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All Journal Berkala Kedokteran Jurnal Penyakit Dalam Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Jurnal Medika Hutama Jurnal Kesehatan Saintika Meditory Muhammadiyah Journal of Geriatric Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) GANESHA MEDICINA MEDICINUS Jurnal Kedokteran Meditek Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD) Cermin Dunia Kedokteran Proceeding Mulawarman International Conference on Tropical Public Health
Ida Bagus Aditya Nugraha
Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Udayana, RSUP Sanglah,Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Hubungan Kadar Lemak Viseral dengan Kejadian Obesitas Lansia yang Menderita Diabetes Mellitus Tipe 2 Nugraha, Ida Bagus Aditya; Semaradana, Wayan Giri Putra; Wijayanti, Ni Made Sri; Adnyani, Ni Made Dwi; Laksmi, Ida Ayu Sri Indra; Hendrajaya, Andre; Alvarocky, Rigky; Idris, Prizan Kenny
Muhammadiyah Journal of Geriatric Vol 2, No 1 (2021): Muhammadiyah Journal of Geriatric
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.521 KB) | DOI: 10.24853/mujg.2.1.33-39

Abstract

Latar Belakang: Lemak viseral berkaitan dengan peningkatan risiko kardiovaskular khususnya pada pasien obesitas dengan Diabetes Mellitus tipe 2 (DMT2). Obesitas khususnya obesitas sentral merupakan kondisi penumpukan lemak pada regio perut atau abdominal yang dibuktikan dengan pengukuran indikator lingkar abdomen (atau rasio lingkar abdomen dengan lingkar pinggang). Diabetes sering terkait dengan obesitas dan khususnya pada lansia merupakan populasi yang sangat rentan. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan kadar lemak visceral dengan kejadian obesitas pada lansia DMT2 di Kabupaten Sumbawa Besar. Metode: Metode yang digunakan kasus kontrol, dengan jumlah sampel penelitian berdasar rumus besar sampel sejumlah 41 sampel pasien lansia DMT2 yang berkunjung ke Poliklinik Geriatri RSUD Sumbawa Besar dan RSU Provinsi Manambai, yang memenuhi kriteria inklusi. Analisis data dengan uji Chi Square lalu dengan menghitung rasio odd. Pengolahan data menggunakan program SPSS 16.0 for Windows. Hasil: Didapatkan hubungan yang bermakna antara tingginya kadar lemak viseral dengan kejadian obesitas pada lansia DMT2 dengan p=0.008 (0.05). Pasien DMT2 dengan kadar lemak viseral tinggi memiliki kemungkinan 6.3 kali untuk mengalami obesitas {IK 95% (1.522 - 26.081)}. Simpulan: Terdapat hubungan tingginya kadar lemak viseral dengan obesitas pada lansia dengan DMT2. Perlu diadakan penelitian lanjutan sehingga memberikan efek preventif pada lansia DMT2 dengan obesitas. 
Diagnostic and Management of Idiophatic Panhypopituitarism A Case Report Ida Bagus Aditya Nugraha; Komang Agus Wira Nugraha; Anak Agung Gede Budhiarta; Ketut Suastika; Wira Gotera; Made Ratna Saraswati; I Made Pande Dwipayana; I Made Siswadi Semadi
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 1 (2024): InaJEMD Vol. 1, No. 1
Publisher : PP PERKENI

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Abstract

Hypopituitarism is marked by decreased secretion of one, several, or all anterior or posterior pituitary hormones. A rare disorder, panhypopituitarism indicates the loss of all the pituitary hormones but often is used in clinical practice to describe a patient's deficiency in growth hormone, gonadotropins, corticotropin, and thyrotropin in whom the posterior pituitary function remains intact. Hypopituitarism may occur because of diverse etiologies and lead to substantial morbidity and mortality. Despite advances in the diagnosis and management of pituitary disorders, hypopituitarism is still associated with increased long-term cardiovascular mortality. We report a rare case of a 22-year-old boy with idiopathic panhypopituitarism. The patient has deficiency of growth hormone, gonadotropin, corticotropin, and thyrotropin, yet the underlying etiology remains unknown in this patient because of lack of imaging data. This is very challenging to do prompt diagnosis and management of panhypopituitarism. The management is needing multiple hormonereplacement therapy, based on the result of pituitary hormone laboratory examination. Prompt treatment is needed to prevent further morbidity and mortality in this patient. hypothyroidism, growth hormon
Comparison of Anti Thyroid Drugs, Radioactive Iodine and Surgery for Graves’ Disease: A Systematic Review and Meta-Analysis Dian Daniella; Ida Bagus Aditya Nugraha; Wira Gotera
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 2 (2024): InaJEMD Vol. 1, No. 2
Publisher : PP PERKENI

