anemia, followed by the low level of hepcidin (adjusted OR=3.677; CI 95%=1.363-9917; p=0.01).CONCLUSION: The high level of sTfR is the most important factor related to anemia in the third trimester, followed by the low level of hepcidin. Low cholecalciferol level tends to favor the incident of anemia. The new cut-off point of third trimester sTfR and third trimester hepcidin were established in this study and may be useful for risk assessment and treatment monitoring for anemia in pregnancy.KEYWORDS: anemia, cholecalciferol, hepcidin, pregnancy, soluble transferrin receptor
Co-Authors Abdurrahman, Muniroh Adhi Pribadi Alamsyah Aziz Andi Rinaldi Anita Deborah Anwar Ardini S. Raksanagara Ardini S. Raksanagara, Ardini S. Astri Novianti Atiek Novianty Aziz, Muhammad Alamsyah Bharata Yudha Birgitta M. Dewayani Budi Handono Budi Setiabudiawan Cytta Nirmala Dian Tjahyadi Edwin Armawan Elsa Pudji Setiawati Elsa Pudji Setiawati Elsa Pudji Setiawati Eppy Darmadi Achmad Farid Husin Ferina Ferina Ferina Ferina Ferina, Ferina Fitria Fitria Hadi Susiarno Hadyana Sukandar Hadyana Sukandar Hadyana Sukandar Hadyana Sukandar Hanom Husni Syam Harsono, Ali Budi Herman Susanto Herry Herman Indra Gazali Irvan Afriandi Johanes Cornelius Mose Johannes Cornelius Mose Jusuf Sulaeman Effendi Jusuf Sulaeman Effendi Jusuf Sulaeman Effendi Jusuf Sulaeman Effendi M. Rizkar Arev Sukarsa Madjid, Tita Husnitawati MARINGAN DIAPARI LUMBAN TOBING Masitoh, Imas Melia Juwita Adha Mira Dyani Dewi Mose, Johannes Cornelius Muniroh Abdurrahman Muniroh Abdurrahman Nurlina Juniar Nurrasyidah, Nurrasyidah Queen Khoirun Nisa Mairo, Queen Khoirun R. M. Sonny Sasotya Rachmat Zulkarnain Raden Tina Dewi Judistiani Radiastomo Samekta Budi Ruswana Anwar Sari Puspa Dewi Sefty Mariany Samosir Setyorini Irianti Sofie R. Krisnadi Sri Endah Rahayuningsih Sunardi Sunardi Susiarno, Hadi Syahbana, Chandra Garnida Teuku Kyan Nuryasin Tita Husnitawati Madjid Tita Husnitawati Madjid Tono Djuwantono Tuti Wahmurti Vita Murniati Tarawan Willa Follona Windy Puspa Kusumah Wiryawan Permadi Yudi Mulyana Hidayat Zulvayanti Zulvayanti