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Abstract

Selection of therapy for Graves’ Disease (GD) has always been a puzzling decision to be taken by both the patient and physician. This is due to the three modalities (Anti Thyroid Drug (ATD), Radioactive Iodine (RAI) and surgery) in with each one being just as established as the other two in being an effective treatment strategy. Therefore, this study was conducted in purpose to compare ATD, RAI and surgery for GD. The author searches from several databases such as PubMed, Directory of Open Access Journals (DOAJ), and Science Direct as well as registers, such as Cochrane Central Register of Controlled Trials (CENTRAL). The systematic review was incorporated to all of seven studies and six studies has been selected to be included in the analysis. ATD has higher risk of relapse compared to RAI (RR 2.77, 95% CI 0.99–7.75); p=0.05) and surgery (RR 6.60, 95% CI 3.76–11.58); p<0.00001). In comparison to surgery, RAI has higher risk of relapse (RR 2.52, 95% CI 0.66–9.67); p 0.18). ATD has lower success rate compared to RAI (RR 0.47, 95% CI 0.35–0.63); p<0.00001) and surgery (RR 0.44, 95% CI 0.34–0.58); p<0.00001). ATD has lower risk of hypothyroid compared to RAI (RR 0.08, 95% CI 0.02–0.27); p<0.0001) and surgery (RR 0.09, 95% CI 0.02–0.40); p=0.001). ATD has the highest risk of relapse compared to RAI and surgery. RAI and surgery did not differ significantly in risk of relapse and hypothyroid.
Approach to Diagnosis and Management of An Elderly Female Patient with Recurrent Hypocalcemia Ida Bagus Aditya Nugraha
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 2 (2024): InaJEMD Vol. 1, No. 2
Publisher : PP PERKENI

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Abstract

Disorders of calcium metabolism are common in the everyday clinical setting. Although hypocalcemia is not as common as hypercalcemia, it can be life-threatening if not properly recognized and treated promptly. Causes of hypocalcemia can be divided into three broad categories, such as parathyroid hormone (PTH) deficiency, high PTH levels, and other causes. There is no literature that specifically discusses the incidence and prevalence of hypocalcemia in general. In general, renal failure is the most common cause of hypocalcemia. This condition is followed by vitamin D deficiency, magnesium deficiency, acute pancreatitis, and others. The clinical presentation of hypocalcemia can vary widely, from asymptomatic to life-threatening. In an emergency, unrecognized or poorly managed hypocalcemia can cause significant morbidity or mortality. Symptomatic patients with classic clinical findings of acute hypocalcemia require immediate resuscitation and evaluation. However, most cases of hypocalcemia are found based on clinical suspicion as well as appropriate laboratory testing. Treatment of hypocalcemia depends on the presence and severity of symptoms, degree of hypocalcemia, and etiology of hypocalcemia. Most cases of hypocalcemia are clinically mild and require only supportive treatment and further laboratory evaluation. Oral calcium absorption may be indicated for outpatient treatment in mild cases. In cases of severe hypocalcemia leading to seizures, tetany, refractory hypotension, or arrhythmias, a more aggressive approach may be required, including intravenous calcium infusion.  
The Comparison of X-ray Finding in Pulmonary Tuberculosis with and without Diabetes Mellitus Ida Bagus Aditya Nugraha; Wira Gotera; Made Nian Anggara
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 2 (2024): InaJEMD Vol. 1, No. 2
Publisher : PP PERKENI

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Abstract

Diabetes Mellitus patients are considered as a high-risk population for the development of Pulmonary Tuberculosis (PTB) by about three-fold. Diabetes Mellitus sufferers by glycated haemoglobin A1C (HbA1C) level. The relative risk (RR) of Tuberculosis (TB) was 3,1 (95% CI 1.6-5.9) for those with HbA1C ≥7%. There are several contradictory opinions regarding the radiological appearance of TBC sufferers with genuine effect of DM. Chest X-ray remains the primary investigation for the assessment of PTB. Pulmonary Tuberculosis is found predominantly in the lung apices. It is not clear whether DM can affect the presentation of TB. Thus, whether diabetic subjects present atypical radiological presentation of PTB is still controversial. There have been several studies with contradictory results regarding the differences in the radiological appearance of PTB patients with and without DM. Clinical studies have shown ambiguous results. Any other risk factors maybe associated with age, sex, smoking status, and nutrition status.
Keganasan Kolorektal dengan Fenomena Raynaud Sekunder Ni Made Dwi Adnyani; Ida Bagus Aditya Nugraha; Gede Kambayana
Cermin Dunia Kedokteran Vol 46 No 12 (2019): Kardiovakular
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i12.396

Abstract

Penyakit Raynaud adalah penyakit vaskuler primer yang ditandai dengan spasme sementara pada arteri kecil dan arteriol, biasanya di jari tangan atau, yang lebih jarang, jari kaki. Penyebab penyakit Raynaud dapat primer atau sekunder; salah satu penyebab sekunder adalah proses keganasan. Dilaporkan kasus pada pasien laki-laki, usia 46 tahun, suku Jawa dengan fenomena Raynaud sekunder diduga akibat kanker kolorektal. Raynaud’s disease is a primary vascular disease characterized by temporary spasm of small arteries and arterioles, usually in fingers or, rarely, in toes. The cause of Raynaud’s disease can be primary and secondary; one of the secondary causes is malignancy. This is a case of a 46 year-old Javanese male with secondary Raynaud’s phenomenon associated with colorectal cancer.
Koinsidens Insulinoma dan Sindrom Cushing: Laporan Kasus Aditya Nugraha, Ida Bagus; Gotera, Wira
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 2 (2025): Juni 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i2.1505

Abstract

Latar belakang: Insulinoma adalah tumor neuroendokrin langka yang menyebabkan pelepasan insulin yang tidak tepat. Penggunaan kortikosteroid kronis adalah penyebab paling umum dari Sindrom Cushing. Tujuan: mempelajari tentang kasus khusus dan langka Deskripsi Kasus: Seorang wanita obesitas berusia 39 tahun dengan riwayat gejala hipoglikemik berulang dirujuk ke rumah sakit kami dengan keluhan utama moon face, striae, dan beberapa plak annular berwarna merah muda di dada dan perut. Dia sebelumnya diobati dengan kortikosteroid dosis tinggi dan jangka panjang selama 8 tahun tanpa mengetahui etiologi dari kondisi hipoglikemia yang terus-menerus. Tes darah menunjukkan kadar insulin puasa dan c-peptida yang tinggi meskipun kadar glukosa plasma rendah. Meskipun pemindaian tomografi terkomputerisasi tidak menunjukkan adanya kelainan, pemeriksaan pencitraan resonansi magnetik menunjukkan adanya massa seperti insulinoma di pankreas. Dosis steroid dan krim antijamur topikal diberikan untuk terapi medis. Ia kemudian dijadwalkan untuk menjalani operasi enukleasi tumor. Setelah operasi, glukosa darahnya kembali ke kisaran normal. Kesimpulan: Dokter harus lebih waspada dalam mendiagnosis pasien dengan hipoglikemia berulang. Penggunaan steroid harus dipertimbangkan dengan bijak, bahkan di daerah dengan sumber daya yang terbatas.
Penapisan dan Diagnosis Diabetes Melitus pada Pelayanan Kesehatan Primer Aditya Nugraha, Ida Bagus
Ganesha Medicina Vol. 5 No. 1 (2025)
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/gm.v5i1.92345

Abstract

Diabetes melitus (DM) merupakan penyakit multifaktorial yang dapat menimbulkan komplikasi baik akut maupun kronis serta dapat menurunkan kualitas hidup penderitanya. Prevalensi DM di seluruh dunia terus meningkat setiap saat. DM sendiri dibedakan menjadi 4 yaitu DM tipe 1, DM tipe 2, DM tipe lain dan diabetes gestasional. Skrining terhadap DM sangat penting karena dapat berimplikasi pada semakin dini terapi diberikan, yang pada akhirnya menurunkan perkembangan DM. Sangat sulit untuk mendiagnosis DM pada fase awal penyakit karena gejalanya biasanya tidak menunjukkan gejala. Pelayanan kesehatan primer (PHC) merupakan pintu masuk awal bagi pasien dalam sistem pelayanan kesehatan khususnya di Indonesia. Puskesmas lebih bergerak pada bidang kesehatan masyarakat dan merupakan tempat yang strategis dalam melakukan skrining dan diagnosis dini penyakit DM. Skrining DM tergantung pada jenis DM dimana tidak dianjurkan untuk melakukan skrining DM tipe 1, skrining setiap 3 bulan pada orang berisiko tinggi/umur > 45 tahun untuk DM tipe 2, dan skrining pada saat diketahui kehamilan untuk diabetes gestasional. Diagnosis DM di Puskesmas dilakukan sesuai dengan pedoman diagnosis DM yang dikeluarkan oleh Kementerian Kesehatan RI atau Perkeni.
AI-Driven Occupational Health and Safety Innovation: The Sehat Kerjaku Application Supporting CHSE at Hospitality Sector Lestari, Ida Ayu Indira dwika; Nugraha, Ida Bagus Aditya; Dewi, Etick Pristyan; Wardana, I Putu Mahendra Adi
Mulawarman International Conference on Tropical Public Health Vol. 2 No. 2 (2025): The 4th MICTOPH
Publisher : Faculty of Public Health Mulawarman University, Indonesia

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Abstract

Background : Stunting remains a significant chronic nutritional problem in Indonesia, particularly among children born to adolescent mothers. These young mothers often face limitations in nutritional knowledge, lower health literacy, and suboptimal reproductive preparedness, which collectively increase the risk of stunting in their children. Objective : This study aimed to conduct a review to determine the association between adolescent mothers’ nutritional knowledge and the incidence of stunting in toddlers, and to identify the contributing factors. Research Methods/ Implementation Methods : This was a systematic review conducting following the PRISMA guidelines and utilizing the Population, Concept, and Context (PCC) framework. Articles were collected through searching the Scopus, PubMed, Google Scholar, and Crossref databases for studies up to October 2025. Two reviewers independently screened and included full- text article that examined Mothers Knowledge and stunting, focusing on the concept of knowledge, adolescent mother, and stunting. Results : A review included five articles. Adolescent mothers’ knowledge had a significant association with the incidence of stunting. This association was often strengthened by confounding factors such as socio-economic status, low education levels, limited access to healthcare services, and inadequate childcare practices. Several studies found that improving maternal nutritional literacy and initiating early prenatal care can effectively reduce the risk of stunting in children. Conclusion/Lesson Learned : Low nutritional knowledge among adolescent mothers is confirmed as an important determinant of stunting in toddlers. Intervention efforts need to be focused on enhancing the education and nutritional literacy of adolescent girls through structured programs, including school-based education, adolescent mother classes in community health centers (Puskesmas), and targeted community campaigns. The integrated approach is crucial to break the intergenerational cycle of stunting and foster the development of quality human resources.
Relationship between Interleukin 6 and Estradiol Levels in Obese and Adult Men Dwipayana, I Made Pande; Semadi, I Made Siswadi; Nugraha, Ida Bagus Aditya; Gotera, Wira; Saraswati, Made Ratna; Suastika, Ketut; Saraswati, Putu Ayu Indah
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.24498

Abstract

Obesity is a chronic disease characterized by a pathophysiological process that causes an increase in adipose tissue mass, leading to an increased risk of morbidity and mortality. Currently, there are many conditions that allow the interaction between environmental factors and genes that lead to various metabolic disease complications, such as diabetes mellitus and heart attack. Health workers are at the forefront of managing obesity and its associated complications. The study was conducted at Ngoerah Hospital from March to October 2024. The target population in this study were adult male medical personnel with and without obesity, working at Ngurah Hospital. The inclusion criteria in this study: male health workers in the environment at Ngoerah Hospital aged 18-45 years and willing to participate in the study by signing informed consent. Exclusion criteria in this study were all male health workers with infectious or inflammatory diseases, and or suffering from malignancies or a history of chemotherapy, and or with the use of hormonal therapy. The sample size of the study was 64 subjects. Data analysis included descriptive statistics, a normality test using the Kolmogorov-Smirnov test, a comparison test using the Mann-Whitney U test, and a correlation test using the Spearman rank correlation. This study was approved by the Research Ethics Commission, approval number 1697/UN14.2.2.VII.14/LT/2024. The results of this study found that IL-6 and estradiol levels in the obese group were higher than the non-obese group, however, the differences were not statistically significant. This may be attributed to the relatively young age of the subjects and the absence of significant inflammation in the early stages of obesity. There was no significant correlation between IL-6 and estradiol in all subjects, obese and non-obese groups.
Co-Authors Adnyani, Ni Made Dwi Alvarocky, Rigky Anak Agung Gde Budhiarta Anak Agung Gde Budhiarta Anak Agung Gede Budhiarta Budhiarta, Anak Agung Gde Budiartha, Anak Agung Gede Dewi, Etick Pristyan Dian Daniella Dwijo Anargha Sindhughosa FRANKY SIMARMATA Franky Simarmata Gede Kambayana Hendrajaya, Andre I Gusti Made Sumapta I Ketut Suastika I Made Pande Dwipayana I Made Siswadi Semadi I Made Siswadi Semadi I Made Siswadi Semadi I Wayan Wawan I Wayan Wita I. K. Suastika Idris, Prizan Kenny Intizam, Marwa Humaira Ketut Suardamana Komang Agus Wira Nugraha Laksmi, Ida Ayu Sri Indra Lestari, Ida Ayu Indira Dwika LP Dea Sasmita P Made Nian Anggara MADE RATNA SARASWATI . Marisye Christantia Ni Made Dwi Adnyani Ni Made Dwi Adnyani Novia, Juvita Pradiptha, I Putu Yupindra R. Prawira Bayu Putra Dewa RIONALDO ANTHONIUS S., Hantono Saraswati, Putu Ayu Indah Semaradana, Wayan Giri Putra Sumapta, I Gusti Made Wardana, I Putu Mahendra Adi Wayan Evie Frida Yustin Wedari, Ni Nyoman Ira Santi Wijayanti, Ni Made Sri Winarka, Made Arie Dwi Wira Gotera